Reactome | CD5L (also called AIM) is secreted from macrophages, binds l...

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created	[InstanceEdit:9947405] May, Bruce, 2025-05-05
dbId	9947416
displayName	CD5L (also called AIM) is secreted from macrophages, binds l...
literatureReference	[LiteratureReference:9968231] CD5L associates with IgM via the J chain [LiteratureReference:9968241] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity [LiteratureReference:9969936] Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells [LiteratureReference:9969928] The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein [LiteratureReference:9969948] Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M
modified	[InstanceEdit:9969965] May, Bruce, 2025-10-25
schemaClass	Summation
text	CD5L (also called AIM) is secreted from macrophages, binds lipopolysaccharide and lipoteichoic acid of bacteria (Sarrias et al. 2005, Martinez et al. 2014) and, hence binds intact bacteria. CD5L forms circulating complexes with soluble IgM (Arai et al. 2013; Hiramoto et al. 2018, Chen et al. 2024, Wang et al. 2024), and dissociates from IgM in disease conditions such as acute or chronic kidney injury (Arai et al. 2016, Yasuda et al. 2024). CD5L interacts with the scavenger receptor CD36 on plasma membranes (inferred from mouse homologs in Kurokawa et al. 2010).

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