Reactome | PPTN11 dephosphorylates SPRY2

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PPTN11 dephosphorylates SPRY2 Show undefined attributes

catalystActivity	[CatalystActivity:10374396] protein tyrosine phosphatase activity of PTPN11 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378664
displayName	PPTN11 dephosphorylates SPRY2
eventOf	[Pathway:R-BTA-1295596] Spry regulation of FGF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1549564] PPTN11 dephosphorylates SPRY2 - Homo sapiens
input	[Complex:R-BTA-1295625] PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PPTN11 dephosphorylates SPRY2
output	[EntityWithAccessionedSequence:R-BTA-74686] GRB2 [cytosol] [Complex:R-BTA-934598] PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane]
precedingEvent	[Reaction:R-BTA-1295613] SPRY2 binds GRB2 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1549564
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1295596] Spry regulation of FGF signaling
(inferredTo)	[Reaction:R-HSA-1549564] PPTN11 dephosphorylates SPRY2

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