Reactome | 53 on 2015-07-02

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53 on 2015-07-02 Show undefined attributes

dbId	9784545
displayName	53 on 2015-07-02
modified	[InstanceEdit:9982963] Weiser, Joel, 2026-02-20
releaseDate	2015-07-02
releaseNumber	53
schemaClass	Release

Referrals

(release)

[UpdateTracker:9784757] Update Tracker - [Reaction:75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892302] Update Tracker - [Complex:389935] SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784665] Update Tracker - [Pathway:1430728] Metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784827] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation, updateIndirectRLE]
[UpdateTracker:9784655] Update Tracker - [Pathway:5654708] Downstream signaling of activated FGFR3 - v53:[updateContainedPathway]
[UpdateTracker:9892490] Update Tracker - [Complex:112360] Grb2:Sos2 [cytosol] - v53:[modifyName]
[UpdateTracker:9892345] Update Tracker - [Complex:1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892370] Update Tracker - [Complex:167137] HIV-1 open pre-initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892493] Update Tracker - [Complex:912507] Meiotic single-stranded DNA complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892279] Update Tracker - [Complex:77067] Capping complex (with freed 5'- GMP) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784761] Update Tracker - [Pathway:195721] Signaling by WNT - v53:[updateContainedPathway]
[UpdateTracker:9784819] Update Tracker - [Pathway:2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) - v53:[updateContainedPathway]
[UpdateTracker:9784585] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9892240] Update Tracker - [Complex:156769] polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] - v53:[removeHasComponent]
[UpdateTracker:9784824] Update Tracker - [Pathway:196071] Metabolism of steroid hormones - v53:[updateIndirectRLE]
[UpdateTracker:9892221] Update Tracker - [Complex:171020] Ras-GTP:RalGDS complex [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892325] Update Tracker - [Complex:74979] RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892574] Update Tracker - [DefinedSet:112322] p-Y-IRS1,p-Y-IRS2 [cytosol] - v53:[modifyName]
[UpdateTracker:9784698] Update Tracker - [Pathway:446219] Synthesis of substrates in N-glycan biosythesis - v53:[updateIndirectRLE]
[UpdateTracker:9784701] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v53:[modifyText]
[UpdateTracker:9892408] Update Tracker - [Complex:2428931] IGF1,2:p-IGF1R:IRS2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784820] Update Tracker - [Pathway:5578749] Transcriptional regulation by small RNAs - v53:[updateContainedRLE]
[UpdateTracker:9784777] Update Tracker - [Pathway:422356] Regulation of insulin secretion - v53:[updateContainedRLE]
[UpdateTracker:9892246] Update Tracker - [Complex:109909] RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] - v53:[addName]
[UpdateTracker:9784644] Update Tracker - [Pathway:5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - v53:[updateContainedRLE]
[UpdateTracker:9784606] Update Tracker - [Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade - v53:[updateContainedPathway]
[UpdateTracker:9892576] Update Tracker - [DefinedSet:162414] THEM4,TRIB3 [cytosol] - v53:[addName]
[UpdateTracker:9892479] Update Tracker - [Complex:749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784780] Update Tracker - [Pathway:1236394] Signaling by ERBB4 - v53:[updateContainedPathway]
[UpdateTracker:9784708] Update Tracker - [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - v53:[modifyText]
[UpdateTracker:9784776] Update Tracker - [Reaction:446201] PMM1,2 isomerise Man6P to Man1P - v53:[modifyText]
[UpdateTracker:9892432] Update Tracker - [Complex:936373] ATG5:ATG12:MAVS [mitochondrial outer membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892259] Update Tracker - [EntityWithAccessionedSequence:165190] RHEB [lysosomal membrane] - v53:[add_removeCompartment]
[UpdateTracker:9892353] Update Tracker - [Complex:83899] RAD52 heptamer [nucleoplasm] - v53:[modifyName]
[UpdateTracker:9784744] Update Tracker - [Pathway:881907] Gastrin-CREB signalling pathway via PKC and MAPK - v53:[add_removeHasEvent]
[UpdateTracker:9892284] Update Tracker - [SimpleEntity:5665835] 7-(2-amino-2-carboxyethyl)-5-hydroxy-3,4-dihydro-2H-1,4-benzothiazin-3-one [melanosome lumen] - v53:[addName]
[UpdateTracker:9784647] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v53:[modifyText]
[UpdateTracker:9892365] Update Tracker - [EntityWithAccessionedSequence:2404176] p-Y349,Y350,Y427-SHC1-1 [cytosol] - v53:[add_removeCompartment, modifyName]
[UpdateTracker:9892238] Update Tracker - [Complex:983131] E3:Ub:substrate [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892500] Update Tracker - [Complex:113425] RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892348] Update Tracker - [Complex:2029140] Mother filament:branching complex [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892336] Update Tracker - [Complex:167082] HIV-1 elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784635] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v53:[updateContainedRLE]
[UpdateTracker:9784727] Update Tracker - [Pathway:3238698] WNT ligand biogenesis and trafficking - v53:[addHasEvent]
[UpdateTracker:9784556] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v53:[updateContainedRLE]
[UpdateTracker:9784571] Update Tracker - [Pathway:2428933] SHC-related events triggered by IGF1R - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784586] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v53:[add_removeHasEvent]
[UpdateTracker:9892357] Update Tracker - [Complex:74695] p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] - v53:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9892550] Update Tracker - [Complex:109696] AKT2:PIP3 [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784767] Update Tracker - [Reaction:165680] Formation of active mTORC1 complex - v53:[add_removeInput, modifyText]
[UpdateTracker:9784731] Update Tracker - [Reaction:165726] Phosphorylation of Ribosomal protein S6 by activated S6K1 - v53:[modifyText]
[UpdateTracker:9892567] Update Tracker - [Complex:109838] p-2S-MAP2K1:MAPK3 [cytosol] - v53:[modifyName]
[UpdateTracker:9784561] Update Tracker - [Pathway:1839128] FGFR4 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference]
[UpdateTracker:9892404] Update Tracker - [Complex:390592] Calcium Bound Sarcomere Protein Complex [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892503] Update Tracker - [Complex:265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] - v53:[addName]
[UpdateTracker:9784671] Update Tracker - [Pathway:194002] Glucocorticoid biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9784559] Update Tracker - [Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - v53:[modifyText]
[UpdateTracker:9784549] Update Tracker - [Pathway:3229121] Glycogen storage diseases - v53:[removeHasEvent]
[UpdateTracker:9784787] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v53:[updateIndirectRLE]
[UpdateTracker:9784544] Update Tracker - [Reaction:165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - v53:[add_removeRegulator]
[UpdateTracker:9892274] Update Tracker - [Complex:164297] NDUFS1:2x4Fe-4S [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9784598] Update Tracker - [Pathway:3247509] Chromatin modifying enzymes - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892313] Update Tracker - [DefinedSet:1433400] Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9784555] Update Tracker - [Pathway:194138] Signaling by VEGF - v53:[updateContainedPathway]
[UpdateTracker:9892400] Update Tracker - [EntityWithAccessionedSequence:113825] p-T68-CHEK2 [nucleoplasm] - v53:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9784688] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v53:[updateContainedPathway]
[UpdateTracker:9892308] Update Tracker - [SimpleEntity:1806200] PI3P [early endosome membrane] - v53:[addName]
[UpdateTracker:9892356] Update Tracker - [Complex:5624478] p21 RAS:GTP:RAF1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784632] Update Tracker - [Pathway:162699] Synthesis of dolichyl-phosphate mannose - v53:[updateContainedRLE]
[UpdateTracker:9892483] Update Tracker - [Complex:112433] Elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784613] Update Tracker - [Pathway:211859] Biological oxidations - v53:[modifyText]
[UpdateTracker:9784836] Update Tracker - [Pathway:69481] G2/M Checkpoints - v53:[updateIndirectRLE]
[UpdateTracker:9892419] Update Tracker - [EntityWithAccessionedSequence:688989] TNFAIP3 [cytosol] - v53:[addName]
[UpdateTracker:9892486] Update Tracker - [Complex:5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784705] Update Tracker - [Reaction:264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - v53:[modifyText]
[UpdateTracker:9784724] Update Tracker - [Pathway:5654743] Signaling by FGFR4 - v53:[updateContainedPathway]
[UpdateTracker:9892495] Update Tracker - [Complex:2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784848] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v53:[modifyText]
[UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE]
[UpdateTracker:9784592] Update Tracker - [Pathway:446205] Synthesis of GDP-mannose - v53:[updateContainedRLE]
[UpdateTracker:9892437] Update Tracker - [Complex:5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784551] Update Tracker - [Reaction:74716] Insulin binds the insulin receptor - v53:[modifyText]
