Reactome | 42 on 2012-09-30

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42 on 2012-09-30 Show undefined attributes

dbId	9788323
displayName	42 on 2012-09-30
modified	[InstanceEdit:9982963] Weiser, Joel, 2026-02-20
releaseDate	2012-09-30
releaseNumber	42
schemaClass	Release

Referrals

(release)

[UpdateTracker:9873091] Update Tracker - [SimpleEntity:389894] trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873111] Update Tracker - [Complex:975037] KRAB-ZNF / KAP Complex [nucleoplasm] - v42:[updateContainedComponent]
[UpdateTracker:9872934] Update Tracker - [SimpleEntity:176056] DNPSG [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873259] Update Tracker - [EntityWithAccessionedSequence:199437] THEM4 [plasma membrane] - v42:[addName]
[UpdateTracker:9873023] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v42:[removeSpecies]
[UpdateTracker:9788404] Update Tracker - [Pathway:168256] Immune System - v42:[updateContainedPathway]
[UpdateTracker:9873261] Update Tracker - [Complex:936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9788409] Update Tracker - [Pathway:388841] Costimulation by the CD28 family - v42:[updateContainedPathway]
[UpdateTracker:9788438] Update Tracker - [Pathway:187037] Signaling by NTRK1 (TRKA) - v42:[updateContainedPathway]
[UpdateTracker:9873034] Update Tracker - [Complex:1678978] FL-TLR9 dimer [endoplasmic reticulum membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873310] Update Tracker - [Complex:749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788363] Update Tracker - [Pathway:400206] Regulation of lipid metabolism by PPARalpha - v42:[updateIndirectRLE]
[UpdateTracker:9873319] Update Tracker - [DefinedSet:1655734] SREBF1A,2 [nucleoplasm] - v42:[addName]
[UpdateTracker:9873219] Update Tracker - [Complex:188017] activated TLR9:PI3K class III [cytosol] - v42:[updateContainedComponent]
[UpdateTracker:9873273] Update Tracker - [Polymer:976898] Amyloid protein A fibril [extracellular region] - v42:[add_removeRepeatedUnit]
[UpdateTracker:9872932] Update Tracker - [SimpleEntity:159298] Nicotine N-glucuronide [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873122] Update Tracker - [Complex:936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9788380] Update Tracker - [Reaction:1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen - v42:[modifyText]
[UpdateTracker:9788421] Update Tracker - [Pathway:1430728] Metabolism - v42:[updateContainedPathway]
[UpdateTracker:9873086] Update Tracker - [SimpleEntity:194723] 4MZYMOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873145] Update Tracker - [Complex:390339] Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872858] Update Tracker - [EntityWithAccessionedSequence:114706] TGFB2 [extracellular region] - v42:[modifyEndCoordinate, modifyName, modifyStartCoordinate]
[UpdateTracker:9872913] Update Tracker - [Complex:977373] Cell surface:CFH, CFHR3:C3bBb [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873235] Update Tracker - [Complex:174697] chylomicron [extracellular region] - v42:[addName]
[UpdateTracker:9872879] Update Tracker - [Complex:975868] IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872902] Update Tracker - [SimpleEntity:176626] DHEA [cytosol] - v42:[modifyName]
[UpdateTracker:9873331] Update Tracker - [SimpleEntity:175978] 3H,4MBNZ [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788378] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v42:[modifyText]
[UpdateTracker:9873178] Update Tracker - [Complex:432133] LDL:p-LRP8 [plasma membrane] - v42:[modifyName]
[UpdateTracker:9873257] Update Tracker - [Complex:936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9872982] Update Tracker - [DefinedSet:2187524] Collagens and tropocollagens [endoplasmic reticulum lumen] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873089] Update Tracker - [Complex:1678926] intracellular TLR:UNC93B1 [endoplasmic reticulum membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872888] Update Tracker - [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873106] Update Tracker - [Complex:1250343] p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873311] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v42:[addLiteratureReference]
[UpdateTracker:9788422] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788445] Update Tracker - [Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873254] Update Tracker - [Complex:202154] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872872] Update Tracker - [SimpleEntity:2066766] 1-3-hydroxy-THA-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788322] Update Tracker - [Pathway:202403] TCR signaling - v42:[updateIndirectRLE]
[UpdateTracker:9873010] Update Tracker - [DefinedSet:975158] Activated TLR7-9 homodimers [endosome membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873220] Update Tracker - [Complex:443647] L1:HNK-1:Laminin [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873059] Update Tracker - [Complex:1358729] NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872883] Update Tracker - [SimpleEntity:213163] 3MEIN [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873302] Update Tracker - [DefinedSet:444472] FPR2 ligands [extracellular region] - v42:[add_removeHasMember]
[UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference]
[UpdateTracker:9788343] Update Tracker - [Pathway:391160] Signal regulatory protein family interactions - v42:[updateContainedRLE]
[UpdateTracker:9788459] Update Tracker - [Pathway:186763] Downstream signal transduction - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873118] Update Tracker - [Complex:445997] Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873335] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v42:[addName, modifyEndCoordinate]
[UpdateTracker:9873320] Update Tracker - [Complex:1981160] Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] - v42:[addHasComponent]
[UpdateTracker:9873040] Update Tracker - [Complex:937070] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9872942] Update Tracker - [DefinedSet:2192854] Collagen alpha-1(XVIII) chains [extracellular region] - v42:[add_removeHasMember]
[UpdateTracker:9873085] Update Tracker - [Complex:1974673] Beta defensin 103:TLR1:TLR2 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872908] Update Tracker - [SimpleEntity:193707] 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788471] Update Tracker - [Reaction:1678742] NAGLU hydrolyses Heparan sulfate chain(4) - v42:[modifyText]
[UpdateTracker:9873055] Update Tracker - [Complex:202240] PLCG1:p-5Y-LAT [plasma membrane] - v42:[modifyName]
[UpdateTracker:9873344] Update Tracker - [SimpleEntity:2066765] DHA-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873132] Update Tracker - [Complex:1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873003] Update Tracker - [DefinedSet:1220585] Resistant ligand-responsive EGFR mutants [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872969] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873087] Update Tracker - [DefinedSet:1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] - v42:[removeCompartment, updateContainedMemberOrCandidate]
[UpdateTracker:9873377] Update Tracker - [Complex:975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873363] Update Tracker - [SimpleEntity:2066768] DPA [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873116] Update Tracker - [EntityWithAccessionedSequence:199300] FOXO1 [nucleoplasm] - v42:[addName]
[UpdateTracker:9788418] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v42:[updateContainedRLE]
[UpdateTracker:9873304] Update Tracker - [Complex:936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9873128] Update Tracker - [Complex:202359] ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788373] Update Tracker - [Pathway:211897] Cytochrome P450 - arranged by substrate type - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788492] Update Tracker - [BlackBoxEvent:422048] Acyl Ghrelin and C-Ghrelin are secreted - v42:[add_removeRegulator]
[UpdateTracker:9788392] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v42:[addLiteratureReference]
[UpdateTracker:9873035] Update Tracker - [Complex:981686] CR1:C3bBb [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788484] Update Tracker - [Pathway:111995] phospho-PLA2 pathway - v42:[updateContainedRLE]
[UpdateTracker:9873012] Update Tracker - [EntityWithAccessionedSequence:184201] PDGFB (82-190) [extracellular region] - v42:[addName]
[UpdateTracker:9873175] Update Tracker - [Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873058] Update Tracker - [DefinedSet:1236393] NRGs/EGF-like ligands:ERBB4 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873180] Update Tracker - [Complex:975639] RBP2:atRAL [cytosol] - v42:[modifyName]
[UpdateTracker:9873214] Update Tracker - [DefinedSet:2187523] Collagen and procollagen triple helices [endoplasmic reticulum lumen] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788329] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v42:[updateContainedPathway]
[UpdateTracker:9788416] Update Tracker - [Pathway:1679131] Trafficking and processing of endosomal TLR - v42:[updateContainedRLE]
[UpdateTracker:9872881] Update Tracker - [SimpleEntity:193782] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873354] Update Tracker - [SimpleEntity:444761] CHS [extracellular region] - v42:[addName]
