POMP (UMP1), proteasome maturation protein which may functio...

created [InstanceEdit:9908064] Orlic-Milacic, Marija, 2024-04-18
dbId 9908065
displayName POMP (UMP1), proteasome maturation protein which may functio...
literatureReference
modified [InstanceEdit:9909124] Orlic-Milacic, Marija, 2024-04-26
schemaClass Summation
text POMP (UMP1), proteasome maturation protein which may function as a homotetramer (Hoefer et al. 2006), binds the formed outer ring (Hirano et al. 2006). Binding of POMP to the outer ring is mutually exclusive with binding of PSMG3:PSMG4 dimer to the outer ring (Hirano et al. 2006), although a transient interaction between PSMG3:PSMG4 and POMP was detected by the analysis of 20S core particle intermediates (Adolf et al. 2024). Dissociation of PSMG3 from the outer ring during formation of half-proteasomes was reported in human cells (Hirano et al. 2006) and shown to happen after the incorporation of beta-3 (PSMB3) (Hirano et al. 2008). POMP initiates the assembly of the inner ring. Beta subunits (PSMBs) of the inner ring assemble onto the inner surface of outer ring. POMP may help prevent the premature dimerization of precursors containing incomplete sets of beta subunits (reviewed in Tomko and Hochstrasser 2013).
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