Reactome | FMO3:FAD N-oxidises TMA to TMAO

Schema > Reaction > Entries

FMO3:FAD N-oxidises TMA to TMAO Show undefined attributes

catalystActivity	[CatalystActivity:10341873] N,N-dimethylaniline monooxygenase activity of FMO3:FAD [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10341875
displayName	FMO3:FAD N-oxidises TMA to TMAO
eventOf	[Pathway:R-BTA-217271] FMO oxidises nucleophiles - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-139970] FMO3:FAD N-oxidises TMA to TMAO - Homo sapiens
input	[SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-30373] TMA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	FMO3:FAD N-oxidises TMA to TMAO Trimethylamine N-oxidised to Trimethylamine-N-oxide
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-140963] TMAO [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-139970
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-217271] FMO oxidises nucleophiles
(inferredTo)	[Reaction:R-HSA-139970] FMO3:FAD N-oxidises TMA to TMAO

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