MYO5A is an actin-based motor protein that contributes to pi...

created [InstanceEdit:9856454] Rothfels, Karen, 2023-12-18
dbId 9856451
displayName MYO5A is an actin-based motor protein that contributes to pi...
modified [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28
schemaClass Summation
text MYO5A is an actin-based motor protein that contributes to pigmentation by regulating the localization of melanosomes. In conjunction with complex members RAB27A and MLPH, MYO5A directs melanosomes to the periphery of melanocytes as a preliminary step to the transfers of melanosomes to adjacent keratinocytes (Bahadoran et al, 2001; Nagashima et al, 2002; Fukuda et al, 2002; Kuroda and Fukuda, 2004; reviewed in Seabra and Coudrier, 2004; Hume and Seabra, 2011).
MYO5A, like its co-complex member RAB27A, is a direct transcriptional target of MITF-M as assessed by ChIP and reporter gene assay (Strub et al, 2011; Alves et al, 2017; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019).
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