A decarboxylated derivative of AGT(25-32) (Angiotensin-(1-8)...

created [InstanceEdit:9945033] May, Bruce, 2025-04-08
dbId 9945034
displayName A decarboxylated derivative of AGT(25-32) (Angiotensin-(1-8)...
literatureReference
modified [InstanceEdit:9945722] May, Bruce, 2025-04-17
schemaClass Summation
text A decarboxylated derivative of AGT(25-32) (Angiotensin-(1-8)) designated Angiotensin A (Ang A) was discovered circulating in human blood (Jankowski et al. 2007). The N-terminal aspartate residue of AGT(25-32) is decarboxylated to yield an alanine residue, thus the sequence of Ang A is Ala-Arg-Val-Tyr-Ile-His-Pro-Phe. The enzyme that catalyzes the decarboxylation reaction is not yet identified.
The C-terminal phenylalanine residue of Ang A is cleaved by ACE2, yielding Alamandine, a ligand of MRGPRD (MrgD) which may act in the counter-regulatory (anti-hypertensive, anti-inflammatory) axis of the renin-angiotensin system (reviewed in Bader et al. 2024, Proença et al. 2024).
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