Reactome | 64 on 2018-03-26

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64 on 2018-03-26 Show undefined attributes

dbId	9779689
displayName	64 on 2018-03-26
modified	[InstanceEdit:9982963] Weiser, Joel, 2026-02-20
releaseDate	2018-03-26
releaseNumber	64
schemaClass	Release

Referrals

(release)

[UpdateTracker:9898918] Update Tracker - [Complex:195942] Segment 4 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898804] Update Tracker - [Complex:1839061] Activated FGFR1 mutants and fusions:PLCG1 [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898540] Update Tracker - [Complex:9013960] viral dsRNA:TLR3:TICAM1:RIPK3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780091] Update Tracker - [Pathway:8878159] Transcriptional regulation by RUNX3 - v64:[updateIndirectRLE]
[UpdateTracker:9779693] Update Tracker - [Pathway:5621481] C-type lectin receptors (CLRs) - v64:[updateIndirectRLE]
[UpdateTracker:9898565] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9898836] Update Tracker - [EntityWithAccessionedSequence:189167] Genomic RNA Segment 8 [endosome lumen] - v64:[add_removeReferenceEntity, add_removeSpecies]
[UpdateTracker:9898797] Update Tracker - [Complex:429424] Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898662] Update Tracker - [Complex:8981605] MB:ferroheme b:O2 [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9898930] Update Tracker - [Complex:421107] CDK5:p35 [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898947] Update Tracker - [Complex:399853] Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's (S522,S518,T509,T514) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779774] Update Tracker - [FailedReaction:3656267] Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan - v64:[add_removeInput]
[UpdateTracker:9780047] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v64:[updateContainedRLE]
[UpdateTracker:9898607] Update Tracker - [Complex:421113] Rac1:GDP [plasma membrane] - v64:[add_removeCompartment, modifyName]
[UpdateTracker:9898549] Update Tracker - [Complex:196497] Membrane enveloped Influenza Virion RNP complex [extracellular region] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9899014] Update Tracker - [EntityWithAccessionedSequence:188857] PB2 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779922] Update Tracker - [FailedReaction:5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - v64:[add_removeInput]
[UpdateTracker:9899068] Update Tracker - [SimpleEntity:947595] PE [external side of plasma membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779754] Update Tracker - [Reaction:5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII - v64:[add_removeCatalystActivity]
[UpdateTracker:9898995] Update Tracker - [Complex:182932] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9780040] Update Tracker - [Pathway:5603041] IRAK4 deficiency (TLR2/4) - v64:[updateContainedRLE]
[UpdateTracker:9779978] Update Tracker - [Pathway:913531] Interferon Signaling - v64:[updateIndirectRLE]
[UpdateTracker:9898596] Update Tracker - [EntityWithAccessionedSequence:202930] CTNNB1(1-115) [cytosol] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9899021] Update Tracker - [Complex:389384] CD28:GRAP2 [plasma membrane] - v64:[addName]
[UpdateTracker:9898790] Update Tracker - [Complex:3239017] phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779704] Update Tracker - [FailedReaction:5683672] Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body - v64:[add_removeInput]
[UpdateTracker:9779821] Update Tracker - [Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - v64:[removeRegulator]
[UpdateTracker:9899044] Update Tracker - [Complex:450269] p38 MAPK:MAPKAPK2,3 [nucleoplasm] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898579] Update Tracker - [Complex:195939] Segment 7 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898976] Update Tracker - [Complex:192682] cRNP [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898890] Update Tracker - [Complex:176061] MGST2 trimer [endoplasmic reticulum membrane] - v64:[modifyName]
[UpdateTracker:9779816] Update Tracker - [Pathway:109581] Apoptosis - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898449] Update Tracker - [EntityWithAccessionedSequence:188858] Genomic RNA Segment 5 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898963] Update Tracker - [EntityWithAccessionedSequence:1614383] FGFR1c P252S [plasma membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9898552] Update Tracker - [Complex:2400008] PI3K Inhibitors:PI3K [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898985] Update Tracker - [EntityWithAccessionedSequence:188833] Genomic RNA Segment 8 [extracellular region] - v64:[add_removeReferenceEntity, add_removeSpecies]
[UpdateTracker:9898779] Update Tracker - [Complex:176047] MGST3 trimer [endoplasmic reticulum membrane] - v64:[modifyName]
[UpdateTracker:9898826] Update Tracker - [EntityWithAccessionedSequence:192983] PB1 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9899078] Update Tracker - [Complex:198825] GSTO1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9779738] Update Tracker - [Pathway:1614635] Sulfur amino acid metabolism - v64:[updateContainedPathway]
[UpdateTracker:9898912] Update Tracker - [Complex:189138] Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779732] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9780065] Update Tracker - [Reaction:140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - v64:[removeRegulator]
[UpdateTracker:9898905] Update Tracker - [CandidateSet:2400011] PI3K mutants,Activator:PI3K [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898489] Update Tracker - [Complex:426501] TNRC6:RISC:Target RNA (inexact match) [cytosol] - v64:[addLiteratureReference, add_removeHasComponent, modifyName]
[UpdateTracker:9779945] Update Tracker - [Pathway:5678420] Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome - v64:[updateContainedRLE]
[UpdateTracker:9898787] Update Tracker - [Complex:192756] Initiated vRNA Transcription Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779879] Update Tracker - [Pathway:3781865] Diseases of glycosylation - v64:[updateContainedPathway]
[UpdateTracker:9899035] Update Tracker - [EntityWithAccessionedSequence:2471753] RDH12 A126V [photoreceptor inner segment membrane] - v64:[add_removeCompartment]
[UpdateTracker:9780118] Update Tracker - [Pathway:69242] S Phase - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9779781] Update Tracker - [FailedReaction:5602170] CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol - v64:[add_removeInput]
[UpdateTracker:9898820] Update Tracker - [SimpleEntity:9023991] 18(S)-RvE1 [extracellular region] - v64:[addName, add_removeReferenceEntity]
[UpdateTracker:9898921] Update Tracker - [Complex:192901] Initiated vRNA-cRNA Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779789] Update Tracker - [Reaction:389354] Activation of Vav1 - v64:[add_removeCatalystActivity]
[UpdateTracker:9898798] Update Tracker - [DefinedSet:1306878] NLRP3 elicitors:NLRP3 [cytosol] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898518] Update Tracker - [Complex:167985] viral dsRNA :TLR3 [endosome membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898887] Update Tracker - [EntityWithAccessionedSequence:195740] NP [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779915] Update Tracker - [BlackBoxEvent:2316352] SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane - v64:[addRegulator, modifyText, removeCatalystActivity]
[UpdateTracker:9898622] Update Tracker - [Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898932] Update Tracker - [DefinedSet:192988] viral mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9899091] Update Tracker - [DefinedSet:450217] MAPKAP2,3 [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9779951] Update Tracker - [Reaction:8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 - v64:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9898792] Update Tracker - [EntityWithAccessionedSequence:421093] Rac1 [plasma membrane] - v64:[add_removeCompartment]
[UpdateTracker:9899069] Update Tracker - [EntityWithAccessionedSequence:192914] M2 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780098] Update Tracker - [Pathway:2206296] MPS II - Hunter syndrome - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779744] Update Tracker - [Reaction:183055] Binding of CBL to EGFR - v64:[add_removeInput]
[UpdateTracker:9779912] Update Tracker - [Pathway:432722] Golgi Associated Vesicle Biogenesis - v64:[updateContainedRLE]
[UpdateTracker:9898919] Update Tracker - [EntityWithAccessionedSequence:188856] Genomic RNA Segment 4 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780038] Update Tracker - [Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene - v64:[add_removeInput]
[UpdateTracker:9780060] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v64:[updateContainedRLE]
[UpdateTracker:9898760] Update Tracker - [Complex:936400] dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779979] Update Tracker - [FailedReaction:2265534] Defective GLB1 does not hydrolyse a glycosaminoglycan - v64:[add_removeInput]
[UpdateTracker:9780122] Update Tracker - [Reaction:5685600] viral HA binds NCRI - v64:[add_removeInput]
[UpdateTracker:9779932] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v64:[add_removeInput]
[UpdateTracker:9898747] Update Tracker - [Complex:1181343] Cerberus:Nodal [extracellular region] - v64:[add_removeHasComponent]
[UpdateTracker:9898864] Update Tracker - [Complex:573354] NoRC [nucleoplasm] - v64:[addHasComponent]
[UpdateTracker:9780161] Update Tracker - [Pathway:5579022] Defective GGT1 causes GLUTH - v64:[add_removeHasEvent]
[UpdateTracker:9898452] Update Tracker - [EntityWithAccessionedSequence:195790] HA [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898574] Update Tracker - [Complex:9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780164] Update Tracker - [Reaction:1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes - v64:[add_removeInput]
[UpdateTracker:9898943] Update Tracker - [EntityWithAccessionedSequence:196479] Genomic RNA Segment 6 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898595] Update Tracker - [Complex:5685594] NCR1:FCRG1A:CD3Z dimer:Hemagglutinin [plasma membrane] - v64:[add_removeEntityOnOtherCell, add_removeHasComponent]
[UpdateTracker:9779857] Update Tracker - [Pathway:186797] Signaling by PDGF - v64:[updateIndirectRLE]
[UpdateTracker:9898663] Update Tracker - [DefinedSet:389743] LCK, CSK [cytosol] - v64:[modifyName]
[UpdateTracker:9898975] Update Tracker - [Complex:450254] p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779873] Update Tracker - [Pathway:71403] Citric acid cycle (TCA cycle) - v64:[addHasEvent]
[UpdateTracker:9779995] Update Tracker - [Reaction:187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 - v64:[addInput, addOutput]
[UpdateTracker:9898600] Update Tracker - [Complex:6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9779944] Update Tracker - [BlackBoxEvent:1989765] Expression of ABCA1 - v64:[addRegulator, modifyText]
[UpdateTracker:9898754] Update Tracker - [DefinedSet:6807023] PTPN1,PTPN2 [cytosol] - v64:[modifyName]
[UpdateTracker:9898638] Update Tracker - [Complex:399854] PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898617] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898855] Update Tracker - [Complex:350287] DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9780039] Update Tracker - [Pathway:844456] The NLRP3 inflammasome - v64:[updateContainedRLE]
[UpdateTracker:9779928] Update Tracker - [Pathway:8852135] Protein ubiquitination - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898842] Update Tracker - [Complex:182939] EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898520] Update Tracker - [Complex:434632] VAV family:PIP2 [plasma membrane] - v64:[add_removeCompartment]
[UpdateTracker:9899062] Update Tracker - [Complex:195766] NP:Lipid Raft [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9780012] Update Tracker - [Pathway:3108232] SUMO E3 ligases SUMOylate target proteins - v64:[addHasEvent]
[UpdateTracker:9779765] Update Tracker - [FailedReaction:5659674] Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - v64:[add_removeInput]
[UpdateTracker:9779832] Update Tracker - [FailedReaction:5604954] Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL - v64:[add_removeInput]
[UpdateTracker:9898708] Update Tracker - [Complex:5419280] 55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780068] Update Tracker - [Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry - v64:[addHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898639] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898673] Update Tracker - [Complex:1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898679] Update Tracker - [Complex:508158] Bcl2:BH3-only protein complex [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779899] Update Tracker - [Pathway:877300] Interferon gamma signaling - v64:[updateContainedRLE]
[UpdateTracker:9780058] Update Tracker - [Reaction:5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9898979] Update Tracker - [Complex:5419272] 55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898577] Update Tracker - [Complex:8951432] RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898753] Update Tracker - [Complex:5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898946] Update Tracker - [Complex:5389851] 55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898881] Update Tracker - [Complex:192650] Initiated cRNA-vRNA Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9899015] Update Tracker - [EntityWithAccessionedSequence:5685584] HA [virion membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779923] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v64:[removeCatalystActivity]
[UpdateTracker:9779916] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v64:[addRegulator]
[UpdateTracker:9898906] Update Tracker - [Complex:377612] Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898884] Update Tracker - [Complex:925458] NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9779829] Update Tracker - [Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - v64:[removeRegulator]
[UpdateTracker:9898923] Update Tracker - [Complex:192703] vRNA Transcription Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780018] Update Tracker - [Pathway:5654710] PI-3K cascade:FGFR3 - v64:[updateContainedRLE]
[UpdateTracker:9898967] Update Tracker - [EntityWithAccessionedSequence:189154] HA2 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898496] Update Tracker - [Complex:195732] palmitylated M2 Tetramer [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898953] Update Tracker - [Complex:2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898939] Update Tracker - [EntityWithAccessionedSequence:189176] NEP/NS2 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9779966] Update Tracker - [Pathway:597592] Post-translational protein modification - v64:[updateContainedPathway]
[UpdateTracker:9898824] Update Tracker - [EntityWithAccessionedSequence:169474] NEP/NS2 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898492] Update Tracker - [EntityWithAccessionedSequence:195743] HA folded, glycosylated, and palmitylated [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779869] Update Tracker - [Pathway:3323169] Defects in biotin (Btn) metabolism - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898697] Update Tracker - [EntityWithAccessionedSequence:188839] Genomic RNA Segment 8 [nucleoplasm] - v64:[add_removeReferenceEntity, add_removeSpecies]
[UpdateTracker:9780113] Update Tracker - [FailedReaction:2263444] Defective SGSH does not hydrolyse Heparan sulfate chain(7) - v64:[add_removeInput]
[UpdateTracker:9779703] Update Tracker - [Pathway:5654708] Downstream signaling of activated FGFR3 - v64:[updateIndirectRLE]
[UpdateTracker:9779722] Update Tracker - [FailedReaction:3656230] Defective B4GALT1 does not transfer Gal to the keratan chain - v64:[add_removeInput]
[UpdateTracker:9899039] Update Tracker - [Complex:188871] RNP Complex:Karyopherin alpha [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9779769] Update Tracker - [Pathway:5654716] Downstream signaling of activated FGFR4 - v64:[updateIndirectRLE]
[UpdateTracker:9898774] Update Tracker - [Complex:350277] importin-alpha:importin-beta [cytosol] - v64:[addName]
[UpdateTracker:9898991] Update Tracker - [EntityWithAccessionedSequence:192893] NA [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779800] Update Tracker - [Pathway:3814836] Glycogen storage disease type XV (GYG1) - v64:[updateContainedRLE]
