Reactome | Following activation of endosomal Toll like receptors (TLR7,...

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created	[InstanceEdit:9860434] Shamovsky, Veronica, 2024-02-06
dbId	9860410
displayName	Following activation of endosomal Toll like receptors (TLR7,...
literatureReference	[LiteratureReference:9860405] A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity [LiteratureReference:9860400] SLC15A4 controls endolysosomal TLR7-9 responses by recruiting the innate immune adaptor TASL [LiteratureReference:9860260] Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling [LiteratureReference:9860259] TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
modified	[InstanceEdit:9909428] Shamovsky, Veronica, 2024-05-13
schemaClass	Summation
text	Following activation of endosomal Toll like receptors (TLR7, TLR8, and TLR9), the SLC15A4:TASL complex mediates the recruitment of interferon regulatory factor 5 (IRF5) to its pLxIS motif (Heinz LX. et al., 2020). The formation of SLC15A4:TASL complex facilities IRF5 phosphorylation and subsequent IRF5 homodimerization downstream of endosomal TLR7-9 (Heinz LX. et al., 2020; Zhang H et al., 2023; Chen X et al., 2023; Boeszoermeny A et al., 2023). Once activated, IRF5 translocates to the nucleus to induce the transcription of genes encoding type I interferons (IFNs) and pro-inflammatory cytokines.

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