Reactome | 70 on 2019-09-09

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70 on 2019-09-09 Show undefined attributes

dbId	9777505
displayName	70 on 2019-09-09
modified	[InstanceEdit:9982963] Weiser, Joel, 2026-02-20
releaseDate	2019-09-09
releaseNumber	70
schemaClass	Release

Referrals

(release)

[UpdateTracker:9900649] Update Tracker - [Complex:5675430] p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777614] Update Tracker - [Reaction:1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - v70:[modifyText]
[UpdateTracker:9777624] Update Tracker - [Pathway:9607240] FLT3 Signaling - v70:[updateContainedRLE]
[UpdateTracker:9900851] Update Tracker - [Complex:1358729] NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900740] Update Tracker - [DefinedSet:8863991] Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900839] Update Tracker - [Complex:5624477] p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900715] Update Tracker - [ChemicalDrug:1217505] Geldanamycin [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900719] Update Tracker - [EntityWithAccessionedSequence:6802502] BRAF V600K [cytosol] - v70:[modifyName]
[UpdateTracker:9900685] Update Tracker - [SimpleEntity:1650779] 2OG [endoplasmic reticulum lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777577] Update Tracker - [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - v70:[add_removeInput]
[UpdateTracker:9900647] Update Tracker - [Complex:390847] DRD1,5:DA [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900782] Update Tracker - [Complex:8936663] phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900622] Update Tracker - [Complex:2400008] PI3K Inhibitors:PI3K [cytosol] - v70:[updateContainedComponent]
[UpdateTracker:9900883] Update Tracker - [Complex:2168892] LRP1:Hemopexin:heme [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900773] Update Tracker - [ChemicalDrug:1217514] IPI-504 [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900626] Update Tracker - [EntityWithAccessionedSequence:8936641] p-BRAF F595L [plasma membrane] - v70:[addDisease, addLiteratureReference, modifyName]
[UpdateTracker:9900745] Update Tracker - [Complex:5624478] p21 RAS:GTP:RAF1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900805] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v70:[add_removeHasComponent]
[UpdateTracker:9900652] Update Tracker - [Complex:5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777590] Update Tracker - [Pathway:5663202] Diseases of signal transduction by growth factor receptors and second messengers - v70:[updateContainedPathway]
[UpdateTracker:9900621] Update Tracker - [SimpleEntity:114570] ATP [extracellular region] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900793] Update Tracker - [ChemicalDrug:1217507] 17-DMAG [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777582] Update Tracker - [Reaction:8955724] TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900795] Update Tracker - [SimpleEntity:880046] SUCCSA [mitochondrial matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900783] Update Tracker - [Complex:8863838] NRGs/EGFLs:p-ERBB4cyt1:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900791] Update Tracker - [Complex:6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777524] Update Tracker - [Reaction:8848585] AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM - v70:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9900862] Update Tracker - [SimpleEntity:29434] SUCCA [cytosol] - v70:[addName]
[UpdateTracker:9900799] Update Tracker - [SimpleEntity:113592] ATP [cytosol] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900797] Update Tracker - [EntityWithAccessionedSequence:5575594] MSH2 R406* [nucleoplasm] - v70:[addName]
[UpdateTracker:9777504] Update Tracker - [Pathway:373076] Class A/1 (Rhodopsin-like receptors) - v70:[updateContainedPathway]
[UpdateTracker:9900634] Update Tracker - [Complex:8936655] moderate kinase activity BRAF mutants:YWHAB [cytosol] - v70:[updateContainedComponent]
[UpdateTracker:9900695] Update Tracker - [SimpleEntity:433123] SUCCA [extracellular region] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777642] Update Tracker - [Reaction:8955869] Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900751] Update Tracker - [Complex:8848002] p-ERBB2 heterodimers:PTK6 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900651] Update Tracker - [Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777547] Update Tracker - [Pathway:200425] Carnitine metabolism - v70:[updateContainedRLE]
[UpdateTracker:9900660] Update Tracker - [EntityWithAccessionedSequence:6802305] BRAF D594V [cytosol] - v70:[modifyName]
[UpdateTracker:9900871] Update Tracker - [EntityWithAccessionedSequence:8936645] p-BRAF G464E [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777631] Update Tracker - [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9777588] Update Tracker - [Pathway:9632693] Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects - v70:[addLiteratureReference, modifyText, updateIndirectRLE]
[UpdateTracker:9777593] Update Tracker - [Reaction:888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - v70:[addLiteratureReference, addOutput, modifyText]
[UpdateTracker:9777516] Update Tracker - [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - v70:[modifyText]
[UpdateTracker:9900654] Update Tracker - [Complex:1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900779] Update Tracker - [Complex:390849] DRD3,4:DA [plasma membrane] - v70:[modifyName, updateContainedComponent]
[UpdateTracker:9777656] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v70:[removeInput]
[UpdateTracker:9900735] Update Tracker - [Complex:6785647] p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900721] Update Tracker - [Complex:171020] Ras-GTP:RalGDS complex [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900707] Update Tracker - [EntityWithAccessionedSequence:6802316] BRAF F595L [cytosol] - v70:[addDisease, addLiteratureReference, modifyName]
[UpdateTracker:9900877] Update Tracker - [DefinedSet:6802629] kinase dead BRAF mutants [cytosol] - v70:[addHasMember, addLiteratureReference]
