Reactome | Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10374968
displayName	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
eventOf	[Pathway:R-BTA-1169408] ISG15 antiviral mechanism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-936552] ISG15 [cytosol] [EntityWithAccessionedSequence:R-BTA-975992] NEDD4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
output	[Complex:R-BTA-1169384] ISG15:NEDD4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1169399
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-1169408] ISG15 antiviral mechanism
(inferredTo)	[Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding

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