Reactome | Upon sensing cytoplasmic LPS, caspase-4 (CASP4) forms oligom...

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created	[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
dbId	9947864
displayName	Upon sensing cytoplasmic LPS, caspase-4 (CASP4) forms oligom...
literatureReference	[LiteratureReference:9652838] Inflammatory caspases are innate immune receptors for intracellular LPS [LiteratureReference:9948183] Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence [LiteratureReference:9948151] SERPINB1-mediated checkpoint of inflammatory caspase activation
modified	[InstanceEdit:9960531] Shamovsky, Veronica, 2025-07-14
schemaClass	Summation
text	Upon sensing cytoplasmic LPS, caspase-4 (CASP4) forms oligomers/dimers (Shi J et al. 2014; Fern�ndez-Duran I et al., 2021). Oligomerization is thought to bring CASP4 molecules into close proximity, facilitating CASP4 activation through self-cleavage (Shi J et al. 2014). SERPINB1 binding to CASP4 monomers limits the activity of CASP4 by preventing CASP4 oligomerization and activation (Choi YJ et al., 2019).

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