[UpdateTracker:9900712] Update Tracker - [EntityWithAccessionedSequence:6802397] BRAF L597V [cytosol] - v70:[modifyName]
[UpdateTracker:9777560] Update Tracker - [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers - v70:[modifyText]
[UpdateTracker:9900825] Update Tracker - [EntityWithAccessionedSequence:6802295] BRAF D594G [cytosol] - v70:[modifyName]
[UpdateTracker:9900697] Update Tracker - [Complex:5675702] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900703] Update Tracker - [Complex:6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900841] Update Tracker - [Complex:6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] - v70:[addDisease, updateContainedComponent]
[UpdateTracker:9777510] Update Tracker - [Pathway:597592] Post-translational protein modification - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900757] Update Tracker - [CandidateSet:8863989] Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9777517] Update Tracker - [Reaction:197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput]
[UpdateTracker:9777592] Update Tracker - [Pathway:375280] Amine ligand-binding receptors - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900759] Update Tracker - [Complex:744890] GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900867] Update Tracker - [EntityWithAccessionedSequence:9632586] p16INK4A R80* [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9900828] Update Tracker - [CandidateSet:1963568] Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9777648] Update Tracker - [Pathway:1643685] Disease - v70:[addHasEvent, updateContainedPathway]
[UpdateTracker:9777638] Update Tracker - [Pathway:199992] trans-Golgi Network Vesicle Budding - v70:[updateIndirectRLE]
[UpdateTracker:9900767] Update Tracker - [Complex:1918081] Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777646] Update Tracker - [Reaction:156682] PLK1 phosphorylates NUDC - v70:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9777520] Update Tracker - [Pathway:5689896] Ovarian tumor domain proteases - v70:[modifyText]
[UpdateTracker:9900629] Update Tracker - [Complex:9631759] Defective NPC [nuclear envelope] - v70:[addName]
[UpdateTracker:9900627] Update Tracker - [DefinedSet:6802579] high kinase activity BRAF mutants [cytosol] - v70:[addDisease, addHasMember, addLiteratureReference]
[UpdateTracker:9900774] Update Tracker - [Complex:2168871] Albumin:ferriheme [extracellular region] - v70:[add_removeHasComponent]
[UpdateTracker:9900720] Update Tracker - [Complex:1963583] NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777537] Update Tracker - [Pathway:112314] Neurotransmitter receptors and postsynaptic signal transmission - v70:[addHasEvent]
[UpdateTracker:9900818] Update Tracker - [Complex:165678] Active mTORC1 complex [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777606] Update Tracker - [Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. - v70:[modifyText]
[UpdateTracker:9900645] Update Tracker - [EntityWithAccessionedSequence:6802354] KRAS G12V [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900683] Update Tracker - [EntityWithAccessionedSequence:6802339] NRAS G12D [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900637] Update Tracker - [Complex:8854324] TBC1D7:TSC1:TSC2 [cytosol] - v70:[addLiteratureReference]
[UpdateTracker:9900761] Update Tracker - [Complex:8936669] p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900775] Update Tracker - [SimpleEntity:113536] SUCCA [mitochondrial matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900742] Update Tracker - [Complex:1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777566] Update Tracker - [Reaction:1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - v70:[modifyText]
[UpdateTracker:9900663] Update Tracker - [EntityWithAccessionedSequence:156702] p-S274,S326-NUDC [cytosol] - v70:[add_removeCompartment]
[UpdateTracker:9900628] Update Tracker - [SimpleEntity:73473] NADH [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900686] Update Tracker - [DefinedSet:8863830] Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900834] Update Tracker - [EntityWithAccessionedSequence:6802359] KRAS G13D [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900802] Update Tracker - [Complex:6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777565] Update Tracker - [Pathway:448706] Interleukin-1 processing - v70:[updateContainedRLE]
[UpdateTracker:9900680] Update Tracker - [SimpleEntity:389573] ATP [peroxisomal matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900688] Update Tracker - [Complex:9635898] ATF4:CEBPB,CEBPG:ASNS gene [nucleoplasm] - v70:[modifyName, updateContainedComponent]
[UpdateTracker:9900741] Update Tracker - [EntityWithAccessionedSequence:6802350] HRAS G12V [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900777] Update Tracker - [SimpleEntity:29360] NAD+ [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777605] Update Tracker - [Pathway:432720] Lysosome Vesicle Biogenesis - v70:[updateContainedRLE]
[UpdateTracker:9777553] Update Tracker - [Pathway:9612973] Autophagy - v70:[updateContainedPathway]
[UpdateTracker:9900625] Update Tracker - [Complex:749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900809] Update Tracker - [DefinedSet:1963580] Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] - v70:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9900826] Update Tracker - [Complex:6802625] RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900778] Update Tracker - [EntityWithAccessionedSequence:6802368] HRAS G13R [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900765] Update Tracker - [Complex:1248749] NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900717] Update Tracker - [SimpleEntity:211579] ATP [endoplasmic reticulum membrane] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777558] Update Tracker - [Pathway:6802957] Oncogenic MAPK signaling - v70:[updateContainedPathway]
