Reactome | Salvage - Sepiapterin is reduced to q-BH2

Schema > Reaction > Entries

Salvage - Sepiapterin is reduced to q-BH2 Show undefined attributes

catalystActivity	[CatalystActivity:10378082] sepiapterin reductase (NADP+) activity of p-SPR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378599
displayName	Salvage - Sepiapterin is reduced to q-BH2
eventOf	[Pathway:R-BTA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Bos taurus [Pathway:R-BTA-203615] eNOS activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1497796] BH2 binding can lead to eNOS uncoupling - Bos taurus
inferredFrom	[Reaction:R-HSA-1497869] Salvage - Sepiapterin is reduced to q-BH2 - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-1497811] sepiapterin [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Salvage - Sepiapterin is reduced to q-BH2 H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-1497857] q-BH2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1497869
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [Pathway:R-BTA-203615] eNOS activation
(precedingEvent)	[Reaction:R-BTA-1497796] BH2 binding can lead to eNOS uncoupling
(inferredTo)	[Reaction:R-HSA-1497869] Salvage - Sepiapterin is reduced to q-BH2

Cite Us!