Reactome | Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements

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Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378642
displayName	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements
eventOf	[Pathway:R-BTA-1181150] Signaling by NODAL - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-199305] FOXO3 [nucleoplasm] [OtherEntity:R-ALL-1535904] FoxO3a-binding Element [nucleoplasm] [DefinedSet:R-BTA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements
output	[Complex:R-BTA-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-BTA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1535903
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1181150] Signaling by NODAL
(inferredTo)	[Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements

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