Reactome | The Eyes absent homolog1 (EYA1) is expressed in metanephric ...

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created	[InstanceEdit:9831756] May, Bruce, 2023-03-24
dbId	9831749
displayName	The Eyes absent homolog1 (EYA1) is expressed in metanephric ...
literatureReference	[LiteratureReference:9792535] Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells [LiteratureReference:9831761] Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
modified	[InstanceEdit:9838648] May, Bruce, 2023-06-23
schemaClass	Summation
text	The Eyes absent homolog1 (EYA1) is expressed in metanephric mesenchyme and specifies metanephric mesenchyme, which interacts with the nephric duct to regulate formation of the ureteric bud (inferred from mouse homologs). Odd skipped related 1 (OSR1, also called ODD1) activates expression of EYA1 in the metanephric mesenchyme (inferred from mouse homologs). Mice lacking Eya1 fail to form kidneys (Xu et al. 1999). Mice that lack Osr1 do not express detectable Eya1, indicating an absolute requirement for Osr1 (James et al. 2006). The Osr1 mutants also have abnormalities of the nephric duct and mesonephros and they fail to form metanephric mesenchyme (James et al. 2006).

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