Reactome | After miR-9 was computationally predicted to form a duplex w...

Schema > Summation > Entries

created	[InstanceEdit:9816137] Orlic-Milacic, Marija, 2022-09-01
dbId	9816138
displayName	After miR-9 was computationally predicted to form a duplex w...
literatureReference	[LiteratureReference:9768650] MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells [LiteratureReference:9768675] c-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level [LiteratureReference:9768693] miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis [LiteratureReference:9932055] C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1
modified	[InstanceEdit:9932065] Orlic-Milacic, Marija, 2024-12-17
schemaClass	Summation
text	After miR-9 was computationally predicted to form a duplex with CDH1 (E-cadherin) mRNA 3'UTR (Ma et al. 2010; Liu et al. 2013; Drakaki et al. 2015; Nishioka et al. 2017), miR-9 was shown to reduce the activity of a luciferase reporter fused to the wild-type 3? UTR of the CDH1 mRNA but not to a mutant 3?UTR carrying altered nucleotides in the miR-9 ?seed-pairing? recognition site.This implies that downregulation of CDH1 by miR-9 depends directly on a single cognate recognition site in the CDH1 mRNA 3?UTR (Ma et al. 2010; Liu et al. 2013; Drakaki et al. 2015). miR-9 expression and CDH1 downregulation are positively regulated by MYC and MYCN which stimulate transcription of miR-9 from the MIR9-3 gene locus (Ma et al. 2010, Liu et al. 2013, Qin et al. 2022).

(summation)

Cite Us!