[UpdateTracker:9788448] Update Tracker - [Pathway:975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - v42:[add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9873190] Update Tracker - [Complex:1679581] C-ter-TLR9 dimer [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9872985] Update Tracker - [Complex:181226] TLR1:TLR2:TLR1/2 ligand:CD14 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788420] Update Tracker - [Reaction:1793207] ARSB hydrolyses C4S/C6S chains - v42:[modifyText]
[UpdateTracker:9873127] Update Tracker - [Complex:1247846] Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873158] Update Tracker - [Complex:975859] IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872949] Update Tracker - [SimpleEntity:200739] 5,10-methylene-THFPG [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788468] Update Tracker - [Reaction:198333] Akt translocates to the nucleus - v42:[modifyText]
[UpdateTracker:9872958] Update Tracker - [Complex:975883] pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788417] Update Tracker - [Reaction:199425] PHLPP dephosphorylates S473 in AKT - v42:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9873093] Update Tracker - [CandidateSet:1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9788414] Update Tracker - [Pathway:1592389] Activation of Matrix Metalloproteinases - v42:[modifyText]
[UpdateTracker:9872867] Update Tracker - [SimpleEntity:215607] CTL [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9872884] Update Tracker - [Complex:168946] TLR1:TLR2 [plasma membrane] - v42:[addLiteratureReference]
[UpdateTracker:9872899] Update Tracker - [SimpleEntity:196066] MePeOH [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872878] Update Tracker - [DefinedSet:2025682] Procollagen C-linked trimers [endoplasmic reticulum lumen] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872962] Update Tracker - [SimpleEntity:196366] pregn-5-ene-3,20-dione-17-ol [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872990] Update Tracker - [DefinedSet:2060922] Tropocollagen type IV [endoplasmic reticulum lumen] - v42:[add_removeCompartment]
[UpdateTracker:9873150] Update Tracker - [Complex:1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873160] Update Tracker - [SimpleEntity:879541] BSP [extracellular region] - v42:[addReferenceEntity]
[UpdateTracker:9788372] Update Tracker - [Pathway:1793185] Chondroitin sulfate/dermatan sulfate metabolism - v42:[updateIndirectRLE]
[UpdateTracker:9873348] Update Tracker - [Complex:1225859] Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788500] Update Tracker - [Pathway:186797] Signaling by PDGF - v42:[updateContainedPathway]
[UpdateTracker:9873143] Update Tracker - [Complex:190399] GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788364] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v42:[updateContainedRLE]
[UpdateTracker:9788503] Update Tracker - [Reaction:1606789] ARSB hydrolyses DS - v42:[modifyText]
[UpdateTracker:9873201] Update Tracker - [Complex:432132] LDL:p-LRP8:FGR [plasma membrane] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9873065] Update Tracker - [Complex:1225858] Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873307] Update Tracker - [EntityWithAccessionedSequence:57562] ITGA2 [plasma membrane] - v42:[modifyEndCoordinate, modifyStartCoordinate]
[UpdateTracker:9873294] Update Tracker - [SimpleEntity:548816] 3ODCT-CoA [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873007] Update Tracker - [Complex:1268012] TIM23 PAM:Precursor Cargo [mitochondrial inner membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873125] Update Tracker - [SimpleEntity:194667] dh4MZYMOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873211] Update Tracker - [EntityWithAccessionedSequence:198638] p-S166,S188-MDM2 [cytosol] - v42:[add_removeHasModifiedResidue, modifyEndCoordinate, modifyName]
[UpdateTracker:9788354] Update Tracker - [Reaction:1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - v42:[modifyText, removeInput, removeOutput]
[UpdateTracker:9788402] Update Tracker - [Pathway:422085] Synthesis, secretion, and deacylation of Ghrelin - v42:[updateContainedRLE]
[UpdateTracker:9873009] Update Tracker - [Complex:2187526] Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] - v42:[updateContainedComponent]
[UpdateTracker:9873159] Update Tracker - [Complex:202177] GADS:p-5Y-LAT [plasma membrane] - v42:[modifyName]
[UpdateTracker:9873349] Update Tracker - [Complex:981652] CD55:C3bBb [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873306] Update Tracker - [EntityWithAccessionedSequence:198614] p-T145-CDKN1A [cytosol] - v42:[addEndCoordinate, addName, addStartCoordinate]
[UpdateTracker:9872956] Update Tracker - [EntityWithAccessionedSequence:202175] p-Y113,128,145-LCP2 [cytosol] - v42:[modifyName]
[UpdateTracker:9873002] Update Tracker - [EntityWithAccessionedSequence:170838] TGFB1 [extracellular region] - v42:[modifyName]
[UpdateTracker:9873056] Update Tracker - [Complex:166281] pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788441] Update Tracker - [Pathway:420092] Glucagon-type ligand receptors - v42:[removeHasEvent]
[UpdateTracker:9788328] Update Tracker - [Pathway:556833] Metabolism of lipids - v42:[addHasEvent, updateContainedPathway]
[UpdateTracker:9873082] Update Tracker - [Complex:975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9872907] Update Tracker - [DefinedSet:1810435] NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873355] Update Tracker - [Complex:975132] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873032] Update Tracker - [EntityWithAccessionedSequence:432136] p-Y-LRP8 [plasma membrane] - v42:[addName]
[UpdateTracker:9873346] Update Tracker - [Complex:199450] PHLPP (Mn2+ cofactor) [cytosol] - v42:[add_removeHasComponent]
[UpdateTracker:9788476] Update Tracker - [Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - v42:[modifyText]
[UpdateTracker:9873325] Update Tracker - [Complex:1250359] SHC1:p-ERBB4 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873170] Update Tracker - [Complex:1225855] Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788397] Update Tracker - [Pathway:1834949] Cytosolic sensors of pathogen-associated DNA - v42:[addHasEvent, updateContainedPathway]
[UpdateTracker:9872906] Update Tracker - [SimpleEntity:215622] CTLA [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788454] Update Tracker - [Pathway:112412] SOS-mediated signalling - v42:[updateContainedRLE]
[UpdateTracker:9873321] Update Tracker - [Complex:975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873263] Update Tracker - [Complex:173635] C4b:C2a:C3b [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788325] Update Tracker - [Pathway:1643685] Disease - v42:[addHasEvent]
[UpdateTracker:9873155] Update Tracker - [Complex:975877] hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788489] Update Tracker - [Pathway:211935] Fatty acids - v42:[updateContainedRLE]
[UpdateTracker:9872865] Update Tracker - [EntityWithAccessionedSequence:52777] CREB1 [nucleoplasm] - v42:[addName, modifyEndCoordinate]
[UpdateTracker:9872917] Update Tracker - [EntityWithAccessionedSequence:200155] AKT1S1 [cytosol] - v42:[addName, modifyEndCoordinate]
[UpdateTracker:9873375] Update Tracker - [SimpleEntity:174404] 5-methyl-THFPG [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873305] Update Tracker - [Complex:1679076] ATP-bound Gp96 dimer:CNPY3:TLR7/8/9 [endoplasmic reticulum membrane] - v42:[addLiteratureReference]
[UpdateTracker:9788493] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v42:[addLiteratureReference, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9873210] Update Tracker - [EntityWithAccessionedSequence:157415] p-T161-CDK1 [cytosol] - v42:[addName, modifyEndCoordinate]
[UpdateTracker:9873300] Update Tracker - [SimpleEntity:215058] 11,12-EET [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873212] Update Tracker - [SimpleEntity:215545] 19OH-PGH2 [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873014] Update Tracker - [Complex:1248755] Shc1:Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873376] Update Tracker - [Complex:446066] CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference]
[UpdateTracker:9873011] Update Tracker - [Complex:2201291] TLR4:LY96 [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873250] Update Tracker - [Complex:450344] p-2S-IRF7:p-2S-IRF7 [cytosol] - v42:[addLiteratureReference]
[UpdateTracker:9873134] Update Tracker - [SimpleEntity:975643] betaC [plasma membrane] - v42:[addName]
[UpdateTracker:9788498] Update Tracker - [Pathway:2024096] HS-GAG degradation - v42:[updateContainedRLE]
[UpdateTracker:9873105] Update Tracker - [DefinedSet:1250318] ERBB4cyt1 homodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873369] Update Tracker - [DefinedSet:937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872923] Update Tracker - [SimpleEntity:426576] PALM [plasma membrane] - v42:[addName]
[UpdateTracker:9873120] Update Tracker - [Complex:1500847] EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872993] Update Tracker - [Complex:1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873240] Update Tracker - [Complex:170069] CCNB:p-T14-CDK1 [cytosol] - v42:[updateContainedComponent]
[UpdateTracker:9873341] Update Tracker - [Complex:975872] p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788349] Update Tracker - [Reaction:426464] Dicer cleaves double-stranded RNA to yield double-stranded siRNA - v42:[addInput, addLiteratureReference]
