Reactome | WT1 (Wilm's tumor gene) was initially reported to function a...

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created	[InstanceEdit:9815998] Orlic-Milacic, Marija, 2022-08-31
dbId	9815997
displayName	WT1 (Wilm's tumor gene) was initially reported to function a...
literatureReference	[LiteratureReference:9767702] The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells [LiteratureReference:9768510] E-cadherin is a WT1 target gene [LiteratureReference:9931215] Wilms' tumor 1 (WT1) promotes ovarian cancer progression by regulating E-cadherin and ERK1/2 signaling [LiteratureReference:9931229] WT1 promotes invasion of NSCLC via suppression of CDH1
modified	[InstanceEdit:9931235] Orlic-Milacic, Marija, 2024-12-11
schemaClass	Summation
text	WT1 (Wilm's tumor gene) was initially reported to function as a direct activator of the CDH1 gene transcription (Hosono et al. 2000), but subsequent studies have identified WT1 as a direct repressor of the CDH1 gene (Brett et al. 2013; Wu et al. 2013; Han et al. 2020).

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