The 3' and 5' ends of DENV genomic -ssRNA interact via compl...

created [InstanceEdit:9923534] Stephan, Ralf, 2024-10-01
dbId 9923514
displayName The 3' and 5' ends of DENV genomic -ssRNA interact via compl...
modified [InstanceEdit:9966301] Stephan, Ralf, 2025-09-14
schemaClass Summation
text The 3' and 5' ends of DENV genomic -ssRNA interact via complementary base pairing to form a circular RNA; this genome circularization, studied in BHK-21 (baby hamster kidney) cells, helps to bring the polymerase-promoter complex near the 3?-transcription initiation site and promotes the correct conformation of the 3? end of the genome during initiation of replication (Filomatori et al., 2006; reviewed in van den Elsen et al., 2021). We inferred this process from the same process involving +ssRNA.
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