Reactome | MIS18BP1 (also known as M18BP1 or Mis18-binding protein 1), ...

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created	[InstanceEdit:9929906] Orlic-Milacic, Marija, 2024-11-29
dbId	9929911
displayName	MIS18BP1 (also known as M18BP1 or Mis18-binding protein 1), ...
literatureReference	[LiteratureReference:9929665] Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability [LiteratureReference:9929888] A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly [LiteratureReference:606344] Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1
schemaClass	Summation
text	MIS18BP1 (also known as M18BP1 or Mis18-binding protein 1), a component of the MIS18 complex that regulates targeting of CENPA to centromeres (Fujita et al. 2007), was reproducibly identified as a CCNA:CDK1 target in a high-throughput screen (Dumitru et al. 2017). In G2, phosphorylation of a consensus CDK site T653 in MIS18BP1, which is dependent on CDK1/CDK2 activity, prevents premature recruitment of MIS18BP1 to the centromeres, while it does not affect the assembly of the MIS18 complex (Stankovic et al. 2017).

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