[UpdateTracker:9873241] Update Tracker - [EntityWithAccessionedSequence:204439] ITGA6(24-1130) [plasma membrane] - v42:[modifyEndCoordinate]
[UpdateTracker:9788481] Update Tracker - [Pathway:913531] Interferon Signaling - v42:[updateIndirectRLE]
[UpdateTracker:9788396] Update Tracker - [Reaction:211924] CYP4B1 12-hydroxylates ARA - v42:[modifyText]
[UpdateTracker:9788346] Update Tracker - [Pathway:1638091] Heparan sulfate/heparin (HS-GAG) metabolism - v42:[updateIndirectRLE]
[UpdateTracker:9873098] Update Tracker - [SimpleEntity:879576] BSP [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788413] Update Tracker - [Pathway:392499] Metabolism of proteins - v42:[addHasEvent]
[UpdateTracker:9788461] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v42:[updateContainedRLE]
[UpdateTracker:9872886] Update Tracker - [Complex:1226013] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873224] Update Tracker - [DefinedSet:1252210] Cargo of TOM40 [mitochondrial intermembrane space] - v42:[add_removeHasMember]
[UpdateTracker:9788338] Update Tracker - [Reaction:975880] MyD88 oligomerization within the complex of activated TLR:MyD88 - v42:[modifyText]
[UpdateTracker:9788415] Update Tracker - [Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873286] Update Tracker - [EntityWithAccessionedSequence:198073] KLRK1 [plasma membrane] - v42:[addName]
[UpdateTracker:9873020] Update Tracker - [Complex:975876] IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873231] Update Tracker - [DefinedSet:2025771] C-linked procollagen type IV trimers [endoplasmic reticulum lumen] - v42:[add_removeCompartment]
[UpdateTracker:9873019] Update Tracker - [Complex:418575] ADP:P2RY1:G-protein Gq (active) [plasma membrane] - v42:[modifyName]
[UpdateTracker:9873218] Update Tracker - [SimpleEntity:390290] 4,8-dimethylnonanoylcarnitine [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788504] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873303] Update Tracker - [EntityWithAccessionedSequence:198615] p-T23-CHUK [cytosol] - v42:[addEndCoordinate, addStartCoordinate, modifyName]
[UpdateTracker:9873152] Update Tracker - [Complex:1977955] ERBB4:ERBB3 heterodimer [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788502] Update Tracker - [Pathway:111996] Ca-dependent events - v42:[updateIndirectRLE]
[UpdateTracker:9873037] Update Tracker - [SimpleEntity:193762] TetraHCA [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872939] Update Tracker - [Complex:981623] CD46:Cell surface:C3b [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9788464] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v42:[addLiteratureReference, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9872873] Update Tracker - [DefinedSet:380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873379] Update Tracker - [Complex:1252229] TIM23 Complex [mitochondrial inner membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873083] Update Tracker - [Complex:975146] IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873234] Update Tracker - [Complex:975130] p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873154] Update Tracker - [CandidateSet:202084] p-T-AKT [cytosol] - v42:[addName]
[UpdateTracker:9873236] Update Tracker - [DefinedSet:192615] FGFR2b homodimer bound to FGF [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9788455] Update Tracker - [Reaction:1433418] Phosphorylation of JAK2 - v42:[addLiteratureReference, add_removeCatalystActivity, modifyText]
[UpdateTracker:9872928] Update Tracker - [SimpleEntity:2066762] 1-3-oxo-THA-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9872925] Update Tracker - [Complex:975867] p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873327] Update Tracker - [SimpleEntity:194704] 14DMLANOL [nuclear envelope] - v42:[addReferenceEntity]
[UpdateTracker:9873238] Update Tracker - [SimpleEntity:193724] 4CHOL7a,24(S)DONE [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873171] Update Tracker - [Complex:187884] fl-TLR9:unmethylated CpG DNA [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873229] Update Tracker - [Complex:937018] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873318] Update Tracker - [EntityWithAccessionedSequence:198644] MDM2 [cytosol] - v42:[modifyEndCoordinate]
[UpdateTracker:9872971] Update Tracker - [SimpleEntity:193720] 5?-CHOL3?,7?,24(s)-triol [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873260] Update Tracker - [SimpleEntity:193829] 5beta-cholestan-7alpha,12alpha,27-triol-3-one [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873246] Update Tracker - [SimpleEntity:193843] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873126] Update Tracker - [Complex:381482] IGF:IGFBP6 [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9873018] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873276] Update Tracker - [DefinedSet:1252224] Cargo of TOM40 [cytosol] - v42:[add_removeHasMember]
[UpdateTracker:9788501] Update Tracker - [Reaction:111883] Hydrolysis of phosphatidylcholine - v42:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9873027] Update Tracker - [DefinedSet:975862] Activated TLR5 or TLR10 homodimer [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872869] Update Tracker - [Complex:975124] MyD88 complexed with the activated TLR receptor [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9872937] Update Tracker - [Complex:202162] p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9873113] Update Tracker - [SimpleEntity:111353] 10-formyl-THFPG [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873314] Update Tracker - [DefinedSet:1963594] NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873299] Update Tracker - [Complex:166850] TLR4:LY96:LPS:CD14 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873243] Update Tracker - [Complex:381536] IGF:IGFBP3:ALS [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9873022] Update Tracker - [DefinedSet:1679066] folded FL-TLR7/8/9 [endoplasmic reticulum membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872905] Update Tracker - [DefinedSet:977144] Amyloid fibril main peptide chains [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872998] Update Tracker - [DefinedSet:481033] Platelet alpha granule contents [extracellular region] - v42:[addHasMember, updateContainedMemberOrCandidate]
[UpdateTracker:9873078] Update Tracker - [Complex:977084] Amyloid fibrils [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788333] Update Tracker - [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - v42:[addLiteratureReference]
[UpdateTracker:9873185] Update Tracker - [Complex:202279] PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9873258] Update Tracker - [Complex:2213008] K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9873289] Update Tracker - [Complex:1614493] Collagen type VI tetramer [endoplasmic reticulum lumen] - v42:[add_removeCompartment, updateContainedComponent]
[UpdateTracker:9872935] Update Tracker - [Complex:420722] GPRC6A receptor:GPRC6A ligands [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788483] Update Tracker - [Pathway:1296071] Potassium Channels - v42:[updateIndirectRLE]
[UpdateTracker:9873097] Update Tracker - [Complex:166272] p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] - v42:[addLiteratureReference]
[UpdateTracker:9873081] Update Tracker - [Complex:975869] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872895] Update Tracker - [SimpleEntity:213144] 6BHT [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9872922] Update Tracker - [EntityWithAccessionedSequence:1169507] p-Y239,Y240,Y317-SHC1-2 [plasma membrane] - v42:[modifyStartCoordinate]
[UpdateTracker:9788474] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v42:[modifyText]
[UpdateTracker:9873136] Update Tracker - [Complex:168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9873272] Update Tracker - [Complex:749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873291] Update Tracker - [Complex:381509] IGF:IGFBP4 [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9788362] Update Tracker - [Pathway:1296072] Voltage gated Potassium channels - v42:[updateContainedRLE]
[UpdateTracker:9873174] Update Tracker - [Complex:2032305] Dll1:Notch2 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873326] Update Tracker - [Complex:416707] PLXNA1:TREM2:DAP12 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873266] Update Tracker - [Complex:1225854] Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788412] Update Tracker - [Pathway:177929] Signaling by EGFR - v42:[updateContainedPathway]
[UpdateTracker:9873094] Update Tracker - [DefinedSet:1963580] Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873374] Update Tracker - [Complex:1250373] PI3K:p-ERBB4cyt1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788399] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v42:[updateContainedRLE]
[UpdateTracker:9873227] Update Tracker - [Complex:166118] p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788390] Update Tracker - [Pathway:877300] Interferon gamma signaling - v42:[updateContainedRLE]
[UpdateTracker:9872916] Update Tracker - [Complex:937020] TRAF6:hp-IRAK1:Pellino [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9872861] Update Tracker - [Complex:975860] MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873275] Update Tracker - [EntityWithAccessionedSequence:114707] TGFB3 [extracellular region] - v42:[modifyEndCoordinate, modifyName, modifyStartCoordinate]