[UpdateTracker:9900743] Update Tracker - [Complex:5675791] MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777533] Update Tracker - [Reaction:8865774] TTLLs polyglutamylate tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900655] Update Tracker - [SimpleEntity:29370] ADP [cytosol] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900670] Update Tracker - [Complex:9625165] HSPA8:LAMP2a multimeric complex [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777559] Update Tracker - [Reaction:5672978] RAF phosphorylates MAP2K dimer - v70:[addRegulator]
[UpdateTracker:9777534] Update Tracker - [Pathway:2187338] Visual phototransduction - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900860] Update Tracker - [Complex:1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777552] Update Tracker - [Pathway:5362517] Signaling by Retinoic Acid - v70:[updateContainedRLE]
[UpdateTracker:9900640] Update Tracker - [EntityWithAccessionedSequence:5632982] PMS2 R134* [nucleoplasm] - v70:[addName]
[UpdateTracker:9900850] Update Tracker - [DefinedSet:1963592] Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900694] Update Tracker - [DefinedSet:1368190] NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900830] Update Tracker - [Polymer:9624156] LAMP2a multimer complex [lysosomal membrane] - v70:[updateContainedRepeatedUnit]
[UpdateTracker:9900823] Update Tracker - [SimpleEntity:5278787] SUCCA [cytoplasm] - v70:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9900819] Update Tracker - [SimpleEntity:114564] ADP [extracellular region] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777655] Update Tracker - [Pathway:69278] Cell Cycle, Mitotic - v70:[updateContainedPathway]
[UpdateTracker:9777634] Update Tracker - [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900813] Update Tracker - [EntityWithAccessionedSequence:8936639] p-BRAF E586K [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900746] Update Tracker - [Complex:975348] HTR3 pentamers:5HT [plasma membrane] - v70:[modifyName, updateContainedComponent]
[UpdateTracker:9900874] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9777637] Update Tracker - [Pathway:112310] Neurotransmitter release cycle - v70:[updateContainedPathway]
[UpdateTracker:9900744] Update Tracker - [SimpleEntity:5696026] ADP [mitochondrial intermembrane space] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900838] Update Tracker - [EntityWithAccessionedSequence:6802458] HRAS Q61R [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777609] Update Tracker - [BlackBoxEvent:9635380] Translation of Atf4 - v70:[addLiteratureReference, modifyText]
[UpdateTracker:9777626] Update Tracker - [Pathway:9630791] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 - v70:[updateContainedRLE]
[UpdateTracker:9900630] Update Tracker - [SimpleEntity:5632460] ATP [cilium] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900722] Update Tracker - [Complex:5653973] RRAGC:GDP [cytosol] - v70:[add_removeHasComponent]
[UpdateTracker:9777529] Update Tracker - [Pathway:1222556] ROS and RNS production in phagocytes - v70:[addHasEvent]
[UpdateTracker:9777572] Update Tracker - [Pathway:9613829] Chaperone Mediated Autophagy - v70:[removeHasEvent]
[UpdateTracker:9900866] Update Tracker - [EntityWithAccessionedSequence:6802495] BRAF V600E;V47_M438del [cytosol] - v70:[modifyName]
[UpdateTracker:9900886] Update Tracker - [EntityWithAccessionedSequence:6802455] NRAS Q61L [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900711] Update Tracker - [Complex:1918083] Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900716] Update Tracker - [Complex:1248743] NRG1/2:p-10Y-ERBB3 [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900781] Update Tracker - [SimpleEntity:29362] NADH [mitochondrial matrix] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900676] Update Tracker - [EntityWithAccessionedSequence:6802442] HRAS Q61K [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900812] Update Tracker - [SimpleEntity:5653871] Lac [Golgi lumen] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777511] Update Tracker - [Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - v70:[modifyText]
[UpdateTracker:9777647] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v70:[updateContainedRLE]
[UpdateTracker:9777573] Update Tracker - [Pathway:9630747] Diseases of Cellular Senescence - v70:[addHasEvent, updateContainedPathway]
[UpdateTracker:9900763] Update Tracker - [SimpleEntity:113526] NAD+ [mitochondrial matrix] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900758] Update Tracker - [Complex:1248746] SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900787] Update Tracker - [Complex:5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900631] Update Tracker - [Complex:981642] C4-binding protein:C4b [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777580] Update Tracker - [Reaction:5672973] MAP2Ks phosphorylate MAPKs - v70:[addRegulator]
[UpdateTracker:9900884] Update Tracker - [EntityWithAccessionedSequence:6802480] KRAS V14I [plasma membrane] - v70:[addDisease, addLiteratureReference, modifyName]
[UpdateTracker:9900691] Update Tracker - [SimpleEntity:188973] Lac [extracellular region] - v70:[add_removeReferenceEntity, removeName]
[UpdateTracker:9900734] Update Tracker - [EntityWithAccessionedSequence:6802385] BRAF G596R [cytosol] - v70:[modifyName]
[UpdateTracker:9777515] Update Tracker - [Pathway:169893] Prolonged ERK activation events - v70:[updateContainedPathway]
[UpdateTracker:9900677] Update Tracker - [EntityWithAccessionedSequence:6802363] NRAS G13D [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900690] Update Tracker - [Complex:6803238] RAS mutants:GTP:RAF [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777532] Update Tracker - [Reaction:1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - v70:[modifyText]
[UpdateTracker:9900817] Update Tracker - [CandidateSet:9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] - v70:[addHasCandidate]
[UpdateTracker:9900814] Update Tracker - [EntityWithAccessionedSequence:6802452] HRAS Q61L [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900724] Update Tracker - [SimpleEntity:389537] 2OG [peroxisomal matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777589] Update Tracker - [Pathway:168256] Immune System - v70:[updateContainedPathway]
