Reactome | Human growth hormone (GH) is a heterogeneous protein hormone...

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created	[InstanceEdit:982796] Jupe, S, 2010-10-28
dbId	982822
displayName	Human growth hormone (GH) is a heterogeneous protein hormone...
literatureReference	[LiteratureReference:982777] Investigation of the monomeric and oligomeric molecular forms of human growth hormone and poly-L-lysine using fluorescence anisotropy measurement method [LiteratureReference:982808] Growth hormone isoforms
modified	[InstanceEdit:1168344] Jupe, S, 2010-12-17
schemaClass	Summation
text	Human growth hormone (GH) is a heterogeneous protein hormone consisting of several isoforms. The peptide is encoded by 2 genes, GH1 and GH2, both give rise to multiple variant forms. Post-translational modification including oligomerization increases the variation (Baumann 2009). Approximately 14% of circulating human Growth Hormone (GH) is in dimer or oligomer form, this number varying from 0 to 100% (Kublickas et al. 2006). The biological activity of these oligomeric forms is variably diminished when compared to the monomer (Baumann 2009).

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