At the site of the vessel wall damage, tissue factor (TF), f...

created [InstanceEdit:9934815] Shamovsky, Veronica, 2025-01-10
dbId 9934816
displayName At the site of the vessel wall damage, tissue factor (TF), f...
literatureReference
modified [InstanceEdit:9944377] Shamovsky, Veronica, 2025-04-04
schemaClass Summation
text At the site of the vessel wall damage, tissue factor (TF), factor VII (FVII), and FX form a ternary complex (Riewald M & Ruf W 2001; Norledge BV et al., 2003; Venkateswarlu D et al., 2003; reviewed in Rapaport SI & Rao LV, 1995; Lee CJ et al., 2010; Vadivel K & Bajaj SP 2012). Within this complex, FVII and FX reciprocally activate each other via proteolytic cleavage generating activated FVIIa and FXa. Once activated, FXa can remain associated with TF:FVII or may dissociate from TF:VII:FXa and TF:VIIa:FXa (Norledge BV et al., 2003; Venkateswarlu D et al., 2003).

This Reactome event shows the release of FXa from the TF:FVII:FXa complex. When released, soluble FXa binds to factor V (FV). The resulting prothrombinase FXa:FVa complex cleaves prothrombin (factor II) to thrombin (factor IIa), a key enzyme that further catalyzes the conversion of fibrinogen to fibrin, leading to the formation of a stable blood clot.

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