[UpdateTracker:9872999] Update Tracker - [Complex:416720] SEMA6D:PLXNA1:TREM2:DAP12 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873268] Update Tracker - [Complex:1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788424] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v42:[updateContainedRLE]
[UpdateTracker:9872890] Update Tracker - [SimpleEntity:380598] HIALD [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873360] Update Tracker - [Complex:1225857] Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873072] Update Tracker - [Complex:975881] hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872964] Update Tracker - [SimpleEntity:548797] 3OHC-CoA [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872870] Update Tracker - [Complex:879427] AGER ligands:AGER:ERK [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788491] Update Tracker - [BlackBoxEvent:1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - v42:[addInput, add_removeRegulator]
[UpdateTracker:9873030] Update Tracker - [Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872974] Update Tracker - [DefinedSet:1220572] Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873233] Update Tracker - [DefinedSet:2192793] Non-fibrillar collagens [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873179] Update Tracker - [Complex:1679073] FL-TLR9 dimer [endolysosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873101] Update Tracker - [Complex:188116] TLR10 homodimer bound to ligand [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9872972] Update Tracker - [Complex:202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788460] Update Tracker - [Reaction:2090043] SGSH hydrolyses Heparan sulfate chain(7) - v42:[add_removeSummation]
[UpdateTracker:9788473] Update Tracker - [Pathway:68886] M Phase - v42:[updateContainedPathway]
[UpdateTracker:9873129] Update Tracker - [EntityWithAccessionedSequence:168104] CHUK [cytosol] - v42:[addEndCoordinate, addName, addStartCoordinate]
[UpdateTracker:9873301] Update Tracker - [SimpleEntity:211937] HTOLB [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873192] Update Tracker - [DefinedSet:1250224] NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873161] Update Tracker - [SimpleEntity:215087] 5,6-EET [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788382] Update Tracker - [Reaction:140355] Arachidonic acid is oxidised to PGG2 by PTGS1 - v42:[modifyText]
[UpdateTracker:9873004] Update Tracker - [EntityWithAccessionedSequence:1368105] Srebf1 [Golgi membrane] - v42:[addName]
[UpdateTracker:9873280] Update Tracker - [Complex:181410] TLR6:TLR2:ligand:CD14:CD36 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873144] Update Tracker - [DefinedSet:1220650] Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873176] Update Tracker - [EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] - v42:[addEndCoordinate, addStartCoordinate]
[UpdateTracker:9872994] Update Tracker - [EntityWithAccessionedSequence:1299435] TAZ [mitochondrial inner membrane] - v42:[addInferredFrom]
[UpdateTracker:9788407] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9873080] Update Tracker - [Complex:1268007] TIM23 SORT:Precursor Cargo [mitochondrial inner membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873202] Update Tracker - [Complex:202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872981] Update Tracker - [Complex:1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873208] Update Tracker - [DefinedSet:977105] Systemic amyloid fibril monomers [extracellular region] - v42:[add_removeHasMember]
[UpdateTracker:9873328] Update Tracker - [DefinedSet:1216523] Non-covalent EGFR tyrosine kinase inhibitors [cytosol] - v42:[removeSpecies]
[UpdateTracker:9873173] Update Tracker - [Complex:170077] CCNB:CDK1 [cytosol] - v42:[updateContainedComponent]
[UpdateTracker:9788479] Update Tracker - [BlackBoxEvent:1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - v42:[addInput, add_removeRegulator]
[UpdateTracker:9873282] Update Tracker - [Complex:937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9788375] Update Tracker - [BlackBoxEvent:1655826] Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) - v42:[addInput, add_removeRegulator]
[UpdateTracker:9788361] Update Tracker - [Reaction:937034] IRAK1 phosphorylates Pellino - v42:[modifyText]
[UpdateTracker:9873130] Update Tracker - [EntityWithAccessionedSequence:975648] BCMO1 [cytosol] - v42:[addName]
[UpdateTracker:9788351] Update Tracker - [Reaction:2090038] NAGLU hydrolyses heparan chain(2) - v42:[add_removeSummation]
[UpdateTracker:9788394] Update Tracker - [Pathway:168138] Toll Like Receptor 9 (TLR9) Cascade - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9873256] Update Tracker - [Complex:166080] IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873124] Update Tracker - [EntityWithAccessionedSequence:68901] CCNB1 [nucleoplasm] - v42:[addName, modifyEndCoordinate]
[UpdateTracker:9873041] Update Tracker - [DefinedSet:1963592] Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788499] Update Tracker - [Reaction:1296127] Activation of voltage gated Potassium channels - v42:[addLiteratureReference]
[UpdateTracker:9873191] Update Tracker - [SimpleEntity:193785] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873117] Update Tracker - [Complex:937033] oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873217] Update Tracker - [DefinedSet:981657] CD55:C3 convertase complexes [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873172] Update Tracker - [Complex:177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873249] Update Tracker - [Complex:202181] Activated ZAP-70 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873181] Update Tracker - [Complex:975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873353] Update Tracker - [EntityWithAccessionedSequence:198629] p-T157-CDKN1B [cytosol] - v42:[addName]
[UpdateTracker:9872880] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v42:[add_removeHasMember, modifyName]
[UpdateTracker:9873046] Update Tracker - [EntityWithAccessionedSequence:57528] IRS2 [cytosol] - v42:[addLiteratureReference, addName, modifyEndCoordinate]
[UpdateTracker:9872996] Update Tracker - [Complex:446086] Type II hemidesmosome [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873016] Update Tracker - [Complex:879365] AGER ligands:AGER [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788495] Update Tracker - [Pathway:1606322] ZBP1(DAI) mediated induction of type I IFNs - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788398] Update Tracker - [Reaction:1679098] Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer - v42:[addLiteratureReference]
[UpdateTracker:9788324] Update Tracker - [Reaction:975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9872968] Update Tracker - [Complex:381473] IGF:IGFBP2 [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9873140] Update Tracker - [Complex:975161] pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873084] Update Tracker - [EntityWithAccessionedSequence:199289] p-T32,S253,S315-FOXO3 [nucleoplasm] - v42:[addName]
[UpdateTracker:9873242] Update Tracker - [Complex:937053] TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873008] Update Tracker - [Complex:166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788431] Update Tracker - [Pathway:140180] COX reactions - v42:[updateContainedRLE]
[UpdateTracker:9872931] Update Tracker - [Complex:140491] PTGS2 dimer [endoplasmic reticulum membrane] - v42:[addHasComponent, addLiteratureReference]
[UpdateTracker:9873017] Update Tracker - [Complex:215989] Laminin-111 [extracellular region] - v42:[modifyName]
[UpdateTracker:9788385] Update Tracker - [Pathway:71387] Metabolism of carbohydrates - v42:[updateContainedPathway]
[UpdateTracker:9873028] Update Tracker - [Complex:629638] RISC loading complex:duplex miRNA [cytosol] - v42:[addHasComponent]
[UpdateTracker:9873090] Update Tracker - [SimpleEntity:390241] 3-ketohexacosanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788388] Update Tracker - [Pathway:1630316] Glycosaminoglycan metabolism - v42:[modifyText, updateContainedPathway]
[UpdateTracker:9873000] Update Tracker - [SimpleEntity:194644] 4,4DMCHtOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9872926] Update Tracker - [Complex:443673] Laminin-111 [extracellular region] - v42:[modifyName]
[UpdateTracker:9788358] Update Tracker - [Pathway:199991] Membrane Trafficking - v42:[addHasEvent]
[UpdateTracker:9872995] Update Tracker - [SimpleEntity:390435] PALM [peroxisomal matrix] - v42:[addName]
[UpdateTracker:9872864] Update Tracker - [Complex:170160] CCNB1:p-T161-CDK1 [nucleoplasm] - v42:[addName]
[UpdateTracker:9788450] Update Tracker - [Reaction:1638032] N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate - v42:[modifyText]
[UpdateTracker:9873200] Update Tracker - [DefinedSet:202282] ZAP-70 and ITK tyrosine kinases [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788458] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v42:[add_removeInput, add_removeOutput, modifyText, removeRegulator]
[UpdateTracker:9872992] Update Tracker - [SimpleEntity:194735] 4C4MZYMOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873021] Update Tracker - [Complex:629637] RISC loading complex:duplex siRNA [cytosol] - v42:[addHasComponent]
[UpdateTracker:9873204] Update Tracker - [EntityWithAccessionedSequence:170066] p-T161-CDK1 [nucleoplasm] - v42:[addEndCoordinate, addName, addStartCoordinate]