[UpdateTracker:9898782] Update Tracker - [Complex:372646] p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898602] Update Tracker - [Complex:5368273] 55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780052] Update Tracker - [Pathway:73887] Death Receptor Signalling - v64:[addHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9780155] Update Tracker - [Pathway:983705] Signaling by the B Cell Receptor (BCR) - v64:[updateIndirectRLE]
[UpdateTracker:9779791] Update Tracker - [Pathway:2173782] Binding and Uptake of Ligands by Scavenger Receptors - v64:[updateIndirectRLE]
[UpdateTracker:9780146] Update Tracker - [Pathway:2142845] Hyaluronan metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9898703] Update Tracker - [DefinedSet:918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779701] Update Tracker - [BlackBoxEvent:2316351] Translocation of Glut4 Vesicle and Docking at the Plasma Membrane - v64:[addLiteratureReference, addRegulator, modifyText, removeCatalystActivity]
[UpdateTracker:9780134] Update Tracker - [Pathway:5663084] Diseases of carbohydrate metabolism - v64:[updateContainedPathway]
[UpdateTracker:9898547] Update Tracker - [Complex:354157] Vinculin bound to alphaIIbbeta3 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899000] Update Tracker - [Complex:3299679] 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898812] Update Tracker - [GenomeEncodedEntity:9028895] Influenza A dsRNA intermediate form [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9780037] Update Tracker - [Reaction:1793207] ARSB hydrolyses C4S/C6S chains - v64:[modifyText]
[UpdateTracker:9898641] Update Tracker - [SimpleEntity:939747] PS [external side of plasma membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898769] Update Tracker - [Complex:399845] NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899003] Update Tracker - [SimpleEntity:1602375] PE [plasma membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898659] Update Tracker - [Complex:918199] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899089] Update Tracker - [Complex:2428921] IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898650] Update Tracker - [Complex:182930] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9780109] Update Tracker - [Reaction:5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9779801] Update Tracker - [Pathway:2206292] MPS VII - Sly syndrome - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898678] Update Tracker - [EntityWithAccessionedSequence:188859] Genomic RNA Segment 3 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779952] Update Tracker - [FailedReaction:5688899] Defective CSF2RA does not bind SFTPs - v64:[add_removeInput]
[UpdateTracker:9898738] Update Tracker - [DefinedSet:1234118] UBE2D1,2,3 [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9779745] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v64:[updateContainedRLE]
[UpdateTracker:9779699] Update Tracker - [FailedReaction:3323184] Defective HLCS does not biotinylate ACACA:Mn2+ - v64:[add_removeInput, modifyText]
[UpdateTracker:9779777] Update Tracker - [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - v64:[updateContainedRLE]
[UpdateTracker:9779934] Update Tracker - [Pathway:1266738] Developmental Biology - v64:[updateIndirectRLE]
[UpdateTracker:9898791] Update Tracker - [EntityWithAccessionedSequence:192994] M2 mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779939] Update Tracker - [Reaction:879862] Passive Transport of Anions into Vesicles by Aquaporin-6 (rat) - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9898664] Update Tracker - [Complex:203487] Fusion Competent Cleaved Trimeric palmitylated HA [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9899055] Update Tracker - [Complex:189171] Influenza A Viral Particle [endosome lumen] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9899064] Update Tracker - [EntityWithAccessionedSequence:195793] HA folded and glycosylated [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779709] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v64:[removeHasEvent]
[UpdateTracker:9780090] Update Tracker - [FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - v64:[add_removeInput]
[UpdateTracker:9779775] Update Tracker - [Pathway:2160916] Hyaluronan uptake and degradation - v64:[updateContainedRLE]
[UpdateTracker:9898882] Update Tracker - [EntityWithAccessionedSequence:192972] NA mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779949] Update Tracker - [Pathway:211000] Gene Silencing by RNA - v64:[updateIndirectRLE]
[UpdateTracker:9779803] Update Tracker - [Pathway:3371599] Defective HLCS causes multiple carboxylase deficiency - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898634] Update Tracker - [Complex:159202] GST A4 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898742] Update Tracker - [Complex:399852] PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779938] Update Tracker - [BlackBoxEvent:4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene - v64:[add_removeOutput]
[UpdateTracker:9898516] Update Tracker - [Complex:918196] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779772] Update Tracker - [Reaction:437192] PDPK1 binds PRKCZ - v64:[add_removeInput, modifyText]
[UpdateTracker:9898698] Update Tracker - [Complex:169074] CPSF:NS1 Complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898648] Update Tracker - [EntityWithAccessionedSequence:188863] Genomic RNA Segment 7 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898537] Update Tracker - [EntityWithAccessionedSequence:2471712] OPN1MW W177R [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9898704] Update Tracker - [Complex:201922] hTCF-4:Beta-catenin [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898475] Update Tracker - [EntityWithAccessionedSequence:195809] Glycosylated and folded HA [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9899072] Update Tracker - [CandidateSet:201920] Beta-catenin [nucleoplasm] - v64:[add_removeHasCandidate]
[UpdateTracker:9898996] Update Tracker - [Complex:188846] Ribonucleoprotein (RNP) Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898457] Update Tracker - [SimpleEntity:1368125] ferriheme b [nucleoplasm] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779761] Update Tracker - [Pathway:1428517] The citric acid (TCA) cycle and respiratory electron transport - v64:[updateContainedPathway]
[UpdateTracker:9898736] Update Tracker - [Complex:2247507] SCARF1:Ligand [endocytic vesicle membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898780] Update Tracker - [Complex:9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780128] Update Tracker - [Pathway:5654695] PI-3K cascade:FGFR2 - v64:[updateContainedRLE]
[UpdateTracker:9898655] Update Tracker - [EntityWithAccessionedSequence:2471646] OPN1LW G338E [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9780044] Update Tracker - [Pathway:5683678] Defective ABCA3 causes SMDP3 - v64:[updateContainedRLE]
[UpdateTracker:9898914] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v64:[addLiteratureReference]
[UpdateTracker:9898764] Update Tracker - [EntityWithAccessionedSequence:196499] Genomic RNA Segment 5 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779888] Update Tracker - [BlackBoxEvent:6789524] Expression of IL4,IL13-downregulated extracellular genes - v64:[addRegulator, modifyText]
[UpdateTracker:9898447] Update Tracker - [Complex:354103] Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780132] Update Tracker - [FailedReaction:5621425] Defective AVP mutants do not bind AVPR1A,B - v64:[add_removeInput, modifyText]
[UpdateTracker:9898563] Update Tracker - [EntityWithAccessionedSequence:2471740] OPN1LW P307L [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9898739] Update Tracker - [SimpleEntity:193720] 5?-CHOL3?,7?,24(s)-triol [mitochondrial matrix] - v64:[modifyName]
[UpdateTracker:9898680] Update Tracker - [Complex:573319] NoRC:pRNA:Hdac:Dnmt [nucleoplasm] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9779688] Update Tracker - [Pathway:426496] Post-transcriptional silencing by small RNAs - v64:[updateContainedRLE]
[UpdateTracker:9898658] Update Tracker - [EntityWithAccessionedSequence:195729] palmitylated M2 [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9899067] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898961] Update Tracker - [Complex:1234123] UBE2D1,2,3:Ubiquitin [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9780043] Update Tracker - [Pathway:2559583] Cellular Senescence - v64:[updateIndirectRLE]
[UpdateTracker:9779902] Update Tracker - [Pathway:6806664] Metabolism of vitamin K - v64:[updateContainedRLE]
[UpdateTracker:9898657] Update Tracker - [SimpleEntity:33625] PS [plasma membrane] - v64:[addName]
[UpdateTracker:9898666] Update Tracker - [Complex:189172] Influenza A Viral Envelope With An Inter-Membrane Spanning HA2 [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779889] Update Tracker - [Reaction:163069] mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol - v64:[add_removeInput]
[UpdateTracker:9779891] Update Tracker - [Reaction:193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - v64:[add_removeOutput]
[UpdateTracker:9898675] Update Tracker - [Complex:195725] Glycosylated, palmitylated and folded HA trimer [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898555] Update Tracker - [Complex:437191] PDPK1:PIP3:PRKCZ [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898479] Update Tracker - [Complex:2018773] p-8Y-FGFR1c P252T dimer [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898844] Update Tracker - [EntityWithAccessionedSequence:192993] PB2 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779955] Update Tracker - [Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence - v64:[updateContainedRLE]
[UpdateTracker:9898476] Update Tracker - [EntityWithAccessionedSequence:188868] Genomic RNA Segment 6 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898550] Update Tracker - [Complex:8953945] Ub:PEX5S [peroxisomal membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898730] Update Tracker - [Complex:5419275] 55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779848] Update Tracker - [Pathway:437980] Activated TAK1 mediates p38 MAP kinase phosphorylation - v64:[updateContainedRLE]
[UpdateTracker:9780108] Update Tracker - [Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus - v64:[modifyText]
[UpdateTracker:9899020] Update Tracker - [Complex:3301928] GSTA5 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9780143] Update Tracker - [Pathway:449147] Signaling by Interleukins - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780015] Update Tracker - [Pathway:177929] Signaling by EGFR - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9899006] Update Tracker - [Complex:3299681] 2xHC-SOD1:Zn2+:Cu2+ [cytosol] - v64:[modifyName]
[UpdateTracker:9899002] Update Tracker - [Complex:8981609] NGB:ferroheme b:O2 [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9898889] Update Tracker - [Complex:196475] Gycosylated NA Tetramer [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9899034] Update Tracker - [Complex:399855] NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898643] Update Tracker - [Complex:192922] vRNP destined for Export [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898874] Update Tracker - [Complex:556812] Pparg:Fatty Acid:Rxra:Mediator:coactivator Complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779881] Update Tracker - [FailedReaction:5602984] Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG - v64:[add_removeInput, modifyText]
[UpdateTracker:9898508] Update Tracker - [Complex:5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779731] Update Tracker - [Reaction:111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - v64:[addRegulator]
[UpdateTracker:9898672] Update Tracker - [Complex:203488] Gycosylated NA Tetramer [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898966] Update Tracker - [Complex:5389843] 55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898599] Update Tracker - [CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898684] Update Tracker - [Complex:3301932] GSTA1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898974] Update Tracker - [EntityWithAccessionedSequence:196491] palmitylated M2 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779741] Update Tracker - [FailedReaction:5688884] Defective CSF2RB does not bind SFTPs - v64:[add_removeInput]
[UpdateTracker:9898849] Update Tracker - [Complex:203485] Membrane Spanning Cleaved Trimeric palmitylated HA [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898569] Update Tracker - [Complex:9013984] TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779841] Update Tracker - [Pathway:168249] Innate Immune System - v64:[updateIndirectRLE]
[UpdateTracker:9898794] Update Tracker - [Complex:450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780163] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v64:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9898734] Update Tracker - [Complex:983689] Antigen:BCR [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9779960] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v64:[removeRegulator]
[UpdateTracker:9779735] Update Tracker - [Reaction:68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - v64:[addCatalystActivity, add_removeOutput, modifyText]
[UpdateTracker:9780141] Update Tracker - [Pathway:69278] Cell Cycle, Mitotic - v64:[removeHasEvent, updateContainedPathway]
[UpdateTracker:9898557] Update Tracker - [SimpleEntity:5676634] 2,3-TE-CoA [cytosol] - v64:[addName]
[UpdateTracker:9898871] Update Tracker - [DefinedSet:434838] p-Y348-SYK/LCK [cytosol] - v64:[add_removeHasMember, modifyName]
[UpdateTracker:9898745] Update Tracker - [Complex:1839062] Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898883] Update Tracker - [Complex:195737] NP:Lipid Raft [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898750] Update Tracker - [Complex:189182] Influenza A Viral Particle With A Fusion Competent HA2 [endosome lumen] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779726] Update Tracker - [Pathway:2142753] Arachidonic acid metabolism - v64:[removeHasEvent]
[UpdateTracker:9898554] Update Tracker - [Complex:749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779957] Update Tracker - [FailedReaction:3322135] Defective MMAA does not protect MUT - v64:[add_removeInput]
[UpdateTracker:9899075] Update Tracker - [DefinedSet:450885] Kainate Receptors [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898593] Update Tracker - [Complex:196496] RNP pre-assembly complex [cytosol] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780036] Update Tracker - [Pathway:70268] Pyruvate metabolism - v64:[addHasEvent, updateContainedPathway]
[UpdateTracker:9779953] Update Tracker - [Pathway:3656237] Defective EXT2 causes exostoses 2 - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898534] Update Tracker - [Complex:3301938] HPGDS dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898483] Update Tracker - [Complex:8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898507] Update Tracker - [Complex:2404185] IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898499] Update Tracker - [Complex:195755] Glycosylated, palmitylated and folded HA trimer:Lipid Raft Complex [plasma membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898468] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898982] Update Tracker - [DefinedSet:904816] Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] - v64:[add_removeHasMember]
[UpdateTracker:9898934] Update Tracker - [Complex:189181] Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780148] Update Tracker - [FailedReaction:2263492] Defective HGSNAT does not acetylate Heparan chain(1) - v64:[add_removeInput]
[UpdateTracker:9779886] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v64:[updateContainedRLE]
[UpdateTracker:9779696] Update Tracker - [Pathway:3000484] Scavenging by Class F Receptors - v64:[updateContainedRLE]
[UpdateTracker:9779714] Update Tracker - [Pathway:442742] CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling - v64:[updateContainedPathway]
[UpdateTracker:9898636] Update Tracker - [Complex:372652] CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780135] Update Tracker - [Reaction:426489] RISC binds inexactly matching target RNAs - v64:[addLiteratureReference]
[UpdateTracker:9779810] Update Tracker - [Pathway:422475] Axon guidance - v64:[updateIndirectRLE]