[UpdateTracker:9892470] Update Tracker - [SimpleEntity:193804] 27OH-CHOL [extracellular region] - v53:[addName]
[UpdateTracker:9784737] Update Tracker - [Pathway:5654738] Signaling by FGFR2 - v53:[updateContainedPathway]
[UpdateTracker:9892387] Update Tracker - [SimpleEntity:2162232] GlcA [cytosol] - v53:[add_removeReferenceEntity]
[UpdateTracker:9892517] Update Tracker - [DefinedSet:167016] p-Y-SHC [cytosol] - v53:[modifyName]
[UpdateTracker:9892417] Update Tracker - [SimpleEntity:5662958] 7-(2-amino-2-carboxyethyl)-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid [melanosome lumen] - v53:[addName]
[UpdateTracker:9892455] Update Tracker - [EntityWithAccessionedSequence:112370] Kras [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892331] Update Tracker - [Complex:109635] pol II closed pre-initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892396] Update Tracker - [Complex:167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892296] Update Tracker - [Complex:921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892282] Update Tracker - [SimpleEntity:29768] AA [cytosol] - v53:[modifyName]
[UpdateTracker:9892248] Update Tracker - [Complex:74703] Insulin:Insulin receptor [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892377] Update Tracker - [Complex:77061] CE:Pol II CTD:Spt5 complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892393] Update Tracker - [DefinedSet:391181] Ligand:GPCR complexes that activate Gs [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9784662] Update Tracker - [Pathway:1226099] Signaling by FGFR in disease - v53:[add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892375] Update Tracker - [Complex:167107] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892208] Update Tracker - [Complex:70583] GLUD hexamer [mitochondrial matrix] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9892268] Update Tracker - [OtherEntity:164292] 4Fe-4S [mitochondrial inner membrane] - v53:[modifyName]
[UpdateTracker:9892559] Update Tracker - [Complex:164295] NDUFS8:2x4Fe-4S [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9784735] Update Tracker - [Reaction:382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - v53:[modifyText]
[UpdateTracker:9892528] Update Tracker - [Complex:975776] p-S139-H2AFX-Nucleosome [nucleoplasm] - v53:[addName]
[UpdateTracker:9892386] Update Tracker - [SimpleEntity:2534050] C14:1-CoA [cytosol] - v53:[addName]
[UpdateTracker:9784565] Update Tracker - [Reaction:109858] MAP2K2 binds MAPK1 - v53:[modifyText]
[UpdateTracker:9784630] Update Tracker - [Pathway:74752] Signaling by Insulin receptor - v53:[addLiteratureReference, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9892476] Update Tracker - [OtherEntity:164296] 2Fe-2S [mitochondrial inner membrane] - v53:[modifyName]
[UpdateTracker:9892256] Update Tracker - [Complex:167102] HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784837] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v53:[modifyText]
[UpdateTracker:9892545] Update Tracker - [Complex:113726] Elongation complex with separated and uncleaved transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784604] Update Tracker - [Pathway:5663202] Diseases of signal transduction by growth factor receptors and second messengers - v53:[updateContainedPathway]
[UpdateTracker:9784624] Update Tracker - [Pathway:5663084] Diseases of carbohydrate metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784699] Update Tracker - [Pathway:69190] DNA strand elongation - v53:[updateIndirectRLE]
[UpdateTracker:9784722] Update Tracker - [Pathway:1963640] GRB2 events in ERBB2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784646] Update Tracker - [Reaction:74743] Dissociation of p-Y427-SHC1 from insulin receptor - v53:[add_removeSummation]
[UpdateTracker:9892389] Update Tracker - [Complex:75912] XRCC4:LIG4 [nucleoplasm] - v53:[addLiteratureReference, addName, add_removeHasComponent]
[UpdateTracker:9892445] Update Tracker - [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9784833] Update Tracker - [Pathway:2586552] Signaling by Leptin - v53:[add_removeHasEvent]
[UpdateTracker:9892262] Update Tracker - [Complex:265452] ABCG5:ABCG8 [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892252] Update Tracker - [Complex:180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784762] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v53:[addHasEvent]
[UpdateTracker:9784712] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784709] Update Tracker - [Pathway:165158] Activation of AKT2 - v53:[updateContainedRLE]
[UpdateTracker:9784628] Update Tracker - [BlackBoxEvent:75850] Addition of the third nucleotide on the nascent transcript - v53:[modifyText]
[UpdateTracker:9892249] Update Tracker - [Complex:75907] PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm] - v53:[addName, add_removeHasComponent]
[UpdateTracker:9784666] Update Tracker - [Pathway:74713] IRS activation - v53:[modifyText, updateContainedRLE]
[UpdateTracker:9784817] Update Tracker - [Reaction:4085028] GNE phosphorylates ManNAc to ManNAc-6-P - v53:[modifyText]
[UpdateTracker:9784673] Update Tracker - [Pathway:433584] Sphingolipid metabolism - v53:[updateContainedRLE]
[UpdateTracker:9892522] Update Tracker - [EntityWithAccessionedSequence:162408] THEM4 [mitochondrial matrix] - v53:[add_removeCompartment]
[UpdateTracker:9784720] Update Tracker - [Reaction:2730887] Autophosphorylation and activation of MEKK1 - v53:[add_removeRegulator]
[UpdateTracker:9892199] Update Tracker - [CandidateSet:383207] ABCA cholesterol transporters [plasma membrane] - v53:[removeHasCandidate, removeHasMember]
[UpdateTracker:9892526] Update Tracker - [Complex:390584] Thin Filament [cytosol] - v53:[add_removeHasComponent]
[UpdateTracker:9784784] Update Tracker - [Pathway:167044] Signalling to RAS - v53:[add_removeHasEvent]
[UpdateTracker:9892440] Update Tracker - [Complex:983126] Ag-substrate:E3:E2:Ub [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892218] Update Tracker - [Complex:390596] ATP:Calcium Bound Sarcomere Protein Complex [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784558] Update Tracker - [Pathway:70895] Branched-chain amino acid catabolism - v53:[updateContainedRLE]
[UpdateTracker:9892435] Update Tracker - [Complex:164293] NDUFS7:4Fe-4S [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9784718] Update Tracker - [Pathway:5628897] TP53 Regulates Metabolic Genes - v53:[updateContainedRLE]
[UpdateTracker:9784729] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9784563] Update Tracker - [Pathway:190377] FGFR2b ligand binding and activation - v53:[addHasEvent]
[UpdateTracker:9892391] Update Tracker - [Complex:77063] Capping complex (initial) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892318] Update Tracker - [Complex:170710] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784643] Update Tracker - [Pathway:5357786] TNFR1-induced proapoptotic signaling - v53:[updateContainedRLE]
[UpdateTracker:9892507] Update Tracker - [Complex:2404190] IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892311] Update Tracker - [Complex:77065] Capping complex (intermediate) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892577] Update Tracker - [DefinedSet:2404184] p-3Y-SHC1 [cytosol] - v53:[add_removeCompartment, add_removeHasMember, modifyName]
[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9892481] Update Tracker - [Complex:74671] p-6Y-insulin receptor [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892414] Update Tracker - [Complex:75882] pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784846] Update Tracker - [Pathway:73857] RNA Polymerase II Transcription - v53:[updateIndirectRLE]
[UpdateTracker:9784689] Update Tracker - [Reaction:74715] Autophosphorylation of insulin receptor - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9784755] Update Tracker - [Pathway:76042] RNA Polymerase II Transcription Initiation And Promoter Clearance - v53:[updateIndirectRLE]
[UpdateTracker:9784583] Update Tracker - [Reaction:983707] SYK autophosphorylates at the activated BCR - v53:[addRegulator]
[UpdateTracker:9784639] Update Tracker - [Reaction:69891] Phosphorylation and activation of CHEK2 by ATM - v53:[addLiteratureReference, addOutput, add_removeCatalystActivity, add_removeInput, modifyText]
[UpdateTracker:9892374] Update Tracker - [Complex:169267] ETF:FAD [mitochondrial matrix] - v53:[modifyName]
[UpdateTracker:9784636] Update Tracker - [Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - v53:[updateContainedPathway]
[UpdateTracker:9892555] Update Tracker - [Complex:265746] KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane] - v53:[addName, updateContainedComponent]
[UpdateTracker:9892561] Update Tracker - [Complex:2559501] Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] - v53:[updateContainedComponent]
[UpdateTracker:9892460] Update Tracker - [Complex:2685692] p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892488] Update Tracker - [Complex:5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892241] Update Tracker - [Complex:2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892277] Update Tracker - [Complex:109943] ERCC1:ERCC4 [nucleoplasm] - v53:[addName]
[UpdateTracker:9784852] Update Tracker - [Pathway:611105] Respiratory electron transport - v53:[updateContainedRLE]
[UpdateTracker:9784582] Update Tracker - [Reaction:380927] p-AMPK phosphorylates TSC1:TSC2 - v53:[modifyText]
