Reactome | 63 on 2017-12-18

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63 on 2017-12-18 Show undefined attributes

dbId	9780166
displayName	63 on 2017-12-18
modified	[InstanceEdit:9982963] Weiser, Joel, 2026-02-20
releaseDate	2017-12-18
releaseNumber	63
schemaClass	Release

Referrals

(release)

[UpdateTracker:9780280] Update Tracker - [Pathway:1912408] Pre-NOTCH Transcription and Translation - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780244] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v63:[modifyText]
[UpdateTracker:9780305] Update Tracker - [Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis - v63:[updateContainedRLE]
[UpdateTracker:9780263] Update Tracker - [Pathway:975634] Retinoid metabolism and transport - v63:[updateContainedRLE]
[UpdateTracker:9897886] Update Tracker - [Complex:749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898236] Update Tracker - [Complex:5340212] CYGB dimer:O2 [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9898208] Update Tracker - [CandidateSet:8986114] Mitochondrial targeting peptides (from matrix proteins) [mitochondrial matrix] - v63:[modifyName]
[UpdateTracker:9898332] Update Tracker - [Complex:5218757] VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780435] Update Tracker - [BlackBoxEvent:8983309] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 - v63:[modifyText]
[UpdateTracker:9898435] Update Tracker - [Complex:6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898200] Update Tracker - [Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897878] Update Tracker - [ChemicalDrug:2399927] MK2206 [cytosol] - v63:[addName]
[UpdateTracker:9897961] Update Tracker - [Complex:114353] DIABLO:XIAP:Caspase-7 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898094] Update Tracker - [CandidateSet:9013956] RIP3:TICAM1:activated TLR3 [endosome membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9897905] Update Tracker - [Complex:182935] EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780409] Update Tracker - [Pathway:203615] eNOS activation - v63:[addHasEvent]
[UpdateTracker:9898089] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898393] Update Tracker - [Complex:9013984] TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780208] Update Tracker - [Pathway:453279] Mitotic G1 phase and G1/S transition - v63:[addLiteratureReference, addSummation, updateContainedPathway]
[UpdateTracker:9780176] Update Tracker - [Reaction:5336182] GPR37 binds prosaptide - v63:[modifyText]
[UpdateTracker:9897954] Update Tracker - [Complex:2453705] TTR:RBP4:atROL [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9897956] Update Tracker - [Complex:392184] ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898002] Update Tracker - [Complex:983227] Kinesin-1 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898353] Update Tracker - [Complex:109626] TFIID [nucleoplasm] - v63:[addHasComponent, addLiteratureReference]
[UpdateTracker:9897947] Update Tracker - [Complex:3928531] EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780203] Update Tracker - [Pathway:112399] IRS-mediated signalling - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898344] Update Tracker - [Complex:2130182] p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898124] Update Tracker - [Complex:205202] GRB2:SOS1:p-KIT complex [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780498] Update Tracker - [Reaction:8852481] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates - v63:[add_removeInput]
[UpdateTracker:9780183] Update Tracker - [Reaction:419426] Cannabinoid receptors can bind cannabinoids - v63:[modifyText]
[UpdateTracker:9898080] Update Tracker - [DefinedSet:8869161] AP-2 cargo [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898075] Update Tracker - [Complex:186795] PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780315] Update Tracker - [Pathway:1643685] Disease - v63:[updateContainedPathway]
[UpdateTracker:9897931] Update Tracker - [Complex:167106] HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780377] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v63:[updateContainedPathway]
[UpdateTracker:9780199] Update Tracker - [Reaction:3928584] p-EPHs bind SRC,FYN,YES,LYN - v63:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9898297] Update Tracker - [Complex:5691129] HFE:TFRC dimer [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898376] Update Tracker - [Complex:164333] G alpha (s):GDP [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9897916] Update Tracker - [Complex:5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780478] Update Tracker - [Pathway:5607764] CLEC7A (Dectin-1) signaling - v63:[updateContainedRLE]
[UpdateTracker:9780259] Update Tracker - [Reaction:6790167] MOD5 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) - v63:[add_removeInput]
[UpdateTracker:9780372] Update Tracker - [Pathway:4420097] VEGFA-VEGFR2 Pathway - v63:[updateContainedRLE]
[UpdateTracker:9898428] Update Tracker - [Complex:204977] NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898196] Update Tracker - [CandidateSet:983226] KLC1,KLC2,KLC3,KLC4 [cytosol] - v63:[addName]
[UpdateTracker:9897967] Update Tracker - [Complex:179864] GRB2:GAB1:PIK3R1 [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9897970] Update Tracker - [Complex:507919] p-STAT5 dimer [cytosol] - v63:[addName, add_removeHasComponent]
[UpdateTracker:9780267] Update Tracker - [Reaction:6786171] FANCD2 deubiquitination by USP1:WDR48 - v63:[modifyText]
[UpdateTracker:9897995] Update Tracker - [Complex:2187256] Scara5:Ligand [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898188] Update Tracker - [SimpleEntity:209800] 1,25(OH)2D [cytosol] - v63:[modifyName]
[UpdateTracker:9898189] Update Tracker - [DefinedSet:1169480] SHC1-2,SHC1-3 [cytosol] - v63:[addName]
[UpdateTracker:9780287] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v63:[updateContainedPathway]
[UpdateTracker:9780425] Update Tracker - [Reaction:6785165] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B - v63:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText, removeRegulator]
[UpdateTracker:9780182] Update Tracker - [BlackBoxEvent:8983313] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 binds Shc1 - v63:[modifyText]
[UpdateTracker:9780328] Update Tracker - [Pathway:203927] MicroRNA (miRNA) biogenesis - v63:[addHasEvent]
[UpdateTracker:9898184] Update Tracker - [Complex:983245] Kinesins:microtubule [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780386] Update Tracker - [Pathway:168188] Toll Like Receptor TLR6:TLR2 Cascade - v63:[updateContainedPathway]
[UpdateTracker:9898336] Update Tracker - [Complex:5218771] VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780375] Update Tracker - [BlackBoxEvent:8983063] JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated - v63:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9898441] Update Tracker - [Complex:209533] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898173] Update Tracker - [Complex:8983138] IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780306] Update Tracker - [Reaction:3928617] EPHB2 binds KALRN - v63:[add_removeInput]
[UpdateTracker:9897929] Update Tracker - [Complex:186789] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897925] Update Tracker - [Complex:2685700] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898115] Update Tracker - [Complex:400679] Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898012] Update Tracker - [Complex:75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9897914] Update Tracker - [Complex:5218769] HSP27 oligomer:F-actin [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780190] Update Tracker - [Pathway:69242] S Phase - v63:[updateContainedPathway]
[UpdateTracker:9897885] Update Tracker - [Complex:5218788] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780444] Update Tracker - [Reaction:3296304] GPR31 is a receptor for 12(S)-HETE - v63:[modifyText]
[UpdateTracker:9897883] Update Tracker - [Complex:350870] Caspase-3 [cytosol] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898277] Update Tracker - [Complex:5654197] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780273] Update Tracker - [Pathway:166658] Complement cascade - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780231] Update Tracker - [Pathway:3928665] EPH-ephrin mediated repulsion of cells - v63:[updateContainedRLE]
[UpdateTracker:9898117] Update Tracker - [Complex:75871] pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9897930] Update Tracker - [Complex:392194] ADP:P2RY12:G-protein Gi (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780479] Update Tracker - [BlackBoxEvent:6797293] Expression of IL18, ALOX5 - v63:[modifyText]
[UpdateTracker:9897902] Update Tracker - [Complex:2685650] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897955] Update Tracker - [EntityWithAccessionedSequence:9008607] IL37(?-218) [extracellular region] - v63:[modifyName]
[UpdateTracker:9898119] Update Tracker - [Complex:114304] XIAP:Caspase-3 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780361] Update Tracker - [Pathway:1834949] Cytosolic sensors of pathogen-associated DNA - v63:[updateIndirectRLE]
[UpdateTracker:9898232] Update Tracker - [Complex:5691094] TFR2 dimer:2xholoTF [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780284] Update Tracker - [Pathway:2454202] Fc epsilon receptor (FCERI) signaling - v63:[updateIndirectRLE]
[UpdateTracker:9898438] Update Tracker - [Complex:5653972] mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780262] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v63:[updateContainedRLE]
[UpdateTracker:9898429] Update Tracker - [SimpleEntity:38117] PIP3 [plasma membrane] - v63:[add_removeReferenceEntity]
[UpdateTracker:9898156] Update Tracker - [Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780252] Update Tracker - [Reaction:167077] Recruitment of elongation factors to form HIV-1 elongation complex - v63:[modifyText]
[UpdateTracker:9897918] Update Tracker - [Complex:432197] AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898193] Update Tracker - [Complex:83551] Pol II initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780368] Update Tracker - [Reaction:8983394] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 - v63:[modifyText]
[UpdateTracker:9898172] Update Tracker - [Complex:419626] SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] - v63:[modifyName, removeHasComponent, updateContainedComponent]
[UpdateTracker:9898191] Update Tracker - [Complex:3928546] p-EPHBs:EFNBs:ITSN1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780391] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v63:[updateContainedRLE]
[UpdateTracker:9898261] Update Tracker - [Complex:209892] GC:25(OH)D [extracellular region] - v63:[modifyName]
[UpdateTracker:9780310] Update Tracker - [Pathway:1268020] Mitochondrial protein import - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780274] Update Tracker - [Pathway:1483206] Glycerophospholipid biosynthesis - v63:[updateContainedPathway]
[UpdateTracker:9898389] Update Tracker - [Complex:8852534] MST1 dimer:2xMST1R dimer [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898241] Update Tracker - [Complex:5654192] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780296] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v63:[removeHasEvent]
[UpdateTracker:9897974] Update Tracker - [Complex:432200] G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898034] Update Tracker - [Complex:8951587] p-VAV family:PIP3:RAC1:GDP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780201] Update Tracker - [Reaction:444572] Zinc is an agonist of GPR39 - v63:[modifyText]
[UpdateTracker:9780173] Update Tracker - [Pathway:6806664] Metabolism of vitamin K - v63:[updateContainedRLE]
[UpdateTracker:9780483] Update Tracker - [BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - v63:[addRegulator, removeCatalystActivity]
[UpdateTracker:9897985] Update Tracker - [Complex:9014322] SARM:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897994] Update Tracker - [Complex:163622] G alpha (s):GTP:Adenylate cyclase [plasma membrane] - v63:[addName, add_removeCompartment, updateContainedComponent]
[UpdateTracker:9898079] Update Tracker - [Complex:2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780412] Update Tracker - [Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade - v63:[updateContainedPathway]
[UpdateTracker:9780319] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v63:[modifyText, updateContainedRLE]
[UpdateTracker:9780200] Update Tracker - [Pathway:196854] Metabolism of vitamins and cofactors - v63:[updateContainedPathway]
