Reactome | PSMD11 (ortholog of yeast Rpn6) binds the PSMD7:PSMD12:PSMD1...

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created	[InstanceEdit:9907997] Orlic-Milacic, Marija, 2024-04-18
dbId	9907995
displayName	PSMD11 (ortholog of yeast Rpn6) binds the PSMD7:PSMD12:PSMD1...
literatureReference	[LiteratureReference:9907904] Molecular architecture and assembly of the eukaryotic proteasome [LiteratureReference:9908541] In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals
modified	[InstanceEdit:9909124] Orlic-Milacic, Marija, 2024-04-26
schemaClass	Summation
text	PSMD11 (ortholog of yeast Rpn6) binds the PSMD7:PSMD12:PSMD13:PSMD14 complex (orthologous to the yeast complex Rpn8:Rpn5:Rpn9:Rpn11) to form the Module 1 subcomplex of the proteasome 19S regulatory particle (19S RP) lid (reviewed in Tomko and Hochstrasse 2013). Binding of human PSMD11 (Rpn6) to the human lid subcomplex composed of PSMD12 (Rpn5), PSMD7 (Rpn8), PSMD13 (Rpn9), and PSMD14 (Rpn11) was confirmed in human embryonic kidney cell line HEK293T (Bai et al. 2019). PSMD11 (Rpn6) likely stabilizes the interaction of PSMD14 (Rpn11) with the heterotrimer of PSMD12 (Rpn5), PSMD7 (Rpn8) and PSMD13 (Rpn9) (Bai et al. 2019).

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