Reactome | cAMP-dependent�transcription factor 3�(ATF3) is an ATF/cAMP-...

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created	[InstanceEdit:9911970] Tiwari, Krishna, 2024-06-06
dbId	9911859
displayName	cAMP-dependent�transcription factor 3�(ATF3) is an ATF/cAMP-...
literatureReference	[LiteratureReference:9911850] ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis [LiteratureReference:9911895] Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis
modified	[InstanceEdit:9918017] Tiwari, Krishna, 2024-08-14
schemaClass	Summation
text	cAMP-dependent�transcription factor 3�(ATF3) is an ATF/cAMP-responsive element-binding protein (CREB) family member whose expression is rapidly induced by a wide range of cellular stresses, including DNA damage, cellular injury, and�oxidative stress�(Liu et al. 2020). ATF3 regulates CD274 (PD-L1) transcription by binding to the PD-L1 promoter directly, inducing its transcription. (Liu et al., 2020, Liu et al., 2023).

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