[UpdateTracker:9897990] Update Tracker - [Complex:68644] RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898378] Update Tracker - [Complex:180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898010] Update Tracker - [Complex:1295546] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] - v63:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9898020] Update Tracker - [Complex:75859] Pol II Promoter Escape Complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780235] Update Tracker - [Reaction:1299476] MPP cleaves targeting peptide (presequence) of inner membrane precursors - v63:[addInput]
[UpdateTracker:9898109] Update Tracker - [Complex:114308] XIAP:Caspase-7 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780392] Update Tracker - [Pathway:388396] GPCR downstream signalling - v63:[removeHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898316] Update Tracker - [Complex:416601] SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9898157] Update Tracker - [Complex:2685694] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898223] Update Tracker - [Complex:1295773] Il7r:Jak1 [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780350] Update Tracker - [Pathway:917937] Iron uptake and transport - v63:[updateContainedRLE]
[UpdateTracker:9780356] Update Tracker - [Reaction:4093330] EPHB binds p120-RasGAP - v63:[add_removeInput]
[UpdateTracker:9898275] Update Tracker - [Complex:5654333] Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780198] Update Tracker - [Pathway:76042] RNA Polymerase II Transcription Initiation And Promoter Clearance - v63:[addLiteratureReference, addSummation]
[UpdateTracker:9898106] Update Tracker - [EntityWithAccessionedSequence:5218694] p-6Y,S732-PTK2 [cytosol] - v63:[addName]
[UpdateTracker:9898431] Update Tracker - [Complex:5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898185] Update Tracker - [Complex:386977] 6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] - v63:[updateContainedComponent]
[UpdateTracker:9780407] Update Tracker - [BlackBoxEvent:8983011] Expression of STAT5 upregulated genes - v63:[modifyText]
[UpdateTracker:9780234] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v63:[updateContainedPathway]
[UpdateTracker:9780236] Update Tracker - [Reaction:9013869] DDX41 binds bacterial c-di-AMP, c-di-GMP - v63:[modifyText]
[UpdateTracker:9898097] Update Tracker - [Complex:3928563] EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898120] Update Tracker - [Complex:3928519] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780348] Update Tracker - [Pathway:6783589] Interleukin-6 family signaling - v63:[add_removeHasEvent]
[UpdateTracker:9898167] Update Tracker - [SimpleEntity:912298] (GlcNAc)2 (Man)8a [endoplasmic reticulum quality control compartment] - v63:[addName]
[UpdateTracker:9898126] Update Tracker - [Complex:2453850] TTR:RBP4:atROL:STRA6 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898234] Update Tracker - [Complex:114305] DIABLO:XIAP:Caspase-3 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9897951] Update Tracker - [Complex:5675702] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898306] Update Tracker - [EntityWithAccessionedSequence:264971] 4xHC-INS(90-110) [secretory granule lumen] - v63:[add_removeHasModifiedResidue]
[UpdateTracker:9898051] Update Tracker - [Complex:109628] pol II promoter:TFIID complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780221] Update Tracker - [Reaction:448603] IL33:IL1RL1 binds IL1RAP-1 - v63:[modifyText]
[UpdateTracker:9898331] Update Tracker - [Complex:1295512] p-Y449-IL7R:JAK1 [plasma membrane] - v63:[modifyName, removeHasComponent]
[UpdateTracker:9898325] Update Tracker - [Complex:5218760] VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9898341] Update Tracker - [Complex:5654189] Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897977] Update Tracker - [Complex:194552] beta-NGF homodimer:p75NTR:NRIF [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897979] Update Tracker - [Complex:2685683] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898424] Update Tracker - [Complex:5218756] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780207] Update Tracker - [Pathway:382551] Transport of small molecules - v63:[addSummation, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898340] Update Tracker - [Complex:8933291] LSR trimer:VLDL [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780191] Update Tracker - [Reaction:1295768] Jak1 binds Il7r - v63:[add_removeInput, modifyText, removeLiteratureReference]
[UpdateTracker:9898116] Update Tracker - [Complex:8868626] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898256] Update Tracker - [Complex:6785208] LIPC dimer:heparin [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9898067] Update Tracker - [Complex:416580] SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9898426] Update Tracker - [Complex:8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897963] Update Tracker - [Complex:2581517] p-Rho:Sag [photoreceptor disc membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898364] Update Tracker - [Complex:5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9898289] Update Tracker - [Complex:3274485] S-farn-Grk1:Rcvrn:Ca2+ [photoreceptor disc membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780254] Update Tracker - [Pathway:70268] Pyruvate metabolism - v63:[updateIndirectRLE]
[UpdateTracker:9897972] Update Tracker - [Complex:8869191] AP-2:cargo [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897875] Update Tracker - [DefinedSet:8866232] AP-2 YXXPhi cargo [plasma membrane] - v63:[addHasMember, addLiteratureReference, updateContainedMemberOrCandidate]
[UpdateTracker:9897897] Update Tracker - [Complex:5218775] VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898372] Update Tracker - [Complex:5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897908] Update Tracker - [Complex:2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898087] Update Tracker - [Complex:2132125] C8 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898301] Update Tracker - [Complex:8848398] IL18:IL18R1:IL18RAP [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780429] Update Tracker - [Pathway:211916] Vitamins - v63:[updateContainedRLE]
[UpdateTracker:9780307] Update Tracker - [Reaction:3928644] EPHB binds ITSN1 - v63:[add_removeInput]
[UpdateTracker:9898255] Update Tracker - [EntityWithAccessionedSequence:6802326] FXR1(2-784)-BRAF(381-766) fusion [cytosol] - v63:[modifyEndCoordinate]
[UpdateTracker:9898091] Update Tracker - [Complex:2424459] p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780349] Update Tracker - [Pathway:2682334] EPH-Ephrin signaling - v63:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898371] Update Tracker - [Complex:5218762] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9897917] Update Tracker - [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898085] Update Tracker - [Complex:422314] GLP1R:Heterotrimeric G(s):GDP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898411] Update Tracker - [Complex:2179328] TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897881] Update Tracker - [Complex:2187240] Ferritin [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9897923] Update Tracker - [Complex:392165] Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898265] Update Tracker - [Complex:8982988] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9897877] Update Tracker - [Complex:1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780381] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v63:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898394] Update Tracker - [Complex:167137] HIV-1 open pre-initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780489] Update Tracker - [Pathway:5683826] Surfactant metabolism - v63:[updateContainedRLE]
[UpdateTracker:9898105] Update Tracker - [Complex:209574] NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780258] Update Tracker - [Pathway:977444] GABA B receptor activation - v63:[updateContainedRLE]
[UpdateTracker:9897988] Update Tracker - [DefinedSet:3828019] Active caspase-3 heterotetramer, calpain-1 [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780326] Update Tracker - [Reaction:373342] CX3CR1 binds CX3CL1 - v63:[modifyText]
[UpdateTracker:9780346] Update Tracker - [Pathway:1483257] Phospholipid metabolism - v63:[updateContainedPathway]
[UpdateTracker:9898346] Update Tracker - [Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898143] Update Tracker - [Complex:5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780424] Update Tracker - [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - v63:[addHasEvent]
[UpdateTracker:9780291] Update Tracker - [Pathway:5621481] C-type lectin receptors (CLRs) - v63:[updateIndirectRLE]
[UpdateTracker:9898351] Update Tracker - [Complex:2685668] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898258] Update Tracker - [Complex:418144] F2R:ARRB1:MAPKs:active SRC-1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780189] Update Tracker - [Pathway:449147] Signaling by Interleukins - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898413] Update Tracker - [Complex:419621] SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9897880] Update Tracker - [Complex:177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897959] Update Tracker - [Complex:3928540] EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780318] Update Tracker - [Reaction:5671707] Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA - v63:[add_removeOutput]
[UpdateTracker:9898074] Update Tracker - [DefinedSet:791493] GPCRs that activate Gq/11 [plasma membrane] - v63:[addHasMember]
[UpdateTracker:9898102] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898140] Update Tracker - [Complex:9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897906] Update Tracker - [DefinedSet:416544] ARHGEF11,ARHGEF12 [cytosol] - v63:[addName]
[UpdateTracker:9780214] Update Tracker - [BlackBoxEvent:8983356] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2 - v63:[modifyText]
[UpdateTracker:9897934] Update Tracker - [SimpleEntity:209906] 25(OH)D [extracellular region] - v63:[modifyName]
[UpdateTracker:9898304] Update Tracker - [Complex:3149533] MMACHC:MMADHC:cob(II)alamin [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9780343] Update Tracker - [Pathway:8868773] rRNA processing in the nucleus and cytosol - v63:[updateIndirectRLE]
[UpdateTracker:9780292] Update Tracker - [Pathway:1502540] Signaling by Activin - v63:[updateContainedPathway]
[UpdateTracker:9780341] Update Tracker - [Reaction:8848392] IL18BP binds IL18 - v63:[modifyText]
[UpdateTracker:9898262] Update Tracker - [Complex:936589] SubI--sulfate complex [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898354] Update Tracker - [Complex:901051] unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1:malectin [endoplasmic reticulum lumen] - v63:[add_removeHasComponent]
[UpdateTracker:9898230] Update Tracker - [CandidateSet:6802720] BRAF/RAF fusion dimers [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898295] Update Tracker - [Complex:9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898259] Update Tracker - [Complex:167129] HIV-1 initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898025] Update Tracker - [Complex:167472] HIV-1 Promoter Escape Complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898368] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898052] Update Tracker - [Complex:8868634] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780193] Update Tracker - [Pathway:912446] Meiotic recombination - v63:[add_removeHasEvent]
[UpdateTracker:9780329] Update Tracker - [Pathway:1280215] Cytokine Signaling in Immune system - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780376] Update Tracker - [Pathway:109606] Intrinsic Pathway for Apoptosis - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898231] Update Tracker - [DefinedSet:2187242] Ligands of SCARA5 [extracellular region] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898111] Update Tracker - [Complex:442565] WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898078] Update Tracker - [Complex:5218765] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898287] Update Tracker - [EntityWithAccessionedSequence:888580] PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] - v63:[addName]
[UpdateTracker:9898084] Update Tracker - [Complex:904821] SLC40A1:HEPH:6Cu2+ [plasma membrane] - v63:[modifyName]
[UpdateTracker:9897942] Update Tracker - [Complex:8856140] APOBR dimer:VLDL [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780240] Update Tracker - [Reaction:4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 - v63:[modifyText]
[UpdateTracker:9898032] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780313] Update Tracker - [Reaction:452102] p-STAT5 dimerizes - v63:[modifyText]
