Reactome | Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

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Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II Show undefined attributes

catalystActivity	[CatalystActivity:10378089] cGMP-dependent protein kinase activity of PRKG2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378597
displayName	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II
eventOf	[Pathway:R-BTA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) - Bos taurus
inferredFrom	[Reaction:R-HSA-1497853] Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-1497791] SPR dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-1497817] p-SPR dimer [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1497853
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(precedingEvent)	[Reaction:R-BTA-1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR)
(inferredTo)	[Reaction:R-HSA-1497853] Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

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