SETDB1 binds the C-terminal region of TRIM28 (KAP1) which co...

created [InstanceEdit:9843639] May, Bruce, 2023-09-08
dbId 9843622
displayName SETDB1 binds the C-terminal region of TRIM28 (KAP1) which co...
literatureReference
modified [InstanceEdit:9909823] May, Bruce, 2024-05-14
schemaClass Summation
text SETDB1 binds the C-terminal region of TRIM28 (KAP1) which contains the PHD and Bromo domains (Schultz et al. 2002). SETDB1 also binds SUMO2 and the binding depends on lysine residues 33, 42, 35, and 42 of SUMO2 (Rosendorf et al. 2006). In the nucleus, SETDB1 exists in a complex with ATF7IP (hAM, mAM) (inferred from mouse homologs in Tsusaka et al. 2019), which stimulates SETDB1 activity and protects SETDB1 from degradation (Wang et al. 2003, Basavapathruni et al. 2016).
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