[UpdateTracker:9779762] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v64:[removeRegulator]
[UpdateTracker:9780064] Update Tracker - [Reaction:2161779] LXA4 is oxidised to 15k-LXA4 by HPGD - v64:[modifyText]
[UpdateTracker:9779730] Update Tracker - [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - v64:[updateContainedRLE]
[UpdateTracker:9899076] Update Tracker - [Complex:203482] Cleaved Trimeric palmitylated HA [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9779994] Update Tracker - [Pathway:5619094] Variant SLC6A14 may confer susceptibility towards obesity - v64:[updateContainedRLE]
[UpdateTracker:9898858] Update Tracker - [SimpleEntity:2230943] ferriheme b [endocytic vesicle lumen] - v64:[add_removeReferenceEntity]
[UpdateTracker:9899052] Update Tracker - [Complex:2428931] IGF1,2:p-IGF1R:IRS2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898783] Update Tracker - [Complex:933482] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779706] Update Tracker - [Reaction:201595] Caspase-mediated cleavage of plakophilin-1 - v64:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9780095] Update Tracker - [Pathway:187577] SCF(Skp2)-mediated degradation of p27/p21 - v64:[updateContainedRLE]
[UpdateTracker:9898530] Update Tracker - [Complex:187516] Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9780033] Update Tracker - [Reaction:5340226] CYGB dioxygenates NO - v64:[add_removeOutput]
[UpdateTracker:9899027] Update Tracker - [Complex:933479] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779981] Update Tracker - [Pathway:1433557] Signaling by SCF-KIT - v64:[updateContainedRLE]
[UpdateTracker:9779747] Update Tracker - [FailedReaction:5628807] Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol - v64:[add_removeInput]
[UpdateTracker:9898713] Update Tracker - [SimpleEntity:5696194] GMP [mitochondrial matrix] - v64:[modifyName]
[UpdateTracker:9898781] Update Tracker - [Complex:432098] Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898743] Update Tracker - [EntityWithAccessionedSequence:188838] Genomic RNA Segment 2 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780027] Update Tracker - [Reaction:109701] PDPK1 binds PIP3 - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9898463] Update Tracker - [EntityWithAccessionedSequence:169251] NP [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9898729] Update Tracker - [CandidateSet:198809] GSTO dimers [cytosol] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9780136] Update Tracker - [Pathway:351906] Apoptotic cleavage of cell adhesion proteins - v64:[updateContainedRLE]
[UpdateTracker:9899045] Update Tracker - [DefinedSet:196484] vRNA (genomic) [cytosol] - v64:[add_removeSpecies, updateContainedMemberOrCandidate]
[UpdateTracker:9898477] Update Tracker - [Complex:6802710] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898631] Update Tracker - [CandidateSet:5624346] IFNG induced TRIMs [cytosol] - v64:[modifyName]
[UpdateTracker:9898784] Update Tracker - [Complex:937325] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898983] Update Tracker - [DefinedSet:187963] FZR1,p-S795-RB1 [nucleoplasm] - v64:[addName, add_removeHasMember]
[UpdateTracker:9898998] Update Tracker - [Complex:3301921] GSTA3 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9779895] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v64:[addCatalystActivity, addLiteratureReference, modifyText, removeInput, removeOutput]
[UpdateTracker:9779971] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v64:[addRegulator]
[UpdateTracker:9898472] Update Tracker - [EntityWithAccessionedSequence:2291936] MLYCD(40-493) [peroxisomal matrix] - v64:[add_removeReferenceEntity]
[UpdateTracker:9780099] Update Tracker - [Pathway:977347] Serine biosynthesis - v64:[addHasEvent]
[UpdateTracker:9898910] Update Tracker - [Complex:1168622] p-CARMA1:MALT1:p-BCL10 [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779825] Update Tracker - [Pathway:4687000] Defective MPDU1 causes CDG-1f - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779759] Update Tracker - [Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - v64:[updateContainedRLE]
[UpdateTracker:9779989] Update Tracker - [Pathway:2206285] MPS VI - Maroteaux-Lamy syndrome - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780125] Update Tracker - [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9779872] Update Tracker - [Reaction:983709] LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) - v64:[add_removeCatalystActivity]
[UpdateTracker:9780130] Update Tracker - [Pathway:68962] Activation of the pre-replicative complex - v64:[addHasEvent]
[UpdateTracker:9898928] Update Tracker - [Complex:8858282] HILPDA:lipid droplet [lipid droplet] - v64:[updateContainedComponent]
[UpdateTracker:9898911] Update Tracker - [Complex:195738] Glycosylated, palmitylated and folded HA trimer [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898497] Update Tracker - [Complex:380768] PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779926] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v64:[updateContainedRLE]
[UpdateTracker:9898862] Update Tracker - [Complex:389746] p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899005] Update Tracker - [EntityWithAccessionedSequence:188877] PA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779856] Update Tracker - [FailedReaction:3656254] Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain - v64:[add_removeInput]
[UpdateTracker:9898900] Update Tracker - [Complex:3239009] phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9780050] Update Tracker - [Pathway:392499] Metabolism of proteins - v64:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780000] Update Tracker - [Pathway:5668914] Diseases of metabolism - v64:[updateContainedPathway]
[UpdateTracker:9779840] Update Tracker - [Pathway:5621480] Dectin-2 family - v64:[updateContainedRLE]
[UpdateTracker:9898724] Update Tracker - [EntityWithAccessionedSequence:192986] NP mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898741] Update Tracker - [Complex:2750166] Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898590] Update Tracker - [Complex:399870] Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898610] Update Tracker - [Complex:450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898837] Update Tracker - [Complex:158548] MGST1 trimer [endoplasmic reticulum membrane] - v64:[modifyName]
[UpdateTracker:9898859] Update Tracker - [DefinedSet:2471659] OPN1LW mutants [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9899028] Update Tracker - [DefinedSet:167916] MAP2K3,MAP2K6 [cytosol] - v64:[modifyName]
[UpdateTracker:9779805] Update Tracker - [Pathway:8951430] RUNX3 regulates WNT signaling - v64:[updateContainedRLE]
[UpdateTracker:9898945] Update Tracker - [EntityWithAccessionedSequence:189151] M2 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898509] Update Tracker - [Complex:180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9780030] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v64:[updateContainedRLE]
[UpdateTracker:9898578] Update Tracker - [DefinedSet:6789363] IL13-upregulated genes for plasma membrane proteins [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9898541] Update Tracker - [SimpleEntity:193757] 3,7,24THCA [mitochondrial matrix] - v64:[addName, add_removeReferenceEntity]
[UpdateTracker:9898490] Update Tracker - [Complex:3301964] GSTM2 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9899049] Update Tracker - [Complex:429434] Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779940] Update Tracker - [Reaction:2465924] OPN1LW binds 11cRAL - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9898625] Update Tracker - [Complex:195736] Gycosylated NA Tetramer:Lipid Raft [Golgi membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898670] Update Tracker - [Complex:1445124] p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898810] Update Tracker - [Complex:5368277] 55S ribosome [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779875] Update Tracker - [Reaction:75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - v64:[add_removeCatalystActivity]
[UpdateTracker:9779795] Update Tracker - [Reaction:8855237] FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 - v64:[add_removeCatalystActivity]
[UpdateTracker:9779793] Update Tracker - [Reaction:351913] Caspase-mediated cleavage of TJP1 - v64:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9898833] Update Tracker - [DefinedSet:187920] p-FZR1,p-RB1 [nucleoplasm] - v64:[addName, removeHasMember]
[UpdateTracker:9898464] Update Tracker - [EntityWithAccessionedSequence:188848] NP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780158] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v64:[add_removeSummation, updateContainedRLE]
[UpdateTracker:9898853] Update Tracker - [Complex:3239002] p38 MAPK:MAPKAPK5 [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9780102] Update Tracker - [Pathway:453279] Mitotic G1 phase and G1/S transition - v64:[updateContainedPathway]
[UpdateTracker:9780083] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v64:[addRegulator]
[UpdateTracker:9779713] Update Tracker - [Reaction:201631] Caspase-mediated cleavage of Desmoglein 3 - v64:[add_removeCatalystActivity]
[UpdateTracker:9898618] Update Tracker - [Complex:377608] Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780004] Update Tracker - [Reaction:351901] Caspase-mediated cleavage of MST3 - v64:[addLiteratureReference, add_removeCatalystActivity, modifyText]
[UpdateTracker:9899066] Update Tracker - [Complex:918190] 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898851] Update Tracker - [SimpleEntity:2162224] GlcA-?1,3-GlcNAc [lysosomal lumen] - v64:[modifyName]
[UpdateTracker:9898519] Update Tracker - [SimpleEntity:113587] OA [mitochondrial matrix] - v64:[modifyName]
[UpdateTracker:9779918] Update Tracker - [Pathway:69017] CDK-mediated phosphorylation and removal of Cdc6 - v64:[updateContainedRLE]
[UpdateTracker:9898778] Update Tracker - [Complex:1169550] p-CARMA1:BCL10:MALT1:TAK1:IKK [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779724] Update Tracker - [Pathway:5619084] ABC transporter disorders - v64:[updateIndirectRLE]
[UpdateTracker:9898460] Update Tracker - [EntityWithAccessionedSequence:195948] PA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898733] Update Tracker - [Complex:377616] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780101] Update Tracker - [FailedReaction:3322971] Defective MUT does not isomerise L-MM-CoA to SUCC-CoA - v64:[removeInput]
[UpdateTracker:9779824] Update Tracker - [Reaction:193736] Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - v64:[add_removeOutput]
[UpdateTracker:9779929] Update Tracker - [Pathway:8963676] Intestinal absorption - v64:[modifyText]
[UpdateTracker:9898478] Update Tracker - [Complex:400543] FFAR4:FFAR4 ligands [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779911] Update Tracker - [Reaction:5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - v64:[modifyText]
[UpdateTracker:9898627] Update Tracker - [Complex:372688] BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898473] Update Tracker - [Complex:6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9779941] Update Tracker - [Reaction:69005] Cdc6 protein is phosphorylated by CDK - v64:[add_removeCatalystActivity]
[UpdateTracker:9899048] Update Tracker - [Complex:8983917] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779925] Update Tracker - [Pathway:162582] Signal Transduction - v64:[updateContainedPathway]
[UpdateTracker:9899012] Update Tracker - [Complex:3301997] GSTM5 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9780133] Update Tracker - [Pathway:500792] GPCR ligand binding - v64:[modifyText]
[UpdateTracker:9898548] Update Tracker - [Complex:188844] RNP:Karyopherin alpha:Karyopherin beta complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898959] Update Tracker - [Complex:350304] DFF:associated with the importin-alpha:importin-beta complex [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898562] Update Tracker - [Complex:1306879] NLRP3 elicitor proteins:NLRP3 [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9898642] Update Tracker - [Complex:354135] Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898993] Update Tracker - [Complex:9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898952] Update Tracker - [EntityWithAccessionedSequence:189179] Genomic RNA Segment 5 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898950] Update Tracker - [SimpleEntity:2046044] LINA [endoplasmic reticulum lumen] - v64:[addName]
[UpdateTracker:9898488] Update Tracker - [SimpleEntity:947592] PS [cytoplasmic side of plasma membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898878] Update Tracker - [Complex:195735] Gycosylated NA Tetramer:Lipid Raft [plasma membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9899008] Update Tracker - [EntityWithAccessionedSequence:195752] NP [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779715] Update Tracker - [Reaction:162425] p-S295-PDE3B hydrolyses cAMP to AMP - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9898628] Update Tracker - [EntityWithAccessionedSequence:192982] NS1 mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898584] Update Tracker - [DefinedSet:2050627] p-8Y-FGFR1c P252X dimers [plasma membrane] - v64:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9898735] Update Tracker - [Complex:195775] Glycosylated NA Tetramer [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898556] Update Tracker - [Complex:192767] vRNP:M1:NEP [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898467] Update Tracker - [EntityWithAccessionedSequence:1251925] Plcg1 [plasma membrane] - v64:[add_removeCompartment]
[UpdateTracker:9780100] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v64:[updateContainedRLE]
[UpdateTracker:9898605] Update Tracker - [EntityWithAccessionedSequence:195762] HA folded, glycosylated, and palmitylated [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9780023] Update Tracker - [Pathway:70350] Fructose catabolism - v64:[updateContainedRLE]
[UpdateTracker:9899050] Update Tracker - [Complex:6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9779985] Update Tracker - [Pathway:3296482] Defects in vitamin and cofactor metabolism - v64:[updateContainedPathway]
[UpdateTracker:9898466] Update Tracker - [EntityWithAccessionedSequence:195915] NA [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9898972] Update Tracker - [DefinedSet:6784990] IL10-downregulated genes for extracellular proteins [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9898500] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9779991] Update Tracker - [Pathway:5619102] SLC transporter disorders - v64:[addHasEvent, updateIndirectRLE]
[UpdateTracker:9779908] Update Tracker - [Reaction:193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - v64:[modifyText]
[UpdateTracker:9898720] Update Tracker - [Complex:377619] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898756] Update Tracker - [SimpleEntity:432045] NO3- [transport vesicle] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9898570] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779935] Update Tracker - [Pathway:2206308] MPS IV - Morquio syndrome B - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779746] Update Tracker - [Pathway:204174] Regulation of pyruvate dehydrogenase (PDH) complex - v64:[addHasEvent]
[UpdateTracker:9898854] Update Tracker - [Complex:1181341] CERBERUS:NODAL [extracellular region] - v64:[add_removeHasComponent]
[UpdateTracker:9779766] Update Tracker - [Reaction:428262] phytoceramide + H2O => stearate + phytosphingosine - v64:[add_removeInput]
[UpdateTracker:9779850] Update Tracker - [Pathway:74749] Signal attenuation - v64:[updateContainedRLE]
[UpdateTracker:9898543] Update Tracker - [Complex:2168084] Viral Proteins [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898957] Update Tracker - [Complex:354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899051] Update Tracker - [EntityWithAccessionedSequence:9008906] PTPN18 gene [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898668] Update Tracker - [Complex:169239] Cleaved HA Influenza A Viral Particle [extracellular region] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780115] Update Tracker - [FailedReaction:3878762] Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) - v64:[removeInput]
