Reactome | This pathway describes the transcriptional and translational...

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created	[InstanceEdit:9840098] Tiwari, Krishna, 2023-07-13
dbId	9840126
displayName	This pathway describes the transcriptional and translational...
literatureReference	[LiteratureReference:9840068] Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta [LiteratureReference:9840047] HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3 [LiteratureReference:9840181] KLF16 Downregulates the Expression of Tumor Suppressor Gene TGFBR3 to Promote Bladder Cancer Proliferation and Migration [LiteratureReference:9840154] MicroRNA let-7a regulates angiogenesis by targeting TGFBR3 mRNA [LiteratureReference:8980116] The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-?
modified	[InstanceEdit:9860104] Tiwari, Krishna, 2024-01-31
schemaClass	Summation
text	This pathway describes the transcriptional and translational regulation of TGFBR3. Regulation of TGFBR3 expression includes different transcription factors (Sp1, MyoD and RAR) (Lopez-Casillas et al., 2003), epigenetic regulators such as HELLS (Hou et al., 2021) and KLP16 (Chen et al., 2022)), and translational regulation by miRNAs (Wang et al., 2019, Zhu et al., 2012).

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