[UpdateTracker:9780266] Update Tracker - [Pathway:6783783] Interleukin-10 signaling - v63:[addHasEvent]
[UpdateTracker:9898298] Update Tracker - [Complex:5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780416] Update Tracker - [BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - v63:[addRegulator]
[UpdateTracker:9898244] Update Tracker - [Complex:8871145] PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898163] Update Tracker - [Complex:8983197] p-Y-STAT3:p-STAT5A,p-STAT5B [nucleoplasm] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780229] Update Tracker - [Pathway:157118] Signaling by NOTCH - v63:[add_removeHasEvent, updateContainedPathway]
[UpdateTracker:9780488] Update Tracker - [Pathway:3000178] ECM proteoglycans - v63:[addHasEvent]
[UpdateTracker:9780432] Update Tracker - [BlackBoxEvent:350158] LGMN degrades GC - v63:[modifyText]
[UpdateTracker:9898390] Update Tracker - [Complex:181802] p-Trk receptor:Shc [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780181] Update Tracker - [Pathway:74751] Insulin receptor signalling cascade - v63:[updateContainedPathway]
[UpdateTracker:9780397] Update Tracker - [Pathway:1430728] Metabolism - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898309] Update Tracker - [SimpleEntity:6803746] NARAC-ETA [lysosomal lumen] - v63:[add_removeReferenceEntity]
[UpdateTracker:9780501] Update Tracker - [Pathway:451927] Interleukin-2 family signaling - v63:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898093] Update Tracker - [Complex:206896] HRAS:GDP [plasma membrane] - v63:[modifyName]
[UpdateTracker:9898142] Update Tracker - [Complex:921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898280] Update Tracker - [Complex:1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898322] Update Tracker - [Complex:187769] Activated Trk receptor complex:Rit-GDP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780370] Update Tracker - [Pathway:181431] Acetylcholine binding and downstream events - v63:[addSummation]
[UpdateTracker:9898141] Update Tracker - [Complex:8982992] IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898382] Update Tracker - [Complex:167403] Opioid:MOR:G protein-GDP complex [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897892] Update Tracker - [DefinedSet:216838] Insulin (docked granule) [secretory granule lumen] - v63:[modifyName]
[UpdateTracker:9780452] Update Tracker - [Reaction:2002428] Removal of fibrillar collagen N-propeptides - v63:[modifyText]
[UpdateTracker:9898018] Update Tracker - [Complex:419623] MET:p-Y-PLXNB1 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9898216] Update Tracker - [Complex:1295539] IL7:p-Y449-IL7R:JAK1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898160] Update Tracker - [Complex:5654320] Activated FGFR4:SHC1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898039] Update Tracker - [Complex:5334658] CLAT:AP1:CLVS:PI(3,5)P2 [clathrin-coated endocytic vesicle] - v63:[add_removeHasComponent]
[UpdateTracker:9898027] Update Tracker - [Complex:449983] IL7:IL7R:JAK1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898274] Update Tracker - [Complex:5655271] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898095] Update Tracker - [Complex:422311] GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897989] Update Tracker - [DefinedSet:8869159] AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] - v63:[addHasMember]
[UpdateTracker:9898107] Update Tracker - [Complex:3928532] EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898122] Update Tracker - [Complex:2424457] p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780332] Update Tracker - [Pathway:110314] Recognition of DNA damage by PCNA-containing replication complex - v63:[updateContainedRLE]
[UpdateTracker:9898221] Update Tracker - [Complex:186839] PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898112] Update Tracker - [EntityWithAccessionedSequence:419549] WDR48 [nucleoplasm] - v63:[addName]
[UpdateTracker:9780209] Update Tracker - [Pathway:5663205] Infectious disease - v63:[addSummation]
[UpdateTracker:9898014] Update Tracker - [Polymer:5218689] HSBP1 oligomer [cytosol] - v63:[addName]
[UpdateTracker:9780494] Update Tracker - [Pathway:69052] Switching of origins to a post-replicative state - v63:[addSummation, updateContainedPathway]
[UpdateTracker:9780362] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v63:[modifyText]
[UpdateTracker:9780321] Update Tracker - [Pathway:162599] Late Phase of HIV Life Cycle - v63:[updateContainedPathway]
[UpdateTracker:9898195] Update Tracker - [Complex:167418] G protein-GDP complex [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897943] Update Tracker - [Complex:9011531] DCA:PDK2 [mitochondrial matrix] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780351] Update Tracker - [Reaction:209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - v63:[modifyText]
[UpdateTracker:9780290] Update Tracker - [Reaction:3928579] Interaction of Src family kinases with p-EPHs - v63:[modifyText]
[UpdateTracker:9898397] Update Tracker - [Complex:392864] Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780440] Update Tracker - [Pathway:2980736] Peptide hormone metabolism - v63:[updateContainedPathway]
[UpdateTracker:9898207] Update Tracker - [Complex:8858255] HDLBP:HDL [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898300] Update Tracker - [Complex:109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898153] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780414] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v63:[updateContainedRLE]
[UpdateTracker:9898290] Update Tracker - [Complex:5685207] CCDC59:TTF1:SFTPC gene [nucleoplasm] - v63:[add_removeHasComponent]
[UpdateTracker:9780217] Update Tracker - [Pathway:1650814] Collagen biosynthesis and modifying enzymes - v63:[updateContainedRLE]
[UpdateTracker:9898073] Update Tracker - [Complex:264931] 6xInsulin:2xZn2+:Ca2+ [secretory granule lumen] - v63:[addHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9780418] Update Tracker - [Pathway:73893] DNA Damage Bypass - v63:[updateIndirectRLE]
[UpdateTracker:9780436] Update Tracker - [Pathway:167152] Formation of HIV elongation complex in the absence of HIV Tat - v63:[addSummation, updateContainedRLE]
[UpdateTracker:9780327] Update Tracker - [Reaction:209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - v63:[modifyText]
[UpdateTracker:9898365] Update Tracker - [Complex:5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898001] Update Tracker - [Complex:75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898349] Update Tracker - [Complex:5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897904] Update Tracker - [EntityWithAccessionedSequence:448446] IL18 [extracellular region] - v63:[modifyName]
[UpdateTracker:9780415] Update Tracker - [Pathway:400508] Incretin synthesis, secretion, and inactivation - v63:[updateContainedPathway]
[UpdateTracker:9898161] Update Tracker - [Complex:9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897938] Update Tracker - [EntityWithAccessionedSequence:6802402] BRAF(1-380)-MACF1(600-7388)fusion [cytosol] - v63:[add_removeReferenceEntity, modifyEndCoordinate, modifyName]
[UpdateTracker:9898218] Update Tracker - [Complex:3928511] p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898251] Update Tracker - [Complex:2213219] Kinesins:Dynactin:microtubule [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898162] Update Tracker - [Complex:9008615] IL18BP:IL37,IL37(?-218) [extracellular region] - v63:[addName, updateContainedComponent]
[UpdateTracker:9898104] Update Tracker - [Complex:3928492] EFNBs:p-EPHBs:SFKs [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897926] Update Tracker - [Complex:422310] GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780445] Update Tracker - [Pathway:449836] Other interleukin signaling - v63:[addHasEvent]
[UpdateTracker:9898155] Update Tracker - [Complex:5655479] MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780495] Update Tracker - [Pathway:418555] G alpha (s) signalling events - v63:[addHasEvent, modifyText]
[UpdateTracker:9898062] Update Tracker - [Complex:5654205] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898150] Update Tracker - [Complex:1225859] Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898183] Update Tracker - [Complex:2029140] Mother filament:branching complex [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898439] Update Tracker - [Complex:5654194] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780459] Update Tracker - [Reaction:5218838] PXN binds p-6Y,S732-PTK2 - v63:[modifyText]
[UpdateTracker:9780447] Update Tracker - [Pathway:1632852] Macroautophagy - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9897997] Update Tracker - [Complex:5340274] NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] - v63:[add_removeHasComponent]
[UpdateTracker:9898246] Update Tracker - [Complex:5218641] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898088] Update Tracker - [Complex:749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898148] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898437] Update Tracker - [Complex:5357453] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9897872] Update Tracker - [Complex:3928499] p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] - v63:[addName, add_removeHasComponent]
[UpdateTracker:9780177] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v63:[updateContainedRLE]
[UpdateTracker:9898178] Update Tracker - [Complex:5334829] FABPs:LCFA [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9780480] Update Tracker - [Pathway:446728] Cell junction organization - v63:[addSummation]
[UpdateTracker:9897911] Update Tracker - [Complex:5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780470] Update Tracker - [Pathway:72306] tRNA processing - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780492] Update Tracker - [Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - v63:[updateContainedRLE]
[UpdateTracker:9780379] Update Tracker - [BlackBoxEvent:9009867] Il2rb and Il2rg are phosphorylated - v63:[modifyText]
[UpdateTracker:9780281] Update Tracker - [Pathway:264876] Insulin processing - v63:[add_removeHasEvent]
[UpdateTracker:9780454] Update Tracker - [BlackBoxEvent:209766] 25(OH)D translocates from lysosomal lumen to cytosol - v63:[modifyText]
[UpdateTracker:9898329] Update Tracker - [Complex:5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898288] Update Tracker - [Complex:6802625] RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780223] Update Tracker - [Reaction:5655483] USP1 autocleavage - v63:[modifyText]
[UpdateTracker:9780174] Update Tracker - [Pathway:1266695] Interleukin-7 signaling - v63:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9780352] Update Tracker - [Pathway:69206] G1/S Transition - v63:[updateContainedPathway]
[UpdateTracker:9780206] Update Tracker - [Reaction:1295519] IL7R is phosphorylated on Y499 - v63:[add_removeInput]
[UpdateTracker:9780186] Update Tracker - [Reaction:140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - v63:[modifyText]
[UpdateTracker:9898064] Update Tracker - [Complex:3240771] EZH2 Gene:E2F1/2/3:DP1/2 [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780295] Update Tracker - [Reaction:5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA - v63:[modifyText]
[UpdateTracker:9898254] Update Tracker - [DefinedSet:169291] MAPKs [cytosol] - v63:[addName]
[UpdateTracker:9898303] Update Tracker - [Complex:186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] - v63:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9897986] Update Tracker - [Complex:8868051] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898158] Update Tracker - [Complex:2685692] p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898033] Update Tracker - [Complex:422322] G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780185] Update Tracker - [Pathway:199991] Membrane Trafficking - v63:[updateIndirectRLE]
[UpdateTracker:9780482] Update Tracker - [Reaction:388855] Prolactin-releasing hormone receptor binds PRH - v63:[modifyText]
[UpdateTracker:9898366] Update Tracker - [Complex:4420141] VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9897919] Update Tracker - [DefinedSet:2187238] Ligands of Scara5 [extracellular region] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780233] Update Tracker - [Pathway:167172] Transcription of the HIV genome - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898137] Update Tracker - [Complex:1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898131] Update Tracker - [Complex:166537] beta-NGF dimer:TrkA receptor [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780175] Update Tracker - [Reaction:449958] IL7:IL7R:JAK1 binds IL2RG:JAK3 - v63:[add_removeInput, modifyText]
