Reactome | HIF-1? (Hypoxia-inducible factor 1-alpha) regulates CD274 (P...

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created	[InstanceEdit:9911970] Tiwari, Krishna, 2024-06-06
dbId	9911946
displayName	HIF-1? (Hypoxia-inducible factor 1-alpha) regulates CD274 (P...
literatureReference	[LiteratureReference:9911867] The relationship between expression of PD-L1 and HIF-1? in glioma cells under hypoxia [LiteratureReference:9911903] PD-L1 is a novel direct target of HIF-1?, and its blockade under hypoxia enhanced MDSC-mediated T cell activation [LiteratureReference:9911971] HIF1?-dependent and independent pathways regulate the expression of PD-L1 in prostate cancer
modified	[InstanceEdit:9912800] Tiwari, Krishna, 2024-06-10
schemaClass	Summation
text	HIF-1? (Hypoxia-inducible factor 1-alpha) regulates CD274 (PD-L1) transcription in response to low oxygen levels in the tumor microenvironment. Under hypoxic conditions, HIF-1? stabilizes and translocates to the nucleus, where it binds to hypoxia-responsive elements (HREs) in the PD-L1 promoter region. This binding recruits co-activators and transcriptional machinery, increasing PD-L1 transcription. Elevated PD-L1 expression helps tumor cells evade immune detection by inhibiting T cell activity. HIF-1?'s role in upregulating PD-L1 under hypoxia highlights its importance in cancer progression and as a potential target for therapies aimed at reducing immune escape in tumors. (Ding et al., 2021, Noman et al.,2014, Xanthopoulou et al., 2023)

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