[UpdateTracker:9899073] Update Tracker - [Complex:354130] Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9899058] Update Tracker - [EntityWithAccessionedSequence:189163] Genomic RNA Segment 7 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9779749] Update Tracker - [FailedReaction:2318373] Defective GUSB does not hydrolyse (HA)2 - v64:[add_removeInput, modifyText]
[UpdateTracker:9779768] Update Tracker - [Pathway:5654720] PI-3K cascade:FGFR4 - v64:[updateContainedRLE]
[UpdateTracker:9898913] Update Tracker - [DefinedSet:176042] MGST trimers [endoplasmic reticulum membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779764] Update Tracker - [Pathway:5579027] Defective CYP27B1 causes VDDR1B - v64:[updateContainedRLE]
[UpdateTracker:9779883] Update Tracker - [Pathway:71387] Metabolism of carbohydrates - v64:[updateContainedPathway]
[UpdateTracker:9779819] Update Tracker - [Pathway:165158] Activation of AKT2 - v64:[updateContainedRLE]
[UpdateTracker:9780110] Update Tracker - [Reaction:183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - v64:[add_removeOutput]
[UpdateTracker:9779967] Update Tracker - [Pathway:5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer - v64:[updateIndirectRLE]
[UpdateTracker:9898538] Update Tracker - [Complex:933473] viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779718] Update Tracker - [Pathway:5619063] Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) - v64:[updateContainedRLE]
[UpdateTracker:9779896] Update Tracker - [Pathway:75158] TRAIL signaling - v64:[addHasEvent]
[UpdateTracker:9780111] Update Tracker - [Reaction:437189] PDK1 binds PKC zeta - v64:[modifyText]
[UpdateTracker:9779984] Update Tracker - [Pathway:3359478] Defective MUT causes MMAM - v64:[updateContainedRLE]
[UpdateTracker:9898526] Update Tracker - [DefinedSet:170997] p-p38 MAPK alpha/beta [cytosol] - v64:[modifyName]
[UpdateTracker:9779930] Update Tracker - [Pathway:1989781] PPARA activates gene expression - v64:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9779788] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v64:[addLiteratureReference]
[UpdateTracker:9898527] Update Tracker - [Complex:9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898553] Update Tracker - [Complex:195945] Sialic Acid Bound Influenza A Viral Particle [plasma membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779817] Update Tracker - [Pathway:2990846] SUMOylation - v64:[updateContainedPathway]
[UpdateTracker:9780104] Update Tracker - [Pathway:438064] Post NMDA receptor activation events - v64:[updateContainedPathway]
[UpdateTracker:9779757] Update Tracker - [Pathway:163125] Post-translational modification: synthesis of GPI-anchored proteins - v64:[updateIndirectRLE]
[UpdateTracker:9779904] Update Tracker - [Pathway:5626467] RHO GTPases activate IQGAPs - v64:[updateContainedRLE]
[UpdateTracker:9779855] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v64:[addRegulator, removeInput, removeOutput]
[UpdateTracker:9780006] Update Tracker - [Pathway:418594] G alpha (i) signalling events - v64:[modifyText]
[UpdateTracker:9898828] Update Tracker - [Complex:354079] Focal Adhesion/Focal contacts [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898521] Update Tracker - [Complex:3301949] GSTM1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898922] Update Tracker - [Complex:5368233] 39S ribosomal subunit [mitochondrial inner membrane] - v64:[addHasComponent, addLiteratureReference]
[UpdateTracker:9898646] Update Tracker - [SimpleEntity:432031] NO3- [cytosol] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9779880] Update Tracker - [Reaction:162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9898448] Update Tracker - [Complex:5621158] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898669] Update Tracker - [SimpleEntity:109758] 2'-deoxycytosine 5'-monophosphate [mitochondrial matrix] - v64:[addName]
[UpdateTracker:9898635] Update Tracker - [Complex:5610612] ub-pS-GLI1:SUFU [ciliary base] - v64:[modifyName]
[UpdateTracker:9898847] Update Tracker - [EntityWithAccessionedSequence:181845] p-5Y-Ntrk3 [plasma membrane] - v64:[addName]
[UpdateTracker:9779845] Update Tracker - [Pathway:9006936] Signaling by TGFB family members - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9779784] Update Tracker - [BlackBoxEvent:6799977] PGLYRP2 hydrolyzes bacterial peptidoglycan - v64:[addRegulator]
[UpdateTracker:9899083] Update Tracker - [Complex:2026086] Fabp4:Ligand of Pparg [nucleoplasm] - v64:[add_removeHasComponent]
[UpdateTracker:9779974] Update Tracker - [Reaction:433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v64:[add_removeOutput]
[UpdateTracker:9898529] Update Tracker - [EntityWithAccessionedSequence:169705] NEP/NS2 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779786] Update Tracker - [Pathway:8963743] Digestion and absorption - v64:[modifyText, updateContainedPathway]
[UpdateTracker:9780020] Update Tracker - [Pathway:5579016] Defective UGT1A4 causes hyperbilirubinemia - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898630] Update Tracker - [Complex:418976] Cadherin:Catenin complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898940] Update Tracker - [Complex:8985808] SLIT1:ROBO1,ROBO2:NCK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780029] Update Tracker - [BlackBoxEvent:2160874] HYAL1 hydrolyses (HA)50 - v64:[addInput, modifyText]
[UpdateTracker:9898988] Update Tracker - [Complex:177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779716] Update Tracker - [BlackBoxEvent:560472] Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) - v64:[addRegulator]
[UpdateTracker:9780048] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v64:[updateContainedRLE]
[UpdateTracker:9898485] Update Tracker - [Complex:168906] 2x DDX58 ligand:2x DDX58:2xATP [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898732] Update Tracker - [SimpleEntity:1500646] PS [endoplasmic reticulum membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779720] Update Tracker - [Pathway:8849175] Threonine catabolism - v64:[addHasEvent]
[UpdateTracker:9898514] Update Tracker - [Complex:1168620] p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] - v64:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9898583] Update Tracker - [EntityWithAccessionedSequence:189148] NEP/NS2 [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898544] Update Tracker - [EntityWithAccessionedSequence:189140] PB2 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898845] Update Tracker - [Complex:377622] Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780070] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v64:[updateContainedRLE]
[UpdateTracker:9898444] Update Tracker - [SimpleEntity:879655] LINA [early endosome] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779946] Update Tracker - [Pathway:9006934] Signaling by Receptor Tyrosine Kinases - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898929] Update Tracker - [EntityWithAccessionedSequence:189173] HA1 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898751] Update Tracker - [DefinedSet:5655215] Activated FGFR1 mutants [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898903] Update Tracker - [Complex:211196] caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] - v64:[addName]
[UpdateTracker:9898632] Update Tracker - [EntityWithAccessionedSequence:169246] PB1 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779815] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v64:[add_removeInput]
[UpdateTracker:9898513] Update Tracker - [Complex:5654974] 2xMMAA mutants:2xMUT [mitochondrial matrix] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779814] Update Tracker - [Pathway:388396] GPCR downstream signalling - v64:[modifyText, updateContainedPathway]
[UpdateTracker:9779897] Update Tracker - [BlackBoxEvent:2025936] Calcineurin Dephosphorylates Nfatc2 - v64:[addOutput]
[UpdateTracker:9779697] Update Tracker - [Reaction:5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9898594] Update Tracker - [EntityWithAccessionedSequence:2011868] p-8Y-FGFR1c P252T [plasma membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9899017] Update Tracker - [DefinedSet:5691527] Activated FGFR1 mutants and fusions [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9780121] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v64:[updateContainedRLE]
[UpdateTracker:9898522] Update Tracker - [Complex:2011961] p-8Y-FGFR1c P252S dimer [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9779992] Update Tracker - [Pathway:69052] Switching of origins to a post-replicative state - v64:[updateIndirectRLE]
[UpdateTracker:9898971] Update Tracker - [Complex:535501] p-3S,T844-IRE1 dimer:ADP (yeast) [endoplasmic reticulum membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898620] Update Tracker - [Complex:936558] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780017] Update Tracker - [Reaction:380780] Activation of Src - v64:[add_removeCatalystActivity]
[UpdateTracker:9898511] Update Tracker - [GenomeEncodedEntity:193303] Influenza H1N1 cRNA (extending) [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898861] Update Tracker - [Complex:193302] vRNA (Genomic):NP Complex [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780157] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v64:[addInput]
[UpdateTracker:9780045] Update Tracker - [Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - v64:[updateContainedRLE]
[UpdateTracker:9899031] Update Tracker - [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898686] Update Tracker - [SimpleEntity:6788814] 2'-deoxycytosine 5'-monophosphate [nucleoplasm] - v64:[addName]
[UpdateTracker:9898482] Update Tracker - [EntityWithAccessionedSequence:195940] PB1 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898469] Update Tracker - [EntityWithAccessionedSequence:169113] NS1 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898981] Update Tracker - [EntityWithAccessionedSequence:195750] Glycosylated NA [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779894] Update Tracker - [Reaction:351877] Caspase-mediated cleavage of Desmoglein 2 - v64:[add_removeCatalystActivity]
[UpdateTracker:9898818] Update Tracker - [EntityWithAccessionedSequence:192987] HA mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779794] Update Tracker - [Pathway:109582] Hemostasis - v64:[updateContainedPathway]
[UpdateTracker:9898640] Update Tracker - [EntityWithAccessionedSequence:188875] Genomic RNA Segment 1 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9780087] Update Tracker - [Reaction:451649] TPL2 phosphorylates MEK1, SEK1 - v64:[modifyText]
[UpdateTracker:9898580] Update Tracker - [CandidateSet:508157] Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] - v64:[removeHasMember]
[UpdateTracker:9779884] Update Tracker - [Reaction:183094] CDC42:GTP binds CBL:Beta-Pix - v64:[add_removeInput]
[UpdateTracker:9898999] Update Tracker - [Complex:186831] PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898465] Update Tracker - [EntityWithAccessionedSequence:5649936] CPT2 gene [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898777] Update Tracker - [Complex:5621160] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899004] Update Tracker - [DefinedSet:9013905] DDX58 ligand [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779847] Update Tracker - [Pathway:2474795] Diseases associated with visual transduction - v64:[updateIndirectRLE]
[UpdateTracker:9779782] Update Tracker - [Pathway:70221] Glycogen breakdown (glycogenolysis) - v64:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9898876] Update Tracker - [Complex:749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898888] Update Tracker - [EntityWithAccessionedSequence:5146789] PB1-F2 [mitochondrial intermembrane space] - v64:[add_removeSpecies]
[UpdateTracker:9898586] Update Tracker - [EntityWithAccessionedSequence:186959] M1 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9780046] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v64:[updateContainedRLE]
[UpdateTracker:9898869] Update Tracker - [EntityWithAccessionedSequence:192977] P1 mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898536] Update Tracker - [Complex:195925] Intracellular assembly complex [plasma membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780085] Update Tracker - [Pathway:2206282] MPS IIIB - Sanfilippo syndrome B - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898486] Update Tracker - [Complex:5610605] pS-GLI1:SUFU [ciliary base] - v64:[modifyName]
[UpdateTracker:9780078] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v64:[add_removeInput]
[UpdateTracker:9779997] Update Tracker - [Reaction:69015] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex - v64:[add_removeCatalystActivity]
[UpdateTracker:9780074] Update Tracker - [Pathway:6806667] Metabolism of fat-soluble vitamins - v64:[updateIndirectRLE]
[UpdateTracker:9779860] Update Tracker - [FailedReaction:1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - v64:[addCatalystActivity]
[UpdateTracker:9780076] Update Tracker - [Pathway:556833] Metabolism of lipids - v64:[updateContainedPathway]
[UpdateTracker:9898986] Update Tracker - [EntityWithAccessionedSequence:192990] M1 mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779864] Update Tracker - [FailedReaction:3656261] Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain - v64:[add_removeInput]
[UpdateTracker:9898728] Update Tracker - [SimpleEntity:8957386] t2E-CoA [mitochondrial matrix] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779988] Update Tracker - [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - v64:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9898877] Update Tracker - [Complex:933472] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898949] Update Tracker - [EntityWithAccessionedSequence:195780] Glycosylated NA [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779933] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v64:[addLiteratureReference]
[UpdateTracker:9898501] Update Tracker - [DefinedSet:418993] Beta-catenin/gamma catenin [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898709] Update Tracker - [Complex:2404186] IGF1,2:IGF1R [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898813] Update Tracker - [SimpleEntity:113578] GMP [cytosol] - v64:[modifyName]
[UpdateTracker:9898954] Update Tracker - [EntityWithAccessionedSequence:188851] PB2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898559] Update Tracker - [EntityWithAccessionedSequence:195946] PB2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898506] Update Tracker - [EntityWithAccessionedSequence:179527] Ntrk2 [plasma membrane] - v64:[modifyName]
[UpdateTracker:9779798] Update Tracker - [Reaction:381412] IGFBP2 binds IGF forming IGF:IGFBP2 - v64:[removeCatalystActivity]
[UpdateTracker:9779818] Update Tracker - [Pathway:3785653] Myoclonic epilepsy of Lafora - v64:[updateContainedRLE]
[UpdateTracker:9898933] Update Tracker - [Complex:354168] GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779727] Update Tracker - [Pathway:163615] PKA activation - v64:[updateContainedRLE]
[UpdateTracker:9898835] Update Tracker - [Complex:933468] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780106] Update Tracker - [BlackBoxEvent:9023204] Insulin secretory granules translocate across the cortical actin network - v64:[removeCatalystActivity]
[UpdateTracker:9779778] Update Tracker - [Pathway:1614558] Degradation of cysteine and homocysteine - v64:[addHasEvent]
[UpdateTracker:9779986] Update Tracker - [Pathway:2187338] Visual phototransduction - v64:[updateIndirectRLE]
[UpdateTracker:9779707] Update Tracker - [Reaction:162863] mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol - v64:[add_removeInput]
[UpdateTracker:9898872] Update Tracker - [DefinedSet:5621130] pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898566] Update Tracker - [DefinedSet:391181] Ligand:GPCR complexes that activate Gs [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9899042] Update Tracker - [Complex:877381] NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898660] Update Tracker - [EntityWithAccessionedSequence:196489] Genomic RNA Segment 3 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898560] Update Tracker - [EntityWithAccessionedSequence:192995] PA mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779690] Update Tracker - [BlackBoxEvent:1031716] Expression of IFNG-stimulated genes - v64:[addInput]
[UpdateTracker:9779802] Update Tracker - [Pathway:6802946] Signaling by moderate kinase activity BRAF mutants - v64:[updateContainedRLE]
[UpdateTracker:9898725] Update Tracker - [EntityWithAccessionedSequence:181796] Bdnf [extracellular region] - v64:[modifyName]