[UpdateTracker:9873366] Update Tracker - [Complex:173737] Cell surface:C3b:CFB [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873264] Update Tracker - [SimpleEntity:215584] 4OH-atRA [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873380] Update Tracker - [SimpleEntity:211944] HOMZ [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9872876] Update Tracker - [SimpleEntity:193835] 4CHOL7a,27DONE [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9788444] Update Tracker - [Pathway:198323] AKT phosphorylates targets in the cytosol - v42:[updateContainedRLE]
[UpdateTracker:9788405] Update Tracker - [Reaction:198599] AKT phosphorylates MDM2 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9872896] Update Tracker - [Complex:216003] Laminin-211 [extracellular region] - v42:[modifyName]
[UpdateTracker:9872943] Update Tracker - [Complex:1226015] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788446] Update Tracker - [Pathway:168188] Toll Like Receptor TLR6:TLR2 Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788348] Update Tracker - [Pathway:68875] Mitotic Prophase - v42:[updateContainedPathway]
[UpdateTracker:9873333] Update Tracker - [Complex:1268008] TIM23 PAM:Cargo [mitochondrial inner membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873358] Update Tracker - [Complex:203463] MHC Class II bearing antigen peptide [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9788326] Update Tracker - [Reaction:389756] AKT interacts and phosphorylates Cot - v42:[add_removeOutput, removeInput]
[UpdateTracker:9788342] Update Tracker - [Pathway:389356] CD28 co-stimulation - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873166] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9872952] Update Tracker - [Complex:977365] CFI:CFH,FHR3:C3b [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788494] Update Tracker - [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute - v42:[addOutput]
[UpdateTracker:9873313] Update Tracker - [Complex:997399] AGER ligands:AGER:Erk [cytosol] - v42:[updateContainedComponent]
[UpdateTracker:9872910] Update Tracker - [DefinedSet:192606] Activated FGFR2b homodimer bound to FGF [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873365] Update Tracker - [Complex:216307] Integrin alphaVbeta8 [plasma membrane] - v42:[add_removeCompartment]
[UpdateTracker:9872909] Update Tracker - [Complex:188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873076] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9873013] Update Tracker - [DefinedSet:181230] Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873248] Update Tracker - [SimpleEntity:975590] atROL [plasma membrane] - v42:[addName]
[UpdateTracker:9873053] Update Tracker - [Complex:1500849] Ligand-responsive EGFR mutants dimer [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873075] Update Tracker - [DefinedSet:1655720] SREBF1A,1C,2 cleaved by S2P [nucleoplasm] - v42:[modifyName]
[UpdateTracker:9872893] Update Tracker - [Complex:437191] PDPK1:PIP3:PRKCZ [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873378] Update Tracker - [EntityWithAccessionedSequence:446012] LAMC2 [extracellular region] - v42:[modifyName]
[UpdateTracker:9873039] Update Tracker - [Complex:381423] IGF:IGFBP5:ALS [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9788482] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v42:[add_removeOutput]
[UpdateTracker:9873342] Update Tracker - [SimpleEntity:975622] atRAL [cytosol] - v42:[addName]
[UpdateTracker:9788452] Update Tracker - [Pathway:162658] Golgi Cisternae Pericentriolar Stack Reorganization - v42:[addLiteratureReference, add_removeHasEvent, add_removeSummation]
[UpdateTracker:9872986] Update Tracker - [SimpleEntity:390271] 4,8-dimethylnonanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873182] Update Tracker - [Complex:2187527] Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] - v42:[updateContainedComponent]
[UpdateTracker:9873029] Update Tracker - [Complex:202302] phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788376] Update Tracker - [Reaction:198298] AKT translocates to the nucleus - v42:[modifyText]
[UpdateTracker:9788411] Update Tracker - [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - v42:[modifyText]
[UpdateTracker:9788374] Update Tracker - [Pathway:1963642] PI3K events in ERBB2 signaling - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873338] Update Tracker - [EntityWithAccessionedSequence:198622] CDKN1B [cytosol] - v42:[addName]
[UpdateTracker:9873024] Update Tracker - [DefinedSet:1220582] Active dimers of ligand-responsive EGFR mutants [plasma membrane] - v42:[removeCompartment, updateContainedMemberOrCandidate]
[UpdateTracker:9872936] Update Tracker - [Complex:1679094] N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9872929] Update Tracker - [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873253] Update Tracker - [SimpleEntity:389982] 3-hydroxypristanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873267] Update Tracker - [Complex:977596] Cell surface:FH,FHR3:C3b [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873067] Update Tracker - [Complex:2065551] SREBP1A,2 dimer [nucleoplasm] - v42:[updateContainedComponent]
[UpdateTracker:9873104] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9788371] Update Tracker - [Reaction:1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate - v42:[modifyText]
[UpdateTracker:9788488] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v42:[modifyText]
[UpdateTracker:9873351] Update Tracker - [Complex:2142729] LTC4S trimer [nuclear envelope] - v42:[addLiteratureReference]
[UpdateTracker:9873373] Update Tracker - [Complex:2201299] TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873309] Update Tracker - [Complex:981635] CR1:C3b [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873148] Update Tracker - [SimpleEntity:352318] 18OH-ARA [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873237] Update Tracker - [Complex:381539] IGF:IGFBP1 [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9788456] Update Tracker - [Reaction:1678650] IDS hydrolyses Heparan sulfate chain(5) - v42:[modifyText]
[UpdateTracker:9873133] Update Tracker - [SimpleEntity:389893] (2S) Pristanoyl-CoA [peroxisomal matrix] - v42:[add_removeReferenceEntity]
[UpdateTracker:9788347] Update Tracker - [Pathway:168249] Innate Immune System - v42:[addHasEvent, updateContainedPathway]
[UpdateTracker:9873279] Update Tracker - [SimpleEntity:176478] CHOL [cytosol] - v42:[addName]
[UpdateTracker:9872967] Update Tracker - [SimpleEntity:390002] 4,8,12-trimethyltridecanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788334] Update Tracker - [Pathway:211000] Gene Silencing by RNA - v42:[updateIndirectRLE]
[UpdateTracker:9872984] Update Tracker - [SimpleEntity:400452] PALM [extracellular region] - v42:[addName]
[UpdateTracker:9872946] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9788356] Update Tracker - [Pathway:1500931] Cell-Cell communication - v42:[updateIndirectRLE]
[UpdateTracker:9873336] Update Tracker - [SimpleEntity:549245] 4-Di-2-ASP [extracellular region] - v42:[addReferenceEntity]
[UpdateTracker:9872900] Update Tracker - [Complex:977599] CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788393] Update Tracker - [Reaction:1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) - v42:[modifyText]
[UpdateTracker:9873151] Update Tracker - [Complex:1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872963] Update Tracker - [SimpleEntity:193747] TetraHCA [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873168] Update Tracker - [SimpleEntity:211927] HPHT [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788359] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v42:[addLiteratureReference]
[UpdateTracker:9788395] Update Tracker - [Pathway:198203] PI3K/AKT activation - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873216] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873038] Update Tracker - [Complex:2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9873142] Update Tracker - [Complex:446010] BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788423] Update Tracker - [BlackBoxEvent:1470009] Phosphorylation of STATs - v42:[modifyText]
[UpdateTracker:9873339] Update Tracker - [DefinedSet:188019] PI3K-containing complexes [cytosol] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872960] Update Tracker - [Complex:1655744] SREBP1A,1C,2 dimer [nucleoplasm] - v42:[modifyName, updateContainedComponent]
[UpdateTracker:9788486] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v42:[addLiteratureReference]
[UpdateTracker:9873026] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788403] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v42:[updateIndirectRLE]
[UpdateTracker:9873162] Update Tracker - [SimpleEntity:975591] RPALM [extracellular region] - v42:[addName]
[UpdateTracker:9873361] Update Tracker - [SimpleEntity:211993] DSQ [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873312] Update Tracker - [EntityWithAccessionedSequence:1011570] HSPG2(22-4391) [extracellular region] - v42:[modifyName]
[UpdateTracker:9872933] Update Tracker - [SimpleEntity:193830] 5beta-cholestan-7alpha,27-diol-3-one [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788440] Update Tracker - [Pathway:1606341] IRF3 mediated activation of type 1 IFN - v42:[addHasEvent, updateContainedRLE]
[UpdateTracker:9873213] Update Tracker - [EntityWithAccessionedSequence:199306] p-T24,S256,S319-FOXO1 [nucleoplasm] - v42:[addName]
[UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
[UpdateTracker:9873015] Update Tracker - [Complex:202151] SLP-76 bound to Gads:LAT [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872871] Update Tracker - [DefinedSet:202318] PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788387] Update Tracker - [Pathway:162582] Signal Transduction - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873206] Update Tracker - [SimpleEntity:211952] HDBQ [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873047] Update Tracker - [CandidateSet:974995] KRAB-ZNF [nucleoplasm] - v42:[addHasCandidate]
[UpdateTracker:9788391] Update Tracker - [Reaction:975633] atROL binds to RBP2 - v42:[modifyText]
[UpdateTracker:9873164] Update Tracker - [EntityWithAccessionedSequence:198335] p-S99-BAD [cytosol] - v42:[modifyEndCoordinate]
[UpdateTracker:9873184] Update Tracker - [SimpleEntity:109496] Mg2+ [mitochondrial matrix] - v42:[addName]
[UpdateTracker:9788355] Update Tracker - [Pathway:2160916] Hyaluronan uptake and degradation - v42:[updateContainedRLE]
[UpdateTracker:9788330] Update Tracker - [Pathway:446728] Cell junction organization - v42:[updateIndirectRLE]
[UpdateTracker:9873066] Update Tracker - [Complex:167985] viral dsRNA :TLR3 [endosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873372] Update Tracker - [DefinedSet:420706] GPRC6A ligands [extracellular region] - v42:[removeSpecies]
[UpdateTracker:9873252] Update Tracker - [Complex:975642] BCMO1:Fe2+ [cytosol] - v42:[modifyName]
[UpdateTracker:9872911] Update Tracker - [SimpleEntity:174968] NAcPAB [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873334] Update Tracker - [Complex:199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane] - v42:[add_removeHasComponent, modifyName]
[UpdateTracker:9788451] Update Tracker - [Pathway:1650814] Collagen biosynthesis and modifying enzymes - v42:[updateContainedRLE]
[UpdateTracker:9788339] Update Tracker - [Reaction:1630306] GLB1 hydrolyses a glycosaminoglycan - v42:[modifyText]
[UpdateTracker:9873225] Update Tracker - [Complex:1306951] NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872965] Update Tracker - [DefinedSet:1250221] ERBB4 homodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872945] Update Tracker - [Complex:1220587] Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872948] Update Tracker - [Complex:1250191] NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872863] Update Tracker - [Complex:975114] oligo-MyD88:activated TLR7-9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873131] Update Tracker - [Complex:1358734] NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788490] Update Tracker - [Reaction:981621] C3 convertases spontaneously dissociate - v42:[add_removeOutput]
[UpdateTracker:9788383] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v42:[modifyText]
[UpdateTracker:9873350] Update Tracker - [Complex:188112] TLR10 homodimer [plasma membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873285] Update Tracker - [Complex:1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872991] Update Tracker - [DefinedSet:976760] Systemic amyloid fibril main peptide chains [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873025] Update Tracker - [Complex:210245] DAP12 dimer:TREM2 [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9872947] Update Tracker - [Complex:975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873069] Update Tracker - [Complex:1650765] Prolyl 4-hydroxylases [endoplasmic reticulum lumen] - v42:[addHasComponent]
[UpdateTracker:9873137] Update Tracker - [Complex:1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872927] Update Tracker - [DefinedSet:1220578] EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873177] Update Tracker - [SimpleEntity:390248] 3-hydroxyhexacosanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873146] Update Tracker - [Complex:2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9873308] Update Tracker - [Complex:1248746] SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872919] Update Tracker - [SimpleEntity:390422] HXDG3P [cytosol] - v42:[add_removeReferenceEntity]
[UpdateTracker:9788469] Update Tracker - [Reaction:975635] BCMO1:Fe2+ cleaves betaC to atRAL - v42:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9872983] Update Tracker - [EntityWithAccessionedSequence:168187] p-MAP3K14 [cytosol] - v42:[modifyName]
[UpdateTracker:9872924] Update Tracker - [DefinedSet:1218825] Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873044] Update Tracker - [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873383] Update Tracker - [Complex:428986] PTGS1 dimer [endoplasmic reticulum membrane] - v42:[addHasComponent]
[UpdateTracker:9788497] Update Tracker - [Reaction:392530] p-S400-Cot phosphorylates NIK - v42:[add_removeOutput, removeInput]
[UpdateTracker:9788465] Update Tracker - [Pathway:1474290] Collagen formation - v42:[updateIndirectRLE]
[UpdateTracker:9872914] Update Tracker - [Complex:975133] p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788467] Update Tracker - [Pathway:2022857] Keratan sulfate degradation - v42:[updateContainedRLE]
[UpdateTracker:9872920] Update Tracker - [Complex:1247845] Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873281] Update Tracker - [SimpleEntity:196344] pregn-5-ene-3,20-dione [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873297] Update Tracker - [Complex:937040] p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788496] Update Tracker - [Reaction:166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex - v42:[addLiteratureReference]
[UpdateTracker:9788368] Update Tracker - [Pathway:180292] GAB1 signalosome - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788341] Update Tracker - [Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - v42:[addLiteratureReference]
[UpdateTracker:9873316] Update Tracker - [Complex:1977956] ERBB4:EGFR heterodimer [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873123] Update Tracker - [DefinedSet:517843] Ligand recognized by chicken TLR2-1 : TLR1-2 heterodimer [extracellular region] - v42:[removeSpecies]
[UpdateTracker:9873284] Update Tracker - [EntityWithAccessionedSequence:199314] p-T32,S197,S262-FOXO4 [nucleoplasm] - v42:[addName]
[UpdateTracker:9873195] Update Tracker - [DefinedSet:1963585] p-6Y-ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873183] Update Tracker - [Complex:937028] IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788442] Update Tracker - [Pathway:500792] GPCR ligand binding - v42:[updateContainedPathway]
[UpdateTracker:9788419] Update Tracker - [Pathway:1989781] PPARA activates gene expression - v42:[updateContainedRLE]
[UpdateTracker:9873298] Update Tracker - [Complex:1985735] Shc1:Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788332] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v42:[modifyText]
[UpdateTracker:9873064] Update Tracker - [SimpleEntity:351779] DSQ-OG [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788453] Update Tracker - [Reaction:1433456] Recruitment of STATs - v42:[modifyText]
[UpdateTracker:9788463] Update Tracker - [BlackBoxEvent:2106625] Duplex siRNA is loaded into Argonaute - v42:[addOutput]
[UpdateTracker:9873340] Update Tracker - [SimpleEntity:216612] 3,16DOH-PALM [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873095] Update Tracker - [SimpleEntity:194657] 4CZYMOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9788331] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873324] Update Tracker - [Complex:1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873005] Update Tracker - [CandidateSet:1963591] Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873194] Update Tracker - [Complex:166050] TLR4:LY96 [plasma membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873209] Update Tracker - [SimpleEntity:211894] HPTXL [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873283] Update Tracker - [DefinedSet:202193] Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788478] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9872885] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788435] Update Tracker - [Reaction:1650808] Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines - v42:[modifyText]
[UpdateTracker:9873371] Update Tracker - [SimpleEntity:211967] HCPM [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9873138] Update Tracker - [DefinedSet:450256] phosphorylated IRF3 and/or IRF7 dimer [cytosol] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873222] Update Tracker - [DefinedSet:192594] FGFR2c homodimer bound to FGF [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873135] Update Tracker - [DefinedSet:1250351] p-ERBB4cyt1 homodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873337] Update Tracker - [DefinedSet:192616] Activated FGFR2c homodimer bound to FGF [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873228] Update Tracker - [DefinedSet:977175] Amyloid fibril monomers [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873239] Update Tracker - [DefinedSet:198605] p-T-CDKN1A/B [cytosol] - v42:[addName]
[UpdateTracker:9788430] Update Tracker - [Pathway:975634] Retinoid metabolism and transport - v42:[modifyText, updateContainedRLE]
[UpdateTracker:9873149] Update Tracker - [EntityWithAccessionedSequence:199421] PHLPP1 [cytosol] - v42:[addName]
[UpdateTracker:9873221] Update Tracker - [SimpleEntity:174961] N4-acetylsulfanilamide [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873193] Update Tracker - [SimpleEntity:194681] 4,4DMCHtOL [nuclear envelope] - v42:[addReferenceEntity]