[UpdateTracker:9898168] Update Tracker - [Complex:5674360] IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897996] Update Tracker - [Complex:2507861] Scara5:Ferritin [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780330] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v63:[updateContainedPathway]
[UpdateTracker:9898345] Update Tracker - [Complex:8952725] Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780213] Update Tracker - [BlackBoxEvent:9012671] p-STAT5 binds CISH, SOCS1 and SOCS2 gene - v63:[modifyText]
[UpdateTracker:9780299] Update Tracker - [Reaction:8956427] RETSAT reduces atROL to at-13,14-dhROL - v63:[removeInput]
[UpdateTracker:9780472] Update Tracker - [Pathway:5627117] RHO GTPases Activate ROCKs - v63:[addHasEvent]
[UpdateTracker:9898235] Update Tracker - [Complex:5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898004] Update Tracker - [Complex:5637693] p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898313] Update Tracker - [CandidateSet:9013962] TICAM1:activated TLR3 complexes [endosome membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898373] Update Tracker - [Complex:2132238] CD59:C5b:C6:C7:C8:C9 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780225] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898226] Update Tracker - [SimpleEntity:2142765] (5Z,11Z,14Z)-8,9-dihydroxyicosatrienoic acid [cytosol] - v63:[addName]
[UpdateTracker:9898324] Update Tracker - [Complex:5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898307] Update Tracker - [DefinedSet:391181] Ligand:GPCR complexes that activate Gs [plasma membrane] - v63:[addHasMember]
[UpdateTracker:9897962] Update Tracker - [Complex:3928541] EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898440] Update Tracker - [DefinedSet:380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane] - v63:[addHasMember, updateContainedMemberOrCandidate]
[UpdateTracker:9780314] Update Tracker - [Pathway:352230] Amino acid transport across the plasma membrane - v63:[updateContainedRLE]
[UpdateTracker:9780453] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v63:[add_removeInput]
[UpdateTracker:9898293] Update Tracker - [Complex:5675791] MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897964] Update Tracker - [DefinedSet:790204] GPCRs that activate Gs [plasma membrane] - v63:[addHasMember]
[UpdateTracker:9780419] Update Tracker - [Pathway:1222449] Mtb iron assimilation by chelation - v63:[updateContainedRLE]
[UpdateTracker:9898123] Update Tracker - [CandidateSet:8849364] Kinesins [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898333] Update Tracker - [Complex:5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780451] Update Tracker - [Reaction:444705] T1R1/T1R3 dimer is the umami taste receptor - v63:[modifyText]
[UpdateTracker:9898009] Update Tracker - [Complex:109635] pol II closed pre-initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898081] Update Tracker - [Complex:1295776] Il7:p-Y449-Il7r:Jak1:Il2rg:p-Jak3 [plasma membrane] - v63:[modifyName, removeHasComponent]
[UpdateTracker:9780389] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v63:[add_removeHasEvent, updateIndirectRLE]
[UpdateTracker:9898415] Update Tracker - [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898227] Update Tracker - [Complex:6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898296] Update Tracker - [EntityWithAccessionedSequence:443318] Sos1 [cytosol] - v63:[modifyEndCoordinate, modifyName]
[UpdateTracker:9898182] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898024] Update Tracker - [Complex:8979216] NR3C2:NR3C2 ligands [cytosol] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9898045] Update Tracker - [Complex:5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898250] Update Tracker - [Complex:6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898054] Update Tracker - [Complex:202676] PIP3:RhoA [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780404] Update Tracker - [Pathway:1306955] GRB7 events in ERBB2 signaling - v63:[addLiteratureReference, modifyText]
[UpdateTracker:9897939] Update Tracker - [Complex:418103] F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898022] Update Tracker - [Complex:170656] (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898369] Update Tracker - [Complex:109876] pol II open pre-initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898269] Update Tracker - [Complex:5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898046] Update Tracker - [Complex:8933293] Lsr trimer:VLDL [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780187] Update Tracker - [Pathway:165160] PDE3B signalling - v63:[addLiteratureReference, addSummation]
[UpdateTracker:9897887] Update Tracker - [Complex:5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897958] Update Tracker - [Complex:1295544] IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780283] Update Tracker - [BlackBoxEvent:5685290] SFTPD gene produces SFTPD protein - v63:[add_removeOutput, modifyText]
[UpdateTracker:9898164] Update Tracker - [Complex:9013961] viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898026] Update Tracker - [Complex:6802711] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780428] Update Tracker - [Pathway:194315] Signaling by Rho GTPases - v63:[updateContainedPathway]
[UpdateTracker:9897968] Update Tracker - [Complex:2424467] p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898114] Update Tracker - [Complex:8848514] IL18R1:IL37,IL37(?-218) [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9780502] Update Tracker - [Reaction:444191] GPR120 is a receptor for unsaturated long-chain free fatty acids - v63:[modifyText]
[UpdateTracker:9898145] Update Tracker - [Complex:5672139] MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780385] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v63:[modifyText]
[UpdateTracker:9897922] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v63:[add_removeHasComponent]
[UpdateTracker:9780331] Update Tracker - [Pathway:194138] Signaling by VEGF - v63:[updateIndirectRLE]
[UpdateTracker:9897898] Update Tracker - [Complex:170659] (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898402] Update Tracker - [Complex:8983137] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780165] Update Tracker - [BlackBoxEvent:1445144] p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) - v63:[add_removeCatalystActivity]
[UpdateTracker:9898098] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v63:[addHasMember, updateContainedMemberOrCandidate]
[UpdateTracker:9780195] Update Tracker - [Pathway:73863] RNA Polymerase I Transcription Termination - v63:[addLiteratureReference]
[UpdateTracker:9780463] Update Tracker - [Pathway:73857] RNA Polymerase II Transcription - v63:[addLiteratureReference, addSummation, updateContainedPathway]
[UpdateTracker:9898328] Update Tracker - [Complex:186831] PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780276] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v63:[modifyText]
[UpdateTracker:9780246] Update Tracker - [Pathway:2187338] Visual phototransduction - v63:[updateIndirectRLE]
[UpdateTracker:9897933] Update Tracker - [Complex:8981947] IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9898100] Update Tracker - [CandidateSet:6802698] p-BRAF/RAF fusion dimers [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780271] Update Tracker - [BlackBoxEvent:350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - v63:[modifyText]
[UpdateTracker:9780253] Update Tracker - [Pathway:2428928] IRS-related events triggered by IGF1R - v63:[updateContainedPathway]
[UpdateTracker:9780497] Update Tracker - [Pathway:8953897] Cellular responses to stimuli - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780422] Update Tracker - [Pathway:881907] Gastrin-CREB signalling pathway via PKC and MAPK - v63:[removeHasEvent]
[UpdateTracker:9898019] Update Tracker - [Complex:5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780355] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v63:[addLiteratureReference, add_removeInput]
[UpdateTracker:9898284] Update Tracker - [DefinedSet:975153] K63-linked polyUb TRAF6 complexes [endosome membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898305] Update Tracker - [Complex:8871150] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780431] Update Tracker - [Reaction:8851352] CCR8 binds CCL1 - v63:[modifyText]
[UpdateTracker:9898425] Update Tracker - [EntityWithAccessionedSequence:449023] IL18 [cytosol] - v63:[modifyName]
[UpdateTracker:9780395] Update Tracker - [Reaction:3928646] EPHAs bind EFNAs - v63:[modifyText]
[UpdateTracker:9780442] Update Tracker - [Pathway:392499] Metabolism of proteins - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898443] Update Tracker - [Complex:2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898013] Update Tracker - [Complex:8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898134] Update Tracker - [Complex:2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898113] Update Tracker - [Complex:2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898247] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898138] Update Tracker - [Complex:182024] NGF dimer:Phosphorylated Trk receptor:clathrin-coated vesicle [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897941] Update Tracker - [Complex:2134522] Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] - v63:[updateContainedComponent]
[UpdateTracker:9780260] Update Tracker - [Pathway:196791] Vitamin D (calciferol) metabolism - v63:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9898154] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898222] Update Tracker - [SimpleEntity:109990] 2-trans-4-cis-decadienoyl-CoA [mitochondrial matrix] - v63:[addName]
[UpdateTracker:9780366] Update Tracker - [Reaction:109701] PDPK1 binds PIP3 - v63:[add_removeInput]
[UpdateTracker:9898271] Update Tracker - [Complex:8868629] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780423] Update Tracker - [BlackBoxEvent:8983425] IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 - v63:[modifyText]
[UpdateTracker:9898374] Update Tracker - [Complex:5693283] mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780396] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v63:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9780504] Update Tracker - [BlackBoxEvent:9007137] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2 - v63:[modifyText]
[UpdateTracker:9780477] Update Tracker - [Reaction:416594] LARG and PDZ-RhoGEF binds to Plexin-B1 - v63:[modifyText]
[UpdateTracker:9897935] Update Tracker - [DefinedSet:8866235] AP-2 cargo [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780413] Update Tracker - [Pathway:109703] PKB-mediated events - v63:[updateContainedPathway]
[UpdateTracker:9780167] Update Tracker - [FailedReaction:5649483] Defective PAH does not hydroxylate L-Phe to L-Tyr - v63:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9897984] Update Tracker - [Complex:109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9897976] Update Tracker - [Complex:5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897891] Update Tracker - [Complex:167985] viral dsRNA :TLR3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780441] Update Tracker - [BlackBoxEvent:9007126] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2 - v63:[modifyText]
[UpdateTracker:9780342] Update Tracker - [Pathway:9012546] Interleukin-18 signaling - v63:[modifyText, updateContainedRLE]
[UpdateTracker:9897882] Update Tracker - [Complex:180282] GRB2:GAB1:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897998] Update Tracker - [Complex:173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898395] Update Tracker - [Complex:3928544] EFNBs:p-EPHBs:PTK2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780222] Update Tracker - [Reaction:5681980] ATG12 binds ATG7 dimer - v63:[add_removeOutput, modifyText]
[UpdateTracker:9898321] Update Tracker - [Complex:350092] CUBN:GC:25(OH)D [cytosol] - v63:[modifyName]
[UpdateTracker:9898375] Update Tracker - [Complex:167125] HIV-1 closed pre-initiation complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780474] Update Tracker - [BlackBoxEvent:8983384] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 - v63:[modifyText]
[UpdateTracker:9780465] Update Tracker - [Pathway:372790] Signaling by GPCR - v63:[removeHasEvent, updateContainedPathway]
[UpdateTracker:9898055] Update Tracker - [Complex:417866] P2RY2:ATP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898427] Update Tracker - [Complex:141643] Caspase-7 [cytosol] - v63:[modifyName]
