Dengue is a mosquito borne viral infection caused by dengue ...

created [InstanceEdit:9920233] Orlic-Milacic, Marija, 2024-08-29
dbId 9920234
displayName Dengue is a mosquito borne viral infection caused by dengue ...
modified [InstanceEdit:9954382] Stephan, Ralf, 2025-06-07
schemaClass Summation
text Dengue is a mosquito borne viral infection caused by dengue virus (DENV), a member of the Flaviviridae family, genus Flavivirus (reviewed in Neufeldt et al. 2018). Dengue is the most common arthropod borne viral infection in the world (reviewed in Rodenhuis-Zybert et al. 2010). Infection with DENV can proceed asymptomatically, result in a self limited dengue fever, or cause a more severe illness in the form of dengue hemorrhagic fever and dengue shock syndrome (DHF, DSS; reviewed in Rodenhuis-Zybert et al., 2010). Four distinct serotypes of DENV exist (DENV1-4), and acquired immunity is serotype-specific (reviewed in Rodenhuis-Zybert et al., 2010). Secondary infection with a heterologous serotype or primary infection in infants born to dengue-immune mothers are risk factors for developing dengue hemorrhagic fever and dengue shock syndrome, due to antibody-enhanced infectivity (reviewed in Rodenhuis-Zybert et al., 2010).

Like other Flaviviridae, DENV is an enveloped, positive-sense RNA (+ssRNA) virus (reviewed in Rodenhuis-Zybert et al., 2010). Mature dengue virions contain genomic +ssRNA and three structural proteins, C, M, and E (reviewed in Rodenhuis-Zybert et al., 2010). Protein C is the capsid protein which encapsulates genomic +ssRNA, forming the ribonucleocapsid (reviewed in Rodenhuis-Zybert et al., 2010). Proteins M and E, 180 copies of each, are anchored in the host cell-derived viral envelope (reviewed in Rodenhuis-Zybert et al., 2010).

As DENV 2 serotype is the most prevalent (Guo et al., 2017), and its strain Dengue virus 2 Thailand/16681/84 is the most frequently used in molecular studies (tied with strain NGC; based on Reactome-conducted analysis of published literature), reference proteins and RNA molecules specific to this strain were used to annotate events in this pathway. In cases where no direct experimental evidence pertaining to Dengue virus 2 Thailand/16681/84 strain was available, viral life cycle events were manually inferred from related dengue strains, as indicated.
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