[UpdateTracker:9900847] Update Tracker - [Complex:5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777535] Update Tracker - [BlackBoxEvent:449058] Interleukin-1 family are secreted - v70:[modifyText]
[UpdateTracker:9900738] Update Tracker - [Complex:5693283] mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777506] Update Tracker - [Pathway:888590] GABA synthesis, release, reuptake and degradation - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900835] Update Tracker - [Complex:5693447] mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777636] Update Tracker - [Reaction:8867370] TTLL3, TTLL8, TTLL10 polyglycylate tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900870] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900730] Update Tracker - [SimpleEntity:139836] ATP [plasma membrane] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900854] Update Tracker - [Complex:5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900669] Update Tracker - [Complex:5672715] p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900796] Update Tracker - [Complex:5675412] p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900754] Update Tracker - [SimpleEntity:9635427] phthiocerol [cytosol] - v70:[addName]
[UpdateTracker:9900849] Update Tracker - [Complex:6802607] RAS mutants:GTP [plasma membrane] - v70:[add_removeHasComponent]
[UpdateTracker:9900832] Update Tracker - [Complex:1358734] NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900662] Update Tracker - [Complex:5672861] mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900671] Update Tracker - [DefinedSet:8936661] 'receiver' RAF [cytosol] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900776] Update Tracker - [SimpleEntity:561075] 2OG [extracellular region] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900696] Update Tracker - [SimpleEntity:114565] ADP [platelet dense granule lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900780] Update Tracker - [Complex:6802633] mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777630] Update Tracker - [Reaction:1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2 - v70:[modifyText]
[UpdateTracker:9777611] Update Tracker - [Pathway:916853] Degradation of GABA - v70:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9777635] Update Tracker - [Pathway:381183] ATF6 (ATF6-alpha) activates chaperone genes - v70:[updateContainedRLE]
[UpdateTracker:9777653] Update Tracker - [Reaction:1250195] SHC1 phosphorylation by ERBB2 heterodimers - v70:[modifyText]
[UpdateTracker:9777550] Update Tracker - [Reaction:1250500] Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex - v70:[modifyText]
[UpdateTracker:9900831] Update Tracker - [Complex:8936725] chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777522] Update Tracker - [Pathway:109606] Intrinsic Pathway for Apoptosis - v70:[updateContainedPathway]
[UpdateTracker:9777551] Update Tracker - [Pathway:8978868] Fatty acid metabolism - v70:[updateIndirectRLE]
[UpdateTracker:9900853] Update Tracker - [EntityWithAccessionedSequence:6802299] BRAF D594N [cytosol] - v70:[modifyName]
[UpdateTracker:9777622] Update Tracker - [Pathway:2187335] The retinoid cycle in cones (daylight vision) - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777562] Update Tracker - [Pathway:8955332] Carboxyterminal post-translational modifications of tubulin - v70:[updateContainedRLE]
[UpdateTracker:9777597] Update Tracker - [Pathway:112315] Transmission across Chemical Synapses - v70:[updateContainedPathway]
[UpdateTracker:9777640] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v70:[modifyText]
[UpdateTracker:9777629] Update Tracker - [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - v70:[modifyText]
[UpdateTracker:9900702] Update Tracker - [Complex:1250305] NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] - v70:[modifyName, updateContainedComponent]
[UpdateTracker:9900693] Update Tracker - [DefinedSet:5653964] RRAGC,RRAGD:GDP [cytosol] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900665] Update Tracker - [SimpleEntity:917955] FeHM [extracellular region] - v70:[addName]
[UpdateTracker:9900692] Update Tracker - [EntityWithAccessionedSequence:6802333] KRAS G12D [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900642] Update Tracker - [Complex:5653945] RagA,B:GTP:RagC,D:GDP [cytosol] - v70:[updateContainedComponent]
[UpdateTracker:9900861] Update Tracker - [Complex:6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] - v70:[addDisease, updateContainedComponent]
[UpdateTracker:9777641] Update Tracker - [Pathway:9640463] Wax biosynthesis - v70:[updateContainedRLE]
[UpdateTracker:9900753] Update Tracker - [SimpleEntity:192305] NADH [peroxisomal matrix] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900888] Update Tracker - [EntityWithAccessionedSequence:6802434] KRAS Q61H [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900804] Update Tracker - [Complex:5672139] MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777567] Update Tracker - [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput]
[UpdateTracker:9900644] Update Tracker - [EntityWithAccessionedSequence:9632585] p16INK4A W110* [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9777595] Update Tracker - [Pathway:6802949] Signaling by RAS mutants - v70:[add_removeHasEvent]
[UpdateTracker:9900880] Update Tracker - [Complex:5653979] Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900658] Update Tracker - [SimpleEntity:8931885] ATP [endoplasmic reticulum lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900842] Update Tracker - [Complex:1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900755] Update Tracker - [EntityWithAccessionedSequence:6802461] NRAS Q61R [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777594] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9900736] Update Tracker - [SimpleEntity:196180] ADP [plasma membrane] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900822] Update Tracker - [Complex:5675701] MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777578] Update Tracker - [Pathway:390651] Dopamine receptors - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777600] Update Tracker - [Pathway:162582] Signal Transduction - v70:[updateContainedPathway]