[UpdateTracker:9892217] Update Tracker - [Complex:167123] RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892253] Update Tracker - [SimpleEntity:192438] glycerol [extracellular region] - v53:[removeName]
[UpdateTracker:9784800] Update Tracker - [Pathway:163685] Integration of energy metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9892399] Update Tracker - [Complex:975778] Unsynapsed chromatin [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE]
[UpdateTracker:9784631] Update Tracker - [Reaction:109862] MAP2K2 phosphorylates MAPK1 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892542] Update Tracker - [Complex:2424459] p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784807] Update Tracker - [Pathway:193704] p75 NTR receptor-mediated signalling - v53:[updateIndirectRLE]
[UpdateTracker:9892525] Update Tracker - [Complex:167129] HIV-1 initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784599] Update Tracker - [Pathway:5654741] Signaling by FGFR3 - v53:[updateContainedPathway]
[UpdateTracker:9784774] Update Tracker - [Pathway:1266738] Developmental Biology - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784759] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v53:[updateContainedPathway]
[UpdateTracker:9784587] Update Tracker - [Reaction:77073] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) - v53:[modifyText]
[UpdateTracker:9892477] Update Tracker - [Complex:5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784797] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784769] Update Tracker - [Reaction:5358592] DNA ligase I ligates single stranded nick in double stranded DNA - v53:[add_removeCatalystActivity]
[UpdateTracker:9784716] Update Tracker - [Pathway:937061] TRIF(TICAM1)-mediated TLR4 signaling - v53:[updateContainedPathway]
[UpdateTracker:9784615] Update Tracker - [Pathway:72172] mRNA Splicing - v53:[updateIndirectRLE]
[UpdateTracker:9892339] Update Tracker - [Complex:2685659] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892288] Update Tracker - [Complex:2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784760] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v53:[updateContainedPathway]
[UpdateTracker:9784851] Update Tracker - [Pathway:3214842] HDMs demethylate histones - v53:[addHasEvent]
[UpdateTracker:9784841] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v53:[modifyText]
[UpdateTracker:9784573] Update Tracker - [Reaction:372693] Phosphorylation of BCAR1 by SRC-PTK2 complex - v53:[addLiteratureReference]
[UpdateTracker:9784609] Update Tracker - [Reaction:75998] Formation of RAD52 heptameric ring structure complexes - v53:[add_removeLiteratureReference, add_removeOutput, modifyText, removeInput]
[UpdateTracker:9784785] Update Tracker - [Pathway:2023837] Signaling by FGFR2 amplification mutants - v53:[updateContainedRLE]
[UpdateTracker:9892373] Update Tracker - [Complex:83591] RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892237] Update Tracker - [Complex:109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] - v53:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9892411] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892480] Update Tracker - [Complex:205202] GRB2:SOS1:p-KIT complex [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892405] Update Tracker - [Complex:74699] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9784717] Update Tracker - [Pathway:72086] mRNA Capping - v53:[updateContainedRLE]
[UpdateTracker:9784678] Update Tracker - [Reaction:380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - v53:[add_removeOutput, modifyText]
[UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference]
[UpdateTracker:9892309] Update Tracker - [Complex:400090] ADRA2A,C:ADR,NAd [plasma membrane] - v53:[addName, updateContainedComponent]
[UpdateTracker:9892413] Update Tracker - [Complex:77056] RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892428] Update Tracker - [Complex:205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892378] Update Tracker - [Complex:165678] Active mTORC1 complex [lysosomal membrane] - v53:[add_removeCompartment, add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9892333] Update Tracker - [Complex:936428] ATG5:ATG12 [cytosol] - v53:[modifyName]
[UpdateTracker:9892281] Update Tracker - [CandidateSet:3656389] MAPK3,(MAPK1) [cytosol] - v53:[modifyName]
[UpdateTracker:9892341] Update Tracker - [Complex:198915] Ligand interacting with NKG2D [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892423] Update Tracker - [DefinedSet:5637671] SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] - v53:[addHasMember, modifyName]
[UpdateTracker:9892340] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892228] Update Tracker - [Complex:109634] TFIIH [nucleoplasm] - v53:[addHasComponent, addLiteratureReference]
[UpdateTracker:9784595] Update Tracker - [Pathway:1250347] SHC1 events in ERBB4 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892394] Update Tracker - [Complex:109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] - v53:[modifyName]
[UpdateTracker:9892206] Update Tracker - [Complex:2855167] RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane] - v53:[add_removeHasComponent]
[UpdateTracker:9784748] Update Tracker - [Pathway:168249] Innate Immune System - v53:[updateContainedPathway]
[UpdateTracker:9892232] Update Tracker - [EntityWithAccessionedSequence:113824] CHEK2 [nucleoplasm] - v53:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9892499] Update Tracker - [Complex:391110] p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892200] Update Tracker - [Complex:113724] Elongation complex prior to separation [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892454] Update Tracker - [EntityWithAccessionedSequence:112368] Hras [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784726] Update Tracker - [Reaction:164509] Binding of gp120 of ENV oligomer to the host CD4 - v53:[modifyText]
[UpdateTracker:9892201] Update Tracker - [SimpleEntity:382539] PC [extracellular region] - v53:[addName]
[UpdateTracker:9784683] Update Tracker - [Reaction:169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF - v53:[modifyText]
[UpdateTracker:9784779] Update Tracker - [Reaction:3371385] TNF-alpha is cleaved by ADAM17 (TACE) - v53:[modifyText]
[UpdateTracker:9784547] Update Tracker - [Pathway:372442] Lipid metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9784627] Update Tracker - [Pathway:2262752] Cellular responses to stress - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9892451] Update Tracker - [Complex:5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784696] Update Tracker - [Pathway:73887] Death Receptor Signalling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892534] Update Tracker - [DefinedSet:5637687] WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] - v53:[addHasMember, modifyName]
[UpdateTracker:9784648] Update Tracker - [Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - v53:[modifyText]
[UpdateTracker:9784711] Update Tracker - [Reaction:112377] Grb2:Sos2:p-Y-Irs1 mediated nucleotide exchange of p21 Ras (IRS) - v53:[modifyText]
[UpdateTracker:9784832] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892406] Update Tracker - [SimpleEntity:31221] Fru 1-P [cytosol] - v53:[addName]
[UpdateTracker:9892317] Update Tracker - [Complex:912463] Synaptonemal Complex:BRCA1:ATR [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892223] Update Tracker - [Complex:113719] Processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892443] Update Tracker - [Complex:109843] p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] - v53:[modifyName]
[UpdateTracker:9784685] Update Tracker - [Pathway:2424491] DAP12 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892215] Update Tracker - [Complex:5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784736] Update Tracker - [Pathway:163125] Post-translational modification: synthesis of GPI-anchored proteins - v53:[updateIndirectRLE]
[UpdateTracker:9892214] Update Tracker - [Complex:2029139] Myosin-Actin filaments [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784796] Update Tracker - [Pathway:69473] G2/M DNA damage checkpoint - v53:[updateContainedRLE]
[UpdateTracker:9892204] Update Tracker - [Complex:2685675] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892566] Update Tracker - [Complex:5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892298] Update Tracker - [Complex:112373] p21 Ras:GTP [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892283] Update Tracker - [DefinedSet:112340] p-2T-MAP2K1 [cytosol] - v53:[modifyName]
[UpdateTracker:9784638] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v53:[addRegulator, modifyText]
[UpdateTracker:9892549] Update Tracker - [DefinedSet:418922] ADORA1,3 [plasma membrane] - v53:[addName, add_removeHasMember]
[UpdateTracker:9784675] Update Tracker - [Pathway:112409] RAF-independent MAPK1/3 activation - v53:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892575] Update Tracker - [Complex:176353] RAD17:RFC [nucleoplasm] - v53:[addName]
[UpdateTracker:9892359] Update Tracker - [Complex:917912] apoTF:TFRC dimer [endosome membrane] - v53:[modifyName]
[UpdateTracker:9784783] Update Tracker - [Pathway:112412] SOS-mediated signalling - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784751] Update Tracker - [Pathway:187037] Signaling by NTRK1 (TRKA) - v53:[updateContainedPathway]
[UpdateTracker:9784576] Update Tracker - [Pathway:427652] Sodium-coupled phosphate cotransporters - v53:[updateIndirectRLE]