[UpdateTracker:9898048] Update Tracker - [SimpleEntity:2142779] (5Z,8Z,14Z)-11,12-dihydroxyicosatrienoic acid [cytosol] - v63:[addName]
[UpdateTracker:9898047] Update Tracker - [Complex:194506] RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897965] Update Tracker - [Complex:2685707] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780439] Update Tracker - [Pathway:373076] Class A/1 (Rhodopsin-like receptors) - v63:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9780461] Update Tracker - [BlackBoxEvent:2730894] NFKB1:RELA translocates from the cytosol to the nucleus - v63:[modifyText]
[UpdateTracker:9898264] Update Tracker - [Complex:8868234] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897873] Update Tracker - [Complex:5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898342] Update Tracker - [Complex:205037] NGF ligand:p75NTR:Nrage:Che1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898248] Update Tracker - [DefinedSet:5675361] MAPK monomers and dimers [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780466] Update Tracker - [Reaction:8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 - v63:[modifyText]
[UpdateTracker:9780301] Update Tracker - [Reaction:8961021] SFTPD binds with itself to form SFTPD 12mer - v63:[add_removeInput]
[UpdateTracker:9780202] Update Tracker - [Pathway:927802] Nonsense-Mediated Decay (NMD) - v63:[updateIndirectRLE]
[UpdateTracker:9898003] Update Tracker - [Complex:391179] Heterotrimeric G-protein Gs (inactive) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780320] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v63:[updateContainedRLE]
[UpdateTracker:9898199] Update Tracker - [EntityWithAccessionedSequence:8848334] IL37 [extracellular region] - v63:[modifyName]
[UpdateTracker:9898350] Update Tracker - [Complex:3928513] EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780316] Update Tracker - [Reaction:8848395] IL18:IL18R1 binds IL18RAP - v63:[modifyText]
[UpdateTracker:9898418] Update Tracker - [DefinedSet:2685648] p-SYK/p-BTK [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9897953] Update Tracker - [Complex:909545] unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57 [endoplasmic reticulum lumen] - v63:[add_removeHasComponent]
[UpdateTracker:9898190] Update Tracker - [Complex:5693284] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898337] Update Tracker - [SimpleEntity:2197633] PI [extracellular region] - v63:[add_removeReferenceEntity]
[UpdateTracker:9898021] Update Tracker - [Complex:5654187] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780354] Update Tracker - [Reaction:444606] T1R2/T1R3 dimer is a sweet taste receptor - v63:[modifyText]
[UpdateTracker:9898175] Update Tracker - [Complex:4093319] p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780485] Update Tracker - [Pathway:114516] Disinhibition of SNARE formation - v63:[addLiteratureReference, addSummation]
[UpdateTracker:9898017] Update Tracker - [Complex:450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898108] Update Tracker - [Complex:1295774] Il7:(p(Y449)-Il7ra:Jak1:Il2rg:Jak3:Pi3k regulatory subunits [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780249] Update Tracker - [Pathway:8978934] Metabolism of cofactors - v63:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898040] Update Tracker - [Complex:1295766] Il7:Il7r:Jak1:Il2rg:Jak3 [plasma membrane] - v63:[modifyName, removeHasComponent]
[UpdateTracker:9898252] Update Tracker - [Complex:5218776] CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898311] Update Tracker - [Complex:167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898044] Update Tracker - [Complex:6802597] BRAF-MACF1 fusion dimer [cytosol] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780303] Update Tracker - [Reaction:114307] Release of SMAC (DIABLO) from mitochondria - v63:[addRegulator, modifyText]
[UpdateTracker:9780302] Update Tracker - [Reaction:8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s - v63:[modifyText]
[UpdateTracker:9898086] Update Tracker - [EntityWithAccessionedSequence:264902] 2xHC-INS(25-54) [secretory granule lumen] - v63:[add_removeHasModifiedResidue]
[UpdateTracker:9897900] Update Tracker - [Complex:167093] HIV-1 promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex* [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898171] Update Tracker - [Complex:419627] ERBB2:p-Y-PLXNB1 [plasma membrane] - v63:[addName]
[UpdateTracker:9780443] Update Tracker - [Pathway:9006931] Signaling by Nuclear Receptors - v63:[updateIndirectRLE]
[UpdateTracker:9780383] Update Tracker - [BlackBoxEvent:5605301] RNA polymerase II polymerizes primary piRNA transcript - v63:[addRegulator, removeCatalystActivity]
[UpdateTracker:9898170] Update Tracker - [Complex:264998] Insulin [secretory granule lumen] - v63:[addName]
[UpdateTracker:9897879] Update Tracker - [Complex:1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780399] Update Tracker - [Reaction:451895] IL2RG binds JAK3 - v63:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9897888] Update Tracker - [Complex:749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780168] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v63:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780405] Update Tracker - [Reaction:114284] Release of Cytochrome c from mitochondria - v63:[addRegulator]
[UpdateTracker:9780402] Update Tracker - [Reaction:113503] PP2A mediated localization of RB1 protein in chromatin - v63:[addLiteratureReference, modifyText]
[UpdateTracker:9898220] Update Tracker - [EntityWithAccessionedSequence:449945] IL7R [plasma membrane] - v63:[addName]
[UpdateTracker:9780394] Update Tracker - [Pathway:1474244] Extracellular matrix organization - v63:[updateContainedPathway]
[UpdateTracker:9898403] Update Tracker - [Complex:3928566] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898233] Update Tracker - [EntityWithAccessionedSequence:3006639] MCF2 [cytosol] - v63:[removeName]
[UpdateTracker:9780403] Update Tracker - [Reaction:4420099] p-6Y-VEGFR2 binds SHB - v63:[modifyText]
[UpdateTracker:9780426] Update Tracker - [Pathway:422085] Synthesis, secretion, and deacylation of Ghrelin - v63:[add_removeHasEvent]
[UpdateTracker:9898225] Update Tracker - [Complex:8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898011] Update Tracker - [Complex:3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897991] Update Tracker - [EntityWithAccessionedSequence:8873916] ARHGEF40 [cytosol] - v63:[addName]
[UpdateTracker:9897978] Update Tracker - [Complex:8855258] RELN:VLDLR:DAB1:SH3KBP1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898053] Update Tracker - [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - v63:[addHasMember, updateContainedMemberOrCandidate]
[UpdateTracker:9897884] Update Tracker - [GenomeEncodedEntity:8957350] CYP4 [endoplasmic reticulum membrane] - v63:[modifyName]
[UpdateTracker:9897993] Update Tracker - [Complex:5693447] mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897874] Update Tracker - [Complex:9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897913] Update Tracker - [Complex:3928555] EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898070] Update Tracker - [DefinedSet:791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - v63:[addHasMember]
[UpdateTracker:9780237] Update Tracker - [Pathway:1500931] Cell-Cell communication - v63:[updateContainedPathway]
[UpdateTracker:9898253] Update Tracker - [Complex:4093320] p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780401] Update Tracker - [Pathway:9006936] Signaling by TGFB family members - v63:[updateContainedPathway]
[UpdateTracker:9898212] Update Tracker - [Complex:109632] pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780309] Update Tracker - [Reaction:169895] Crk's SH3 domain engages C3G - v63:[modifyText]
[UpdateTracker:9897957] Update Tracker - [Complex:744890] GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780212] Update Tracker - [Reaction:420688] GABAB heterodimeric receptor binds GABA - v63:[modifyText]
[UpdateTracker:9898015] Update Tracker - [Complex:205018] NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897895] Update Tracker - [Complex:6785173] LIPC dimer:LMF1,2 [endoplasmic reticulum membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898318] Update Tracker - [Complex:2685666] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780473] Update Tracker - [Pathway:109704] PI3K Cascade - v63:[addLiteratureReference, addSummation, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898061] Update Tracker - [Complex:8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780500] Update Tracker - [Reaction:8848335] IL37 binds IL18R1 - v63:[modifyText]
[UpdateTracker:9898432] Update Tracker - [Complex:2187254] SCARA5:Ligand [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780171] Update Tracker - [Reaction:162352] Phosphorylation of PDE3B by AKT-1 - v63:[addLiteratureReference]
[UpdateTracker:9898214] Update Tracker - [Complex:8868620] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898267] Update Tracker - [Complex:432187] AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897946] Update Tracker - [Complex:5654186] Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898049] Update Tracker - [Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780371] Update Tracker - [Pathway:113510] E2F mediated regulation of DNA replication - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898240] Update Tracker - [Complex:3928554] EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780382] Update Tracker - [Pathway:211897] Cytochrome P450 - arranged by substrate type - v63:[updateIndirectRLE]
[UpdateTracker:9780268] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9897903] Update Tracker - [Complex:2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898147] Update Tracker - [Complex:8871149] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897896] Update Tracker - [SimpleEntity:2239415] PI [endocytic vesicle lumen] - v63:[add_removeReferenceEntity]
[UpdateTracker:9898420] Update Tracker - [Complex:3149544] MTRR:MTR:cob(II)alamin [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9898355] Update Tracker - [Complex:109697] PDPK1:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898063] Update Tracker - [Complex:2167884] TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780211] Update Tracker - [BlackBoxEvent:6807242] 25(OH)D translocates from ER membrane to extracellular region - v63:[modifyText]
[UpdateTracker:9898152] Update Tracker - [Complex:9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898132] Update Tracker - [Complex:8983180] p-Y-STAT3:p-STAT5A,p-STAT5B [cytosol] - v63:[modifyName]
[UpdateTracker:9897973] Update Tracker - [Complex:109878] pol II transcription complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898023] Update Tracker - [Complex:8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780487] Update Tracker - [Pathway:416572] Sema4D induced cell migration and growth-cone collapse - v63:[updateContainedRLE]
[UpdateTracker:9780308] Update Tracker - [Pathway:165158] Activation of AKT2 - v63:[addLiteratureReference, addSummation, updateContainedRLE]
[UpdateTracker:9898294] Update Tracker - [Complex:5655344] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897909] Update Tracker - [Complex:3240769] SUZ12 Gene:E2F1/2/3:DP1/2 [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780406] Update Tracker - [Pathway:8983432] Interleukin-15 signaling - v63:[updateContainedRLE]
[UpdateTracker:9898408] Update Tracker - [CandidateSet:8986177] Mitochondrial targeting peptides (from inner membrane proteins) [mitochondrial matrix] - v63:[modifyName]
[UpdateTracker:9897894] Update Tracker - [Complex:180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898059] Update Tracker - [EntityWithAccessionedSequence:8982823] p-STAT3 [cytosol] - v63:[removeLiteratureReference]
[UpdateTracker:9780475] Update Tracker - [Pathway:500792] GPCR ligand binding - v63:[updateIndirectRLE]
[UpdateTracker:9898273] Update Tracker - [Complex:167094] HIV-1 promoter:TFIID complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898285] Update Tracker - [Complex:2132123] MAC [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897890] Update Tracker - [Complex:8866319] VLDL [smooth endoplasmic reticulum] - v63:[add_removeHasComponent]
[UpdateTracker:9898386] Update Tracker - [EntityWithAccessionedSequence:1176066] KPNA4 [cytosol] - v63:[modifyName]
[UpdateTracker:9780398] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v63:[modifyText]
[UpdateTracker:9898041] Update Tracker - [Complex:182031] Active Trk receptor:Frs3:Crk [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898129] Update Tracker - [Complex:1226015] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780239] Update Tracker - [Pathway:1640170] Cell Cycle - v63:[updateContainedPathway]
