Reactome | Resolution of AP sites via the multiple-nucleotide patch replacement pathway

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Resolution of AP sites via the multiple-nucleotide patch replacement pathway Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443282
displayName	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
eventOf	[Pathway:R-BTA-73933] Resolution of Abasic Sites (AP sites) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17139] base-excision repair, gap-filling
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-5649856] Oxidative damage to the AP site - Bos taurus [Reaction:R-BTA-5649854] Recruitment of POLB to oxidatively damaged AP site - Bos taurus [Reaction:R-BTA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Bos taurus [Pathway:R-BTA-110362] POLB-Dependent Long Patch Base Excision Repair - Bos taurus [Pathway:R-BTA-5651801] PCNA-Dependent Long Patch Base Excision Repair - Bos taurus
inferredFrom	[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
precedingEvent	[Pathway:R-BTA-73927] Depurination - Bos taurus [Pathway:R-BTA-73928] Depyrimidination - Bos taurus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-110373
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-73933] Resolution of Abasic Sites (AP sites)
(inferredTo)	[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway

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