Proteolytic processing is necessary for the correct insertio...

created [InstanceEdit:9906026] Stephan, Ralf, 2024-03-29
dbId 9906013
displayName Proteolytic processing is necessary for the correct insertio...
modified [InstanceEdit:9906582] Stephan, Ralf, 2024-03-30
schemaClass Summation
text Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. An unknown peptidase cleaves the N-terminal 78 amino acids of UQCRFS1, producing several unspecified N-terminal fragments that remain in the complex until cleared by TTC19. Possible candidates for the peptidase are the UQCRC1 and UQCRC2 subunits (as hinted at in the cattle model) or the SPY complex (Bottani et al., 2017; Fernandez-Vizarra & Zeviani, 2018).
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