Reactome | PC is converted to PS by PTDSS1

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PC is converted to PS by PTDSS1 Show undefined attributes

catalystActivity	[CatalystActivity:10378530] transferase activity of PTDSS1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10378532
displayName	PC is converted to PS by PTDSS1
eventOf	[Pathway:R-BTA-1483101] Synthesis of PS - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1482776] PS is hydrolyzed to 1-acyl LPS by PLA2G2A - Bos taurus [Reaction:R-BTA-1482771] PS is hydrolyzed to 1-acyl LPS by PLA2[9] - Bos taurus [Reaction:R-BTA-1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10] - Bos taurus
inferredFrom	[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens
input	[SimpleEntity:R-ALL-200736] L-Ser [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is converted to PS by PTDSS1
output	[SimpleEntity:R-ALL-264618] Cho [cytosol] [SimpleEntity:R-ALL-1500646] PS [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-BTA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Bos taurus [Reaction:R-BTA-1483219] PC is exchanged with PI by PITPNB - Bos taurus [Reaction:R-BTA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Bos taurus [Reaction:R-BTA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1483186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1483101] Synthesis of PS
(precedingEvent)	[Reaction:R-BTA-1482776] PS is hydrolyzed to 1-acyl LPS by PLA2G2A [Reaction:R-BTA-1482771] PS is hydrolyzed to 1-acyl LPS by PLA2[9] [Reaction:R-BTA-1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10]
(inferredTo)	[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1