Endogenous CCNA2 is exclusively nuclear in S phase but shows...

created [InstanceEdit:9929553] Orlic-Milacic, Marija, 2024-11-26
dbId 9929556
displayName Endogenous CCNA2 is exclusively nuclear in S phase but shows...
literatureReference
schemaClass Summation
text Endogenous CCNA2 is exclusively nuclear in S phase but shows both nuclear and cytosolic localization from early G2 (Gheghiani et al. 2017, Silva Cascales et al. 2021). WEE1 activity does not affect the intracellular distribution of CCNA2 (Gheghiani et al. 2017, Silva Cascales et al. 2021). Inhibition of CDK1 and CDK2 catalytic activity does not compromise cytoplasmic accumulation of CCNA2 once initiated (Silva Cascales et al. 2021). CDK1 appears to facilitate the translocation of CCNA2 to the cytosol, while CDK2 has no effect, although both CDK1 and CDK2 co-immunoprecipitate with cytosolic CCNA2 (Silva Cascales et al. 2021). Cytosolic CCNA2 promotes PLK1 activation (Silva Cascales et al. 2021).
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