[UpdateTracker:9777563] Update Tracker - [Pathway:1251932] PLCG1 events in ERBB2 signaling - v70:[updateContainedRLE]
[UpdateTracker:9777548] Update Tracker - [Pathway:418594] G alpha (i) signalling events - v70:[updateContainedPathway]
[UpdateTracker:9900752] Update Tracker - [Complex:5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900806] Update Tracker - [Complex:6785640] p-ERBB2 heterodimers:MEMO1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900666] Update Tracker - [Complex:5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777512] Update Tracker - [Reaction:9604969] Active FLT3 binds PTPN11 - v70:[addLiteratureReference, modifyText]
[UpdateTracker:9777639] Update Tracker - [Pathway:3858494] Beta-catenin independent WNT signaling - v70:[updateIndirectRLE]
[UpdateTracker:9777521] Update Tracker - [Pathway:375276] Peptide ligand-binding receptors - v70:[updateContainedPathway]
[UpdateTracker:9777645] Update Tracker - [Pathway:381042] PERK regulates gene expression - v70:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9777526] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v70:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9777557] Update Tracker - [Pathway:8957322] Metabolism of steroids - v70:[updateContainedPathway]
[UpdateTracker:9777649] Update Tracker - [Pathway:1963640] GRB2 events in ERBB2 signaling - v70:[updateContainedRLE]
[UpdateTracker:9900816] Update Tracker - [EntityWithAccessionedSequence:6802472] KRAS T58I [plasma membrane] - v70:[addLiteratureReference, modifyName]
[UpdateTracker:9900878] Update Tracker - [Complex:6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900698] Update Tracker - [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9777545] Update Tracker - [Pathway:196807] Nicotinate metabolism - v70:[updateContainedRLE]
[UpdateTracker:9900789] Update Tracker - [EntityWithAccessionedSequence:6802498] BRAF V600E [cytosol] - v70:[addHasModifiedResidue, modifyName]
[UpdateTracker:9777643] Update Tracker - [Reaction:8869633] NMRK1 phosphorylates NR to yield NMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900837] Update Tracker - [Complex:9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - v70:[addDisease]
[UpdateTracker:9777541] Update Tracker - [Pathway:449147] Signaling by Interleukins - v70:[updateContainedPathway]
[UpdateTracker:9900704] Update Tracker - [CandidateSet:1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900863] Update Tracker - [DefinedSet:391181] Ligand:GPCR complexes that activate Gs [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900748] Update Tracker - [EntityWithAccessionedSequence:6802369] BRAF G464E [cytosol] - v70:[modifyName]
[UpdateTracker:9900623] Update Tracker - [DefinedSet:8936667] phosphorylated RAFs:YWHAB [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9777581] Update Tracker - [Pathway:111471] Apoptotic factor-mediated response - v70:[addHasEvent]
[UpdateTracker:9777601] Update Tracker - [Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR - v70:[modifyText]
[UpdateTracker:9900762] Update Tracker - [Complex:390955] HTR1B,D,E,F,HTR5A:5HT [plasma membrane] - v70:[modifyName, updateContainedComponent]
[UpdateTracker:9777555] Update Tracker - [Pathway:381119] Unfolded Protein Response (UPR) - v70:[updateIndirectRLE]
[UpdateTracker:9777644] Update Tracker - [Pathway:380108] Chemokine receptors bind chemokines - v70:[addHasEvent]
[UpdateTracker:9900635] Update Tracker - [Complex:6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol] - v70:[addDisease, updateContainedComponent]
[UpdateTracker:9900852] Update Tracker - [SimpleEntity:194697] NADH [endoplasmic reticulum lumen] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900887] Update Tracker - [Complex:9615717] HSPA8 bound autophagic substrates [cytosol] - v70:[updateContainedComponent]
[UpdateTracker:9900833] Update Tracker - [SimpleEntity:197238] QUIN [cytosol] - v70:[add_removeReferenceEntity, modifyName]
[UpdateTracker:9777576] Update Tracker - [Pathway:187687] Signalling to ERKs - v70:[updateContainedPathway]
[UpdateTracker:9900706] Update Tracker - [Complex:9631070] PL:HSPA8:Autophagy substrate [late endosome membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777556] Update Tracker - [Pathway:68884] Mitotic Telophase/Cytokinesis - v70:[removeHasEvent]
[UpdateTracker:9777613] Update Tracker - [Reaction:390846] D2D3,4 bind to DA - v70:[modifyText, removeLiteratureReference]
[UpdateTracker:9900710] Update Tracker - [Complex:2168866] MetHb [extracellular region] - v70:[updateContainedComponent]
[UpdateTracker:9900760] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777575] Update Tracker - [BlackBoxEvent:1791118] Expression of ASNS (Asparagine Synthetase) - v70:[modifyText]
[UpdateTracker:9900684] Update Tracker - [Complex:5624470] p21 RAS:GTP:p-S338-RAF1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900646] Update Tracker - [EntityWithAccessionedSequence:6802308] BRAF E586K [cytosol] - v70:[modifyName]
[UpdateTracker:9777544] Update Tracker - [Reaction:1248744] Shc1 binds phosphorylated ERBB2:EGFR heterodimers - v70:[modifyText]
[UpdateTracker:9777599] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v70:[updateIndirectRLE]
[UpdateTracker:9900803] Update Tracker - [Complex:5674003] p21 RAS:GTP:BRAP [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777608] Update Tracker - [FailedReaction:9630795] p16INK4A mutants do not bind CDK4,CDK6 - v70:[addLiteratureReference, modifyText]
[UpdateTracker:9900821] Update Tracker - [SimpleEntity:192307] NAD+ [peroxisomal matrix] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777587] Update Tracker - [Pathway:381033] ATF6 (ATF6-alpha) activates chaperones - v70:[updateIndirectRLE]
[UpdateTracker:9900714] Update Tracker - [SimpleEntity:113593] ATP [mitochondrial matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777632] Update Tracker - [Reaction:8955706] TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900664] Update Tracker - [Complex:2168851] HPX:Hemes [extracellular region] - v70:[updateContainedComponent]
