Reactome | Polyubiquitinated RUNX3 is degraded by the proteasome

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Polyubiquitinated RUNX3 is degraded by the proteasome Show undefined attributes

catalystActivity	[CatalystActivity:9864668] endopeptidase activity of 26S proteasome [nucleoplasm]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9964976
displayName	Polyubiquitinated RUNX3 is degraded by the proteasome
eventOf	[Pathway:R-MMU-8941858] Regulation of RUNX3 expression and activity - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-8952400] Runx3 [cytosol]
isInDisease	false
isInferred	true
name	Polyubiquitinated RUNX3 is degraded by the proteasome
output	6 × [DefinedSet:R-MMU-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-MMU-8952399] Polyubiquitinated RUNX3 translocates to the cytosol - Mus musculus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8952408
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8941858] Regulation of RUNX3 expression and activity
(inferredTo)	[BlackBoxEvent:R-HSA-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome

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