Reactome | During the mitochondrial unfolded protein response (mtUPR), ...

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created	[InstanceEdit:9857073] May, Bruce, 2023-12-31
dbId	9857086
displayName	During the mitochondrial unfolded protein response (mtUPR), ...
literatureReference	[LiteratureReference:4793701] Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress [LiteratureReference:4793704] Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress
schemaClass	Summation
text	During the mitochondrial unfolded protein response (mtUPR), HSF1 is activated by phosphorylation (Katiyar et al. 2020, also observed during heat shock in Sarge et al. 1993), translocation from the cytosol to the nucleus (Baler et al. 1993, Sarge et al. 1993, Sutandy et al. 2023, Katiyar et al. 2020), trimerization (Baler et al. 1993 and inferred from the mouse homolog in Sarge et al. 1993, Katiyar et al. 2020), and possible oxidation of two cysteine residues (Cys-35 and Cys-105, inferred from the mouse homolog in Anh and Thiele 2003) in an uncharacterized order of events. These alterations expose the DNA-binding domain of HSF1, causing HSF1 to bind DNA elements of target genes (Baler et al. 1993).

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