[UpdateTracker:9900732] Update Tracker - [SimpleEntity:5696069] ATP [mitochondrial intermembrane space] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777604] Update Tracker - [Reaction:2465924] OPN1LW binds 11cRAL - v70:[removeInput, removeOutput]
[UpdateTracker:9900643] Update Tracker - [DefinedSet:6802631] genetically or chemically inactive BRAF [cytosol] - v70:[addDisease, updateContainedMemberOrCandidate]
[UpdateTracker:9900856] Update Tracker - [Complex:8863831] NRGs/EGFLs:p-ERBB4cyt1:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900689] Update Tracker - [Complex:5658227] p21 RAS:GTP:RAS GAPs [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900771] Update Tracker - [Complex:203655] LYPLA1 dimer [cytosol] - v70:[addName]
[UpdateTracker:9900672] Update Tracker - [Complex:1248755] Shc1:Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900879] Update Tracker - [Complex:8981350] p21 RAS:GTP:RASA1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900820] Update Tracker - [EntityWithAccessionedSequence:6802292] KRAS D153V [plasma membrane] - v70:[addLiteratureReference, modifyName]
[UpdateTracker:9777579] Update Tracker - [Pathway:8953897] Cellular responses to stimuli - v70:[removeHasEvent, updateContainedPathway]
[UpdateTracker:9900729] Update Tracker - [Complex:6802666] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] - v70:[addDisease, updateContainedComponent]
[UpdateTracker:9777549] Update Tracker - [Pathway:1963642] PI3K events in ERBB2 signaling - v70:[updateContainedRLE]
[UpdateTracker:9900668] Update Tracker - [DefinedSet:8863835] NRGs/EGFLs:p-ERBB4:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900865] Update Tracker - [Complex:1250191] NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777596] Update Tracker - [Pathway:9630750] Evasion of Oncogene Induced Senescence Due to p16INK4A Defects - v70:[addLiteratureReference, modifyText, updateIndirectRLE]
[UpdateTracker:9777570] Update Tracker - [FailedReaction:9630792] p16INK4A mutants do not bind CDK4 - v70:[addLiteratureReference, modifyText]
[UpdateTracker:9777603] Update Tracker - [FailedReaction:2466834] Defective OPN1SW causes tritanopia - v70:[removeInput]
[UpdateTracker:9777651] Update Tracker - [Pathway:196849] Metabolism of water-soluble vitamins and cofactors - v70:[updateIndirectRLE]
[UpdateTracker:9900699] Update Tracker - [DefinedSet:390818] DRD3,4 [plasma membrane] - v70:[modifyName, removeHasMember]
[UpdateTracker:9777571] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v70:[modifyText, removeLiteratureReference]
[UpdateTracker:9900750] Update Tracker - [EntityWithAccessionedSequence:6802281] BRAF T599dup [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9900858] Update Tracker - [Complex:6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777654] Update Tracker - [Pathway:1632852] Macroautophagy - v70:[addHasEvent]
[UpdateTracker:9777538] Update Tracker - [Reaction:1248753] Shc1 binds phosphorylated ERBB2:ERBB3 heterodimers - v70:[modifyText]
[UpdateTracker:9777612] Update Tracker - [Pathway:983712] Ion channel transport - v70:[updateContainedPathway]
[UpdateTracker:9777607] Update Tracker - [Pathway:2474795] Diseases associated with visual transduction - v70:[updateIndirectRLE]
[UpdateTracker:9900618] Update Tracker - [EntityWithAccessionedSequence:6802381] BRAF G469A [cytosol] - v70:[addHasModifiedResidue, modifyName]
[UpdateTracker:9777650] Update Tracker - [Pathway:112316] Neuronal System - v70:[updateContainedPathway]
[UpdateTracker:9900829] Update Tracker - [SimpleEntity:159939] SUCCA [nucleoplasm] - v70:[addName]
[UpdateTracker:9900788] Update Tracker - [Complex:5675414] p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777525] Update Tracker - [Pathway:449836] Other interleukin signaling - v70:[removeHasEvent]
[UpdateTracker:9900844] Update Tracker - [Complex:5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777598] Update Tracker - [Pathway:170968] Frs2-mediated activation - v70:[addHasEvent]
[UpdateTracker:9900889] Update Tracker - [Complex:9622841] Substrate:LAMP2a [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900674] Update Tracker - [SimpleEntity:8931884] ADP [endoplasmic reticulum lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900794] Update Tracker - [EntityWithAccessionedSequence:9632587] p16INK4A E120* [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9777616] Update Tracker - [Pathway:168249] Innate Immune System - v70:[addHasEvent, updateContainedPathway]
[UpdateTracker:9900747] Update Tracker - [Complex:5672712] p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900868] Update Tracker - [SimpleEntity:1650769] SUCCA [endoplasmic reticulum lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900869] Update Tracker - [Complex:1250316] NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900890] Update Tracker - [Complex:6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900678] Update Tracker - [Complex:8952725] Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900726] Update Tracker - [Complex:981633] C4b-binding protein:Factor I [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777618] Update Tracker - [Pathway:2262752] Cellular responses to stress - v70:[addHasEvent, updateContainedPathway]
[UpdateTracker:9777543] Update Tracker - [Pathway:9632697] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 - v70:[updateContainedRLE]
[UpdateTracker:9900891] Update Tracker - [Complex:9644309] ATF4:CEBPB,CEBPG [nucleoplasm] - v70:[add_removeHasComponent, modifyName]
[UpdateTracker:9777546] Update Tracker - [Pathway:8848584] Wax and plasmalogen biosynthesis - v70:[updateIndirectRLE]
[UpdateTracker:9777615] Update Tracker - [BlackBoxEvent:3000263] TCN2:RCbl is degraded to release RCbl - v70:[removeOutput]
[UpdateTracker:9900875] Update Tracker - [Complex:109796] p21 RAS:GDP [plasma membrane] - v70:[add_removeHasComponent]
