Reactome | The 20S core particle (20S CP) of 26S proteasome consists of...

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created	[InstanceEdit:9907917] Orlic-Milacic, Marija, 2024-04-18
dbId	9907916
displayName	The 20S core particle (20S CP) of 26S proteasome consists of...
literatureReference	[LiteratureReference:9907904] Molecular architecture and assembly of the eukaryotic proteasome [LiteratureReference:9908256] Dissecting beta-ring assembly pathway of the mammalian 20S proteasome [LiteratureReference:9908278] Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
modified	[InstanceEdit:9908896] Orlic-Milacic, Marija, 2024-04-23
schemaClass	Summation
text	The 20S core particle (20S CP) of 26S proteasome consists of four axially stacked heteroheptameric rings - two inner rings and two outer rings (reviewed in Tomko and Hochstrasser 2013). Based on sequential siRNA-mediated knockdown of beta (PSMB) subunits of the inner ring in human embryonic kidney cell line HEK293T (Hirano et al. 2008) and the isolation of human 20S CP intermediates (Hirano et al. 2008; Adolf et al. 2024), the incorporation of the beta-7 (PSMB4) subunit into the inner ring is tightly coupled with dimerization of half-mers, thus forming immature 20S proteasomes.

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