Reactome | Genome-wide ChIP-on-chip experiments using the Kelly and SJ-...

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created	[InstanceEdit:9816162] Orlic-Milacic, Marija, 2022-09-01
dbId	9816145
displayName	Genome-wide ChIP-on-chip experiments using the Kelly and SJ-...
literatureReference	[LiteratureReference:9932055] C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1 [LiteratureReference:9768675] c-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level [LiteratureReference:9768693] miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
modified	[InstanceEdit:9932063] Orlic-Milacic, Marija, 2024-12-16
schemaClass	Summation
text	Genome-wide ChIP-on-chip experiments using the Kelly and SJ-NB-12 neuroblastoma cells, which express high levels of endogenous MYCN and MYC, respectively, due in both cases to gene amplification, showed that the endogenous MYCN and MYC proteins bound directly to a conserved CpG island region encompassing canonical MYC binding sites (CACGTG) in the MIR9-3 gene locus (Ma et al. 2010). Positive regulation of miR-9-3 expression by MYC was confirmed in human embryonic kidney cell line HEK293 (Liu et al. 2013). MYC was also shown to be enriched on the promoter of the MIR9-1 gene by ChIP in human fibroblast cell lines HFL-1 and MRC-5 and to stimulate miR-9-1 expression in both mouse and human (Qin et al. 2022).

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