[UpdateTracker:9780156] Update Tracker - [Pathway:2173789] TGF-beta receptor signaling activates SMADs - v64:[updateIndirectRLE]
[UpdateTracker:9898870] Update Tracker - [CandidateSet:450307] Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9780149] Update Tracker - [Pathway:2514856] The phototransduction cascade - v64:[updateIndirectRLE]
[UpdateTracker:9898931] Update Tracker - [SimpleEntity:5683630] PE [autophagosome membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9899054] Update Tracker - [Complex:188954] Sialic Acid Bound Influenza A Viral Particle [plasma membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779711] Update Tracker - [Pathway:212436] Generic Transcription Pathway - v64:[updateIndirectRLE]
[UpdateTracker:9899033] Update Tracker - [Complex:3772127] phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779852] Update Tracker - [Pathway:3781860] Diseases associated with N-glycosylation of proteins - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898994] Update Tracker - [Complex:983693] Antigen:p-BCR:SYK [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9899009] Update Tracker - [Complex:451281] Kainate receptor-glutamate complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779828] Update Tracker - [Pathway:5357609] Glycogen storage disease type II (GAA) - v64:[add_removeHasEvent, modifyText]
[UpdateTracker:9779729] Update Tracker - [FailedReaction:2453818] Defective STRA6 does not transport atROL - v64:[add_removeInput]
[UpdateTracker:9779787] Update Tracker - [Reaction:351871] Caspase-mediated cleavage of Z0-2 - v64:[add_removeCatalystActivity, add_removeSummation]
[UpdateTracker:9898831] Update Tracker - [Complex:6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779878] Update Tracker - [Pathway:5579029] Metabolic disorders of biological oxidation enzymes - v64:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898525] Update Tracker - [Complex:2050642] Activated FGFR1c P252X mutants [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9779717] Update Tracker - [Pathway:109704] PI3K Cascade - v64:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898909] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780041] Update Tracker - [Pathway:1643685] Disease - v64:[updateContainedPathway]
[UpdateTracker:9898545] Update Tracker - [SimpleEntity:163438] TAG [lipid droplet] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898722] Update Tracker - [Complex:443900] Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898856] Update Tracker - [Complex:177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898901] Update Tracker - [EntityWithAccessionedSequence:188840] Genomic RNA Segment 5 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9898587] Update Tracker - [EntityWithAccessionedSequence:189137] PB1 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898866] Update Tracker - [EntityWithAccessionedSequence:187760] p-S272,T222,T334-MAPKAPK2 [cytosol] - v64:[removeName]
[UpdateTracker:9779943] Update Tracker - [Pathway:6803157] Antimicrobial peptides - v64:[updateContainedRLE]
[UpdateTracker:9898487] Update Tracker - [Complex:918200] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898809] Update Tracker - [EntityWithAccessionedSequence:195751] Glycosylated NA [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9780013] Update Tracker - [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9898450] Update Tracker - [Complex:8951722] 2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9779950] Update Tracker - [Pathway:381340] Transcriptional regulation of white adipocyte differentiation - v64:[updateContainedRLE]
[UpdateTracker:9898841] Update Tracker - [Complex:1176067] NS1 homodimer:Importin [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898767] Update Tracker - [Complex:195950] Segment 2 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780094] Update Tracker - [Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - v64:[updateContainedRLE]
[UpdateTracker:9779913] Update Tracker - [Pathway:1640170] Cell Cycle - v64:[updateContainedPathway]
[UpdateTracker:9779836] Update Tracker - [Reaction:391871] Autophosphorylation of NCAM1 bound Fyn - v64:[add_removeCatalystActivity]
[UpdateTracker:9898532] Update Tracker - [SimpleEntity:3221703] guanosine 5'-monophosphate [endocytic vesicle lumen] - v64:[modifyName]
[UpdateTracker:9779733] Update Tracker - [FailedReaction:2318585] Defective HYAL1 does not hydrolyse Chondroitin chains - v64:[add_removeInput, modifyText]
[UpdateTracker:9780151] Update Tracker - [Pathway:450294] MAP kinase activation - v64:[updateIndirectRLE]
[UpdateTracker:9899074] Update Tracker - [Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779839] Update Tracker - [Reaction:381503] IGFBP6 binds IGF forming IGF:IGFBP6 - v64:[removeCatalystActivity]
[UpdateTracker:9780119] Update Tracker - [Pathway:622312] Inflammasomes - v64:[updateIndirectRLE]
[UpdateTracker:9779804] Update Tracker - [Pathway:2206302] MPS I - Hurler syndrome - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779885] Update Tracker - [Reaction:111930] Adenylate cyclase produces cAMP - v64:[addRegulator]
[UpdateTracker:9898571] Update Tracker - [EntityWithAccessionedSequence:192712] M1 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780031] Update Tracker - [Reaction:391913] FPR2 binds FPR2 ligands - v64:[modifyText]
[UpdateTracker:9780032] Update Tracker - [Pathway:1482801] Acyl chain remodelling of PS - v64:[updateContainedRLE]
[UpdateTracker:9779721] Update Tracker - [FailedReaction:2282889] Defective ARSB does not hydrolyse C4S/C6S chains - v64:[add_removeInput, modifyText]
[UpdateTracker:9779977] Update Tracker - [Pathway:352238] Breakdown of the nuclear lamina - v64:[addHasEvent]
[UpdateTracker:9779736] Update Tracker - [Reaction:2197645] SCARF1 (SREC-I) binds ligands - v64:[add_removeInput]
[UpdateTracker:9780096] Update Tracker - [Pathway:8978868] Fatty acid metabolism - v64:[addHasEvent, updateContainedPathway]
[UpdateTracker:9898588] Update Tracker - [EntityWithAccessionedSequence:189155] M1 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898927] Update Tracker - [SimpleEntity:428126] DHCE [endoplasmic reticulum membrane] - v64:[addName]
[UpdateTracker:9780077] Update Tracker - [Reaction:68944] Orc1 is phosphorylated by cyclin A/CDK2 - v64:[add_removeCatalystActivity]
[UpdateTracker:9779920] Update Tracker - [Reaction:451681] Tpl2 phosphorylates Mek1, Sek1 - v64:[modifyText]
[UpdateTracker:9898493] Update Tracker - [SimpleEntity:9027649] ESTG [cytosol] - v64:[addName]
[UpdateTracker:9898601] Update Tracker - [EntityWithAccessionedSequence:188867] Genomic RNA Segment 4 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898718] Update Tracker - [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] - v64:[addName]
[UpdateTracker:9898969] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898606] Update Tracker - [DefinedSet:6784668] APOA4,APOA5,APOC2,CIDEC,FGF21 genes [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9898608] Update Tracker - [Complex:6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899038] Update Tracker - [Complex:354080] Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898865] Update Tracker - [DefinedSet:5621145] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9899081] Update Tracker - [Complex:8856647] CIDEA:CIDEC:lipid droplet [lipid droplet] - v64:[updateContainedComponent]
[UpdateTracker:9899036] Update Tracker - [Complex:1297378] ATP sensitive K+ channels (SUR1) [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898515] Update Tracker - [Complex:749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898721] Update Tracker - [DefinedSet:450343] p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9779853] Update Tracker - [Pathway:8982491] Glycogen metabolism - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898665] Update Tracker - [Complex:198820] GSTO2 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898455] Update Tracker - [Complex:426510] TNRC6:Nonendonucleolytic RISC:Target RNA (exact match) [cytosol] - v64:[addLiteratureReference, add_removeHasComponent, modifyName]
[UpdateTracker:9898456] Update Tracker - [DefinedSet:975153] K63-linked polyUb TRAF6 complexes [endosome membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779812] Update Tracker - [Pathway:195258] RHO GTPase Effectors - v64:[updateIndirectRLE]
[UpdateTracker:9899053] Update Tracker - [SimpleEntity:2046064] adenosine 5'-monophosphate [endoplasmic reticulum membrane] - v64:[addName]
[UpdateTracker:9899001] Update Tracker - [EntityWithAccessionedSequence:195782] M1 [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898799] Update Tracker - [SimpleEntity:1524083] PE [mitochondrial inner membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898873] Update Tracker - [EntityWithAccessionedSequence:189169] Genomic RNA Segment 1 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898827] Update Tracker - [Complex:744890] GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898695] Update Tracker - [Complex:1169392] ISGylated NS1 [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9779976] Update Tracker - [Pathway:444473] Formyl peptide receptors bind formyl peptides and many other ligands - v64:[updateContainedRLE]
[UpdateTracker:9779861] Update Tracker - [Pathway:74751] Insulin receptor signalling cascade - v64:[updateIndirectRLE]
[UpdateTracker:9898705] Update Tracker - [Complex:8866926] lipid droplet [lipid droplet] - v64:[add_removeHasComponent]
[UpdateTracker:9779948] Update Tracker - [Pathway:72766] Translation - v64:[modifyText]
[UpdateTracker:9780056] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v64:[updateIndirectRLE]
[UpdateTracker:9779931] Update Tracker - [Reaction:8869425] PLA1A hydrolyses PS to 2-acyl LPS - v64:[add_removeInput]
[UpdateTracker:9779820] Update Tracker - [Reaction:442938] activated MAPK3/MAPK6 migrates to nucleus - v64:[modifyText]
[UpdateTracker:9898454] Update Tracker - [Complex:399851] PlexinA1-4:FYN:CDK5:p-CRMPs (S522,S518,T509,T514) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898935] Update Tracker - [Complex:5419262] 55S ribosome:mRNA:tRNA [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780093] Update Tracker - [Pathway:372790] Signaling by GPCR - v64:[modifyText, updateContainedPathway]
[UpdateTracker:9899092] Update Tracker - [SimpleEntity:29626] GMP [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898645] Update Tracker - [EntityWithAccessionedSequence:195756] M2 [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9780080] Update Tracker - [Reaction:187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - v64:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9780003] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898714] Update Tracker - [Complex:8862370] HSD17B13:lipid droplet [lipid droplet] - v64:[updateContainedComponent]
[UpdateTracker:9780001] Update Tracker - [Pathway:2187335] The retinoid cycle in cones (daylight vision) - v64:[updateContainedRLE]
[UpdateTracker:9780140] Update Tracker - [Pathway:6802957] Oncogenic MAPK signaling - v64:[updateIndirectRLE]
[UpdateTracker:9898880] Update Tracker - [EntityWithAccessionedSequence:377598] MyrG,p-Y530-SRC [plasma membrane] - v64:[addHasModifiedResidue, add_removeCompartment, add_removeReferenceEntity, modifyName]
[UpdateTracker:9779835] Update Tracker - [Reaction:434362] Recruitment Of Cytoplasmic Proteins To Vesicles - v64:[modifyText]
[UpdateTracker:9898531] Update Tracker - [EntityWithAccessionedSequence:189133] Genomic RNA Segment 6 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9780010] Update Tracker - [Pathway:9006931] Signaling by Nuclear Receptors - v64:[addHasEvent]
[UpdateTracker:9898451] Update Tracker - [EntityWithAccessionedSequence:188876] Genomic RNA Segment 4 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779694] Update Tracker - [Pathway:8866376] Reelin signalling pathway - v64:[updateContainedRLE]
[UpdateTracker:9898498] Update Tracker - [Complex:182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898615] Update Tracker - [Complex:203489] palmitylated M2 Tetramer [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898763] Update Tracker - [SimpleEntity:109378] dCMP [cytosol] - v64:[addName]
[UpdateTracker:9898653] Update Tracker - [Complex:2026079] Pparg:Ligand:Rxra [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898637] Update Tracker - [Complex:195794] M2 Tetramer [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898592] Update Tracker - [DefinedSet:450305] MAP2K7,MAP2K4 [cytosol] - v64:[modifyName]
[UpdateTracker:9898978] Update Tracker - [Complex:983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780137] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v64:[updateIndirectRLE]
[UpdateTracker:9779980] Update Tracker - [FailedReaction:5678418] Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol - v64:[removeInput]
[UpdateTracker:9780014] Update Tracker - [Reaction:8867876] OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane - v64:[add_removeOutput]
[UpdateTracker:9898737] Update Tracker - [Complex:5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780028] Update Tracker - [Pathway:3296469] Defects in cobalamin (B12) metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9780154] Update Tracker - [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - v64:[removeCatalystActivity]
[UpdateTracker:9779708] Update Tracker - [Reaction:390329] Dephosphorylation of AKT by PP2A - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9779827] Update Tracker - [BlackBoxEvent:573343] Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9780005] Update Tracker - [BlackBoxEvent:6790038] Expression of HSP90B1 - v64:[removeInput]
[UpdateTracker:9780086] Update Tracker - [Pathway:71291] Metabolism of amino acids and derivatives - v64:[updateContainedPathway]
[UpdateTracker:9780049] Update Tracker - [Pathway:5602358] Diseases associated with the TLR signaling cascade - v64:[updateIndirectRLE]
[UpdateTracker:9779961] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v64:[add_removeInput]
[UpdateTracker:9898699] Update Tracker - [EntityWithAccessionedSequence:188872] Genomic RNA Segment 1 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779996] Update Tracker - [Pathway:112399] IRS-mediated signalling - v64:[updateIndirectRLE]
[UpdateTracker:9898629] Update Tracker - [Complex:1215929] Integrin alphaIIb beta3:SRC [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898523] Update Tracker - [Complex:6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898970] Update Tracker - [Complex:5419282] 55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898964] Update Tracker - [SimpleEntity:430042] 7MGMP [cytosol] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779862] Update Tracker - [Pathway:109703] PKB-mediated events - v64:[updateIndirectRLE]
[UpdateTracker:9898458] Update Tracker - [Complex:918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898719] Update Tracker - [Complex:3301963] GSTA2 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9899059] Update Tracker - [Complex:913727] viral dsRNA:IFIH1 [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9898495] Update Tracker - [SimpleEntity:193739] 3,7,24THCA-CoA [cytosol] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898755] Update Tracker - [Complex:211225] DFFA:DFFB [nucleoplasm] - v64:[addName]
[UpdateTracker:9898582] Update Tracker - [Complex:195728] Gycosylated NA Tetramer [plasma membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898762] Update Tracker - [Complex:188845] RNP Complex:Karyopherin alpha [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779919] Update Tracker - [Pathway:5652084] Fructose metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9780025] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v64:[updateContainedRLE]
[UpdateTracker:9898542] Update Tracker - [Complex:2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9779773] Update Tracker - [Pathway:1280218] Adaptive Immune System - v64:[updateIndirectRLE]
[UpdateTracker:9779867] Update Tracker - [Reaction:1602374] PS is hydrolyzed to 1-acyl LPS by PLA2[15] - v64:[add_removeInput]
[UpdateTracker:9898980] Update Tracker - [EntityWithAccessionedSequence:196492] Genomic RNA Segment 2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779990] Update Tracker - [Pathway:69481] G2/M Checkpoints - v64:[updateContainedPathway]
[UpdateTracker:9899019] Update Tracker - [Complex:390372] SLIT1:ROBO2 [plasma membrane] - v64:[addEntityOnOtherCell]
[UpdateTracker:9779700] Update Tracker - [BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - v64:[removeCatalystActivity]
