The HUSH complex binds ATF7IP:SETDB1 (Timms et al. 2016) and...

created [InstanceEdit:9851274] May, Bruce, 2023-10-16
dbId 9851280
displayName The HUSH complex binds ATF7IP:SETDB1 (Timms et al. 2016) and...
literatureReference
modified [InstanceEdit:9909823] May, Bruce, 2024-05-14
schemaClass Summation
text The HUSH complex binds ATF7IP:SETDB1 (Timms et al. 2016) and MORC2 (Tchasovnikarova et al. 2017, Liu et al. 2018). Trimethylation of lysine-16 on ATF7IP is required for interaction with MPHOSPH8 of the HUSH complex (inferred from mouse homologs in Liu et al. 2018). SETDB1 trimethylates histone H3 on lysine-9 (Seczynska et al. 2022) and MORC2 acts to compact chromatin (Tchasovnikarova et al. 2017) at loci bound by the HUSH complex.
Cite Us!