Reactome | IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

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IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 Show undefined attributes

catalystActivity	[CatalystActivity:10376137] protein tyrosine kinase activity of IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10376139
displayName	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
eventOf	[Pathway:R-BTA-1266695] Interleukin-7 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-6785165] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-9025978] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5 phosphorylates STAT5
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-8982988] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-9025969] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-1295540
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1266695] Interleukin-7 signaling
(precedingEvent)	[Reaction:R-BTA-6785165] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
(inferredTo)	[BlackBoxEvent:R-HSA-1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

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