[UpdateTracker:9779755] Update Tracker - [FailedReaction:3656257] Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan - v64:[add_removeInput]
[UpdateTracker:9899011] Update Tracker - [Complex:188849] Ribonucleoprotein (RNP) Complex [cytosol] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9899085] Update Tracker - [Complex:195941] Influenza A Viral Particle [extracellular region] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898936] Update Tracker - [Complex:195947] Segment 1 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898796] Update Tracker - [Complex:2011926] FGFR1c S252T mutant dimer [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898868] Update Tracker - [EntityWithAccessionedSequence:192996] NS2 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898893] Update Tracker - [EntityWithAccessionedSequence:192845] NEP/NS2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780124] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v64:[updateContainedRLE]
[UpdateTracker:9780120] Update Tracker - [Pathway:8951671] RUNX3 regulates YAP1-mediated transcription - v64:[updateContainedRLE]
[UpdateTracker:9779748] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779987] Update Tracker - [Pathway:3359475] Defective MMAA causes MMA, cblA type - v64:[updateContainedRLE]
[UpdateTracker:9898612] Update Tracker - [EntityWithAccessionedSequence:169238] PB2 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780081] Update Tracker - [Pathway:2142700] Synthesis of Lipoxins (LX) - v64:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9898702] Update Tracker - [Complex:3302017] GSTT2 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9779959] Update Tracker - [Reaction:433578] phytoceramide + H2O => stearate + phytosphingosine - v64:[add_removeInput]
[UpdateTracker:9779958] Update Tracker - [Reaction:8862090] PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G - v64:[removeInput]
[UpdateTracker:9898740] Update Tracker - [EntityWithAccessionedSequence:189131] PA [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9779822] Update Tracker - [Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants - v64:[add_removeCatalystActivity]
[UpdateTracker:9779854] Update Tracker - [Reaction:453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - v64:[addRegulator]
[UpdateTracker:9898898] Update Tracker - [Complex:187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9779758] Update Tracker - [Reaction:381543] IGFBP4 binds IGF forming IGF:IGFBP4 - v64:[removeCatalystActivity]
[UpdateTracker:9780062] Update Tracker - [FailedReaction:4686998] Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 - v64:[add_removeInput, modifyText]
[UpdateTracker:9899082] Update Tracker - [Complex:399838] Fyn:pCdk5:p35 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898706] Update Tracker - [EntityWithAccessionedSequence:189162] Genomic RNA Segment 3 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9779823] Update Tracker - [BlackBoxEvent:6797267] Expression of CD36 - v64:[add_removeInput]
[UpdateTracker:9899060] Update Tracker - [EntityWithAccessionedSequence:192683] HA1 [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898860] Update Tracker - [EntityWithAccessionedSequence:196487] HA folded, glycosylated, and palmitylated [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9899016] Update Tracker - [Complex:913526] p-Y701-STAT1 dimer [nucleoplasm] - v64:[addName]
[UpdateTracker:9898822] Update Tracker - [Complex:374150] GPER1:ESTG [plasma membrane] - v64:[modifyName]
[UpdateTracker:9779924] Update Tracker - [Reaction:2161775] ALOX12 oxidises LTA4 to LXA4/B4 - v64:[add_removeInput]
[UpdateTracker:9898715] Update Tracker - [DefinedSet:8985807] SLIT1:ROBO1,ROBO2 [plasma membrane] - v64:[removeSpecies, updateContainedMemberOrCandidate]
[UpdateTracker:9780002] Update Tracker - [Pathway:1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - v64:[updateIndirectRLE]
[UpdateTracker:9898621] Update Tracker - [EntityWithAccessionedSequence:196480] Genomic RNA Segment 1 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898879] Update Tracker - [Complex:5389838] 55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898667] Update Tracker - [SimpleEntity:193732] 3,7,24THCA-CoA [peroxisomal matrix] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779770] Update Tracker - [BlackBoxEvent:844440] NLRP3 activation by elicitor proteins - v64:[add_removeInput]
[UpdateTracker:9898785] Update Tracker - [Complex:9015016] p-Y693-STAT4:p-Y701-STAT1:IL12A gene [nucleoplasm] - v64:[add_removeHasComponent]
[UpdateTracker:9898504] Update Tracker - [Complex:195787] Glycosylated and folded HA trimer [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9899084] Update Tracker - [EntityWithAccessionedSequence:188843] PB1 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898885] Update Tracker - [Complex:389935] SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779837] Update Tracker - [Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 - v64:[modifyText]
[UpdateTracker:9780162] Update Tracker - [Pathway:75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - v64:[addHasEvent]
[UpdateTracker:9898459] Update Tracker - [EntityWithAccessionedSequence:2471668] OPN1LW R247* [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9898731] Update Tracker - [Complex:180522] p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898821] Update Tracker - [Complex:5621144] CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898891] Update Tracker - [EntityWithAccessionedSequence:181791] Ntf4 [extracellular region] - v64:[modifyName]
[UpdateTracker:9898484] Update Tracker - [EntityWithAccessionedSequence:202950] CTNNB1(116-376) [cytosol] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9899013] Update Tracker - [DefinedSet:187726] p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] - v64:[addName]
[UpdateTracker:9898505] Update Tracker - [SimpleEntity:6787810] 2OH-PALM [peroxisomal matrix] - v64:[addName]
[UpdateTracker:9898710] Update Tracker - [Complex:195943] Segment 6 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898941] Update Tracker - [CandidateSet:879544] LCFAs [cytosol] - v64:[add_removeHasCandidate]
[UpdateTracker:9898852] Update Tracker - [EntityWithAccessionedSequence:188827] Genomic RNA Segment 2 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898692] Update Tracker - [EntityWithAccessionedSequence:169089] M2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898539] Update Tracker - [Complex:196494] palmitylated M2 Tetramer [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779751] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v64:[addHasEvent]
[UpdateTracker:9780105] Update Tracker - [Pathway:372442] Lipid metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9899022] Update Tracker - [Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779799] Update Tracker - [BlackBoxEvent:1989766] Expression of CTGF - v64:[removeRegulator]
[UpdateTracker:9779740] Update Tracker - [FailedReaction:2206299] Defective IDUA does not hydrolyse Heparan sulfate chain(6) - v64:[add_removeInput]
[UpdateTracker:9898619] Update Tracker - [Complex:195949] Segment 8 RNP [cytosol] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779691] Update Tracker - [FailedReaction:5262921] Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) - v64:[add_removeInput, modifyText, removeCatalystActivity]
[UpdateTracker:9898609] Update Tracker - [Complex:450241] p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9780071] Update Tracker - [Pathway:5579028] Defective CYP17A1 causes AH5 - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898962] Update Tracker - [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779999] Update Tracker - [BlackBoxEvent:6797293] Expression of IL18, ALOX5 - v64:[modifyText]
[UpdateTracker:9780066] Update Tracker - [Reaction:5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII - v64:[add_removeCatalystActivity]
[UpdateTracker:9779760] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v64:[removeRegulator]
[UpdateTracker:9779962] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v64:[updateIndirectRLE]
[UpdateTracker:9780021] Update Tracker - [Pathway:451524] MAPK activation in TLR cascade - v64:[updateIndirectRLE]
[UpdateTracker:9779734] Update Tracker - [Reaction:173483] BAMBI interferes with the interaction of type I receptor with type II receptor - v64:[removeCatalystActivity]
[UpdateTracker:9898772] Update Tracker - [Complex:2445094] IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780063] Update Tracker - [Reaction:68947] Ubiquitinated Orc1 enters the cytosol - v64:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
[UpdateTracker:9899025] Update Tracker - [Complex:5357454] VE-cadherin-Catenin complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899070] Update Tracker - [Complex:933467] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898757] Update Tracker - [Complex:192631] Viral Proteins [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898524] Update Tracker - [Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898987] Update Tracker - [EntityWithAccessionedSequence:188832] NP [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898693] Update Tracker - [EntityWithAccessionedSequence:192322] HSD17B4(1-736) [peroxisomal matrix] - v64:[modifyName, modifyStartCoordinate]
[UpdateTracker:9780084] Update Tracker - [Pathway:192105] Synthesis of bile acids and bile salts - v64:[updateIndirectRLE]
[UpdateTracker:9779882] Update Tracker - [Pathway:69473] G2/M DNA damage checkpoint - v64:[updateContainedPathway]
[UpdateTracker:9899063] Update Tracker - [CandidateSet:3301978] GST dimers [cytosol] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898956] Update Tracker - [EntityWithAccessionedSequence:6797733] RAD51D gene [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9779858] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v64:[updateContainedRLE]
[UpdateTracker:9899057] Update Tracker - [DefinedSet:192849] vRNA (genomic) [nucleoplasm] - v64:[add_removeSpecies, updateContainedMemberOrCandidate]
[UpdateTracker:9780089] Update Tracker - [Pathway:389356] CD28 co-stimulation - v64:[updateIndirectRLE]
[UpdateTracker:9898897] Update Tracker - [Complex:381702] RAPGEF3:cAMP complex [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898984] Update Tracker - [Complex:195803] Glycosylated and folded HA trimer [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9780123] Update Tracker - [Pathway:5688890] Defective CSF2RA causes SMDP4 - v64:[updateContainedRLE]
[UpdateTracker:9779982] Update Tracker - [Pathway:2179392] EGFR Transactivation by Gastrin - v64:[updateContainedRLE]
[UpdateTracker:9898938] Update Tracker - [Complex:5655296] Activated FGFR1 mutants:FRS2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780103] Update Tracker - [Pathway:5603027] IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) - v64:[updateContainedRLE]
[UpdateTracker:9899061] Update Tracker - [Complex:6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9780072] Update Tracker - [BlackBoxEvent:983702] Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b) - v64:[addLiteratureReference]
[UpdateTracker:9779965] Update Tracker - [Pathway:109606] Intrinsic Pathway for Apoptosis - v64:[updateContainedPathway]
[UpdateTracker:9779973] Update Tracker - [FailedReaction:3791349] Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) - v64:[removeInput]
[UpdateTracker:9898603] Update Tracker - [Complex:182956] CBL:Beta-Pix:CDC42:GTP [cytosol] - v64:[add_removeHasComponent]
[UpdateTracker:9898937] Update Tracker - [DefinedSet:451654] p-S218,S222-MAP2K1,p-S257,T261-MAP2K4 [cytosol] - v64:[addName]
[UpdateTracker:9898613] Update Tracker - [EntityWithAccessionedSequence:188826] Genomic RNA Segment 3 [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898573] Update Tracker - [Complex:169075] NS1:viral dsRNA Complex [cytosol] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9780057] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v64:[removeRegulator]
[UpdateTracker:9779797] Update Tracker - [Pathway:69206] G1/S Transition - v64:[updateContainedPathway]
[UpdateTracker:9898597] Update Tracker - [Complex:9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779692] Update Tracker - [Pathway:3906995] Diseases associated with O-glycosylation of proteins - v64:[updateIndirectRLE]
[UpdateTracker:9779927] Update Tracker - [Pathway:2559580] Oxidative Stress Induced Senescence - v64:[updateContainedRLE]
[UpdateTracker:9899071] Update Tracker - [Complex:195819] Glycosylated and folded HA trimer [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898775] Update Tracker - [Complex:203484] Post Fusion Cleaved Trimeric palmitylated HA [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898572] Update Tracker - [EntityWithAccessionedSequence:192965] NA mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898585] Update Tracker - [EntityWithAccessionedSequence:169243] PA [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780147] Update Tracker - [Reaction:351876] Caspase-mediated cleavage of occludin - v64:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9899043] Update Tracker - [CandidateSet:191731] beta-catenin [plasma membrane] - v64:[add_removeHasCandidate]
[UpdateTracker:9898644] Update Tracker - [Complex:195797] M2 Tetramer [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898701] Update Tracker - [Complex:5357459] p-S665-VE-cadherin-Catenin complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779830] Update Tracker - [Pathway:75153] Apoptotic execution phase - v64:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898815] Update Tracker - [Complex:5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780007] Update Tracker - [Pathway:5579002] Defective UGT1A1 causes hyperbilirubinemia - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898955] Update Tracker - [SimpleEntity:193842] 5beta-cholestan-3alpha,7alpha,26-triol [cytosol] - v64:[add_removeReferenceEntity]
[UpdateTracker:9779776] Update Tracker - [Pathway:447115] Interleukin-12 family signaling - v64:[updateIndirectRLE]
[UpdateTracker:9898807] Update Tracker - [CandidateSet:9013962] TICAM1:activated TLR3 complexes [endosome membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779743] Update Tracker - [Reaction:381487] IGFBP1 binds IGF forming IGF:IGFBP1 - v64:[removeCatalystActivity]
[UpdateTracker:9898677] Update Tracker - [Complex:933478] dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898839] Update Tracker - [SimpleEntity:939760] PE [cytoplasmic side of plasma membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9780145] Update Tracker - [Pathway:881907] Gastrin-CREB signalling pathway via PKC and MAPK - v64:[updateIndirectRLE]
[UpdateTracker:9898723] Update Tracker - [Complex:3302032] GSTP1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898575] Update Tracker - [EntityWithAccessionedSequence:189168] M1 [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779859] Update Tracker - [Reaction:202917] Caspase-mediated cleavage of Desmoglein 1 - v64:[add_removeCatalystActivity]
[UpdateTracker:9898924] Update Tracker - [EntityWithAccessionedSequence:169216] PB1-F2 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898806] Update Tracker - [SimpleEntity:197230] NCA [cytosol] - v64:[addName]
[UpdateTracker:9898561] Update Tracker - [Complex:5621133] CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9899032] Update Tracker - [Complex:450598] AUF1 Tetramer: Destabilized mRNA Complex [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9780129] Update Tracker - [Pathway:1793185] Chondroitin sulfate/dermatan sulfate metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9779907] Update Tracker - [Pathway:433584] Sphingolipid metabolism - v64:[updateContainedRLE]
[UpdateTracker:9779905] Update Tracker - [BlackBoxEvent:8984964] IL12A gene transcription and translation - v64:[add_removeInput]
[UpdateTracker:9780079] Update Tracker - [Pathway:69580] p53-Dependent G1/S DNA damage checkpoint - v64:[updateIndirectRLE]
[UpdateTracker:9779993] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v64:[addRegulator]
[UpdateTracker:9779975] Update Tracker - [BlackBoxEvent:216883] Exocytosis of Insulin - v64:[removeCatalystActivity]
[UpdateTracker:9780126] Update Tracker - [Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K - v64:[addLiteratureReference]
[UpdateTracker:9779893] Update Tracker - [Pathway:5602498] MyD88 deficiency (TLR2/4) - v64:[updateContainedRLE]