[UpdateTracker:9900661] Update Tracker - [DefinedSet:1963594] NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900798] Update Tracker - [Complex:5653972] mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900632] Update Tracker - [Complex:6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900790] Update Tracker - [Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900659] Update Tracker - [SimpleEntity:113582] ADP [nucleoplasm] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900701] Update Tracker - [SimpleEntity:113581] ADP [mitochondrial matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777508] Update Tracker - [Pathway:2559580] Oxidative Stress Induced Senescence - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777513] Update Tracker - [Pathway:9615710] Late endosomal microautophagy - v70:[removeHasEvent]
[UpdateTracker:9900713] Update Tracker - [Complex:6792757] HTR3A pentamer:5HT [plasma membrane] - v70:[addHasComponent, modifyName]
[UpdateTracker:9777583] Update Tracker - [Reaction:1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - v70:[modifyText]
[UpdateTracker:9900639] Update Tracker - [EntityWithAccessionedSequence:6802489] BRAF V600E;V169_M438del [cytosol] - v70:[modifyName]
[UpdateTracker:9777633] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v70:[removeInput]
[UpdateTracker:9777539] Update Tracker - [BlackBoxEvent:1791173] Expression of ATF3 - v70:[modifyText]
[UpdateTracker:9777554] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v70:[modifyText]
[UpdateTracker:9900708] Update Tracker - [Complex:5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777561] Update Tracker - [Pathway:380994] ATF4 activates genes in response to endoplasmic reticulum stress - v70:[updateContainedRLE]
[UpdateTracker:9777623] Update Tracker - [Pathway:5688426] Deubiquitination - v70:[updateContainedPathway]
[UpdateTracker:9900785] Update Tracker - [DefinedSet:1963585] p-6Y-ERBB2 heterodimers [plasma membrane] - v70:[modifyName, updateContainedMemberOrCandidate]
[UpdateTracker:9900769] Update Tracker - [SimpleEntity:389583] SUCCA [peroxisomal matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777523] Update Tracker - [Reaction:8869607] NMRK2 phosphorylates NAR to yield NAMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9900824] Update Tracker - [Complex:2168874] Hemoglobin alpha:ferriheme b [extracellular region] - v70:[add_removeHasComponent]
[UpdateTracker:9900840] Update Tracker - [ChemicalDrug:2399768] GSK1059615 [cytosol] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900656] Update Tracker - [EntityWithAccessionedSequence:9632582] p16INK4A R58* [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9900728] Update Tracker - [Complex:5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777602] Update Tracker - [Reaction:8955873] Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9777507] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v70:[addHasEvent]
[UpdateTracker:9900800] Update Tracker - [SimpleEntity:5688282] NAD+ [mitochondrial intermembrane space] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777569] Update Tracker - [Pathway:382551] Transport of small molecules - v70:[updateContainedPathway]
[UpdateTracker:9900857] Update Tracker - [Complex:1306951] NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900687] Update Tracker - [Complex:2203498] HPX:ferriheme b [extracellular region] - v70:[add_removeHasComponent]
[UpdateTracker:9900855] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900848] Update Tracker - [SimpleEntity:5632457] ADP [cilium] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900846] Update Tracker - [SimpleEntity:114571] ATP [platelet dense granule lumen] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900827] Update Tracker - [Complex:9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] - v70:[modifyName]
[UpdateTracker:9900807] Update Tracker - [Complex:9622836] Substrate:LAMP2a:HSP90 [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900845] Update Tracker - [EntityWithAccessionedSequence:8936647] p-BRAF L597V [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900727] Update Tracker - [Complex:5674005] p21 RAS:GTP:ub-BRAP [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777540] Update Tracker - [Pathway:9006931] Signaling by Nuclear Receptors - v70:[addHasEvent, modifyText, updateIndirectRLE]
[UpdateTracker:9900770] Update Tracker - [Complex:1963579] NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900872] Update Tracker - [SimpleEntity:113594] 2OG [mitochondrial matrix] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900786] Update Tracker - [DefinedSet:2316432] Activator:PI3K [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900733] Update Tracker - [EntityWithAccessionedSequence:8936651] p-BRAF V600K [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777519] Update Tracker - [Pathway:1250196] SHC1 events in ERBB2 signaling - v70:[updateContainedRLE]
[UpdateTracker:9900725] Update Tracker - [EntityWithAccessionedSequence:6802331] KRAS G12C [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777528] Update Tracker - [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - v70:[modifyText]
[UpdateTracker:9777518] Update Tracker - [Reaction:4332359] Active calmodulin binds CAMK2 - v70:[addLiteratureReference, addRegulator, modifyText]
[UpdateTracker:9900784] Update Tracker - [DefinedSet:981700] C4b [extracellular region] - v70:[addName]
[UpdateTracker:9777652] Update Tracker - [Pathway:109581] Apoptosis - v70:[updateContainedPathway]
[UpdateTracker:9900705] Update Tracker - [SimpleEntity:29358] ATP [nucleoplasm] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9777527] Update Tracker - [Pathway:9630794] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 - v70:[updateContainedRLE]
[UpdateTracker:9777531] Update Tracker - [Pathway:4086398] Ca2+ pathway - v70:[updateContainedRLE]
[UpdateTracker:9900766] Update Tracker - [Complex:5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900673] Update Tracker - [DefinedSet:390959] HTR1B,D,E,F,HTR5A [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900836] Update Tracker - [Complex:6802674] mutant RAS:inactive BRAF:RAF1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900792] Update Tracker - [Complex:6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900811] Update Tracker - [Complex:1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777586] Update Tracker - [Pathway:1280215] Cytokine Signaling in Immune system - v70:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900801] Update Tracker - [DefinedSet:8863990] NRGs/EGFLs:p-ERBB4:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900641] Update Tracker - [EntityWithAccessionedSequence:5444512] MLH1 H329P [nucleoplasm] - v70:[addName]
