Reactome | ERCC1:ERCC4 [nucleoplasm]

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ERCC1:ERCC4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-BTA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Bos taurus [Complex:R-BTA-6782142] TC-NER incision complex [nucleoplasm] - Bos taurus [Complex:R-BTA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Bos taurus [Complex:R-BTA-6785734] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] - Bos taurus
consumedByEvent	[Reaction:R-BTA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER - Bos taurus [Reaction:R-BTA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Bos taurus [Reaction:R-BTA-9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA - Bos taurus [Reaction:R-BTA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10340202
displayName	ERCC1:ERCC4 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-BTA-54427] ERCC1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-67445] ERCC4 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm] - Homo sapiens
maxDepth	2
name	ERCC1:ERCC4
producedByEvent	[Reaction:R-BTA-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Bos taurus [Reaction:R-BTA-109955] Formation of ERCC1:XPF heterodimeric complex - Bos taurus [BlackBoxEvent:R-BTA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Bos taurus [Reaction:R-BTA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Bos taurus [BlackBoxEvent:R-BTA-5686663] Completion of SSA - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-109943
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[BlackBoxEvent:R-BTA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) [Reaction:R-BTA-6782224] 3' incision by ERCC5 (XPG) in TC-NER [Reaction:R-BTA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER [Reaction:R-BTA-109955] Formation of ERCC1:XPF heterodimeric complex [BlackBoxEvent:R-BTA-5686663] Completion of SSA
(input)	[Reaction:R-BTA-6785732] DNA nucleases bind monoubiquitinated ID2 complex [Reaction:R-BTA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER [Reaction:R-BTA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER [Reaction:R-BTA-9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA
(hasComponent)	[Complex:R-BTA-6785734] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] [Complex:R-BTA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-BTA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-BTA-6782142] TC-NER incision complex [nucleoplasm] [Complex:R-BTA-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-BTA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-BTA-5691046] GG-NER incision complex:Open bubble dsDNA [nucleoplasm] [Complex:R-BTA-9980007] ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-BTA-9980005] ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(activeUnit)	[CatalystActivity:10410214] DNA endonuclease activity of TC-NER incision complex [nucleoplasm] [CatalystActivity:10408006] endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm] [CatalystActivity:10406363] DNA endonuclease activity of ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm]

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