[UpdateTracker:9897969] Update Tracker - [Complex:5654190] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898392] Update Tracker - [Complex:3301926] GSTM4 dimer [cytosol] - v63:[modifyName]
[UpdateTracker:9897928] Update Tracker - [Complex:8848366] IL18:IL18R1 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780286] Update Tracker - [Pathway:2473224] Antagonism of Activin by Follistatin - v63:[modifyText]
[UpdateTracker:9780333] Update Tracker - [Pathway:975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - v63:[updateContainedRLE]
[UpdateTracker:9898206] Update Tracker - [Complex:5252081] V-ATPase:ATP6AP1 [endosome membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898396] Update Tracker - [Complex:3928533] EFNBs:p-EPHBs:KALRN [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898299] Update Tracker - [EntityWithAccessionedSequence:3000454] polySUMO2-K297-SP100 [nucleoplasm] - v63:[removeInferredFrom]
[UpdateTracker:9780228] Update Tracker - [Pathway:448424] Interleukin-17 signaling - v63:[modifyText, updateContainedRLE]
[UpdateTracker:9898174] Update Tracker - [Complex:5218639] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780364] Update Tracker - [Reaction:209944] 25(OH)D binds GC - v63:[modifyText]
[UpdateTracker:9780179] Update Tracker - [Pathway:112314] Neurotransmitter receptors and postsynaptic signal transmission - v63:[updateContainedPathway]
[UpdateTracker:9898237] Update Tracker - [Complex:5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898410] Update Tracker - [Complex:392865] Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897950] Update Tracker - [Complex:5654191] Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898343] Update Tracker - [Complex:5654331] Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898238] Update Tracker - [Complex:5654199] Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897924] Update Tracker - [EntityWithAccessionedSequence:2247912] Notch1 gene [nucleoplasm] - v63:[modifyName]
[UpdateTracker:9780288] Update Tracker - [Pathway:8854691] Interleukin-20 family signaling - v63:[add_removeHasEvent]
[UpdateTracker:9780220] Update Tracker - [Reaction:1299478] MPP cleaves targeting peptide (presequence) of matrix precursors - v63:[addInput]
[UpdateTracker:9898302] Update Tracker - [Complex:444662] TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] - v63:[add_removeCompartment]
[UpdateTracker:9898007] Update Tracker - [EntityWithAccessionedSequence:6802536] p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] - v63:[add_removeReferenceEntity, modifyEndCoordinate, modifyName]
[UpdateTracker:9898380] Update Tracker - [Complex:5675700] MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898312] Update Tracker - [Complex:399877] Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898270] Update Tracker - [Complex:917889] holoTF [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9898398] Update Tracker - [SimpleEntity:1022112] (GlcNAc)2 (Man)8a [cytosol] - v63:[addName]
[UpdateTracker:9898266] Update Tracker - [DefinedSet:112270] G alpha (i) [plasma membrane] - v63:[modifyName]
[UpdateTracker:9898016] Update Tracker - [Complex:170683] (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898005] Update Tracker - [Complex:389331] CDC42-GDP [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780172] Update Tracker - [Reaction:5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 - v63:[modifyText]
[UpdateTracker:9898068] Update Tracker - [Complex:167101] HIV-1 transcription complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898060] Update Tracker - [Complex:3159272] 2xMMAA:2xMUT:AdoCbl [mitochondrial matrix] - v63:[add_removeHasComponent]
[UpdateTracker:9898330] Update Tracker - [Complex:8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780357] Update Tracker - [Pathway:69236] G1 Phase - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898383] Update Tracker - [DefinedSet:1433400] Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780255] Update Tracker - [Pathway:113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1 - v63:[addLiteratureReference, addSummation, updateContainedRLE]
[UpdateTracker:9780462] Update Tracker - [Reaction:4420143] p-6Y-VEGFR2 binds SH2D2A - v63:[modifyText]
[UpdateTracker:9898181] Update Tracker - [Complex:205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898422] Update Tracker - [Complex:2132050] C5b:C6:C7:C8 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780417] Update Tracker - [Pathway:202403] TCR signaling - v63:[updateIndirectRLE]
[UpdateTracker:9780468] Update Tracker - [BlackBoxEvent:5601926] RNA polymerase II polymerizes primary piRNA transcript - v63:[addRegulator, removeCatalystActivity]
[UpdateTracker:9898379] Update Tracker - [Complex:8855235] RELN:VLDLR:DAB1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897869] Update Tracker - [SimpleEntity:2142783] (5Z,8Z,11Z)-14,15-dihydroxyicosatrienoic acid [cytosol] - v63:[addName]
[UpdateTracker:9898072] Update Tracker - [CandidateSet:2400011] PI3K mutants,Activator:PI3K [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898279] Update Tracker - [Complex:1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898029] Update Tracker - [EntityWithAccessionedSequence:8853148] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] - v63:[add_removeHasModifiedResidue]
[UpdateTracker:9897971] Update Tracker - [SimpleEntity:6793364] (GlcNAc)2 (Man)8a [Golgi lumen] - v63:[addName]
[UpdateTracker:9898239] Update Tracker - [CandidateSet:8873941] GNAS [plasma membrane] - v63:[addName]
[UpdateTracker:9898385] Update Tracker - [Complex:4093322] p-EPHBs:EFNBs:RASA1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780499] Update Tracker - [Pathway:204174] Regulation of pyruvate dehydrogenase (PDH) complex - v63:[updateContainedRLE]
[UpdateTracker:9780434] Update Tracker - [Pathway:3928662] EPHB-mediated forward signaling - v63:[updateContainedRLE]
[UpdateTracker:9898278] Update Tracker - [Complex:8873894] STARD5:DCA,LCA [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9898362] Update Tracker - [Complex:5654185] Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780178] Update Tracker - [Reaction:3928588] EPHBs binds PTK2 - v63:[add_removeInput]
[UpdateTracker:9780408] Update Tracker - [Pathway:69231] Cyclin D associated events in G1 - v63:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9898242] Update Tracker - [Complex:166543] beta-NGF dimer:TrkA receptor dimer [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898159] Update Tracker - [Complex:5637694] p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898430] Update Tracker - [EntityWithAccessionedSequence:8983130] p-Y705-STAT3 [cytosol] - v63:[add_removeHasModifiedResidue, modifyName]
[UpdateTracker:9898065] Update Tracker - [Complex:6802710] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780448] Update Tracker - [BlackBoxEvent:8983424] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 - v63:[modifyText]
[UpdateTracker:9898203] Update Tracker - [Complex:396910] G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898035] Update Tracker - [Complex:2424464] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897992] Update Tracker - [Complex:1264843] IL7R:JAK1 [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9898291] Update Tracker - [Complex:2186742] p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898192] Update Tracker - [Complex:392168] Heterotrimeric G-protein Gi (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897927] Update Tracker - [Complex:350888] CASP3(29-175):CASP3(176-277) [cytosol] - v63:[modifyName]
[UpdateTracker:9780243] Update Tracker - [Pathway:9006934] Signaling by Receptor Tyrosine Kinases - v63:[updateContainedPathway]
[UpdateTracker:9897981] Update Tracker - [Complex:392161] G alpha (i): GTP [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898180] Update Tracker - [Complex:83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780458] Update Tracker - [Reaction:5218834] Fak/Src phosphorylate p130Cas - v63:[modifyText]
[UpdateTracker:9898135] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898384] Update Tracker - [Complex:2132110] C8 [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9780339] Update Tracker - [Pathway:2160456] Phenylketonuria - v63:[add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9898127] Update Tracker - [Complex:1226013] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780344] Update Tracker - [Pathway:73980] RNA Polymerase III Transcription Termination - v63:[addLiteratureReference, addSummation]
[UpdateTracker:9898198] Update Tracker - [Complex:6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780347] Update Tracker - [Pathway:69306] DNA Replication - v63:[updateContainedPathway]
[UpdateTracker:9780336] Update Tracker - [Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - v63:[modifyText]
[UpdateTracker:9898110] Update Tracker - [Complex:3240767] EED Gene:E2F1/2/3:DP1/2 [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780278] Update Tracker - [Pathway:162582] Signal Transduction - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780294] Update Tracker - [Reaction:4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - v63:[modifyText]
[UpdateTracker:9898245] Update Tracker - [EntityWithAccessionedSequence:194637] LBR [nuclear envelope] - v63:[addName]
[UpdateTracker:9898008] Update Tracker - [Complex:6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898176] Update Tracker - [Complex:449967] IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780248] Update Tracker - [Pathway:112315] Transmission across Chemical Synapses - v63:[updateContainedPathway]
[UpdateTracker:9898058] Update Tracker - [Complex:3928518] EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898050] Update Tracker - [Polymer:2470128] Cleaved collagen type V fibril [extracellular region] - v63:[removeRepeatedUnit]
[UpdateTracker:9780493] Update Tracker - [Reaction:442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - v63:[add_removeInput, add_removeOutput]
[UpdateTracker:9780340] Update Tracker - [Pathway:1474165] Reproduction - v63:[updateContainedPathway]
[UpdateTracker:9780400] Update Tracker - [Pathway:2586552] Signaling by Leptin - v63:[updateContainedRLE]
[UpdateTracker:9780450] Update Tracker - [BlackBoxEvent:8983335] IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome - v63:[modifyText]
[UpdateTracker:9780449] Update Tracker - [Pathway:422475] Axon guidance - v63:[updateIndirectRLE]
[UpdateTracker:9898144] Update Tracker - [Complex:2395763] nascent CM:atREs [cytosol] - v63:[add_removeHasComponent]
[UpdateTracker:9780324] Update Tracker - [Pathway:8957322] Metabolism of steroids - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898352] Update Tracker - [Complex:5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898334] Update Tracker - [Complex:392844] Heterotrimeric G-protein Gs (active) [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780421] Update Tracker - [Reaction:1295516] IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits - v63:[modifyText]
[UpdateTracker:9898179] Update Tracker - [DefinedSet:5618094] SH [cytosol] - v63:[add_removeHasMember]
[UpdateTracker:9898433] Update Tracker - [EntityWithAccessionedSequence:210475] UNC13B [cytosol] - v63:[removeInferredFrom]
[UpdateTracker:9898416] Update Tracker - [Complex:5654188] Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898310] Update Tracker - [Complex:419404] CNRs:Cannabinoids [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780238] Update Tracker - [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - v63:[add_removeInput, removeOutput]
[UpdateTracker:9780218] Update Tracker - [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - v63:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, modifyText]
[UpdateTracker:9897920] Update Tracker - [EntityWithAccessionedSequence:6802466] QKI(1-504)-RAF1(278-648) fusion [cytosol] - v63:[modifyEndCoordinate, modifyName]
[UpdateTracker:9780265] Update Tracker - [Pathway:1474290] Collagen formation - v63:[updateIndirectRLE]
[UpdateTracker:9897949] Update Tracker - [Complex:5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898228] Update Tracker - [DefinedSet:9008576] IL37,IL37(?-218) [extracellular region] - v63:[addName]
[UpdateTracker:9898323] Update Tracker - [SimpleEntity:6788988] MurNAc [peptidoglycan-based cell wall] - v63:[addName]
[UpdateTracker:9898130] Update Tracker - [Complex:5357487] p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780387] Update Tracker - [Reaction:1497883] Ferrous iron reduces the BH3 radical back to BH4 - v63:[add_removeOutput]
