Tet3 supplied by maternal cytoplasm is the major enzyme cata...

created [InstanceEdit:9817627] May, Bruce, 2022-09-26
dbId 9817701
displayName Tet3 supplied by maternal cytoplasm is the major enzyme cata...
literatureReference
modified [InstanceEdit:9823275] May, Bruce, 2023-01-05
schemaClass Summation
text Tet3 supplied by maternal cytoplasm is the major enzyme catalyzing oxidation of 5-methylcytidine to 5-hydroxymethylcytidine in the male pronucleus (Gu et al. 2011, Wossidlo et al. 2011, Iqbal et al. 2011, Santos et al. 2013). Tet3-catalyzed demethylation is part of the second phase of active demethylation in the male pronucleus (Santos et al. 2013). The first phase appears to be catalyzed by cytidine deamination followed by base excision repair (Santos et al. 2013). Accumulation of 5-hydroxymethylcytidine requires the cytosine methylases Dnmt3a and Dnmt1 (Amouroux et al. 2016). In mouse embryonic stem cells 5-hydroxymethylcytidine is mostly associated with euchromatin and depends on pre-existing 5-methylcytidine (Ficz et al. 2011). Tet3 is associated with Stgp4 and Mettl23 bound to chromatin (Hatanaka et al. 2017). Tet1 and Tet2 may also play a role in production of hydroxycytidine in the paternal genome (Ficz et al. 2011).
Cite Us!