[UpdateTracker:9892364] Update Tracker - [Complex:77064] Capping complex (hydrolyzed) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892354] Update Tracker - [Complex:157171] Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784725] Update Tracker - [Pathway:165159] MTOR signalling - v53:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784557] Update Tracker - [Reaction:109857] MAP2K1 binds MAPK3 - v53:[modifyText]
[UpdateTracker:9892275] Update Tracker - [Complex:75905] XRCC5:XRCC6 [nucleoplasm] - v53:[addName]
[UpdateTracker:9892449] Update Tracker - [Complex:167015] Activated TrkA receptor:p-SHC [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892312] Update Tracker - [Complex:912484] Meiotic D-loop complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784795] Update Tracker - [Pathway:211000] Gene Silencing by RNA - v53:[updateIndirectRLE]
[UpdateTracker:9892401] Update Tracker - [Complex:744890] GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892211] Update Tracker - [Complex:162387] p-T309,S474-AKT2:PIP3 [plasma membrane] - v53:[addName]
[UpdateTracker:9892412] Update Tracker - [SimpleEntity:5339515] C1P [Golgi membrane] - v53:[addName]
[UpdateTracker:9892456] Update Tracker - [EntityWithAccessionedSequence:49859] AKT2 [cytosol] - v53:[addName]
[UpdateTracker:9784801] Update Tracker - [Pathway:5654736] Signaling by FGFR1 - v53:[updateContainedPathway]
[UpdateTracker:9784815] Update Tracker - [Reaction:109955] Formation of ERCC1:XPF heterodimeric complex - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892416] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892202] Update Tracker - [Complex:167132] HIV-1 transcription complex containing 11 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892226] Update Tracker - [Complex:157174] Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784584] Update Tracker - [Pathway:75893] TNF signaling - v53:[modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9892330] Update Tracker - [Complex:5624477] p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784578] Update Tracker - [Reaction:1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions - v53:[add_removeOutput]
[UpdateTracker:9892473] Update Tracker - [Complex:167120] HIV-1 transcription complex containing transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892299] Update Tracker - [Complex:390591] ADP:Calcium Bound Sarcomere Protein Complex [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892466] Update Tracker - [Complex:2685683] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892371] Update Tracker - [Complex:159100] NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784567] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784597] Update Tracker - [Pathway:983705] Signaling by the B Cell Receptor (BCR) - v53:[updateIndirectRLE]
[UpdateTracker:9892421] Update Tracker - [Complex:975775] H2AFX-Nucleosome [nucleoplasm] - v53:[modifyName]
[UpdateTracker:9892540] Update Tracker - [Complex:917833] apoTF:TFRC dimer [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892278] Update Tracker - [Complex:1839062] Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9892369] Update Tracker - [Complex:170707] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892380] Update Tracker - [Complex:167182] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892372] Update Tracker - [Complex:167283] HIV-1 paused processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892290] Update Tracker - [DefinedSet:912722] K48-Ub [cytosol] - v53:[addName]
[UpdateTracker:9892509] Update Tracker - [Complex:74685] Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784768] Update Tracker - [Reaction:429714] monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP - v53:[modifyText]
[UpdateTracker:9784732] Update Tracker - [Reaction:1369028] ABCAs mediate lipid efflux - v53:[modifyText, removeLiteratureReference]
[UpdateTracker:9784719] Update Tracker - [Pathway:5218921] VEGFR2 mediated cell proliferation - v53:[add_removeHasEvent]
[UpdateTracker:9892472] Update Tracker - [DefinedSet:389744] PTPN6,PTPN11 [cytosol] - v53:[modifyName]
[UpdateTracker:9892258] Update Tracker - [EntityWithAccessionedSequence:917974] apoTF [endosome membrane] - v53:[modifyName]
[UpdateTracker:9784778] Update Tracker - [Reaction:112378] SOS mediated nucleotide exchange of RAS (SHC) - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892438] Update Tracker - [Complex:917834] holoTF:TFRC dimer [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784847] Update Tracker - [Pathway:168188] Toll Like Receptor TLR6:TLR2 Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784564] Update Tracker - [Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS - v53:[modifyText]
[UpdateTracker:9784704] Update Tracker - [Pathway:187687] Signalling to ERKs - v53:[updateContainedPathway]
[UpdateTracker:9892579] Update Tracker - [Complex:75164] MRN [nucleoplasm] - v53:[modifyName]
[UpdateTracker:9892573] Update Tracker - [Complex:981776] MRN:CtIP [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892343] Update Tracker - [Complex:167471] HIV-1 transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784782] Update Tracker - [Reaction:2672196] Viral serpin blocks caspase-8 activity - v53:[modifyText]
[UpdateTracker:9892431] Update Tracker - [Complex:167199] P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784758] Update Tracker - [Pathway:162594] Early Phase of HIV Life Cycle - v53:[updateIndirectRLE]
[UpdateTracker:9784804] Update Tracker - [Reaction:1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 - v53:[add_removeLiteratureReference, add_removeSummation]
[UpdateTracker:9784808] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v53:[add_removeSummation]
[UpdateTracker:9784775] Update Tracker - [Pathway:190241] FGFR2 ligand binding and activation - v53:[updateContainedPathway]
[UpdateTracker:9892568] Update Tracker - [Complex:110010] GRB10:INSR [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892536] Update Tracker - [Complex:176312] RAD9:HUS1:RAD1 [nucleoplasm] - v53:[addName]
[UpdateTracker:9784770] Update Tracker - [Pathway:165181] Inhibition of TSC complex formation by PKB - v53:[modifyText, updateContainedRLE]
[UpdateTracker:9892422] Update Tracker - [Complex:163929] HP subcomplex [mitochondrial inner membrane] - v53:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9784695] Update Tracker - [Pathway:450294] MAP kinase activation - v53:[add_removeHasEvent]
[UpdateTracker:9892271] Update Tracker - [Complex:3785779] DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892447] Update Tracker - [Complex:113721] Arrested processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892497] Update Tracker - [EntityWithAccessionedSequence:162419] p-S295-PDE3B [cytosol] - v53:[modifyName]
[UpdateTracker:9784590] Update Tracker - [Pathway:1280218] Adaptive Immune System - v53:[updateContainedPathway]
[UpdateTracker:9892560] Update Tracker - [DefinedSet:790204] GPCRs that activate Gs [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9892461] Update Tracker - [Complex:390590] Inactive Sarcomere Protein Complex [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784829] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v53:[modifyText]
[UpdateTracker:9784850] Update Tracker - [Pathway:112411] MAPK1 (ERK2) activation - v53:[addLiteratureReference, modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9784750] Update Tracker - [Pathway:1643685] Disease - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9784660] Update Tracker - [Pathway:167162] RNA Polymerase II HIV Promoter Escape - v53:[updateContainedRLE]
[UpdateTracker:9784749] Update Tracker - [Reaction:176956] Formation of GINS complex - v53:[add_removeInput]
[UpdateTracker:9784845] Update Tracker - [Pathway:166208] mTORC1-mediated signalling - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9892469] Update Tracker - [EntityWithAccessionedSequence:3008668] RBPJ [nucleoplasm] - v53:[addName]
[UpdateTracker:9892257] Update Tracker - [Complex:167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892407] Update Tracker - [Complex:167139] CE:Pol II CTD:Spt5 complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892207] Update Tracker - [Complex:5672861] mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] - v53:[add_removeCompartment, updateContainedComponent]
[UpdateTracker:9892556] Update Tracker - [SimpleEntity:428671] HD2NAL [cytosol] - v53:[addName]
[UpdateTracker:9892570] Update Tracker - [Complex:2685650] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784634] Update Tracker - [Pathway:168142] Toll Like Receptor 10 (TLR10) Cascade - v53:[updateContainedPathway]
[UpdateTracker:9892450] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892446] Update Tracker - [Complex:167460] HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784651] Update Tracker - [Reaction:216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - v53:[modifyText]
[UpdateTracker:9892430] Update Tracker - [Complex:1839061] Activated FGFR1 mutants and fusions:PLCG1 [cytosol] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9892392] Update Tracker - [Complex:2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892314] Update Tracker - [SimpleEntity:5676634] 2,3-TE-CoA [cytosol] - v53:[addName]
[UpdateTracker:9784805] Update Tracker - [Reaction:265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - v53:[modifyText]
