NS3 subunit of the DENV replication complex unwinds viral RN...

created [InstanceEdit:9923534] Stephan, Ralf, 2024-10-01
dbId 9923513
displayName NS3 subunit of the DENV replication complex unwinds viral RN...
modified [InstanceEdit:9954383] Stephan, Ralf, 2025-06-07
schemaClass Summation
text NS3 subunit of the DENV replication complex unwinds viral RNA and melts its secondary structures, in the presence of any nucleoside triphosphate and Mn2+ or Mg2+ ions (Swarbrick et al., 2017; Xu et al., 2005; Incicco et al., 2023; Osawa et al., 2023; reviewed in van den Elsen et al., 2021). Interactions of NS3 with NS4B and NS5 within the replication complex enhance and modulate its helicase activity, and are critical for efficient viral RNA replication (Cui et al., 1998; Tay et al., 2015; Kundharapu & Chowdary, 2022; van den Elsen et al., 2021).
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