[UpdateTracker:9898848] Update Tracker - [DefinedSet:198703] p-p38 MAPK alpha/beta [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898997] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779901] Update Tracker - [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 - v64:[modifyText]
[UpdateTracker:9898707] Update Tracker - [SimpleEntity:5681998] PE [phagophore assembly site membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9780152] Update Tracker - [Reaction:382058] Nck binds to the active PDGF receptor - v64:[modifyText]
[UpdateTracker:9780112] Update Tracker - [Pathway:2024101] CS/DS degradation - v64:[updateContainedRLE]
[UpdateTracker:9898711] Update Tracker - [Complex:169102] NS1:PAB II Complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9899030] Update Tracker - [Complex:189147] Influenza A Viral Envelope with a fusion competent HA2 [endosome lumen] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898805] Update Tracker - [Complex:983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899037] Update Tracker - [DefinedSet:2050635] FGFR1c P252X mutant dimers [plasma membrane] - v64:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9898857] Update Tracker - [Complex:195723] Glycosylated, palmitylated and folded HA trimer:Lipid Raft Complex [Golgi membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898825] Update Tracker - [Complex:381680] RAPGEF4:cAMP Complex [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9779937] Update Tracker - [BlackBoxEvent:1655843] Expression of Fatty Acid Synthase (FASN) - v64:[addRegulator]
[UpdateTracker:9898558] Update Tracker - [Complex:192768] vRNP:M1:NEP:NP [cytosol] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898727] Update Tracker - [EntityWithAccessionedSequence:203497] NA [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779890] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v64:[updateContainedRLE]
[UpdateTracker:9780042] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v64:[add_removeOutput]
[UpdateTracker:9780092] Update Tracker - [FailedReaction:5601843] Defective CYP17A1 does not 17-hydroxylate PREG - v64:[add_removeInput]
[UpdateTracker:9779742] Update Tracker - [Pathway:69202] Cyclin E associated events during G1/S transition - v64:[updateIndirectRLE]
[UpdateTracker:9898808] Update Tracker - [Complex:6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9898546] Update Tracker - [Complex:437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898744] Update Tracker - [EntityWithAccessionedSequence:192981] HA mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9898892] Update Tracker - [Complex:422311] GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780067] Update Tracker - [Reaction:201636] Caspase-mediated cleavage of Desmoplakin - v64:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9779906] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v64:[addLiteratureReference]
[UpdateTracker:9898800] Update Tracker - [Complex:2404190] IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898840] Update Tracker - [CandidateSet:9013956] RIP3:TICAM1:activated TLR3 [endosome membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779808] Update Tracker - [Pathway:444257] RSK activation - v64:[addHasEvent]
[UpdateTracker:9898656] Update Tracker - [EntityWithAccessionedSequence:188389] hyperphosphorylated RB1 [nucleoplasm] - v64:[addHasModifiedResidue]
[UpdateTracker:9898651] Update Tracker - [Complex:8862077] PILRA:PIANP,NPDC1,CLEC4G,COLEC12 trimer [plasma membrane] - v64:[removeHasComponent]
[UpdateTracker:9779968] Update Tracker - [Reaction:8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 - v64:[add_removeOutput]
[UpdateTracker:9898681] Update Tracker - [DefinedSet:6789520] IL4,IL13-downregulated genes for extracellular proteins [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9899010] Update Tracker - [DefinedSet:450253] p-MAPK8,9,10 [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9899065] Update Tracker - [Complex:195951] Segment 5 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9779874] Update Tracker - [BlackBoxEvent:187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - v64:[add_removeOutput]
[UpdateTracker:9780160] Update Tracker - [Pathway:8935690] Digestion - v64:[addLiteratureReference, modifyText]
[UpdateTracker:9898819] Update Tracker - [Complex:1299470] TIMM9:TIMM10:TIMM10B:TIM22:Protein [mitochondrial inner membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9780073] Update Tracker - [FailedReaction:4793949] Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) - v64:[add_removeInput]
[UpdateTracker:9779846] Update Tracker - [Pathway:375165] NCAM signaling for neurite out-growth - v64:[updateContainedRLE]
[UpdateTracker:9899079] Update Tracker - [DefinedSet:451647] MAP2K1,MAP2K4 [cytosol] - v64:[addName]
[UpdateTracker:9780114] Update Tracker - [Reaction:202939] Caspase-mediated cleavage of E-Cadherin - v64:[add_removeCatalystActivity]
[UpdateTracker:9898690] Update Tracker - [EntityWithAccessionedSequence:196477] Genomic RNA Segment 7 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898925] Update Tracker - [EntityWithAccessionedSequence:192966] NS2 mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779698] Update Tracker - [Reaction:183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - v64:[add_removeInput]
[UpdateTracker:9779963] Update Tracker - [Reaction:193508] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA - v64:[add_removeInput]
[UpdateTracker:9898768] Update Tracker - [EntityWithAccessionedSequence:2011861] p-8Y-FGFR1c P252S [plasma membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9898598] Update Tracker - [Complex:6802666] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9780024] Update Tracker - [Pathway:71336] Pentose phosphate pathway - v64:[updateIndirectRLE]
[UpdateTracker:9899090] Update Tracker - [Complex:422275] Protein Kinase C, alpha type: DAG [plasma membrane] - v64:[addLiteratureReference, add_removeHasComponent]
[UpdateTracker:9780053] Update Tracker - [Pathway:5083628] Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 - v64:[updateContainedRLE]
[UpdateTracker:9898894] Update Tracker - [Complex:6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779702] Update Tracker - [Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9898968] Update Tracker - [Complex:5621149] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779725] Update Tracker - [Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - v64:[updateContainedRLE]
[UpdateTracker:9898462] Update Tracker - [Complex:8951514] RUNX3:CTNNB1:TCF7L2,(LEF1) [nucleoplasm] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779767] Update Tracker - [Pathway:4793950] Defective MAN1B1 causes MRT15 - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779728] Update Tracker - [Pathway:400206] Regulation of lipid metabolism by PPARalpha - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898712] Update Tracker - [Complex:5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779877] Update Tracker - [FailedReaction:3814838] Defective GYG1 is not autoglucosyolated - v64:[removeInput]
[UpdateTracker:9779752] Update Tracker - [Pathway:69306] DNA Replication - v64:[removeHasEvent]
[UpdateTracker:9780008] Update Tracker - [Pathway:9012546] Interleukin-18 signaling - v64:[modifyText, updateContainedRLE]
[UpdateTracker:9899087] Update Tracker - [EntityWithAccessionedSequence:169073] M1 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898694] Update Tracker - [Complex:189177] Acidified Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779806] Update Tracker - [Pathway:5637812] Signaling by EGFRvIII in Cancer - v64:[updateIndirectRLE]
[UpdateTracker:9779779] Update Tracker - [Reaction:2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 - v64:[modifyText]
[UpdateTracker:9898902] Update Tracker - [Complex:3299731] CCS:Zn2+:Cu1+ dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9780159] Update Tracker - [Pathway:69002] DNA Replication Pre-Initiation - v64:[updateContainedPathway]
[UpdateTracker:9898908] Update Tracker - [Complex:211208] Caspase cleaved DFFA (117) [nucleoplasm] - v64:[addName]
[UpdateTracker:9898567] Update Tracker - [DefinedSet:2012029] FGFR1c P252X mutants [plasma membrane] - v64:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9780127] Update Tracker - [Pathway:9020702] Interleukin-1 signaling - v64:[updateIndirectRLE]
[UpdateTracker:9898691] Update Tracker - [Complex:189164] Influenza A Viral Envelope Fused With The Endocytic Vesicle Membrane By An Inter-Membrane Spanning HA2 [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779865] Update Tracker - [Reaction:5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9899088] Update Tracker - [DefinedSet:450226] p-MAPK8,9,10 [cytosol] - v64:[modifyName]
[UpdateTracker:9779970] Update Tracker - [Reaction:351948] Mitochondrial recruitment of Drp1 - v64:[addRegulator, modifyText]
[UpdateTracker:9779723] Update Tracker - [Pathway:111931] PKA-mediated phosphorylation of CREB - v64:[updateIndirectRLE]
[UpdateTracker:9779813] Update Tracker - [Pathway:5688849] Defective CSF2RB causes SMDP5 - v64:[updateContainedRLE]
[UpdateTracker:9898688] Update Tracker - [Complex:192906] vRNP:M1 for Export [nucleoplasm] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779849] Update Tracker - [Pathway:2206281] Mucopolysaccharidoses - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9899007] Update Tracker - [Complex:434005] IKKs_complex (Inhibitor of kappa B kinases) [cytosol] - v64:[modifyName]
[UpdateTracker:9898533] Update Tracker - [EntityWithAccessionedSequence:189174] Genomic RNA Segment 2 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898749] Update Tracker - [Complex:389920] p-BTLA-HVEM complex [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898843] Update Tracker - [Complex:169237] Ribonucleoprotein (RNP) Complex [extracellular region] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898850] Update Tracker - [SimpleEntity:744239] GMP [Golgi lumen] - v64:[modifyName]
[UpdateTracker:9779917] Update Tracker - [FailedReaction:2262743] Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) - v64:[add_removeInput]
[UpdateTracker:9898830] Update Tracker - [Complex:5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898512] Update Tracker - [Complex:180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779834] Update Tracker - [Pathway:186763] Downstream signal transduction - v64:[updateContainedRLE]
[UpdateTracker:9898654] Update Tracker - [Complex:381656] GLP-1:GLP-1R [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898503] Update Tracker - [Complex:1015697] ISGF3 bound to ISRE promotor elements [nucleoplasm] - v64:[add_removeHasComponent]
[UpdateTracker:9898846] Update Tracker - [DefinedSet:6790043] STAT3-upregulated genes for extracellular proteins [nucleoplasm] - v64:[add_removeHasMember]
[UpdateTracker:9898789] Update Tracker - [Complex:180326] EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898771] Update Tracker - [Complex:189144] Influenza A Viral Envelope [endosome lumen] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779763] Update Tracker - [Reaction:5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - v64:[addInput]
[UpdateTracker:9780069] Update Tracker - [Pathway:6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - v64:[updateContainedRLE]
[UpdateTracker:9898716] Update Tracker - [SimpleEntity:193778] 3,7,24THCA [cytosol] - v64:[addName, add_removeReferenceEntity]
[UpdateTracker:9779750] Update Tracker - [Pathway:5578996] Defective CYP27A1 causes CTX - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898576] Update Tracker - [Complex:450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898614] Update Tracker - [Complex:195724] Glycosylated NA Tetramer [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898510] Update Tracker - [Complex:1433419] PTPRU:KIT [plasma membrane] - v64:[modifyName]
[UpdateTracker:9898689] Update Tracker - [EntityWithAccessionedSequence:189165] HA1 [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779876] Update Tracker - [FailedReaction:5604975] Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL - v64:[add_removeInput]
[UpdateTracker:9898746] Update Tracker - [DefinedSet:1454912] ABCCs [plasma membrane] - v64:[removeHasMember]
[UpdateTracker:9898904] Update Tracker - [Complex:203481] Cleaved Trimeric palmitylated HA [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780035] Update Tracker - [Pathway:3656253] Defective EXT1 causes exostoses 1, TRPS2 and CHDS - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779866] Update Tracker - [Pathway:389513] CTLA4 inhibitory signaling - v64:[updateContainedRLE]
[UpdateTracker:9898886] Update Tracker - [DefinedSet:380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9898491] Update Tracker - [SimpleEntity:193843] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol [cytosol] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898591] Update Tracker - [SimpleEntity:879520] LINA [extracellular region] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898942] Update Tracker - [Complex:377614] Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898832] Update Tracker - [Complex:444172] Gpr120:Fatty acid [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779695] Update Tracker - [Reaction:177926] Dephosphorylation of PAG by SHP2 - v64:[add_removeLiteratureReference]
[UpdateTracker:9779887] Update Tracker - [Reaction:110011] Binding of Grb10 to the insulin receptor - v64:[modifyText]
[UpdateTracker:9779868] Update Tracker - [BlackBoxEvent:68948] Ubiquitinated Orc1 is degraded by the proteasome - v64:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9779903] Update Tracker - [Pathway:5654696] Downstream signaling of activated FGFR2 - v64:[updateIndirectRLE]
[UpdateTracker:9779807] Update Tracker - [Pathway:180292] GAB1 signalosome - v64:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9780144] Update Tracker - [BlackBoxEvent:9023194] Insulin secretory granules dock at the plasma membrane - v64:[removeCatalystActivity]
[UpdateTracker:9898623] Update Tracker - [Complex:933483] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780139] Update Tracker - [Reaction:5672304] IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 - v64:[addRegulator]
[UpdateTracker:9779969] Update Tracker - [Pathway:1237044] Erythrocytes take up carbon dioxide and release oxygen - v64:[updateContainedRLE]
[UpdateTracker:9898788] Update Tracker - [Complex:1445126] Phospho AS160:14-3-3 [cytoplasmic vesicle membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9779998] Update Tracker - [Pathway:8984722] Interleukin-35 Signalling - v64:[updateContainedRLE]
[UpdateTracker:9780022] Update Tracker - [Pathway:1480926] O2/CO2 exchange in erythrocytes - v64:[updateIndirectRLE]
[UpdateTracker:9898951] Update Tracker - [Complex:9013961] viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779790] Update Tracker - [Pathway:3229121] Glycogen storage diseases - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898803] Update Tracker - [SimpleEntity:113579] GMP [extracellular region] - v64:[modifyName]
[UpdateTracker:9898899] Update Tracker - [EntityWithAccessionedSequence:195773] M2 [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898470] Update Tracker - [Complex:2197638] SCARF1:Ligand [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9780059] Update Tracker - [Reaction:5621354] CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate - v64:[add_removeInput]
[UpdateTracker:9898948] Update Tracker - [GenomeEncodedEntity:6790580] Influenza A dsRNA intermediate form [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898958] Update Tracker - [EntityWithAccessionedSequence:195741] palmitylated M2 [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779831] Update Tracker - [Pathway:2206291] MPS IIIC - Sanfilippo syndrome C - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898838] Update Tracker - [Complex:6802711] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898717] Update Tracker - [EntityWithAccessionedSequence:189146] Genomic RNA Segment 4 [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898481] Update Tracker - [Complex:2026076] Pparg:Ligand [nucleoplasm] - v64:[add_removeHasComponent]
[UpdateTracker:9898960] Update Tracker - [EntityWithAccessionedSequence:192969] NS1 mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898652] Update Tracker - [Complex:3302010] GSTT1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898990] Update Tracker - [SimpleEntity:400158] LINA [nucleoplasm] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898517] Update Tracker - [Complex:1181345] Lefty1,2:Nodal [extracellular region] - v64:[add_removeHasComponent]
