Reactome | Expression of the MGLL gene, encoding Monoglyceride lipase r...

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created	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
dbId	9859275
displayName	Expression of the MGLL gene, encoding Monoglyceride lipase r...
literatureReference	[LiteratureReference:9858073] H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development [LiteratureReference:9859770] PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control
modified	[InstanceEdit:9971043] Orlic-Milacic, Marija, 2025-11-04
schemaClass	Summation
text	Expression of the MGLL gene, encoding Monoglyceride lipase responsible for conversion of monoacylglycerides to free fatty acids and glycerol, is positively regulated in fat tissue by the PPARG:RXRA heterodimer and KMT2C (MLL3)/KMT2D (MLL4) histone methyltransferase complexes. Treatment of rats with PPARG agonist rosiglitazone increases mRNA levels of MGLL (also known as MGL) and other lipolysis enzymes in subcutaneous and visceral white adipose tissue (Festuccia et al. 2006). Expression of the Mgll gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).

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