[UpdateTracker:9784707] Update Tracker - [Reaction:167153] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) - v53:[modifyText]
[UpdateTracker:9784710] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v53:[modifyText]
[UpdateTracker:9784679] Update Tracker - [Pathway:179812] GRB2 events in EGFR signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892544] Update Tracker - [Complex:1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784620] Update Tracker - [Reaction:5578744] Importin-8 imports AGO2:miRNA into the nucleus - v53:[add_removeCatalystActivity]
[UpdateTracker:9892514] Update Tracker - [EntityWithAccessionedSequence:1368993] ABCB7(23-752) [mitochondrial inner membrane] - v53:[addStartCoordinate, modifyName]
[UpdateTracker:9784691] Update Tracker - [Pathway:112399] IRS-mediated signalling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892273] Update Tracker - [Complex:167071] HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892349] Update Tracker - [Complex:73716] RNA Polymerase I Transcription Initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784641] Update Tracker - [Reaction:1369052] ABCAs mediate lipid influx - v53:[addInput, addOutput, modifyText, removeLiteratureReference]
[UpdateTracker:9784730] Update Tracker - [Pathway:74160] Gene expression (Transcription) - v53:[updateIndirectRLE]
[UpdateTracker:9892496] Update Tracker - [Complex:2424464] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784747] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892515] Update Tracker - [Complex:109796] p21 RAS:GDP [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892494] Update Tracker - [Complex:983134] E3:K48-polyubiquitinated substrate [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9892467] Update Tracker - [Complex:72074] Spliceosomal Intermediate C Complex [nucleoplasm] - v53:[removeHasComponent]
[UpdateTracker:9892502] Update Tracker - [Complex:176256] Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784601] Update Tracker - [Reaction:453200] SYK autophosphorylates - v53:[addRegulator, modifyText]
[UpdateTracker:9892363] Update Tracker - [Complex:418897] ADORA1,3:Ade-Rib [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892562] Update Tracker - [Complex:77066] Capping complex (GpppN..) [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892323] Update Tracker - [Complex:2685672] p-SHC1:GRB2:SOS [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784579] Update Tracker - [Pathway:5654696] Downstream signaling of activated FGFR2 - v53:[updateContainedPathway]
[UpdateTracker:9784652] Update Tracker - [Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - v53:[updateContainedRLE]
[UpdateTracker:9784658] Update Tracker - [Reaction:1562626] Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) - v53:[add_removeOutput, modifyText]
[UpdateTracker:9784772] Update Tracker - [Reaction:164515] Fusogenic activation of gp41 - v53:[modifyText]
[UpdateTracker:9784738] Update Tracker - [Pathway:446210] Synthesis of UDP-N-acetyl-glucosamine - v53:[updateContainedRLE]
[UpdateTracker:9784625] Update Tracker - [Pathway:373760] L1CAM interactions - v53:[updateIndirectRLE]
[UpdateTracker:9892379] Update Tracker - [Complex:1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784818] Update Tracker - [Pathway:170984] ARMS-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9892358] Update Tracker - [Complex:264759] BMP1-3:Zn2+ [extracellular region] - v53:[modifyName]
[UpdateTracker:9892195] Update Tracker - [Complex:975781] Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892523] Update Tracker - [Complex:109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892222] Update Tracker - [Complex:109876] pol II open pre-initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892504] Update Tracker - [Complex:167127] HIV-1 transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892285] Update Tracker - [OtherEntity:83893] Heteroduplex DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand [nucleoplasm] - v53:[addName]
[UpdateTracker:9892301] Update Tracker - [Complex:2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892398] Update Tracker - [Complex:165189] RHEB:GTP [lysosomal membrane] - v53:[add_removeCompartment]
[UpdateTracker:9784661] Update Tracker - [Pathway:162582] Signal Transduction - v53:[add_removeHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784816] Update Tracker - [Pathway:1280215] Cytokine Signaling in Immune system - v53:[addHasEvent, updateContainedPathway]
[UpdateTracker:9892225] Update Tracker - [Complex:2424467] p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892427] Update Tracker - [Complex:75906] XRCC5:XRCC6:DNA DSBs [nucleoplasm] - v53:[addName, updateContainedComponent]
[UpdateTracker:9892289] Update Tracker - [Complex:443900] Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784855] Update Tracker - [Pathway:74751] Insulin receptor signalling cascade - v53:[add_removeHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784810] Update Tracker - [Pathway:3781865] Diseases of glycosylation - v53:[addHasEvent]
[UpdateTracker:9892458] Update Tracker - [Complex:389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892263] Update Tracker - [Complex:75859] Pol II Promoter Escape Complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892475] Update Tracker - [Complex:442565] WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784575] Update Tracker - [Reaction:216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - v53:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9892347] Update Tracker - [Complex:5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892512] Update Tracker - [Complex:2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892383] Update Tracker - [Complex:1861699] Mother filament:branching complex:daughter filament [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784637] Update Tracker - [Pathway:1839117] Signaling by cytosolic FGFR1 fusion mutants - v53:[removeHasEvent]
[UpdateTracker:9892310] Update Tracker - [Complex:74694] p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9784677] Update Tracker - [BlackBoxEvent:167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition - v53:[modifyText]
[UpdateTracker:9784611] Update Tracker - [Reaction:917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - v53:[add_removeOutput, modifyText]
[UpdateTracker:9892463] Update Tracker - [DefinedSet:400086] ADRA2A,C [plasma membrane] - v53:[addName]
[UpdateTracker:9892498] Update Tracker - [Complex:167193] Tat-containing elongation complex prior to separation [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892321] Update Tracker - [EntityWithAccessionedSequence:112346] Sos2 [cytosol] - v53:[modifyName]
[UpdateTracker:9784687] Update Tracker - [Reaction:3371353] Soluble TNF-alpha binds TNFR1 - v53:[modifyText]
[UpdateTracker:9892552] Update Tracker - [Complex:176949] Unwinding complex at replication fork [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892303] Update Tracker - [Complex:113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784676] Update Tracker - [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 - v53:[modifyText]
[UpdateTracker:9784694] Update Tracker - [Reaction:917987] TFRC dimer binds 2xholoTF - v53:[modifyText]
[UpdateTracker:9784831] Update Tracker - [Pathway:427589] Type II Na+/Pi cotransporters - v53:[updateContainedRLE]
[UpdateTracker:9892532] Update Tracker - [Complex:176952] GINS complex [nucleoplasm] - v53:[add_removeHasComponent]
[UpdateTracker:9892537] Update Tracker - [DefinedSet:2424473] p-SYK/p-BTK [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9892459] Update Tracker - [OtherEntity:75220] Holliday structure [nucleoplasm] - v53:[addName]
[UpdateTracker:9784670] Update Tracker - [Pathway:76009] Platelet Aggregation (Plug Formation) - v53:[updateContainedPathway]
[UpdateTracker:9784835] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9892415] Update Tracker - [Complex:265692] KCNJ11:ATP [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784607] Update Tracker - [Pathway:372790] Signaling by GPCR - v53:[updateContainedPathway]
[UpdateTracker:9784656] Update Tracker - [Reaction:83582] TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. - v53:[modifyText]
[UpdateTracker:9892351] Update Tracker - [DefinedSet:109782] RAS [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892367] Update Tracker - [Complex:112367] Grb2:Sos2:p-Y-Shc1 [cytosol] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784781] Update Tracker - [Pathway:5654700] FRS-mediated FGFR2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784771] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v53:[modifyText]
[UpdateTracker:9784626] Update Tracker - [Reaction:165692] Phosphorylation of 4E-BP1 by activated mTORC1 - v53:[add_removeSummation]
[UpdateTracker:9784642] Update Tracker - [Reaction:372705] Recruitment of BCAR1 to PTK2 complex - v53:[addLiteratureReference]
[UpdateTracker:9784773] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892329] Update Tracker - [Complex:179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784745] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v53:[modifyText]
[UpdateTracker:9892276] Update Tracker - [Complex:2428923] IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784621] Update Tracker - [Reaction:2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - v53:[add_removeInput, modifyText]
[UpdateTracker:9892260] Update Tracker - [Complex:5637697] p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892491] Update Tracker - [Complex:109849] p-S,T-MAP2K2:MAPK1 [cytosol] - v53:[modifyName]
