Reactome | PIP5K1C (also known as PIPKIgamma or Phosphatidylinositol 4-...

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created	[InstanceEdit:9935210] Orlic-Milacic, Marija, 2025-01-13
dbId	9935214
displayName	PIP5K1C (also known as PIPKIgamma or Phosphatidylinositol 4-...
literatureReference	[LiteratureReference:9935213] Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin [LiteratureReference:9768742] Multiple post-translational modifications regulate E-cadherin transport during apoptosis [LiteratureReference:392559] Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
modified	[InstanceEdit:9935221] Orlic-Milacic, Marija, 2025-01-13
schemaClass	Summation
text	PIP5K1C (also known as PIPKIgamma or Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma), an enzyme initially implicated in the regulation of focal adhesions (Ling et al. 2002), was shown to be involved in trafficking of CDH1 (E-cadherin) to the plasma membrane and regulation of adherens junctions (Ling et al. 2007). Endogenous human PIP5K1C and CDH1 were shown to bind and co-localize in human breast carcinoma cell lines (Ling et al. 2007). Experiments with recombinant mouse PIP5K1C and recombinant human CDH1 have shown that PIP5K1C binds to the C-terminus of CDH1 (Ling et al. 2007). O-glycosylation of the C-terminus of CDH1 during apoptosis prevents PIP5K1C binding (Geng et al. 2012). Binding of CDH1 to catenins does not affect PIP5K1C binding (Ling et al. 2007).

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