Reactome | (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

Schema > Reaction > Entries

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) Show undefined attributes

catalystActivity	[CatalystActivity:10339637] 5'-nucleotidase activity of NT5C1A tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10339639
displayName	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)
eventOf	[Pathway:R-BTA-73621] Pyrimidine catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-109380] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) - Homo sapiens
input	[DefinedSet:R-ALL-500347] (d)CMP, TMP, (d)UMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) CMP + H2O => cytidine + phosphate dCMP + H2O => 2'-deoxycytidine + phosphate dTMP + H2O => thymidine + phosphate UMP + H2O => uridine + phosphate dUMP + H2O => 2'-deoxyuridine + phosphate
output	[DefinedSet:R-ALL-500346] (d)C, T, (d)U [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:R-HSA-71505] Positive regulation by 'ADP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-109380
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-73621] Pyrimidine catabolism
(inferredTo)	[Reaction:R-HSA-109380] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

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