[UpdateTracker:9900709] Update Tracker - [SimpleEntity:1130844] NADH [cytoplasm] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900764] Update Tracker - [EntityWithAccessionedSequence:5444526] MLH1 S252* [nucleoplasm] - v70:[addName]
[UpdateTracker:9900882] Update Tracker - [SimpleEntity:427523] NAD+ [nucleoplasm] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900650] Update Tracker - [SimpleEntity:352330] NAD+ [extracellular region] - v70:[add_removeReferenceEntity]
[UpdateTracker:9777628] Update Tracker - [BlackBoxEvent:3209111] Translation of p14ARF mRNA is inhibited by miR-24 - v70:[add_removeOutput]
[UpdateTracker:9777591] Update Tracker - [Reaction:1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. - v70:[modifyText]
[UpdateTracker:9900681] Update Tracker - [Complex:6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777509] Update Tracker - [Pathway:68877] Mitotic Prometaphase - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777514] Update Tracker - [Pathway:5674135] MAP2K and MAPK activation - v70:[updateContainedRLE]
[UpdateTracker:9900876] Update Tracker - [Complex:6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900756] Update Tracker - [Complex:9632904] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900657] Update Tracker - [EntityWithAccessionedSequence:5632980] PMS2 R628* [nucleoplasm] - v70:[addName]
[UpdateTracker:9777617] Update Tracker - [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers - v70:[addRegulator, modifyText]
[UpdateTracker:9900885] Update Tracker - [Complex:6802611] RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900682] Update Tracker - [SimpleEntity:1132064] NAD+ [cytoplasm] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900624] Update Tracker - [DefinedSet:975326] HTR3 pentamers [plasma membrane] - v70:[modifyName, removeHasMember]
[UpdateTracker:9900873] Update Tracker - [EntityWithAccessionedSequence:9632588] p16INK4A E88* [cytosol] - v70:[addHasModifiedResidue]
[UpdateTracker:9777625] Update Tracker - [Pathway:196741] Cobalamin (Cbl, vitamin B12) transport and metabolism - v70:[updateContainedRLE]
[UpdateTracker:9900731] Update Tracker - [SimpleEntity:211606] ADP [endoplasmic reticulum membrane] - v70:[addName, add_removeReferenceEntity]
[UpdateTracker:9900723] Update Tracker - [Complex:9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900859] Update Tracker - [Complex:9625181] LAMP2a multimer complex:GFAP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777621] Update Tracker - [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput]
[UpdateTracker:9777620] Update Tracker - [Pathway:2559583] Cellular Senescence - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900675] Update Tracker - [EntityWithAccessionedSequence:6802347] NRAS G12S [plasma membrane] - v70:[modifyName]
[UpdateTracker:9777584] Update Tracker - [Pathway:9006934] Signaling by Receptor Tyrosine Kinases - v70:[updateIndirectRLE]
[UpdateTracker:9900881] Update Tracker - [SimpleEntity:194653] NAD+ [endoplasmic reticulum lumen] - v70:[add_removeReferenceEntity]
[UpdateTracker:9900843] Update Tracker - [Complex:9620204] HSPA8:Substrate:LAMP2a [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777564] Update Tracker - [BlackBoxEvent:5229111] AP4 transports APP from trans-Golgi network to endosome lumen - v70:[addCatalystActivity, modifyText]
[UpdateTracker:9900679] Update Tracker - [DefinedSet:1250325] p-ERBB4cyt1 [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900749] Update Tracker - [EntityWithAccessionedSequence:6802343] HRAS G12S [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900653] Update Tracker - [EntityWithAccessionedSequence:6802374] BRAF G466E [cytosol] - v70:[modifyName]
[UpdateTracker:9777585] Update Tracker - [Pathway:9632700] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 - v70:[updateContainedRLE]
[UpdateTracker:9777627] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v70:[modifyText]
[UpdateTracker:9900739] Update Tracker - [CandidateSet:2400011] PI3K mutants,Activator:PI3K [plasma membrane] - v70:[updateContainedMemberOrCandidate]
[UpdateTracker:9900737] Update Tracker - [EntityWithAccessionedSequence:5632954] MSH6 L222* [nucleoplasm] - v70:[addName]
[UpdateTracker:9900648] Update Tracker - [EntityWithAccessionedSequence:6802446] NRAS Q61K [plasma membrane] - v70:[modifyName]
[UpdateTracker:9900700] Update Tracker - [Complex:5693284] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900636] Update Tracker - [Complex:1963590] p-ERBB2 heterodimers:MATK [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777568] Update Tracker - [Pathway:446652] Interleukin-1 family signaling - v70:[updateIndirectRLE]
[UpdateTracker:9777619] Update Tracker - [Pathway:68886] M Phase - v70:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9900638] Update Tracker - [Complex:5675413] p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] - v70:[updateContainedComponent]
[UpdateTracker:9900815] Update Tracker - [EntityWithAccessionedSequence:6802491] BRAF V600E;V47_D380del [cytosol] - v70:[modifyName]
[UpdateTracker:9900633] Update Tracker - [Complex:2168846] Hemoglobin beta:ferriheme b [extracellular region] - v70:[add_removeHasComponent]
[UpdateTracker:9777536] Update Tracker - [Reaction:1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut - v70:[modifyText]
[UpdateTracker:9777610] Update Tracker - [Pathway:194002] Glucocorticoid biosynthesis - v70:[addHasEvent]
[UpdateTracker:9900768] Update Tracker - [DefinedSet:9615715] Substrates for chaperone mediated autophagy [cytosol] - v70:[addHasMember]
[UpdateTracker:9900810] Update Tracker - [Complex:5675700] MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] - v70:[updateContainedComponent]
[UpdateTracker:9777530] Update Tracker - [Pathway:196071] Metabolism of steroid hormones - v70:[updateContainedPathway]

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