[UpdateTracker:9784830] Update Tracker - [Pathway:5654716] Downstream signaling of activated FGFR4 - v53:[updateContainedPathway]
[UpdateTracker:9784714] Update Tracker - [Reaction:76576] Addition of nucleotides 10 and 11 on the growing transcript: Third Transition - v53:[modifyText]
[UpdateTracker:9892247] Update Tracker - [Complex:164288] NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9892434] Update Tracker - [Complex:2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] - v53:[addName]
[UpdateTracker:9784572] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v53:[updateContainedRLE]
[UpdateTracker:9892429] Update Tracker - [EntityWithAccessionedSequence:112371] Nras [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784659] Update Tracker - [Pathway:2172127] DAP12 interactions - v53:[updateContainedPathway]
[UpdateTracker:9784739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v53:[updateContainedPathway]
[UpdateTracker:9784791] Update Tracker - [Reaction:3785768] MRN complex binds DNA double strand breaks - v53:[add_removeInput, modifyText, removeLiteratureReference]
[UpdateTracker:9892516] Update Tracker - [Complex:3785763] DNA DSBs:MRN [nucleoplasm] - v53:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9892464] Update Tracker - [EntityWithAccessionedSequence:350754] apoTF [extracellular region] - v53:[modifyName]
[UpdateTracker:9784633] Update Tracker - [Reaction:83660] Membrane-anchored TNF-alpha binds TNFR1 - v53:[modifyText]
[UpdateTracker:9784588] Update Tracker - [Pathway:73776] RNA Polymerase II Promoter Escape - v53:[updateContainedRLE]
[UpdateTracker:9784552] Update Tracker - [Reaction:75172] Formation of RAD50:MRE11 complex - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892533] Update Tracker - [SimpleEntity:29508] Mal-CoA [cytosol] - v53:[modifyName]
[UpdateTracker:9892546] Update Tracker - [Complex:186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892558] Update Tracker - [Complex:74702] Insulin:p-6Y-insulin receptor [endosome membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784669] Update Tracker - [Reaction:193653] NGF homodimer binds to p75NTR - v53:[modifyText]
[UpdateTracker:9892539] Update Tracker - [Complex:2445094] IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784825] Update Tracker - [Pathway:445144] Signal transduction by L1 - v53:[updateContainedRLE]
[UpdateTracker:9784813] Update Tracker - [Pathway:372708] p130Cas linkage to MAPK signaling for integrins - v53:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9892236] Update Tracker - [Complex:165191] RHEB:GDP [lysosomal membrane] - v53:[add_removeCompartment]
[UpdateTracker:9784838] Update Tracker - [Pathway:180336] SHC1 events in EGFR signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784740] Update Tracker - [Pathway:186797] Signaling by PDGF - v53:[updateContainedPathway]
[UpdateTracker:9892390] Update Tracker - [Complex:2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784792] Update Tracker - [Pathway:110056] MAPK3 (ERK1) activation - v53:[modifyText, removeHasEvent, updateContainedRLE]
[UpdateTracker:9892287] Update Tracker - [Complex:167081] HIV-1 processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784812] Update Tracker - [Reaction:165708] Dissociation of phosphorylated 4EBP1 from eIF4E - v53:[modifyText]
[UpdateTracker:9892198] Update Tracker - [Complex:2685694] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892571] Update Tracker - [OtherEntity:75156] 3' overhanging DNA at resected DSB ends [nucleoplasm] - v53:[modifyName]
[UpdateTracker:9784672] Update Tracker - [Reaction:194023] HSD11B2,HSD11B1 dimer oxidise CORT to COR - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892425] Update Tracker - [Complex:390579] Thin Filament With Troponin Bound Calcium [cytosol] - v53:[add_removeHasComponent]
[UpdateTracker:9892319] Update Tracker - [Complex:936400] dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892409] Update Tracker - [Complex:75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892448] Update Tracker - [Complex:2685687] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784794] Update Tracker - [Pathway:917937] Iron uptake and transport - v53:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9784840] Update Tracker - [Reaction:4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - v53:[add_removeInput, add_removeOutput]
[UpdateTracker:9892376] Update Tracker - [Complex:5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892395] Update Tracker - [Complex:167119] HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784802] Update Tracker - [Pathway:3700989] Transcriptional Regulation by TP53 - v53:[updateIndirectRLE]
[UpdateTracker:9892418] Update Tracker - [Complex:74982] PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784733] Update Tracker - [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - v53:[updateContainedRLE]
[UpdateTracker:9892300] Update Tracker - [Complex:175440] viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892327] Update Tracker - [Complex:113722] Aborted elongation complex after arrest [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784857] Update Tracker - [Pathway:449147] Signaling by Interleukins - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892304] Update Tracker - [Complex:75902] pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784741] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v53:[modifyText]
[UpdateTracker:9784623] Update Tracker - [Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence - v53:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784668] Update Tracker - [Pathway:74749] Signal attenuation - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784788] Update Tracker - [Pathway:422475] Axon guidance - v53:[updateContainedPathway]
[UpdateTracker:9892366] Update Tracker - [Complex:83551] Pol II initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892453] Update Tracker - [Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784786] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784690] Update Tracker - [Reaction:162721] dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose - v53:[modifyText]
[UpdateTracker:9892334] Update Tracker - [SimpleEntity:216762] CHOL [transport vesicle membrane] - v53:[addName]
[UpdateTracker:9892489] Update Tracker - [Complex:2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892457] Update Tracker - [Complex:167106] HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892452] Update Tracker - [Complex:164835] ATPase:ATP [mitochondrial inner membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892465] Update Tracker - [SimpleEntity:5676631] VLC3HA-CoA [cytosol] - v53:[addName]
[UpdateTracker:9784700] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v53:[updateContainedPathway]
[UpdateTracker:9892520] Update Tracker - [Complex:169268] ETF:FADH2 [mitochondrial matrix] - v53:[modifyName]
[UpdateTracker:9784654] Update Tracker - [BlackBoxEvent:75869] Addition of the fourth nucleotide on the Nascent Transcript: Second Transition - v53:[modifyText]
[UpdateTracker:9784594] Update Tracker - [Pathway:167160] RNA Pol II CTD phosphorylation and interaction with CE during HIV infection - v53:[updateContainedRLE]
[UpdateTracker:9784617] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v53:[removeOutput]
[UpdateTracker:9784849] Update Tracker - [Reaction:75873] Addition of Nucleotides 5 through 9 on the growing Transcript - v53:[modifyText]
[UpdateTracker:9784743] Update Tracker - [Pathway:5655332] Signaling by FGFR3 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
[UpdateTracker:9784650] Update Tracker - [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - v53:[add_removeInput]
[UpdateTracker:9892360] Update Tracker - [Complex:5637704] p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892326] Update Tracker - [DefinedSet:418907] ADORA2A,B [plasma membrane] - v53:[addName]
[UpdateTracker:9892410] Update Tracker - [Complex:70019] BCKDH [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9892462] Update Tracker - [Complex:164294] NDUFA10:FAD [mitochondrial inner membrane] - v53:[addName]
[UpdateTracker:9784608] Update Tracker - [Pathway:3928662] EPHB-mediated forward signaling - v53:[updateContainedRLE]
[UpdateTracker:9892332] Update Tracker - [Complex:83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892433] Update Tracker - [Complex:5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] - v53:[add_removeCompartment, updateContainedComponent]
[UpdateTracker:9892239] Update Tracker - [Complex:2685707] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784753] Update Tracker - [Pathway:169893] Prolonged ERK activation events - v53:[updateContainedPathway]
[UpdateTracker:9892231] Update Tracker - [Complex:5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892324] Update Tracker - [Complex:2130185] p-Y-WRC [cytosol] - v53:[addHasComponent]
[UpdateTracker:9784653] Update Tracker - [Reaction:4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - v53:[modifyText]
[UpdateTracker:9892506] Update Tracker - [SimpleEntity:1638840] C1P [plasma membrane] - v53:[addName]
[UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9784562] Update Tracker - [Reaction:4084999] NEU1 hydrolyses Neu5Ac from glycoconjugates - v53:[modifyText]
[UpdateTracker:9784764] Update Tracker - [Reaction:74712] Dissociation of IRS-P from insulin receptor - v53:[add_removeOutput]
