SGO1 (also known as SGOL1 or Shugoshin 1), a protein esse...

SGO1 (also known as SGOL1 or Shugoshin 1), a protein essential for cohesion of sister chromatids and proper seggregation of duplicated chromosomes during mitosis, was found to bind to CCNA2 specifically in G2 as compared with S phase (Pagliuca et al. 2011) and was reproducibly identified as a substrate of CCNA:CDK1 (Dumitru et al. 2017).

SGO1 was shown to be phosphorylated by CDK1 in vivo at an evolutionarily conserved consensus CDK1/2 site T346, and this site was shown to be phosphorylated in vitro by the CCNB1:CDK1 complex, while CCNA:CDK1 complexes were not tested as catalysts (Liu et al. 2013). CDK1-mediated phosphorylation of SGO1 facilitates SGO1-mediated recruitment of PP2A to the cohesin complex, thus preventing premature separation of duplicated chromosomes (Liu et al. 2013).