[UpdateTracker:9898272] Update Tracker - [Complex:421104] RND1:GTP [plasma membrane] - v63:[addName]
[UpdateTracker:9780227] Update Tracker - [Reaction:3928597] EPH:EFN dimers tetramerise - v63:[modifyText]
[UpdateTracker:9897936] Update Tracker - [Complex:2186744] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780359] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v63:[modifyText]
[UpdateTracker:9898283] Update Tracker - [Complex:8862707] Resolvin E1:CMKLR1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780251] Update Tracker - [Pathway:170984] ARMS-mediated activation - v63:[updateContainedRLE]
[UpdateTracker:9897960] Update Tracker - [Complex:167104] HIV-1 promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780279] Update Tracker - [Pathway:977443] GABA receptor activation - v63:[updateIndirectRLE]
[UpdateTracker:9897983] Update Tracker - [Complex:392164] G-protein alpha (i):GDP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780378] Update Tracker - [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - v63:[add_removeOutput]
[UpdateTracker:9898219] Update Tracker - [Complex:2160891] HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897975] Update Tracker - [Complex:167119] HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9780264] Update Tracker - [Reaction:5218828] PTK2/SRC-1 phosphorylates BCAR1 - v63:[modifyText]
[UpdateTracker:9898370] Update Tracker - [Complex:2134514] Tight Junction Complex:PARD6A:RHOA [cell junction] - v63:[add_removeHasComponent]
[UpdateTracker:9898030] Update Tracker - [EntityWithAccessionedSequence:3008955] PPP2R3B [nucleoplasm] - v63:[addName]
[UpdateTracker:9780437] Update Tracker - [Pathway:170968] Frs2-mediated activation - v63:[updateContainedRLE]
[UpdateTracker:9897899] Update Tracker - [EntityWithAccessionedSequence:6802546] QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] - v63:[modifyEndCoordinate]
[UpdateTracker:9898099] Update Tracker - [Complex:5654300] Activated FGFR3:SHC1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898363] Update Tracker - [Complex:6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780170] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v63:[modifyText, removeLiteratureReference]
[UpdateTracker:9898042] Update Tracker - [Complex:2685701] p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780380] Update Tracker - [Pathway:69278] Cell Cycle, Mitotic - v63:[updateContainedPathway]
[UpdateTracker:9780467] Update Tracker - [BlackBoxEvent:157937] NICD3 traffics to the nucleus - v63:[modifyText]
[UpdateTracker:9780464] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v63:[addHasEvent, updateContainedPathway]
[UpdateTracker:9898096] Update Tracker - [Complex:5654203] Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898338] Update Tracker - [Complex:5218774] NOX2 complex:RAC1:GTP [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898217] Update Tracker - [Complex:5685200] CCDC59:TTF1:SFTPB gene [nucleoplasm] - v63:[add_removeHasComponent]
[UpdateTracker:9898387] Update Tracker - [Complex:6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780247] Update Tracker - [Pathway:420499] Class C/3 (Metabotropic glutamate/pheromone receptors) - v63:[updateContainedRLE]
[UpdateTracker:9780363] Update Tracker - [Pathway:416550] Sema4D mediated inhibition of cell attachment and migration - v63:[updateContainedRLE]
[UpdateTracker:9780476] Update Tracker - [Pathway:74158] RNA Polymerase III Transcription - v63:[updateContainedPathway]
[UpdateTracker:9780180] Update Tracker - [Reaction:3928628] VAV exchanges GTP for GDP on RAC1, activating it - v63:[add_removeOutput, removeInput]
[UpdateTracker:9780226] Update Tracker - [Pathway:380108] Chemokine receptors bind chemokines - v63:[updateContainedRLE]
[UpdateTracker:9898057] Update Tracker - [Complex:164384] G-protein with G(s) alpha:GDP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897876] Update Tracker - [EntityWithAccessionedSequence:5229006] p-5Y,S732-PTK2 [cytosol] - v63:[addName]
[UpdateTracker:9898125] Update Tracker - [Complex:201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897915] Update Tracker - [Complex:422306] ADCY5,6,8:G-alpha(s):GTP [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898423] Update Tracker - [Complex:5655267] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898128] Update Tracker - [Complex:5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897912] Update Tracker - [DefinedSet:205013] Active Caspases 2, 3 [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780505] Update Tracker - [Pathway:453276] Regulation of mitotic cell cycle - v63:[addSummation]
[UpdateTracker:9780311] Update Tracker - [Reaction:5655481] USP1:WDR48 binds monoUb:K164-PCNA - v63:[modifyText]
[UpdateTracker:9898400] Update Tracker - [Complex:177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780338] Update Tracker - [BlackBoxEvent:1912415] NOTCH3 gene transcription - v63:[addLiteratureReference, addRegulator, modifyText]
[UpdateTracker:9898202] Update Tracker - [Complex:3928543] EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780469] Update Tracker - [Pathway:76005] Response to elevated platelet cytosolic Ca2+ - v63:[updateContainedPathway]
[UpdateTracker:9780433] Update Tracker - [Reaction:444204] GPR120 is a receptor for unsaturated long-chain free fatty acids - v63:[modifyText]
[UpdateTracker:9898169] Update Tracker - [Complex:5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780205] Update Tracker - [Reaction:8862700] CMKLR1 binds Resolvin E1 - v63:[add_removeInput, modifyText]
[UpdateTracker:9780503] Update Tracker - [Pathway:181438] Toll Like Receptor 2 (TLR2) Cascade - v63:[updateContainedPathway]
[UpdateTracker:9898357] Update Tracker - [Complex:2132193] VTN:C5b-C9 [extracellular region] - v63:[updateContainedComponent]
[UpdateTracker:9780230] Update Tracker - [Pathway:8985947] Interleukin-9 signaling - v63:[modifyText, updateContainedRLE]
[UpdateTracker:9898281] Update Tracker - [Complex:164358] G alpha (s):GTP [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898421] Update Tracker - [Complex:8868232] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898407] Update Tracker - [Complex:201446] BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898092] Update Tracker - [Complex:8855875] VLDL [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9898434] Update Tracker - [Complex:5654279] Activated FGFR2:SHC1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898414] Update Tracker - [Complex:109696] AKT2:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898276] Update Tracker - [Complex:418179] F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897952] Update Tracker - [Complex:3209097] DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898282] Update Tracker - [EntityWithAccessionedSequence:8853122] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] - v63:[add_removeHasModifiedResidue]
[UpdateTracker:9898213] Update Tracker - [Complex:917834] holoTF:TFRC dimer [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898118] Update Tracker - [Complex:5672861] mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898056] Update Tracker - [SimpleEntity:912516] Fe3+ [extracellular region] - v63:[add_removeReferenceEntity]
[UpdateTracker:9897945] Update Tracker - [Complex:2685659] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780242] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v63:[updateContainedRLE]
[UpdateTracker:9898210] Update Tracker - [Complex:182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898377] Update Tracker - [Complex:2685672] p-SHC1:GRB2:SOS [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9780270] Update Tracker - [Pathway:1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898036] Update Tracker - [Complex:189847] Activated Trk receptor complex:Rit-GTP:Raf [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898419] Update Tracker - [DefinedSet:2424473] p-SYK/p-BTK [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780192] Update Tracker - [Reaction:449978] IL7 binds IL7R:JAK1 - v63:[modifyText]
[UpdateTracker:9780411] Update Tracker - [Reaction:71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - v63:[modifyText]
[UpdateTracker:9898286] Update Tracker - [Complex:8959915] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] - v63:[addHasComponent, modifyName]
[UpdateTracker:9898367] Update Tracker - [Complex:201841] BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780360] Update Tracker - [Pathway:73854] RNA Polymerase I Promoter Clearance - v63:[addLiteratureReference]
[UpdateTracker:9780304] Update Tracker - [Reaction:8950387] CANX binds EBI3 - v63:[modifyText]
[UpdateTracker:9780210] Update Tracker - [Pathway:418594] G alpha (i) signalling events - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898224] Update Tracker - [DefinedSet:5218759] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] - v63:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9897901] Update Tracker - [Complex:8854464] VLDL:VLDLR [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780446] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v63:[updateContainedRLE]
[UpdateTracker:9898359] Update Tracker - [Complex:165678] Active mTORC1 complex [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898292] Update Tracker - [Complex:8867751] PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780410] Update Tracker - [Pathway:5601884] PIWI-interacting RNA (piRNA) biogenesis - v63:[updateContainedRLE]
[UpdateTracker:9780196] Update Tracker - [Pathway:1222499] Latent infection - Other responses of Mtb to phagocytosis - v63:[updateIndirectRLE]
[UpdateTracker:9898166] Update Tracker - [EntityWithAccessionedSequence:888582] PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] - v63:[addName]
[UpdateTracker:9780277] Update Tracker - [Reaction:8951586] p-VAV family:PIP3 binds RAC1:GDP - v63:[add_removeInput]
[UpdateTracker:9898205] Update Tracker - [Complex:2134509] Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] - v63:[updateContainedComponent]
[UpdateTracker:9780325] Update Tracker - [Reaction:448629] IL33 binds IL1RL1 - v63:[modifyText]
[UpdateTracker:9898308] Update Tracker - [Complex:5675701] MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898260] Update Tracker - [Complex:6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780219] Update Tracker - [Pathway:73894] DNA Repair - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780275] Update Tracker - [BlackBoxEvent:6789524] Expression of IL4,IL13-downregulated extracellular genes - v63:[modifyText]
[UpdateTracker:9898121] Update Tracker - [Complex:8868624] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897982] Update Tracker - [CandidateSet:3301978] GST dimers [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780367] Update Tracker - [Pathway:9006925] Intracellular signaling by second messengers - v63:[updateContainedPathway]
[UpdateTracker:9898335] Update Tracker - [EntityWithAccessionedSequence:373368] CX3CL1 [extracellular region] - v63:[addName, add_removeCompartment, removeEndCoordinate, removeStartCoordinate]
[UpdateTracker:9898201] Update Tracker - [Complex:5357462] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898243] Update Tracker - [Complex:350115] CUBN:GC:25(OH)D [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898165] Update Tracker - [Complex:110452] DAkt1:PIP3 complex [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780272] Update Tracker - [Reaction:917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - v63:[add_removeOutput]
[UpdateTracker:9780297] Update Tracker - [Pathway:9014843] Interleukin-33 signaling - v63:[modifyText, updateContainedRLE]
[UpdateTracker:9898000] Update Tracker - [CandidateSet:9007110] p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [cytosol] - v63:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9780257] Update Tracker - [BlackBoxEvent:507937] STAT5 dimers translocate to the nucleus - v63:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9780169] Update Tracker - [Reaction:352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - v63:[add_removeCatalystActivity]
[UpdateTracker:9780335] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v63:[addLiteratureReference, addSummation, add_removeHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9898069] Update Tracker - [Complex:8981951] IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] - v63:[addLiteratureReference, modifyName, updateContainedComponent]
[UpdateTracker:9780393] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v63:[modifyText]
[UpdateTracker:9780197] Update Tracker - [Pathway:400685] Sema4D in semaphorin signaling - v63:[updateIndirectRLE]
[UpdateTracker:9780384] Update Tracker - [Pathway:426486] Small interfering RNA (siRNA) biogenesis - v63:[add_removeHasEvent]