[UpdateTracker:9784713] Update Tracker - [Reaction:433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[UpdateTracker:9892572] Update Tracker - [Complex:2671844] LEP:p-LEPR:p-JAK2:SH2B1:p-IRS1,2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892293] Update Tracker - [Complex:109878] pol II transcription complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784568] Update Tracker - [Reaction:167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript - v53:[modifyText]
[UpdateTracker:9892255] Update Tracker - [SimpleEntity:193717] 24OH-CHOL [extracellular region] - v53:[addName]
[UpdateTracker:9892508] Update Tracker - [EntityWithAccessionedSequence:76302] p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] - v53:[addHasModifiedResidue, modifyName]
[UpdateTracker:9892213] Update Tracker - [Complex:77384] p-6Y-insulin receptor [endosome membrane] - v53:[modifyName]
[UpdateTracker:9784684] Update Tracker - [Pathway:2428924] IGF1R signaling cascade - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784574] Update Tracker - [Reaction:5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - v53:[modifyText]
[UpdateTracker:9892541] Update Tracker - [Complex:418926] ADORA2A,B:Ade-Rib [plasma membrane] - v53:[addName, updateContainedComponent]
[UpdateTracker:9784640] Update Tracker - [Pathway:451927] Interleukin-2 family signaling - v53:[add_removeHasEvent, updateContainedPathway]
[UpdateTracker:9784715] Update Tracker - [Pathway:380972] Energy dependent regulation of mTOR by LKB1-AMPK - v53:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9892485] Update Tracker - [Complex:914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892420] Update Tracker - [Polymer:912740] K48polyUb [cytosol] - v53:[updateContainedRepeatedUnit]
[UpdateTracker:9892229] Update Tracker - [Complex:164838] ATPase:ADP:Pi [mitochondrial inner membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892316] Update Tracker - [EntityWithAccessionedSequence:141718] INSR(28-758) [endosome membrane] - v53:[modifyName]
[UpdateTracker:9784856] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v53:[updateIndirectRLE]
[UpdateTracker:9784569] Update Tracker - [Pathway:1369062] ABC transporters in lipid homeostasis - v53:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9892235] Update Tracker - [Complex:175247] Ku proteins bound to viral DNA [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892203] Update Tracker - [SimpleEntity:1678617] aldehydo-L-iduronic acid [lysosomal lumen] - v53:[addName]
[UpdateTracker:9784756] Update Tracker - [Reaction:2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants - v53:[modifyText]
[UpdateTracker:9892269] Update Tracker - [Complex:167125] HIV-1 closed pre-initiation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784580] Update Tracker - [Pathway:5668914] Diseases of metabolism - v53:[updateContainedPathway]
[UpdateTracker:9784618] Update Tracker - [Pathway:5654706] FRS-mediated FGFR3 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892320] Update Tracker - [Complex:165175] TSC1:TSC2 [cytosol] - v53:[add_removeCompartment, add_removeHasComponent]
[UpdateTracker:9784591] Update Tracker - [Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis - v53:[addRegulator]
[UpdateTracker:9784667] Update Tracker - [Pathway:109704] PI3K Cascade - v53:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9892294] Update Tracker - [Complex:2685668] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784554] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v53:[modifyText]
[UpdateTracker:9784589] Update Tracker - [Reaction:427656] SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol - v53:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9784603] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9784548] Update Tracker - [Pathway:168256] Immune System - v53:[updateContainedPathway]
[UpdateTracker:9784728] Update Tracker - [Reaction:216757] 4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane - v53:[modifyText]
[UpdateTracker:9892531] Update Tracker - [Complex:73717] RNA Polymerase I promoter escape complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892224] Update Tracker - [Complex:167100] HIV-1 transcription complex containing 9 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892216] Update Tracker - [Complex:167185] HIV-1 elongation complex containing Tat [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784560] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v53:[updateContainedPathway]
[UpdateTracker:9892227] Update Tracker - [SimpleEntity:1497805] Asc.- [cytosol] - v53:[removeName]
[UpdateTracker:9892554] Update Tracker - [Complex:111343] Covalent CE:GMP intermediate complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784616] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v53:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784692] Update Tracker - [Reaction:165195] GTP loading by Rheb - v53:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9784823] Update Tracker - [Pathway:5358508] Mismatch Repair - v53:[updateIndirectRLE]
[UpdateTracker:9892291] Update Tracker - [DefinedSet:1456465] ABCD1-3 dimers [peroxisomal membrane] - v53:[modifyName]
[UpdateTracker:9892551] Update Tracker - [CandidateSet:976075] E3 ligases in proteasomal degradation [cytosol] - v53:[addHasCandidate]
[UpdateTracker:9892518] Update Tracker - [DefinedSet:188019] PI3K-containing complexes [cytosol] - v53:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9892487] Update Tracker - [Complex:167184] HIV-1 Tat-containing processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892535] Update Tracker - [Complex:1225859] Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784622] Update Tracker - [Pathway:205017] NFG and proNGF binds to p75NTR - v53:[updateContainedRLE]
[UpdateTracker:9892565] Update Tracker - [DefinedSet:2197675] WAVE2, WASP, N-WASP [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9784553] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9892242] Update Tracker - [Complex:451638] NFKB1:MAP3K8:TNIP2 [cytosol] - v53:[addName]
[UpdateTracker:9892468] Update Tracker - [Complex:176269] ATR:ATRIP [nucleoplasm] - v53:[addName]
[UpdateTracker:9892519] Update Tracker - [Complex:74186] F1Fo ATP synthase [mitochondrial inner membrane] - v53:[modifyName]
[UpdateTracker:9892484] Update Tracker - [Complex:2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784602] Update Tracker - [Reaction:447074] AMPK phosphorylates Raptor in the mTORC1 complex - v53:[add_removeOutput]
[UpdateTracker:9784600] Update Tracker - [Reaction:165162] Phosphorylation of TSC2 by PKB - v53:[modifyText]
[UpdateTracker:9892337] Update Tracker - [Complex:5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784806] Update Tracker - [Pathway:186763] Downstream signal transduction - v53:[add_removeHasEvent]
[UpdateTracker:9892220] Update Tracker - [Complex:912476] Synaptonemal Complex:BRCA1 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892441] Update Tracker - [Complex:167101] HIV-1 transcription complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784605] Update Tracker - [Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs - v53:[updateContainedRLE]
[UpdateTracker:9892543] Update Tracker - [Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784581] Update Tracker - [Pathway:1839122] Signaling by activated point mutants of FGFR1 - v53:[modifyText]
[UpdateTracker:9784629] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v53:[add_removeInput, modifyText]
[UpdateTracker:9892492] Update Tracker - [Complex:113720] Paused processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892381] Update Tracker - [Complex:167482] HIV-1 aborted elongation complex after arrest [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892524] Update Tracker - [Complex:162401] AKT2:THEM4,TRIB3 [cytosol] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784814] Update Tracker - [Pathway:187706] Signalling to p38 via RIT and RIN - v53:[add_removeHasEvent]
[UpdateTracker:9784843] Update Tracker - [Pathway:173107] Binding and entry of HIV virion - v53:[updateContainedRLE]
[UpdateTracker:9784706] Update Tracker - [Reaction:532549] MPI isomerises Fru6P to Man6P - v53:[modifyText]
[UpdateTracker:9892397] Update Tracker - [Complex:2685666] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892307] Update Tracker - [Complex:112363] Grb2:Sos2:p-Y-Irs1 [cytosol] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892501] Update Tracker - [EntityWithAccessionedSequence:74684] p-Y427-SHC1 [cytosol] - v53:[modifyName]
[UpdateTracker:9892209] Update Tracker - [DefinedSet:112369] p21 Ras [plasma membrane] - v53:[modifyName]
[UpdateTracker:9892442] Update Tracker - [EntityWithAccessionedSequence:75236] p-5T-MDC1 [nucleoplasm] - v53:[addHasModifiedResidue, modifyName]
[UpdateTracker:9784839] Update Tracker - [Pathway:5653656] Vesicle-mediated transport - v53:[addLiteratureReference, addSummation]
[UpdateTracker:9784763] Update Tracker - [Pathway:382551] Transport of small molecules - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892548] Update Tracker - [Complex:164289] NDUFA9:FAD [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9784842] Update Tracker - [Pathway:167172] Transcription of the HIV genome - v53:[updateIndirectRLE]
[UpdateTracker:9784742] Update Tracker - [Pathway:2033514] FGFR3 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation]
[UpdateTracker:9892478] Update Tracker - [Complex:158334] kallikrein:alpha2-macroglobulin [extracellular region] - v53:[updateContainedComponent]
