Reactome | ROS and RNS production in phagocytes

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ROS and RNS production in phagocytes Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444544
displayName	ROS and RNS production in phagocytes
eventOf	[Pathway:R-BTA-168249] Innate Immune System - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23005] cell redox homeostasis
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Bos taurus [Reaction:R-BTA-6789092] NOX2 generates superoxide anion from oxygen - Bos taurus [Reaction:R-BTA-1222516] Intraphagosomal pH is lowered to 5 by V-ATPase - Bos taurus [BlackBoxEvent:R-BTA-6788999] HV1-mediated H+ transfer - Bos taurus [Pathway:R-BTA-8941413] Events associated with phagocytolytic activity of PMN cells - Bos taurus [Reaction:R-BTA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Bos taurus
inferredFrom	[Pathway:R-HSA-1222556] ROS and RNS production in phagocytes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	ROS and RNS production in phagocytes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-1222556
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-168249] Innate Immune System
(inferredTo)	[Pathway:R-HSA-1222556] ROS and RNS production in phagocytes
(hasEncapsulatedEvent)	[Pathway:R-BTA-5668599] RHO GTPases Activate NADPH Oxidases [Pathway:R-BTA-8941413] Events associated with phagocytolytic activity of PMN cells

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