[UpdateTracker:9780298] Update Tracker - [Pathway:68949] Orc1 removal from chromatin - v63:[addSummation]
[UpdateTracker:9780353] Update Tracker - [Pathway:400511] Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) - v63:[add_removeHasEvent]
[UpdateTracker:9898133] Update Tracker - [DefinedSet:3928376] EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780481] Update Tracker - [BlackBoxEvent:927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - v63:[addRegulator, removeCatalystActivity]
[UpdateTracker:9780188] Update Tracker - [Reaction:8956439] Retsat reduces atROL to at-13,14-dhROL - v63:[add_removeInput]
[UpdateTracker:9898315] Update Tracker - [Complex:373695] SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9780471] Update Tracker - [Reaction:350186] CUBN binds GC:25(OH)D - v63:[modifyText]
[UpdateTracker:9780194] Update Tracker - [BlackBoxEvent:9009700] IL2RB and IL2RG are phosphorylated - v63:[modifyText]
[UpdateTracker:9780456] Update Tracker - [Pathway:556833] Metabolism of lipids - v63:[updateContainedPathway]
[UpdateTracker:9898149] Update Tracker - [Complex:5672087] RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780491] Update Tracker - [Pathway:111457] Release of apoptotic factors from the mitochondria - v63:[updateContainedRLE]
[UpdateTracker:9780365] Update Tracker - [Pathway:1500620] Meiosis - v63:[updateContainedPathway]
[UpdateTracker:9898317] Update Tracker - [Complex:2187239] Ferritin [extracellular region] - v63:[add_removeHasComponent]
[UpdateTracker:9780224] Update Tracker - [Pathway:69239] Synthesis of DNA - v63:[updateContainedPathway]
[UpdateTracker:9898071] Update Tracker - [Complex:350085] CUBN:GC:25(OH)D [lysosomal lumen] - v63:[modifyName]
[UpdateTracker:9780460] Update Tracker - [Pathway:1483076] Synthesis of CL - v63:[modifyText]
[UpdateTracker:9898038] Update Tracker - [Complex:8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897987] Update Tracker - [Complex:179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897999] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897940] Update Tracker - [SimpleEntity:5694175] (GlcNAc)2 (Man)8a [endoplasmic reticulum lumen] - v63:[addName]
[UpdateTracker:9780204] Update Tracker - [BlackBoxEvent:209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen - v63:[modifyText]
[UpdateTracker:9780484] Update Tracker - [Reaction:917805] CYBRD1:Heme reduces Fe3+ to Fe2+ - v63:[add_removeInput]
[UpdateTracker:9898037] Update Tracker - [SimpleEntity:948029] (GlcNAc)2 (Man)8a [endoplasmic reticulum-Golgi intermediate compartment membrane] - v63:[addName]
[UpdateTracker:9898399] Update Tracker - [Complex:448691] Caspase-1 tetramer [cytosol] - v63:[modifyName]
[UpdateTracker:9897932] Update Tracker - [Complex:6781946] USP13:UFD1L:SKP2 [nucleoplasm] - v63:[add_removeHasComponent]
[UpdateTracker:9780232] Update Tracker - [Pathway:5668914] Diseases of metabolism - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780427] Update Tracker - [Reaction:416559] Inactivation of Rho-GTP by p190RhoGAP - v63:[add_removeInput, add_removeOutput]
[UpdateTracker:9898028] Update Tracker - [Complex:9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897937] Update Tracker - [Complex:416587] SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] - v63:[addName, updateContainedComponent]
[UpdateTracker:9780420] Update Tracker - [Pathway:73864] RNA Polymerase I Transcription - v63:[addLiteratureReference, modifyText, updateContainedPathway]
[UpdateTracker:9898031] Update Tracker - [Complex:5637704] p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780300] Update Tracker - [Pathway:74160] Gene expression (Transcription) - v63:[updateContainedPathway]
[UpdateTracker:9780438] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v63:[add_removeHasEvent]
[UpdateTracker:9780285] Update Tracker - [Reaction:6784462] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs - v63:[add_removeInput]
[UpdateTracker:9780337] Update Tracker - [Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - v63:[add_removeRegulator, modifyText]
[UpdateTracker:9780486] Update Tracker - [Pathway:674695] RNA Polymerase II Pre-transcription Events - v63:[addLiteratureReference, addSummation]
[UpdateTracker:9898090] Update Tracker - [Complex:879427] AGER ligands:AGER:ERK [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898083] Update Tracker - [Complex:206946] HRAS:GTP [plasma membrane] - v63:[modifyName]
[UpdateTracker:9780457] Update Tracker - [Pathway:169893] Prolonged ERK activation events - v63:[updateIndirectRLE]
[UpdateTracker:9898327] Update Tracker - [Complex:2685687] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897921] Update Tracker - [Complex:2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9897944] Update Tracker - [Complex:2179287] TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780374] Update Tracker - [Pathway:168249] Innate Immune System - v63:[updateContainedPathway]
[UpdateTracker:9898211] Update Tracker - [Complex:9013960] viral dsRNA:TLR3:TICAM1:RIPK3 [endosome membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780312] Update Tracker - [Pathway:445717] Aquaporin-mediated transport - v63:[updateContainedPathway]
[UpdateTracker:9898186] Update Tracker - [Complex:182939] EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898077] Update Tracker - [Complex:3928549] EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898136] Update Tracker - [Complex:109797] GRB2-1:SOS1 [cytosol] - v63:[addLiteratureReference]
[UpdateTracker:9897980] Update Tracker - [Complex:182000] Active Trk receptor:Plcg1 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780388] Update Tracker - [BlackBoxEvent:8983299] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 - v63:[modifyText]
[UpdateTracker:9780241] Update Tracker - [Pathway:444209] Free fatty acid receptors - v63:[updateContainedRLE]
[UpdateTracker:9898177] Update Tracker - [Complex:1227905] E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] - v63:[modifyName]
[UpdateTracker:9898268] Update Tracker - [Complex:182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898442] Update Tracker - [Complex:8959916] Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9898101] Update Tracker - [DefinedSet:8867603] CLASP proteins:cargo [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898436] Update Tracker - [Complex:2400008] PI3K Inhibitors:PI3K [cytosol] - v63:[updateContainedComponent]
[UpdateTracker:9898082] Update Tracker - [DefinedSet:790205] Ligands of GPCRs that activate Gs [extracellular region] - v63:[addHasMember]
[UpdateTracker:9897966] Update Tracker - [Complex:162387] p-T309,S474-AKT2:PIP3 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898066] Update Tracker - [Complex:109630] pol II promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm] - v63:[updateContainedComponent]
[UpdateTracker:9898187] Update Tracker - [DefinedSet:2197675] WAVE2, WASP, N-WASP [plasma membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780282] Update Tracker - [Pathway:9008059] Interleukin-37 signaling - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898417] Update Tracker - [Complex:209577] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9780430] Update Tracker - [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP - v63:[addOutput]
[UpdateTracker:9780490] Update Tracker - [Pathway:5362517] Signaling by Retinoic Acid - v63:[updateContainedRLE]
[UpdateTracker:9780322] Update Tracker - [BlackBoxEvent:8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 - v63:[modifyText]
[UpdateTracker:9898360] Update Tracker - [Complex:2169047] TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898347] Update Tracker - [Complex:6802701] p-BRAF-MACF1 fusion dimer [cytosol] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898314] Update Tracker - [Complex:2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780215] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v63:[addSummation]
[UpdateTracker:9898043] Update Tracker - [DefinedSet:984770] Kinesins [cytosol] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9898404] Update Tracker - [Complex:909542] unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone [endoplasmic reticulum lumen] - v63:[add_removeHasComponent]
[UpdateTracker:9780358] Update Tracker - [Reaction:1264832] JAK1 binds IL7R - v63:[add_removeInput, modifyText, removeLiteratureReference]
[UpdateTracker:9897889] Update Tracker - [Complex:5357442] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780245] Update Tracker - [BlackBoxEvent:8983872] JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 - v63:[modifyText]
[UpdateTracker:9898326] Update Tracker - [DefinedSet:5357488] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] - v63:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9898229] Update Tracker - [Complex:419551] USP1:WDR48 [nucleoplasm] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780496] Update Tracker - [Pathway:109581] Apoptosis - v63:[updateContainedPathway]
[UpdateTracker:9898348] Update Tracker - [Complex:190070] Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9898406] Update Tracker - [Complex:6811381] RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] - v63:[updateContainedComponent]
[UpdateTracker:9898151] Update Tracker - [Complex:5654258] Activated FGFR1:SHC1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898381] Update Tracker - [Complex:5655337] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780256] Update Tracker - [Pathway:202424] Downstream TCR signaling - v63:[updateContainedRLE]
[UpdateTracker:9898356] Update Tracker - [Complex:5218781] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9898339] Update Tracker - [Complex:2685675] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898319] Update Tracker - [Complex:5332999] Cav3:Trim72:Dysf:Anxa6:Anxa1:Anxa2 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898204] Update Tracker - [Complex:209558] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9897907] Update Tracker - [Complex:209534] NGF ligand:p75NTR:Irak2:Myd88 [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898257] Update Tracker - [Complex:5637697] p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9780373] Update Tracker - [Reaction:3296233] T2Rs bind bitter-tasting compounds - v63:[modifyText]
[UpdateTracker:9898194] Update Tracker - [Complex:3928500] EFNAs:p-EPHAs:SFKs [plasma membrane] - v63:[add_removeHasComponent]
[UpdateTracker:9898361] Update Tracker - [Complex:5682904] Atg10:Atg7 dimer:Atg12 [cytosol] - v63:[add_removeHasComponent, modifyName]
[UpdateTracker:9780317] Update Tracker - [Reaction:8951552] LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ - v63:[addOutput, removeInput]
[UpdateTracker:9780269] Update Tracker - [BlackBoxEvent:5246466] Slc22a17 binds Lcn2, internalising it, releasing Fe3+ - v63:[add_removeOutput]
[UpdateTracker:9898388] Update Tracker - [SimpleEntity:390241] 3-ketohexacosanoyl-CoA [peroxisomal matrix] - v63:[add_removeReferenceEntity]
[UpdateTracker:9780289] Update Tracker - [Pathway:6806667] Metabolism of fat-soluble vitamins - v63:[updateIndirectRLE]
[UpdateTracker:9898409] Update Tracker - [DefinedSet:8868710] CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedMemberOrCandidate]
[UpdateTracker:9780293] Update Tracker - [Pathway:211000] Gene Silencing by RNA - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898215] Update Tracker - [EntityWithAccessionedSequence:8848396] IL18BP [extracellular region] - v63:[addName]
[UpdateTracker:9898139] Update Tracker - [Complex:5218790] VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1 [plasma membrane] - v63:[modifyName, updateContainedComponent]
[UpdateTracker:9780334] Update Tracker - [Pathway:8984722] Interleukin-35 Signalling - v63:[updateContainedRLE]
[UpdateTracker:9897893] Update Tracker - [EntityWithAccessionedSequence:6802530] FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] - v63:[modifyEndCoordinate]
[UpdateTracker:9898405] Update Tracker - [Complex:8866238] AP-2:cargo [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9898249] Update Tracker - [SimpleEntity:5694172] (GlcNAc)2 (Man)8a [COPII-coated ER to Golgi transport vesicle] - v63:[addName]
[UpdateTracker:9780323] Update Tracker - [Pathway:432040] Vasopressin regulates renal water homeostasis via Aquaporins - v63:[addHasEvent]
[UpdateTracker:9780216] Update Tracker - [Pathway:8953854] Metabolism of RNA - v63:[updateContainedPathway]
[UpdateTracker:9780455] Update Tracker - [Pathway:1257604] PIP3 activates AKT signaling - v63:[removeHasEvent]
[UpdateTracker:9898358] Update Tracker - [Complex:5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] - v63:[updateContainedComponent]

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