[UpdateTracker:9784803] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - v53:[modifyText]
[UpdateTracker:9892444] Update Tracker - [Complex:2029148] p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] - v53:[updateContainedComponent]
[UpdateTracker:9784674] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v53:[updateIndirectRLE]
[UpdateTracker:9892254] Update Tracker - [Complex:914049] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784798] Update Tracker - [Pathway:163210] Formation of ATP by chemiosmotic coupling - v53:[updateContainedRLE]
[UpdateTracker:9892439] Update Tracker - [DefinedSet:189382] HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] - v53:[modifyName]
[UpdateTracker:9892322] Update Tracker - [Complex:2029134] p-Y,S,T-WRC [cytosol] - v53:[addHasComponent]
[UpdateTracker:9784834] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v53:[add_removeHasEvent]
[UpdateTracker:9784664] Update Tracker - [Reaction:109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - v53:[add_removeOutput, removeInput]
[UpdateTracker:9784790] Update Tracker - [Reaction:5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - v53:[addLiteratureReference, modifyText]
[UpdateTracker:9784614] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v53:[updateContainedRLE]
[UpdateTracker:9784682] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v53:[addRegulator]
[UpdateTracker:9892547] Update Tracker - [Complex:167472] HIV-1 Promoter Escape Complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892346] Update Tracker - [Complex:2685700] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784703] Update Tracker - [Pathway:975871] MyD88 cascade initiated on plasma membrane - v53:[updateContainedPathway]
[UpdateTracker:9892361] Update Tracker - [Complex:176204] Rad17-RFC complex bound to DNA [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892280] Update Tracker - [Complex:2029154] WAVE Regulatory Complex [cytosol] - v53:[addHasComponent]
[UpdateTracker:9784645] Update Tracker - [Pathway:5675482] Regulation of necroptotic cell death - v53:[updateIndirectRLE]
[UpdateTracker:9784577] Update Tracker - [Pathway:446199] Synthesis of Dolichyl-phosphate - v53:[updateContainedRLE]
[UpdateTracker:9784596] Update Tracker - [BlackBoxEvent:167121] Addition of the third nucleotide on the nascent HIV-1 transcript - v53:[modifyText]
[UpdateTracker:9892335] Update Tracker - [DefinedSet:2685648] p-SYK/p-BTK [plasma membrane] - v53:[updateContainedMemberOrCandidate]
[UpdateTracker:9784809] Update Tracker - [Pathway:109703] PKB-mediated events - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892297] Update Tracker - [SimpleEntity:2162207] DHB [mitochondrial inner membrane] - v53:[addName]
[UpdateTracker:9784681] Update Tracker - [Reaction:451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - v53:[addRegulator, modifyText]
[UpdateTracker:9784663] Update Tracker - [Pathway:176974] Unwinding of DNA - v53:[updateContainedRLE]
[UpdateTracker:9784619] Update Tracker - [Pathway:72163] mRNA Splicing - Major Pathway - v53:[updateContainedRLE]
[UpdateTracker:9892474] Update Tracker - [Complex:5624470] p21 RAS:GTP:p-S338-RAF1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892292] Update Tracker - [CandidateSet:175597] (TDP1,TDP2) [nucleoplasm] - v53:[addHasCandidate, modifyName]
[UpdateTracker:9784822] Update Tracker - [Pathway:2428928] IRS-related events triggered by IGF1R - v53:[updateContainedPathway]
[UpdateTracker:9892388] Update Tracker - [Complex:2404185] IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784723] Update Tracker - [Pathway:2682334] EPH-Ephrin signaling - v53:[updateIndirectRLE]
[UpdateTracker:9892251] Update Tracker - [OtherEntity:84009] ss-gap-reannealed DNA [nucleoplasm] - v53:[modifyName]
[UpdateTracker:9892261] Update Tracker - [Complex:112372] p21 Ras:GDP [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784826] Update Tracker - [Pathway:159236] Transport of Mature mRNA derived from an Intron-Containing Transcript - v53:[updateContainedRLE]
[UpdateTracker:9892384] Update Tracker - [EntityWithAccessionedSequence:75234] p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm] - v53:[addHasModifiedResidue, modifyName]
[UpdateTracker:9892295] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784657] Update Tracker - [Reaction:1839094] Activated FGFR1 mutants and fusions bind PLCG1 - v53:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9892424] Update Tracker - [OtherEntity:75914] Ligatable DNA DSB ends [nucleoplasm] - v53:[addName]
[UpdateTracker:9892219] Update Tracker - [Complex:2424457] p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784754] Update Tracker - [Pathway:71291] Metabolism of amino acids and derivatives - v53:[updateIndirectRLE]
[UpdateTracker:9892244] Update Tracker - [DefinedSet:198916] NKG2D ligand [plasma membrane] - v53:[removeHasMember]
[UpdateTracker:9892234] Update Tracker - [Complex:74678] Insulin:p-6Y-Insulin receptor [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9892205] Update Tracker - [Complex:167091] HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892352] Update Tracker - [Complex:109697] PDPK1:PIP3 [plasma membrane] - v53:[modifyName]
[UpdateTracker:9784680] Update Tracker - [Reaction:164834] Enzyme-bound ATP is released - v53:[modifyText]
[UpdateTracker:9784746] Update Tracker - [Reaction:74747] Dephosphorylation of p-Y-IRS1,p-Y-IRS2 - v53:[add_removeInput]
[UpdateTracker:9892355] Update Tracker - [Complex:158255] A2M tetramer [extracellular region] - v53:[addName]
[UpdateTracker:9892513] Update Tracker - [Complex:2428921] IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784858] Update Tracker - [Pathway:72202] Transport of Mature Transcript to Cytoplasm - v53:[updateIndirectRLE]
[UpdateTracker:9784702] Update Tracker - [Pathway:177929] Signaling by EGFR - v53:[updateContainedPathway]
[UpdateTracker:9892362] Update Tracker - [CandidateSet:5357750] RIPK1 deubiquitinases [cytosol] - v53:[addHasMember, modifyName]
[UpdateTracker:9892482] Update Tracker - [Complex:109801] GRB2-1:p-4S-SOS1 [cytosol] - v53:[add_removeHasComponent, modifyName]
[UpdateTracker:9892569] Update Tracker - [EntityWithAccessionedSequence:112366] p-Y-Shc1 [cytosol] - v53:[modifyName]
[UpdateTracker:9784546] Update Tracker - [Pathway:5654687] Downstream signaling of activated FGFR1 - v53:[updateContainedPathway]
[UpdateTracker:9892245] Update Tracker - [Complex:1861625] Actin filament bound Myosin-X [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9892530] Update Tracker - [Complex:167286] HIV-1 arrested processive elongation complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892529] Update Tracker - [Complex:77053] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892382] Update Tracker - [Complex:176281] ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm] - v53:[addName, updateContainedComponent]
[UpdateTracker:9892511] Update Tracker - [Complex:74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] - v53:[modifyName, updateContainedComponent]
[UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]
[UpdateTracker:9784721] Update Tracker - [Pathway:2559583] Cellular Senescence - v53:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9892306] Update Tracker - [DefinedSet:112336] MAP2K1 [cytosol] - v53:[addName]
[UpdateTracker:9784570] Update Tracker - [Reaction:109822] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 - v53:[add_removeOutput, modifyText, removeInput]
[UpdateTracker:9784566] Update Tracker - [Pathway:4839726] Chromatin organization - v53:[updateContainedPathway]
[UpdateTracker:9892350] Update Tracker - [Complex:2685701] p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] - v53:[updateContainedComponent]
[UpdateTracker:9784610] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v53:[add_removeHasEvent]
[UpdateTracker:9892557] Update Tracker - [Complex:109797] GRB2-1:SOS1 [cytosol] - v53:[modifyName]
[UpdateTracker:9892510] Update Tracker - [Complex:111261] Pol II transcription complex containing transcript to +30 [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784593] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference, updateContainedPathway]
[UpdateTracker:9892344] Update Tracker - [Complex:75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9784859] Update Tracker - [Reaction:169270] ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 - v53:[modifyText]
[UpdateTracker:9784811] Update Tracker - [Reaction:167117] Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition - v53:[modifyText]
[UpdateTracker:9892286] Update Tracker - [Complex:75890] pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] - v53:[updateContainedComponent]
[UpdateTracker:9892436] Update Tracker - [DefinedSet:508181] KIC, KMVA, KIV [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9784693] Update Tracker - [Pathway:77075] RNA Pol II CTD phosphorylation and interaction with CE - v53:[updateContainedRLE]
[UpdateTracker:9892385] Update Tracker - [DefinedSet:508261] BCAA-CoAs [mitochondrial matrix] - v53:[addName]
[UpdateTracker:9892338] Update Tracker - [Complex:72157] Spliced mRNP [nucleoplasm] - v53:[removeHasComponent]
[UpdateTracker:9784752] Update Tracker - [Pathway:375165] NCAM signaling for neurite out-growth - v53:[add_removeHasEvent]
[UpdateTracker:9784789] Update Tracker - [Reaction:446195] DOLK phosphorylates DCHOL to DOLP - v53:[modifyText]

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