[UpdateTracker:9873167] Update Tracker - [SimpleEntity:548829] 3ODC-CoA [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872980] Update Tracker - [SimpleEntity:215064] 14,15-EET [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9872894] Update Tracker - [DefinedSet:1963584] p-Y877-ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788408] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873057] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9788410] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v42:[removeHasEvent]
[UpdateTracker:9788485] Update Tracker - [Reaction:203862] Dicer cleaves pre-miRNA to yield duplex miRNA - v42:[addInput, addLiteratureReference]
[UpdateTracker:9788386] Update Tracker - [Pathway:418346] Platelet homeostasis - v42:[updateIndirectRLE]
[UpdateTracker:9872976] Update Tracker - [Complex:190928] Activated FGFR bound to PI3K [cytosol] - v42:[updateContainedComponent]
[UpdateTracker:9872903] Update Tracker - [EntityWithAccessionedSequence:389738] p-S400-MAP3K8 [cytosol] - v42:[modifyName]
[UpdateTracker:9873274] Update Tracker - [EntityWithAccessionedSequence:195662] SC5D [endoplasmic reticulum membrane] - v42:[modifyName]
[UpdateTracker:9788369] Update Tracker - [Pathway:426486] Small interfering RNA (siRNA) biogenesis - v42:[updateContainedRLE]
[UpdateTracker:9873079] Update Tracker - [Complex:1252243] PAM Complex [mitochondrial inner membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9788350] Update Tracker - [Pathway:937041] IKK complex recruitment mediated by RIP1 - v42:[updateContainedRLE]
[UpdateTracker:9873061] Update Tracker - [SimpleEntity:217320] MTZ-SOX [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788472] Update Tracker - [Reaction:202216] Phosphorylation of SLP-76 - v42:[modifyText]
[UpdateTracker:9872938] Update Tracker - [Complex:1678956] C-ter-TLR9 dimer [endolysosome membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873367] Update Tracker - [Complex:437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788352] Update Tracker - [Reaction:975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 - v42:[add_removeLiteratureReference]
[UpdateTracker:9873198] Update Tracker - [DefinedSet:157461] CCNB [cytosol] - v42:[addName]
[UpdateTracker:9788340] Update Tracker - [Reaction:1678708] SGSH hydrolyses Heparan sulfate chain(2) - v42:[modifyText]
[UpdateTracker:9873042] Update Tracker - [DefinedSet:879455] AGER ligands [extracellular region] - v42:[add_removeHasMember]
[UpdateTracker:9788327] Update Tracker - [Pathway:373076] Class A/1 (Rhodopsin-like receptors) - v42:[updateContainedPathway]
[UpdateTracker:9788400] Update Tracker - [Pathway:389357] CD28 dependent PI3K/Akt signaling - v42:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9873244] Update Tracker - [Complex:975107] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873109] Update Tracker - [Complex:168949] TLR6:TLR2 [plasma membrane] - v42:[addLiteratureReference]
[UpdateTracker:9873153] Update Tracker - [SimpleEntity:159247] Benzo(a)pyrene-7,8-diol-glutathione conjugate [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873382] Update Tracker - [Complex:981684] CD55:C3b [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873315] Update Tracker - [Complex:173752] Cell surface:C3b:Bb:Properdin [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873322] Update Tracker - [SimpleEntity:2066764] DPA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9872957] Update Tracker - [SimpleEntity:194633] 14DMLANOL [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873099] Update Tracker - [Complex:2152295] Collagen type XVIII [extracellular region] - v42:[updateContainedComponent]
[UpdateTracker:9873215] Update Tracker - [EntityWithAccessionedSequence:1169451] SHC1-3 [cytosol] - v42:[modifyStartCoordinate]
[UpdateTracker:9873247] Update Tracker - [Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] - v42:[addLiteratureReference, addSummation]
[UpdateTracker:9788367] Update Tracker - [Pathway:196071] Metabolism of steroid hormones - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788344] Update Tracker - [Pathway:166658] Complement cascade - v42:[updateIndirectRLE]
[UpdateTracker:9873119] Update Tracker - [Complex:975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872877] Update Tracker - [SimpleEntity:193745] 4CHOL7a,12a,24(S)TONE [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9788432] Update Tracker - [Reaction:446089] BP180 interacts extracellularly with Laminin 332 - v42:[add_removeInput]
[UpdateTracker:9873115] Update Tracker - [EntityWithAccessionedSequence:975606] LRAT [endoplasmic reticulum membrane] - v42:[addName]
[UpdateTracker:9873031] Update Tracker - [Complex:1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873188] Update Tracker - [DefinedSet:977357] C4bC2a, C3bBb [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873270] Update Tracker - [SimpleEntity:200640] 5,10-methenyl-THFPG [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873287] Update Tracker - [Complex:1614447] Collagen type VI dimer [endoplasmic reticulum lumen] - v42:[add_removeCompartment, updateContainedComponent]
[UpdateTracker:9873147] Update Tracker - [SimpleEntity:193757] 3,7,24THCA [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788427] Update Tracker - [Pathway:432142] Platelet sensitization by LDL - v42:[updateContainedRLE]
[UpdateTracker:9788428] Update Tracker - [Pathway:446107] Type I hemidesmosome assembly - v42:[updateContainedRLE]
[UpdateTracker:9873343] Update Tracker - [SimpleEntity:216620] 19HETE [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788477] Update Tracker - [Pathway:2024101] CS/DS degradation - v42:[updateContainedRLE]
[UpdateTracker:9873323] Update Tracker - [SimpleEntity:215075] 12-HETE [endoplasmic reticulum lumen] - v42:[addReferenceEntity, modifyName]
[UpdateTracker:9873163] Update Tracker - [Complex:349628] Integrin alpha2beta1:Laminin-332 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873278] Update Tracker - [Complex:1268011] TIM23 SORT:Cargo [mitochondrial inner membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788437] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v42:[add_removeInput, modifyText]
[UpdateTracker:9873207] Update Tracker - [Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788439] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v42:[modifyText, updateContainedRLE]
[UpdateTracker:9788462] Update Tracker - [Pathway:983705] Signaling by the B Cell Receptor (BCR) - v42:[updateContainedPathway]
[UpdateTracker:9873045] Update Tracker - [DefinedSet:1368190] NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872915] Update Tracker - [SimpleEntity:213151] N-demethylated loperamide [endoplasmic reticulum lumen] - v42:[addReferenceEntity, modifyName]
[UpdateTracker:9873073] Update Tracker - [Complex:416459] FPR2:FPR2 ligands [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788447] Update Tracker - [Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - v42:[addLiteratureReference]
[UpdateTracker:9788433] Update Tracker - [Pathway:1474228] Degradation of the extracellular matrix - v42:[updateContainedPathway]
[UpdateTracker:9873262] Update Tracker - [Complex:1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872987] Update Tracker - [EntityWithAccessionedSequence:199305] FOXO3 [nucleoplasm] - v42:[addName]
[UpdateTracker:9788466] Update Tracker - [Reaction:1678716] IDUA hydrolyses Heparan sulfate chain(1) - v42:[modifyText]
[UpdateTracker:9873265] Update Tracker - [Complex:198360] PDK1:AKT:PIP3 [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9872970] Update Tracker - [EntityWithAccessionedSequence:975603] RBP2 [cytosol] - v42:[addName]
[UpdateTracker:9873043] Update Tracker - [Complex:749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873036] Update Tracker - [SimpleEntity:193716] 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9872955] Update Tracker - [EntityWithAccessionedSequence:197736] CD47 [plasma membrane] - v42:[addName]
[UpdateTracker:9788426] Update Tracker - [Pathway:112399] IRS-mediated signalling - v42:[updateIndirectRLE]
[UpdateTracker:9872953] Update Tracker - [Complex:975875] IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788475] Update Tracker - [BlackBoxEvent:1031716] Expression of IFNG-stimulated genes - v42:[add_removeOutput]
[UpdateTracker:9788370] Update Tracker - [Pathway:2142845] Hyaluronan metabolism - v42:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873269] Update Tracker - [DefinedSet:173750] C3 convertases [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788360] Update Tracker - [Pathway:373080] Class B/2 (Secretin family receptors) - v42:[updateContainedPathway]
[UpdateTracker:9873001] Update Tracker - [DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873205] Update Tracker - [SimpleEntity:193778] 3,7,24THCA [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788443] Update Tracker - [Pathway:1474244] Extracellular matrix organization - v42:[addLiteratureReference, modifyText, updateContainedPathway]
[UpdateTracker:9873063] Update Tracker - [EntityWithAccessionedSequence:61605] PTGS2 [endoplasmic reticulum membrane] - v42:[add_removeCompartment]
