In mice, the Sox17 transcription factor is expressed in pros...

created [InstanceEdit:9825083] May, Bruce, 2023-01-23
dbId 9825050
displayName In mice, the Sox17 transcription factor is expressed in pros...
literatureReference
modified [InstanceEdit:9830221] May, Bruce, 2023-02-28
schemaClass Summation
text In mice, the Sox17 transcription factor is expressed in prospective definitive endoderm cells before intercalation of the definitive endoderm cells with the visceral endoderm (Viotti et al. 2014). Sox17 is necessary for gut endoderm formation in mice (Viotti et al. 2014). TCF7L2:CTNNB1 from WNT signaling (inferred from mouse homologs) and phosphorylated SMAD2 and SMAD3 from NODAL signaling (inferred from human pluripotent stem cells in Brown et al. 2011, Teo et al. 2011) bind the promoter of the SOX17 gene. EOMES, TBXT, MIXL1 (inferred from mouse homologs), and GATA6 that are expressed in the primitive streak bind the SOX17 promoter (Chia et al. 2019). FOXA2 and GATA4, endodermal transcription factors, bind a distal enhancer element that may interact with a downstream transcription start site of the SOX17 gene (inferred from mouse homologs).
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