[UpdateTracker:9898528] Update Tracker - [Complex:399868] Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898816] Update Tracker - [Complex:169145] NS1 Homodimer [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779737] Update Tracker - [Pathway:4720454] Defective ALG9 causes CDG-1l - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898834] Update Tracker - [EntityWithAccessionedSequence:8953907] PEX5 isoform S [peroxisomal membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9780088] Update Tracker - [Pathway:5250941] Negative epigenetic regulation of rRNA expression - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9898977] Update Tracker - [Complex:182935] EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780150] Update Tracker - [Pathway:1430728] Metabolism - v64:[updateContainedPathway]
[UpdateTracker:9899024] Update Tracker - [Complex:9014322] SARM:TICAM1:viral dsRNA:TLR3 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780075] Update Tracker - [Reaction:381496] Formation of the IGF:IGFBP3:ALS complex - v64:[removeCatalystActivity]
[UpdateTracker:9898480] Update Tracker - [Complex:179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9779826] Update Tracker - [Reaction:1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes - v64:[add_removeInput]
[UpdateTracker:9779785] Update Tracker - [Pathway:73843] 5-Phosphoribose 1-diphosphate biosynthesis - v64:[updateContainedRLE]
[UpdateTracker:9898917] Update Tracker - [Complex:6802625] RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9779792] Update Tracker - [Pathway:3560782] Diseases associated with glycosaminoglycan metabolism - v64:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780011] Update Tracker - [Pathway:5619115] Disorders of transmembrane transporters - v64:[updateContainedPathway]
[UpdateTracker:9898696] Update Tracker - [Complex:3302022] GSTZ1 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9780116] Update Tracker - [Reaction:5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9898765] Update Tracker - [EntityWithAccessionedSequence:169241] M1 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780131] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v64:[updateIndirectRLE]
[UpdateTracker:9899046] Update Tracker - [EntityWithAccessionedSequence:3788737] IL8 gene [nucleoplasm] - v64:[addName]
[UpdateTracker:9779842] Update Tracker - [FailedReaction:2263496] Defective NAGLU does not hydrolyse Heparan sulfate chain(4) - v64:[add_removeInput, modifyText]
[UpdateTracker:9898647] Update Tracker - [Complex:933470] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779983] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v64:[add_removeInput]
[UpdateTracker:9899047] Update Tracker - [EntityWithAccessionedSequence:169118] NS1 [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898453] Update Tracker - [Complex:8983916] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899023] Update Tracker - [Complex:445264] Preprolactin:Translocon:TRAP [endoplasmic reticulum membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898474] Update Tracker - [Complex:187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898766] Update Tracker - [EntityWithAccessionedSequence:195815] Glycosylated NA [endoplasmic reticulum membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898671] Update Tracker - [Complex:1252245] TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] - v64:[modifyName]
[UpdateTracker:9780034] Update Tracker - [Pathway:909733] Interferon alpha/beta signaling - v64:[updateContainedRLE]
[UpdateTracker:9898761] Update Tracker - [EntityWithAccessionedSequence:169252] HA2 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9898685] Update Tracker - [EntityWithAccessionedSequence:192985] PA mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898758] Update Tracker - [EntityWithAccessionedSequence:181803] p-5Y-Ntrk2 [plasma membrane] - v64:[modifyName]
[UpdateTracker:9899077] Update Tracker - [Complex:389749] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898814] Update Tracker - [EntityWithAccessionedSequence:188829] Genomic RNA Segment 6 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9899029] Update Tracker - [DefinedSet:203795] MAP kinase p38 alpha/beta [nucleoplasm] - v64:[modifyName]
[UpdateTracker:9898471] Update Tracker - [Complex:9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898944] Update Tracker - [EntityWithAccessionedSequence:188874] Genomic RNA Segment 8 [cytosol] - v64:[add_removeReferenceEntity, add_removeSpecies]
[UpdateTracker:9779972] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9779780] Update Tracker - [FailedReaction:5617096] Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 - v64:[add_removeInput]
[UpdateTracker:9898461] Update Tracker - [Complex:399867] Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899041] Update Tracker - [Complex:169142] NS1 Homodimer:PKR Complex [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9899018] Update Tracker - [Complex:169143] NS1 dimer [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898683] Update Tracker - [Complex:169245] Influenza A Viral Envelope [extracellular region] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779892] Update Tracker - [Pathway:3656244] Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898626] Update Tracker - [Complex:5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9899040] Update Tracker - [EntityWithAccessionedSequence:196493] Glycosylated NA [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779833] Update Tracker - [Reaction:5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
[UpdateTracker:9898687] Update Tracker - [Complex:187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898726] Update Tracker - [Complex:1168619] p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane] - v64:[add_removeHasComponent, modifyName, updateContainedComponent]
[UpdateTracker:9898829] Update Tracker - [EntityWithAccessionedSequence:189152] NA [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898752] Update Tracker - [EntityWithAccessionedSequence:189175] Inter-Membrane Spanning HA2 [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779809] Update Tracker - [Pathway:165160] PDE3B signalling - v64:[updateContainedRLE]
[UpdateTracker:9779954] Update Tracker - [Pathway:2206280] MPS IX - Natowicz syndrome - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9898992] Update Tracker - [Complex:180523] PXN:MyrG-SRC [plasma membrane] - v64:[add_removeHasComponent, modifyName]
[UpdateTracker:9898759] Update Tracker - [EntityWithAccessionedSequence:188828] Genomic RNA Segment 7 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9898604] Update Tracker - [Complex:2428923] IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898973] Update Tracker - [DefinedSet:167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] - v64:[modifyName]
[UpdateTracker:9780055] Update Tracker - [Pathway:9014843] Interleukin-33 signaling - v64:[modifyText]
[UpdateTracker:9898535] Update Tracker - [EntityWithAccessionedSequence:1614386] FGFR1c P252T [plasma membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9780054] Update Tracker - [Pathway:212165] Epigenetic regulation of gene expression - v64:[updateContainedPathway]
[UpdateTracker:9780107] Update Tracker - [Reaction:6806831] CYB5Rs reduce MetHb to HbA - v64:[add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9898494] Update Tracker - [EntityWithAccessionedSequence:195770] M2 [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9779843] Update Tracker - [Reaction:186819] SH2 domain of Src binds to the active receptor - v64:[add_removeInput]
[UpdateTracker:9898682] Update Tracker - [EntityWithAccessionedSequence:192973] NP mRNA [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779964] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v64:[updateContainedRLE]
[UpdateTracker:9779796] Update Tracker - [FailedReaction:4720478] Defective ALG9 does not add the seventh mannose to the N-glycan precursor - v64:[add_removeInput]
[UpdateTracker:9779811] Update Tracker - [Pathway:1483206] Glycerophospholipid biosynthesis - v64:[updateIndirectRLE]
[UpdateTracker:9780009] Update Tracker - [Pathway:203615] eNOS activation - v64:[updateContainedRLE]
[UpdateTracker:9898863] Update Tracker - [Complex:8953904] PEX2:PEX10:PEX12 [peroxisomal membrane] - v64:[addName]
[UpdateTracker:9898823] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779783] Update Tracker - [Pathway:5619099] Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) - v64:[updateContainedRLE]
[UpdateTracker:9779719] Update Tracker - [BlackBoxEvent:573384] Transcription of intergenic spacer of the rRNA gene - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9780117] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v64:[add_removeSummation]
[UpdateTracker:9898915] Update Tracker - [Complex:983461] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779838] Update Tracker - [Pathway:388841] Costimulation by the CD28 family - v64:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9898916] Update Tracker - [Complex:195796] Glycosylated NA Tetramer [endocytic vesicle membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898920] Update Tracker - [Complex:195952] Segment 3 RNP [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9898649] Update Tracker - [Complex:354137] Focal complex [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780026] Update Tracker - [Pathway:5654687] Downstream signaling of activated FGFR1 - v64:[updateIndirectRLE]
[UpdateTracker:9898802] Update Tracker - [Complex:3302042] GSTM3 dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898773] Update Tracker - [Polymer:1296409] NLRP3 elicitors:NLRP3 oligomer [cytosol] - v64:[updateContainedRepeatedUnit]
[UpdateTracker:9898748] Update Tracker - [Complex:421098] p-Y15-CDK5:p35 [plasma membrane] - v64:[addName]
[UpdateTracker:9779863] Update Tracker - [Pathway:162710] Synthesis of glycosylphosphatidylinositol (GPI) - v64:[updateContainedRLE]
[UpdateTracker:9898896] Update Tracker - [Complex:5419267] 55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] - v64:[updateContainedComponent]
[UpdateTracker:9779756] Update Tracker - [Pathway:5602680] MyD88 deficiency (TLR5) - v64:[updateContainedRLE]
[UpdateTracker:9898770] Update Tracker - [Complex:422310] GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9780097] Update Tracker - [Reaction:388830] PI3K binds ICOS - v64:[addRegulator]
[UpdateTracker:9898661] Update Tracker - [CandidateSet:191727] beta-catenin [cytosol] - v64:[add_removeHasCandidate]
[UpdateTracker:9898674] Update Tracker - [Complex:377606] p-Y530-SRC:CSK [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898568] Update Tracker - [Complex:6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent]
[UpdateTracker:9898581] Update Tracker - [Complex:377620] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] - v64:[updateContainedComponent]
[UpdateTracker:9898875] Update Tracker - [Complex:192667] vRNP Export Complex [nucleoplasm] - v64:[updateContainedComponent]
[UpdateTracker:9898589] Update Tracker - [DefinedSet:791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - v64:[updateContainedMemberOrCandidate]
[UpdateTracker:9779870] Update Tracker - [Pathway:2206307] MPS IIIA - Sanfilippo syndrome A - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779910] Update Tracker - [BlackBoxEvent:1989761] Expression of APOA5 - v64:[addRegulator]
[UpdateTracker:9898989] Update Tracker - [Complex:170993] Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9779956] Update Tracker - [FailedReaction:5602147] Defective CYP2R1 does not 25-hydroxylate vitamin D - v64:[add_removeInput]
[UpdateTracker:9898801] Update Tracker - [EntityWithAccessionedSequence:179528] Ntrk3 [plasma membrane] - v64:[addName]
[UpdateTracker:9898793] Update Tracker - [EntityWithAccessionedSequence:189141] NP [endosome lumen] - v64:[add_removeSpecies]
[UpdateTracker:9898616] Update Tracker - [SimpleEntity:1500581] PE [endoplasmic reticulum membrane] - v64:[add_removeReferenceEntity]
[UpdateTracker:9898811] Update Tracker - [EntityWithAccessionedSequence:169250] HA1 [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9780019] Update Tracker - [FailedReaction:2466834] Defective OPN1SW causes tritanopia - v64:[add_removeInput]
[UpdateTracker:9898633] Update Tracker - [Complex:195727] M2 Tetramer [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898611] Update Tracker - [Complex:196488] Trimeric palmitylated HA [extracellular region] - v64:[add_removeSpecies]
[UpdateTracker:9779936] Update Tracker - [Pathway:68949] Orc1 removal from chromatin - v64:[updateContainedRLE]
[UpdateTracker:9779739] Update Tracker - [Pathway:5687613] Diseases associated with surfactant metabolism - v64:[updateIndirectRLE]
[UpdateTracker:9898867] Update Tracker - [DefinedSet:450289] MAPK8,9,10 [cytosol] - v64:[modifyName]
[UpdateTracker:9898907] Update Tracker - [Complex:1445135] Phospho AS160:14-3-3 [cytoplasmic vesicle membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9898895] Update Tracker - [Complex:189157] Influenza A Viral Envelope Inserted Into The Endocytic Vesicle Membrane [endocytic vesicle membrane] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9898786] Update Tracker - [Complex:188853] RNP:Karyopherin alpha:Karyopherin beta complex [cytosol] - v64:[updateContainedComponent]
[UpdateTracker:9898817] Update Tracker - [EntityWithAccessionedSequence:195788] HA folded and glycosylated [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9898795] Update Tracker - [EntityWithAccessionedSequence:2471708] OPN1LW C203R [photoreceptor disc membrane] - v64:[add_removeCompartment]
[UpdateTracker:9898502] Update Tracker - [DefinedSet:400551] FFAR4 ligands [extracellular region] - v64:[add_removeHasMember]
[UpdateTracker:9780153] Update Tracker - [Pathway:3878781] Glycogen storage disease type IV (GBE1) - v64:[updateContainedRLE]
[UpdateTracker:9898676] Update Tracker - [Complex:195761] palmitylated M2 Tetramer [Golgi membrane] - v64:[add_removeSpecies]
[UpdateTracker:9899056] Update Tracker - [Complex:192720] Viral Polymerase [nucleoplasm] - v64:[add_removeSpecies]
[UpdateTracker:9779710] Update Tracker - [Pathway:389359] CD28 dependent Vav1 pathway - v64:[updateContainedRLE]
[UpdateTracker:9898564] Update Tracker - [Complex:389921] GRB2:pBTLA:HVEM [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9898776] Update Tracker - [Complex:2011924] FGFR1c P252S mutant dimer [plasma membrane] - v64:[modifyName, updateContainedComponent]
[UpdateTracker:9899026] Update Tracker - [Complex:3302038] GSTT2B dimer [cytosol] - v64:[modifyName]
[UpdateTracker:9898700] Update Tracker - [DefinedSet:192803] viral mRNA [cytosol] - v64:[add_removeSpecies]
[UpdateTracker:9780138] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v64:[updateContainedRLE]
[UpdateTracker:9779909] Update Tracker - [Pathway:2173788] Downregulation of TGF-beta receptor signaling - v64:[updateContainedRLE]
[UpdateTracker:9780016] Update Tracker - [Reaction:162798] mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol - v64:[add_removeInput]
[UpdateTracker:9779871] Update Tracker - [Pathway:199991] Membrane Trafficking - v64:[updateIndirectRLE]
[UpdateTracker:9779844] Update Tracker - [Pathway:166520] Signaling by NTRKs - v64:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9899086] Update Tracker - [EntityWithAccessionedSequence:8953944] Ub-C11-PEX5S [peroxisomal membrane] - v64:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9779771] Update Tracker - [Pathway:182971] EGFR downregulation - v64:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9779712] Update Tracker - [Reaction:879863] Passive Transport of Anions out of Vesicles by Aquaporin-6 (rat) - v64:[add_removeInput, add_removeOutput]
[UpdateTracker:9898965] Update Tracker - [SimpleEntity:164121] AMP [nucleoplasm] - v64:[addName]
[UpdateTracker:9898551] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v64:[add_removeHasComponent]
[UpdateTracker:9779947] Update Tracker - [BlackBoxEvent:6786110] JAK1 binds IL4R in IL13-bound IL13R type II - v64:[modifyText]
[UpdateTracker:9898926] Update Tracker - [Complex:189149] Ribonucleoprotein (RNP) Complex [endosome lumen] - v64:[add_removeSpecies, updateContainedComponent]
[UpdateTracker:9779942] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v64:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779900] Update Tracker - [Pathway:422356] Regulation of insulin secretion - v64:[updateIndirectRLE]

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