[UpdateTracker:9873077] Update Tracker - [Complex:202345] phospho tyrosine ZAP-70 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788457] Update Tracker - [Pathway:1168372] Downstream signaling events of B Cell Receptor (BCR) - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788353] Update Tracker - [Pathway:975871] MyD88 cascade initiated on plasma membrane - v42:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9872921] Update Tracker - [DefinedSet:173759] C5 convertases [plasma membrane] - v42:[removeCompartment, updateContainedMemberOrCandidate]
[UpdateTracker:9788436] Update Tracker - [Pathway:168142] Toll Like Receptor 10 (TLR10) Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9872891] Update Tracker - [SimpleEntity:215100] 8,9-EET [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9788406] Update Tracker - [Pathway:211979] Eicosanoids - v42:[removeHasEvent]
[UpdateTracker:9788449] Update Tracker - [Reaction:2090079] GLB1 hydrolyses linker chain(2) - v42:[modifyText]
[UpdateTracker:9873033] Update Tracker - [Complex:443666] L1:Laminin [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873139] Update Tracker - [DefinedSet:1843077] p-ERBB4 JM-A homodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872930] Update Tracker - [SimpleEntity:193760] 5beta-cholestan-7alpha,24(S)-diol-3-one [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872951] Update Tracker - [Complex:1963590] p-ERBB2 heterodimers:MATK [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873295] Update Tracker - [DefinedSet:1220648] EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9873356] Update Tracker - [DefinedSet:1963571] Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872973] Update Tracker - [Complex:1220654] Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788480] Update Tracker - [Reaction:1793186] IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS - v42:[modifyText]
[UpdateTracker:9873050] Update Tracker - [SimpleEntity:193442] 25(S) DHCA-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9788336] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v42:[add_removeHasEvent, modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9873288] Update Tracker - [Complex:202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873290] Update Tracker - [CandidateSet:1963568] Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9788425] Update Tracker - [Pathway:1236394] Signaling by ERBB4 - v42:[updateContainedPathway]
[UpdateTracker:9873054] Update Tracker - [Complex:975870] p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873187] Update Tracker - [Complex:190361] Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873121] Update Tracker - [DefinedSet:791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9872892] Update Tracker - [Complex:166360] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873006] Update Tracker - [DefinedSet:190352] Activated FGFR [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788487] Update Tracker - [Pathway:1638074] Keratan sulfate/keratin metabolism - v42:[updateIndirectRLE]
[UpdateTracker:9788377] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v42:[updateContainedRLE]
[UpdateTracker:9872882] Update Tracker - [Complex:173749] Cell surface:C3b:Bb [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873357] Update Tracker - [DefinedSet:1250341] p-ERBB4 homodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873100] Update Tracker - [Complex:975864] oligo-MyD88:activated TLR5 or 10 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872875] Update Tracker - [SimpleEntity:380593] HIAA [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873359] Update Tracker - [SimpleEntity:390246] tetracosanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873223] Update Tracker - [EntityWithAccessionedSequence:1169488] SHC1-2 [cytosol] - v42:[modifyStartCoordinate]
[UpdateTracker:9788429] Update Tracker - [Reaction:2090085] HGSNAT oligomer acetylates Heparan chain(1) - v42:[add_removeSummation]
[UpdateTracker:9788345] Update Tracker - [Reaction:188002] Rab5-mediated recruitment of class III PI3K to TLR9 - v42:[addLiteratureReference]
[UpdateTracker:9872862] Update Tracker - [DefinedSet:981676] CR1:C3bBb, C4bC2a complexes [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788401] Update Tracker - [Reaction:202245] Phosphorylation of TBSMs in LAT - v42:[modifyText]
[UpdateTracker:9873230] Update Tracker - [SimpleEntity:193842] 5beta-cholestan-3alpha,7alpha,26-triol [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788434] Update Tracker - [Reaction:1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - v42:[modifyText]
[UpdateTracker:9873332] Update Tracker - [Complex:432119] LDL:LRP8 [plasma membrane] - v42:[modifyName]
[UpdateTracker:9872898] Update Tracker - [Complex:975626] RBP2:atROL [cytosol] - v42:[add_removeCompartment, add_removeHasComponent, modifyName]
[UpdateTracker:9873381] Update Tracker - [EntityWithAccessionedSequence:202210] PDPK1 [cytosol] - v42:[addName]
[UpdateTracker:9873317] Update Tracker - [SimpleEntity:2066767] delta2-THA-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873352] Update Tracker - [Complex:216001] Laminin-332 [extracellular region] - v42:[addName, add_removeHasComponent]
[UpdateTracker:9872866] Update Tracker - [DefinedSet:2187520] Non-fibrillar collagens [endoplasmic reticulum lumen] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788337] Update Tracker - [Reaction:2162227] GUSB tetramer hydrolyses (HA)2 - v42:[add_removeSummation]
[UpdateTracker:9788379] Update Tracker - [Reaction:432129] FGR binds and phosphorylates LRP8 - v42:[modifyText]
[UpdateTracker:9873186] Update Tracker - [Complex:192466] PNLIP:CLPS [extracellular region] - v42:[addName]
[UpdateTracker:9872874] Update Tracker - [EntityWithAccessionedSequence:202364] p-5Y-LAT [plasma membrane] - v42:[addHasModifiedResidue, modifyName]
[UpdateTracker:9873203] Update Tracker - [Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[UpdateTracker:9873292] Update Tracker - [SimpleEntity:389996] 3-ketopristanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873088] Update Tracker - [SimpleEntity:217269] TAMO [endoplasmic reticulum lumen] - v42:[addReferenceEntity]
[UpdateTracker:9872944] Update Tracker - [Complex:190350] Activated FGFR:p-FRS2 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872868] Update Tracker - [DefinedSet:981661] CD46, CR1:C4b:C3b complexes [plasma membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873049] Update Tracker - [SimpleEntity:390249] trans-2,3-dehydrohexacosanoyl-CoA [peroxisomal matrix] - v42:[addReferenceEntity]
[UpdateTracker:9872904] Update Tracker - [Complex:174554] C3b:Bb:C3b:Properdin [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873169] Update Tracker - [SimpleEntity:549243] 4-Di-2-ASP [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873364] Update Tracker - [SimpleEntity:194661] ZYMONE [endoplasmic reticulum membrane] - v42:[addReferenceEntity]
[UpdateTracker:9873092] Update Tracker - [SimpleEntity:174957] NAcPAS [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9788470] Update Tracker - [Reaction:210274] SIRP beta binds TYROBP - v42:[modifyText]
[UpdateTracker:9873052] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9788389] Update Tracker - [Reaction:1678921] Full-length TLR3/7/8/9 binds to UNC93B1 - v42:[addLiteratureReference, modifyText]
[UpdateTracker:9873062] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873096] Update Tracker - [SimpleEntity:171149] CHOL [extracellular region] - v42:[addName]
[UpdateTracker:9873165] Update Tracker - [SimpleEntity:193708] 5bCHOL3a,7a,24(s),27-tetrol [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873074] Update Tracker - [SimpleEntity:193777] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol [mitochondrial matrix] - v42:[addReferenceEntity]
[UpdateTracker:9873255] Update Tracker - [SimpleEntity:175980] MMETOH [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873048] Update Tracker - [SimpleEntity:213285] 5beta-cholestan-3alpha,7alpha,24(S)-triol [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9872897] Update Tracker - [EntityWithAccessionedSequence:204441] ITGA3(33-1051) [plasma membrane] - v42:[modifyEndCoordinate, modifyName]
[UpdateTracker:9873051] Update Tracker - [SimpleEntity:211973] 4OH-EST17b [cytosol] - v42:[addReferenceEntity]
[UpdateTracker:9873226] Update Tracker - [DefinedSet:2192795] Collagens and tropocollagens [extracellular region] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9873368] Update Tracker - [DefinedSet:114657] TGF beta [extracellular region] - v42:[removeHasMember]
[UpdateTracker:9873189] Update Tracker - [DefinedSet:1679054] intracellular TLR3/7/8/9 [endoplasmic reticulum membrane] - v42:[updateContainedMemberOrCandidate]
[UpdateTracker:9788357] Update Tracker - [Pathway:1250342] PI3K events in ERBB4 signaling - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9873245] Update Tracker - [Complex:981542] Cell surface:C3b [plasma membrane] - v42:[add_removeHasComponent]
[UpdateTracker:9873293] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873156] Update Tracker - [Complex:1220652] Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9872940] Update Tracker - [Complex:215995] Integrin alpha7beta1:Laminin-211, 221, 411, 512, 521 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9873329] Update Tracker - [EntityWithAccessionedSequence:1169439] p-Y194,Y195,Y272-SHC1-3 [plasma membrane] - v42:[modifyStartCoordinate]
[UpdateTracker:9873110] Update Tracker - [SimpleEntity:171076] CHEST [extracellular region] - v42:[addName]

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