Reactome | Human kinesin-7, or CENP-E was one of the first kinesins to ...

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created	[InstanceEdit:984623] Jupe, S, 2010-11-02
dbId	984643
displayName	Human kinesin-7, or CENP-E was one of the first kinesins to ...
literatureReference	[LiteratureReference:984613] CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase [LiteratureReference:984636] Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E [LiteratureReference:984664] Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E [LiteratureReference:984760] The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A
schemaClass	Summation
text	Human kinesin-7, or CENP-E was one of the first kinesins to be discovered (Yen et al. 1991). It is essential for mammalian development, having a role in stabilizing kinetochore-microtubule capture (Putkey et al. 2002), CENP-E is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules and localizes to kinetochores throughout all phases of mitotic chromosome movement (early premetaphase through anaphase A). Though originally reported to be minus-end-directed it is now believed to be a plus-end-directed dimeric kinesin (Espeut et al. 2008). It is sequestered in the cytoplasm until nuclear envelope breakdown and then localizes to its chromosomal cargo at the kinetochores (Brown et al. 1996).

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